60results about How to "Promote tissue repair" patented technology

A product for implantation within a soft tissue site of the human or animal body comprises a pulverized or morselized matrix of a substantially non-mineralized native soft tissue (NSTM) of the human or animal body, provided in a therapeutic amount to induce growth of native tissue or organs and healing at the tissue site. The NSTM is composed of at least one soft tissue selected from the group consisting of cartilage, meniscus, intervertebral disc, ligament, tendon, muscle, fascia, periosteum, pericardium, perichondrium, skin, nerve, blood vessels, and heart valves or from organs such as bladder, lung, kidney, liver, pancreas, thyroid, or thymus. Preferably, the NSTM is composed of a soft tissue of the same type of tissue native to the repair site. In another embodiment, the NSTM includes soft tissue of a different type than the tissue repair site.

The current invention provides a method for mobilising endothelial progenitor cells (EPC) and/or mesenchymal stem cells (MSC) in a patient, wherein the method comprises the steps of (i) administering a vascular endothelial growth factor receptor (VEGFR) agonist to the patient; and (ii) administering an antagonist of CXCR4 to the patient. Also provided are uses of EPC and MSC harvested using the methods of the invention.

Disclosed herein are compositions and methods for the improved delivery of cells to a target tissue. In some embodiments, the compositions comprise stem cells, in particular cardiac stem cells, and the target tissue is damaged or diseased cardiac tissue. In several embodiments, the methods, in combination with the compositions, yield enhanced delivery, retention, and/or engraftment of the cells into the target tissue, thereby inducing improved functional recovery.

The invention relates to a nerve growth factor sponginum and a preparation method thereof, belonging to the technical field of medicine. The sponginum comprises nerve growth factor with weight percent content being 0.01-2% and collagen sponge or gelatin sponge matrix, the nerve growth factor is fixed on the collagen sponge or gelatin sponge matrix in a crosslinking way by an aldehydes crosslinker. The sponginum can cause the nerve growth factor to be released to the nerve pathology or wound tissue partial position continuously for a long time in effective dose, and play a role in effectively curing nerve tissue damage.

A medical and recreational devise comprises at least two laminas. The laminas comprises sources of magnetic field. The sources of the magnetic field located on one of the laminas faced to another one completely or partially by like and/or unlike magnetic poles, and at least one of said laminas are congruent to a treated part of body and attached to the treated part of body. A method of using said medical and recreational devise comprises the step: attached at least one of said laminas to the treated part of body, attached to lower or upper extremity to unload the affected extremity, and attached another set of said laminas to a bed parallel to the first one. The magnets embedded in said laminas attached to an affected part of the extremity faced to like poles to the magnets embedded to said laminas attached to the bed.

The invention provides a wound repair composition. A formula of the wound repair composition comprises the following components in percentage by weight: 10-50 percent of chitosan mucilage, 10-50 percent of an extracting solution of a staphylococcus aureus metabolic product and 0-80 percent of medicament auxiliary materials, wherein the chitosan mucilage is a solution consisting of chitosan and an aqueous solution of an acid; the volume concentration of the acid in the aqueous solution of the acid is 0.8-1.2 percent; and the mass concentration of the chitosan in the chitosan mucilage is 1-3 percent. The invention further provides a preparation method of the wound repair composition and an application thereof as a medicament for treating skin or mucosal injure. The wound repair composition provided by the invention has the advantages of capabilities of promoting tissue repair, promoting wound healing and promoting the growth of epidermal cells, good infection inhibiting effect, high biocompatibility, realization of flat healed wounds, freeness from adverse side reactions, relieving in patient pain, convenience for nursing and using, easiness for storing, and the like.

Described are tissue graft constructs that include submucosa and other extracellular matrix materials that incorporate a number of exogenous proteins. Further described are methods for making tissue graft constructs that include stripping endogenous heparin binding proteins from a porcine graft material and thereafter binding one or more human growth factors to the native heparin molecules that are retained within the graft material. Such graft materials may be used in methods for the treatment of wounds in patients.

The invention discloses activated carbon infusion solution, preparation method therefore and use thereof for the manufacture of drug for treating cancer. The activated carbon infusion solution contains pure activated carbon microparticles injection solution, activated carbon microparticles injection solution, activated carbon injection solution adsorbing catalyst and various injection solutions carrying drugs, all of which are for intravenous use. It characterizes that the surface area of material activated carbon used is greater than or equal to 400-10000 M²/g or higher, heavy metal content is less than or equal to 0.1-10 ppm, other dissoluble metal ion content is less than or equal to 0.1-10 ppm, crozzle is less than 2%, total pore cubage is greater than 0.3-6 cm²/g, 0.15% methylene blue adsorptive value is greater than 6-30, the diameter of the activated carbon microparticles contained in this activated carbon infusion solution are ranged from 35 μm to 2 nm, the diameters are mainly ranged from 6 μm to 3 μm are not more than 1%, the microparticles which greatest diameter is 35 μm to 6 μm have not more than 2×10⁴/mg activated carbon micropowder. When this activated carbon microparticles are intravenously injected into blood, they have good compatibility with tissues, have no toxicity or side effect, have no harmful stimulation, have no immunogenicity, they are safe and effective. They have incredible curative effect in treating cancer, blood vessels, atherosclerosis, coronary heart disease, cerebral thrombosis, infectious diseases, azotemia, acute organic and inorganic poison poisoning.

The invention concerns antimicrobial compositions comprising free fatty acids emulsified with membrane lipids or hydrolysed derivatives thereof, and pharmaceutical formulations comprising same. The compositions can be used in the treatment of prophylaxis of microbial infections. They can also regulate the rate of blood clotting rendering them suitable for incorporation in catheter locking solutions and for use in wound care.

A polypeptide, a DNA molecule encoding the polypeptide, a vector, a preparation method and a use therefor are disclosed. The polypeptide comprises an amino acid sequence represented by formula (I) or formula (II): formula (I) comprises an amino acid sequence represented by SEQ ID NO: 1; formula (II) comprises an amino acid sequence obtained by subjecting the amino acid sequence represented by SEQ ID NO: 1 to modification, substituted, and deletion or addition of one or more amino acids. The polypeptide may be used in the preparation of drugs that treat or prevent diseases related to infections caused by bacteria, and can also be used in the preparation of drugs that promote tissue repair and wound healing.

The invention discloses recombinant ternary fusion collagen and its application, belonging to the field of genetic engineering. The recombinant ternary fusion collagen includes recombinant human-like collagen and new lactobionic acid with a mass ratio of 25-35%; the recombinant human-like collagen is formed by fusing human-like collagen with 3GF growth factor, which includes A first region with at least 80% sequence homology of human-like collagen and a second region with at least 80% sequence homology with each human cell growth factor, and a connecting peptide is arranged between the first region and the second region. Compared with the traditional human-like collagen, it is easier to be absorbed by the human body. The fusion collagen provided by the present invention is absorbed faster and more thoroughly. At the same time, it can also promote human metabolism, wound healing and tissue repair, yellowing, skin rejuvenation, and improvement Melasma, freckles and other pigmentation, wrinkles and skin tone effect, is a breakthrough new fusion collagen with comprehensive effects.

A biocompatible scaffold is provided that includes a biocompatible scaffold substrate and an amount of a demethylation agent or a methylation inhibitor, in an amount effective to induce and/or promote tissue repair and regeneration. The demethylation agent or methylation inhibitor can be a cytidine analog. The scaffold can further include an effective amount of one or more of a target specific growth factor, a cytokine, a signaling molecule or a pharmaceutically acceptable carrier. The scaffold can be constructed of a natural or non-natural material; one alternative is a gel formed by the catalytic activity of transglutaminase.

Described are methods and compositions for treatment of reproductive or urogenital mucosal tissue damage using Extracellular Matrix (ECM) solution and, particularly, Extracellular Matrix Hydrogel (ECMH) solution delivered to the target site for tissue repair, restoration, remodeling, or reconstruction.

The present disclosure relates to the technical field of medical equipment and discloses an anastomotic/occlusion reinforcing and repairing composite member which includes a reinforcing and repairing portion, a protection portion and a connecting thread, wherein two ends of the reinforcing and repairing portion are detachably connected by the connecting thread; and the protection portion penetrates into a space enclosed by the two ends of the reinforcing and repairing portion. The present disclosure also provides a preparation and application method of the anastomotic/occlusion reinforcing and repairing composite member.

The invention relates to a microballons/nanometer yarn composite bracket loaded with exosomes and growth factors and a preparation method of the microballons/nanometer yarn composite bracket. The composite bracket is prepared by that the microballons are adhered to the surface of nanometer yarn, wherein the nanometer yarn is nanometer yarn adopting a core/shell structure; and the microballons arepolylactic acid glycolic acid copolymer microballons of which the inner parts are loaded with fibroblast growth factors. The microballons/nanometer yarn composite bracket disclosed by the invention has high stretch mechanical property and excellent biocompatibility; the structure of the nanometer yarn has larger aperture; tissue repair can be promoted by the exosomes loaded by a fiber core layer,and three-dimensional infiltration of urinary tract relevant cells is facilitated; and the microballons can release fibroblast growth factors, so that the microballons/nanometer yarn composite bracketcan be applied to fields of tissue engineering urethra and the like.

The invention discloses a method for preparing a tissue engineering scaffold with an anisotropic pore structure. The method comprises the following steps of: placing polymer solution and porogen into specific equipment; performing heat exchange of subzones by using a plurality of temperature zones and the polymer solution, and precisely controlling the temperature change curves and the heat exchange directions of the polymer solution and the porogen; and fixing the phase separation degree, removing the porogen and solvent and drying. The method can realize precise and controllable anisotropism of the pore structure inside the scaffold by performing the precise and controllable heat exchange of the subzones on the prepared polymer scaffold so as to meet the requirements of tissue engineering application and improve the repairing effect. In addition, the invention also discloses equipment for implementing the method.

The invention provides a degradable toothbrush main material with a self-cleaning function. The toothbrush main material is prepared by the following steps of mixing chitosan, a radix notoginseng extract, a honeysuckle extract, carboxymethyl chitosan, a nanomaterial, biotin, lysine and collagen to prepare a mixed solution; adding a degradable resin material, and carrying out a cross-linking reaction under the action of a cross-linking agent to prepare a textile material; adding polybutylene terephthalate, a lubricant, an antioxidant and polyethylene glycol 200, and performing fusing, dissolving, extruding and cooling to obtain textile particles; and carrying out electrostatic spinning. According to the invention, nanoparticles are adopted to cooperate with the radix notoginseng extract andthe honeysuckle extract, so that the plasticity and elasticity of the material are enhanced, and the self-cleaning, bacteriostasis and efficient decontamination effects of the toothbrush main material are realized; and therefore, the toothbrush main material ensures the oral health of people and is suitable for commercial popularization.

The invention provides a small needle knife composed of a needle knife handle, a needle knife body and a needle knife blade connected one by one. The needle knife handle is in the shape of a horse shoe. A cylindrical needle knife tail is arranged on the tail end of the needle knife handle. When the needle knife is used, the cylindrical needle knife tail arranged at the front end of the needle knife handle allows a moxa cone to be installed on the needle knife tail for heating when the needle knife is retained in vitro partially, so that through thermal conduction, the amount of bleeding is reduced after the needle knife cuts tissues, aseptic inflammation of the diseased tissues is eliminated, muscle spasms at parts attached to bones are eliminated and relieved, and thus tissue adhesion can be more effectively loosened and softened. Meanwhile, the needle knife can warm channels and relax collaterals, and improve tissue repair of wounded parts. The needle knife can reduce the pain of patients, and integrates the treatment functions of a needle knife and a silver needle, so that the medical costs of the patients can be reduced. The design of the horse-shoe-shaped needle knife handle reduces the area of the needle knife handle and the weight of the needle knife tail, so that the needle knife body is prevented from tilting due to overweight of the needle knife tail, and the needle knife is very convenient for use.