16 results about "Artificial tissue" patented technology

The invention provides an egg white-sourced protein-based biological hydrogel as well as a preparation method and application thereof. The method comprises the following steps: separating and purifying ovomucoid in egg white by adopting an ethanol fractional precipitation method, and accurately controlling the final concentration of ethanol in a system in two ethanol precipitation processes, so that the final concentration a of ethanol in the system in the primary ethanol precipitation process and the final concentration b of ethanol in the system in the secondary ethanol precipitation process meet the condition that a is greater than or equal to 40 vol% and less than or equal to 62%; other miscellaneous proteins, salts and other small molecular impurities in the egg white can be removed, and the ovomucoid is efficiently separated and purified from the egg white; the modified ovomucoid obtained by covalently modifying the ovomucoid separated and purified by the method by using a modifier has the rheological characteristics of rapid crosslinking, shear thinning and the like, and can form the protein-based biological hydrogel under the action of a photoinitiator. The rapid prototyping and mechanical properties of the hydrogel are met, and the hydrogel has a wide application prospect in preparation of 3D biological printing materials, 4D biological printing materials, artificial organs, artificial tissues and dressings.

Systems and methods for determining spontaneous behavior of engineered tissues are described herein. In one example aspect, a waveform may be obtained that includes a functional response of an engineered tissue over a period of time. A frequency-based global classifier may be applied to the waveform to generate a first classification score, where the first classification score indicates whether the waveform includes periodic constrictions of the engineered tissue over the time period. When the first classification score indicates that periodic contraction does not exist within the waveform, a local classifier may be applied to the waveform, thereby generating a second classification score. The second classification score indicates whether the waveform includes spontaneous constriction of the engineered tissue over the time period. A behavioral feature may then be generated for the engineered tissue during the time period based on the second classification score.

An artificial tissue includes: a first layer that is made of a conductive material and is provided on a front surface side of the artificial tissue, the first layer having a front surface portion and a side surface portion; a second layer that is made of a conductive material and is provided on a back surface side of the first layer, the second layer having a front surface and a side surface; and a support layer that supports the first layer and the second layer from a back surface side of the artificial tissue, in which the front surface portion of the first layer covers the front surface of the second layer, and the side surface portion of the first layer covers the side surface of the second layer.

Provided is a highly safe articular cartilage regeneration material. This articular cartilage regeneration material contains: a scaffold-free artificial tissue in which synovial-derived mesenchymal stem cells cultured with a serum-free medium form a three-dimensional structure; and an extracellular matrix derived from mesenchymal stem cells. The articular cartilage regeneration material is implanted so as to be attached to a site of lost or damaged articular cartilage.

Systems and methods for processing functional response waveforms obtained from artificial tissue are described herein. In one example aspect, the systems and methods include obtaining a first waveform including a systolic response and a relaxation response of artificial tissue during a systolic-relaxation cycle. A model is then fitted to the first waveform, wherein the model independently parameterizes the growth of the contraction response and the relaxation response. A second waveform is then generated from the model fitted to the first waveform such that the second waveform includes a noise filtered representation of the first waveform. Feature values may then be extracted from the second waveform, which feature values may be used for noise filtering and to achieve a high fidelity and high capacity synthetic training dataset to develop artificial intelligence (AI) or otherwise for downstream tasks, such as drug discovery and development.

Systems and methods for geometric coding of tissue phenotypes are described herein. In at least some aspects, the systems and methods include obtaining images of artificial tissue under a first set of conditions. The system and method further includes extracting a first region from the image such that the first region defines the artificial tissue within the image. The systems and methods further include extracting one or more geometric features from the first region, wherein the one or more geometric features provide a shape-based characterization of the artificial tissue. The systems and methods further include generating a first tissue descriptor based on the one or more geometric features. The first tissue descriptor may encode a phenotype of the artificial tissue under the first set of conditions. Still further, in some aspects, the systems and methods may include implementing quality control (QC) of artificial tissue.

Systems and methods for detecting spontaneous tissue contraction are described herein. In one example aspect, a functional response waveform may be processed that includes obtaining a first waveform that includes at least one contraction response and at least one relaxation response of engineered tissue. A predicted contraction type may be determined for a plurality of contraction types (e.g., a single type and a dual type) of the first waveform. A model may be fitted to the first waveform based on the predicted contraction type, wherein the model parameterizes a growth of at least one contraction response of the engineered tissue independently of a growth of at least one relaxation response of the engineered tissue. A second waveform may be generated from the model fitted to the first waveform such that the second waveform includes a noise filtered representation of the first waveform.

The invention relates to a fully disposable system for casting, polymerizing and compressing a hydrogel. The invention further relates to a method for producing a scaffold for the generation of artificial tissue products using said disposable system.

Systems and methods for detecting spontaneous tissue contraction are described herein. In one exemplary embodiment, a functional response waveform may be processed, including obtaining a first waveform that includes at least one contraction response and at least one relaxation response of the manipulated tissue. A predicted contraction type may be determined from among a plurality of contraction types (e.g., single and dual types) for the first waveform. A model may be fitted to the first waveform based on the predicted contraction type, and the model parameterizes the growth of at least one contraction response of the manipulated tissue independently of the growth of at least one relaxation response of the manipulated tissue. A second waveform may be generated from the model fitted to the first waveform such that the second waveform includes a noise-filtered representation of the first waveform.

Systems and methods for modeling contraction deflection of a flexible tissue scaffold are disclosed herein. The systems and methods include obtaining images of a flexible stent at a plurality of points in time, wherein the flexible stent is depicted to deflect along a first dimension due to contraction forces exerted thereon at the plurality of points in time. Curves are fitted to the images such that each curve extends along a centerline of the flexible stent within the respective image. Displacement values are determined from the curves that provide measurements along the first dimension between respective curves and a reference line extending along a second dimension perpendicular to the first dimension. A model may then be generated based on the displacement values. The model characterizes contraction forces exerted on the flexible stent over the plurality of points in time.

The purpose of the present invention is to provide tendon / ligament-like artificial tissues with sufficient strength. The present invention provides tendon / ligament-like artificial tissues having sufficient strength, by embedding mesodermal stem cells, mesenchymal stem cells, or such in a gel having strength to withstand tension loading, and culturing the cells while applying tension loading to the gel and while adding cells and gel. Human iPS cells, tissue stem cells, or such can be used for mesodermal and mesenchymal stem cells, and such.

This application relates to pre-assembled bioprosthetic valves and sealing catheters. The valved catheter includes a bioprosthetic valve, such as a heart valve, and a tubular catheter sealed with a bioresorbable material. The bioprosthetic heart valve comprises artificial tissue that has been treated to allow for long-term dry storage without valvular functional decline. The bioprosthetic heart valve may have independent bovine pericardial leaflets or a whole porcine valve. The sealing catheter includes a tubular matrix impregnated with a bioresorbable medium such as gelatin or collagen. The valved catheter is stored dry in an encapsulation material, wherein a desiccant bag is provided with a limited capacity to absorb moisture from the encapsulation material to prevent the bioprosthetic tissue from drying beyond a point that would impair its usability as a bioprosthetic heart valve. The heart valve may be sutured within the sealing catheter or coupled to the sealing catheter via a snap-fit ​​connection.

A system and method for determining the spontaneous behavior of manipulated tissue are described herein. In one exemplary embodiment, a waveform containing the functional response of manipulated tissue over a period of time may be obtained. A frequency-based global classifier may be applied to the waveform to generate a first classification score, which indicates whether the waveform contains periodic contractions of the manipulated tissue over the period. If the first classification score indicates that periodic contractions are not present in the waveform, a local classifier may be applied to the waveform to generate a second classification score, which indicates whether the waveform contains spontaneous contractions of the manipulated tissue over the period. Then, based on the second classification score, a behavioral profile of the manipulated tissue over the period can be generated.

The invention provides a bioactivity artificial tissue mediated bionic robot autonomous energy supply method, and belongs to the crossing field of synthetic biology and micro-robot technology. The artificial biological tissue is of a three-layer coaxial spiral splicing-free integrated structure, sequentially comprises a power shrinkage layer, a coupling power generation layer and a bionic current collection layer from inside to outside, is formed through a micro-scale 3D forming and interface fusion process, is free of metal components, has the core volume smaller than or equal to 0.5 cm and the weight smaller than or equal to 5 g and has the functions of mechanical shrinkage, biological power generation and electric signal conduction. A special low-viscosity energy liquid is matched, the pH is 7.2-7.4, the viscosity is smaller than or equal to 5 mPas, energy is supplied through permeation of the spiral gap micro-channel, and the endurance of single supplement is larger than or equal to 48 h. The biological self-powered robot integrates the integrated tissue and the special energy liquid, solves the problems of high energy loss, poor biocompatibility and limited microminiaturization of the existing equipment, and can be widely applied to the scenes of medical minimally invasive implantation, micro space inspection, unmanned environment monitoring and the like.

The invention relates to a fully disposable system for casting, polymerizing and compressing a hydrogel. The invention further relates to a method for producing a scaffold for the generation of artificial tissue products using said disposable system.

Provided is a highly safe method for treating articular cartilage. This method for treating articular cartilage comprises a step for introducing a scaffold-free artificial tissue in which serum-free cultured synovial membrane-derived mesenchymal stem cells form a three-dimensional structure.