350results about How to "Convenient induction" patented technology

An apparatus for delivering a bioactive material to a subterranean layer of a skin architecture is provided that includes a head including one or more needles that are operable to penetrate a stratum corneum of a skin. A bioactive material is disposed on one or more of the needles, whereby movement of the head operates to pick up the bioactive material and to deliver a portion of the bioactive material to a selected location, the selected location being a dermis, or an epidermis, or both the dermis and the epidermis. In more particular embodiments, the bioactive material is a macromolecule substance that is part of a group of substances, the group consisting of a protein, a vitamin, a gene, a growth agent, a drug, and a peptide. The needles create an injury that triggers collagen production from one or more fibroblasts in the skin.

The subject invention provides novel soluble PD-1 (sPD-1) proteins, nucleic acids, and fusion constructs thereof, for enhancing humoral and cell-mediated immunity of a subject. Also provided are therapeutic compositions comprising the sPD-1 proteins, nucleic acids, and fusion constructs of the subject invention. In a preferred embodiment, the therapeutic composition is formulated as a vaccine composition. Advantageously, the sPD-1 proteins, nucleic acids, and therapeutic compositions provide protective immunity against pathogenic infection including HIV infection. In additon, the subject invention can be used in the prevention and/or treatment of tumor or cancer.

The invention provides a method for planning a path of a lift object for a crane. The method comprises the following steps of: projecting an obstacle on a working plane of the crane; performing polar radius-oriented processing on the projection and transforming a coordinate expression form of the obstacle into a polar coordinate expression form; analyzing the obstacle which is positioned on the path of the lift object to ensure that the lift object can pass through the path; and determining a lifting path according to a lifting principle. By the method for planning the path of the lift object for the crane, distances among obstacles can be calculated quickly and efficiently, the planned lifting path can be searched precisely, and the lifting safety and reliability of the lift object can be improved.

The present invention relates to a novel system for generating transformed dihaploid corn plants. In particular, the invention relates to the production of haploid corn callus, transformation of that tissue, dihaploidization, and regeneration of transgenic plants. Transgenic dihaploid corn plants can then be easily produced.

A pot, having a bottom and a continuous sidewall, defining a fluid or substance containing space therein. The pot further includes a plurality of fins extending along the bottom exterior surface of the pot, in various configurations, but preferably in a series of raised, curved arms that radiate out from the center of the pot and terminate at its outer edge, defining a plurality of spaces between each radiating arm. This configuration of raised, radiating arms along the exterior bottom wall of the pot increase the surface area of the bottom of the pot and absorbs the heat from the gas burner into the pot, thereby increasing the heating performance of the liquid or substance being heated therein. There may be further provided small mounds or waves on the interior bottom of the pot for further increasing the surface of the pot interior, which helps channel the heat in a circular motion, and helps induction of heat into the substance. A second embodiment includes a plurality of metal dowel members secured to the bottom of a container to absorb the heat from the gas burner into the pot, thereby increasing the heating performance of the liquid or substance being heated therein.

The invention belongs to the technical fields of immunology and tumor therapy, and relates to a preparation method and a use of a TCR gene modified CD8+T memory stem cell. The method comprises the following steps: co-incubating a tumor antigen and an immature dendritic cell to obtain a specific tumor antigen-supported mature dendritic cell, co-culturing the specific tumor antigen-supported maturedendritic cell and a CD8+ naive T cell, and adding a stem cell differentiation inhibitor to promote the generation of a CD8+ stem cell-like memory T lymphocyte; separating the CD8+ stem cell-like memory T lymphocyte; and cloning a T cell receptor gene (TCR) for specifically identifying a specific antigenic epitope, and carrying out lentivirus packaging or retroviral vector cotransfection on an autologous CD8+ Tscm cell to in-vitro prepare a CD8+ TCR-Tscm cell specific for different tumor specific antigens. The CD8+ TCR-Tscm cell prepared by the method has the advantages of overcoming of the tumor heterogeneity, high specificity, few adverse reactions, and highly-efficient and lasting tumor preventing and treating effects.

A semiconductor device is fabricated having a metal stress inducing layer that facilitates channel mobility. A gate dielectric layer is formed over a semiconductor substrate. The metal stress inducing layer is formed over the gate dielectric layer. The metal stress inducing layer has a selected conductivity type and is formed and composed to yield a select stress amount and type. A gate layer, such as a polysilicon layer, is formed over the metal stress inducing layer. The gate layer and the metal stress inducing layer are patterned to define gate structures.

The invention belongs to the field of artificial intelligence of a computer application technology, relates to an application of a swarm intelligence optimization method of an intelligence optimization algorithm, and particularly relates to a traffic flow forecasting method for an intelligent traffic system. A mixed artificial fish swarm optimization support vector regression method is applied to traffic flow forecasting. The construction process of the mixed optimization method is characterized in that a particle swarm algorithm is applied to improve the behavior selection of the artificial fish swarm algorithm aiming at the problem that the effect of a step-length factor in the artificial fish swarm algorithm on the algorithm is insufficient to reduce the step-length effect, then the support vector regression is optimized to conduct parameter selection to further build a mixed artificial fish swarm optimization traffic flow forecasting model. The method has the advantages of being capable of overcoming the shortcomings of the artificial fish swarm algorithm, acquires better combination regression parameters compared with the single swarm intelligence optimization algorithm application, and improves the traffic flow forecasting accuracy accordingly. The mixed optimization method is applicable to actual traffic flow predication and other engineering optimization.

The invention relates to an application of femto-second laser in the surface treatment of the pure titanium implanting material, belonging to the technical field of application of laser in the material surface treatment. The application method comprises the following steps: in the air, the femto-laser impulse is in normal incidence and focused right on the top of the lump pure titanium implanting material which is ground and dried, a light spot with a radius of 5um is formed at the surface of the pure titanium implanting material, the femto-laser processing parameters are defined as follows: the impulse repeat frequency is 1 kHz, the single impulse power is from 5 to 200 micro joule, the impulse width is 50 femtosecond, the impulse center wavelength is 800 nanometer, the line interval of the laser processing is between 10 to 100 micron, the laser scanning speed is between 0.5 to 1.2 mm/sec, the laser polarization direction is regulated to be parallel to the laser scanning direction, the femto-laser scans the whole surface of the pure titanium implanting material, a titanium based biomedical material with an oxide layer generated on the titanium surface, even roughness, and a pattern of strips, holes, grooves or the combined pattern thereof formed on the pure titanium implanting material is made.

A conveyor system for receiving corn cobs with husks still attached thereto after harvesting of the corn from the cobs, and detaching the husks from the cobs, including a conveyor inclined at an angle of at least about 30 degrees and bounding a passage for receiving a flow of the cobs including the husks attached thereto, the conveyor including apparatus configured and operable for mechanically grasping and detaching the husks from the cobs and pulling the detached husks through the conveyor, and at least one blower configured and operable for urging the husks within the passage toward the apparatus. The conveyor system can be provided in connection with a cob collection device, such as on a trailer to be towed by a harvester. The conveyor system can also include an additional conveyor or conveyors, optionally including apparatus for removing or cleaning crop residue from the cobs.

The invention belongs to the field of plant tissue cultivation, and particularly relates to a method of cutting propagation of a peony immature stem. The method includes the steps of material selection, cutting cultivation, indoor management, oversummer maintenance, overwinter management and strong seedling cultivation. By using low-frequency ultrasonic waves to conduct processing, rooting can be promoted, plant cell division can be remarkably accelerated and induced, the cell growth is stimulated, protein synthesis of protoplast can be accelerated, and the adventitious bud reproducibility can be improved. Due to the fact that intermittent irradiation is adopted, no drastic cavitation effect can be produced, and partial damage to cells caused by the ultrasonic waves can be avoided. Due to the fact that cultivation and rooting are conducted in the dark cultivation process, growth inhibitor is greatly reduced, and rooting is facilitated. The complete and specific method including the steps of oversummer maintenance, auxiliary bud inducing, overwinter management and strong seedling cultication is provided, and therefore application of the peony rapid cutting propagation technology in actual production is promoted, and the method has significance in large-scale production of peony seedlings.

The invention discloses a HA (hydroxylapatite) micro-nano whisker reinforced calcium phosphate ceramic material which is characterized by using calcium phosphate as a material matrix phase and mixing hydroxyapatite (HA) micro-nano whisker as a reinforcing phase for improving material mechanical properties. The preparation process is as follows: respectively synthesizing a calcium phosphate matrix phase precursor powder material and a hydroxyapatite micro-nano whisker reinforced phase material; then doping 3 ~ 10% of the hydroxyapatite micro-nano whisker to composite into ceramic body powder for preparing a porous ceramic body, finally calcining by a muffle furnace to obtain the reinforced porous bioactive calcium phosphate ceramic. Biological materials are a calcium phosphate component and a hydroxyapatite component which have similar chemical compositions with natural bones, the ceramic has excellent bioactivity due to a finely specially made porous structure, the mechanical properties of the ceramic are reinforced by doping of the micro-nano hydroxyapatite whisker, and the porous ceramic used as a bone repair material has the excellent bioactivity and good mechanical properties and has a wide application prospect in clinical departments of orthopedics.

The invention discloses a method for breeding chamomile. The method disclosed by the invention comprises the following steps: (1) inoculating chamomile seeds onto a seed germination culture medium to carry out sterile seedling cultivation so as to produce sterile seedlings; (2) taking hypocotyls of the sterile seedlings as explants, inoculating the explants onto a callus induction culture medium to carry out callus induction culture so as to generate calluses by virtue of induction; (3) inoculating the calluses generated by induction onto an adventitious bud differentiation culture medium to carry out adventitious bud induction differentiation culture so as to obtain adventitious buds; (4) inoculating the adventitious buds onto a rooting culture medium to carry out rooting culture and culturing adventitious roots by virtue of induction so as to obtain rooted seedlings; and (5) hardening and transplanting the rooted seedlings so as to finally obtain the chamomile. In a regeneration system established by the method disclosed by the invention, callus inductivity reaches up to 86.63%, differentiation rate of the adventitious buds reaches up to 25.5%, rooting rate reaches up to 100%, and transplanting survival rate reaches up to 100%, thus a large number of excellent chamomile test-tube plantlets can be obtained in short term so as to realize large-scale factory production.

The invention discloses an intelligent industry patrol mining instrument, a patrol mining system and an intelligent patrol mining method based on radio frequency identification, wherein, the intelligent industry patrol mining instrument comprises memory modules, interface modules, clock modules and a microprocessor CPU of a display and touch screen circuit; the CPU is connected with a frequency identification circuit module through a voltage conversion circuit; the frequency identification circuit module can identify corresponding radio frequency electronic tags pasted on the equipment to be treated with patrolled mining. The intelligent patrol mining system comprises an upper management system and n intelligent industry patrol mining instruments and equipment groups to be treated with patrol mining; each machine of the equipment groups to be treated with patrol mining is pasted with a radio frequency electronic label; the upper management system is provided with an upper management machine and a database server for managing and scheduling the whole patrol mining task, information data of storing equipment groups and historical patrol mining data; the intelligent patrol mining instrument integrates with patrol mining software system and matches with the upper management system software of the upper management machine and the database server to finish the industry patrol mining task.

The present invention relates to the use of 3-dimensional (3D) synthetic or animal-derived bioscaffolds as substrates for the improved growth and differentiation of hPS (Human pluripotent stem cells); these scaffolds being adapted for use in conjunction with existing cell culture lab plastic-ware. More specifically, it relates to the seeding of these scaffolds, either alone or in conjunction with various biologic matrix coatings, with hPS cells for the improved differentiation of said hPS cells into hepatocyte or hepatocyte-like cell types. The invention also relates to the seeding of partially-differentiated hepatocyte progenitors onto scaffolds for further differentiation into more mature hepatocyte-cell types.

A magnetic core extends in a longitudinal direction and contains at least one stacking of sheets consisting of magnetic material and stacked in a direction of stacking perpendicular to the longitudinal direction, at least one plate of heat-conducting material, presenting first and second opposing faces, and at least one cooling tube positioned in contact with the said first face of the plate in which a heat-bearing fluid is designed to circulate. The plate extends in a plane parallel to the longitudinal direction and to the direction of stacking, its second face being positioned in thermal contact with the sheets in the stacking.

The invention discloses a primary fir wood culture bud induction method. The method comprises the following steps: inoculating an explant as a coppice shoot of a fir wood base part and subjected to sterile explant treatment to a bud induction culture medium subjected to high-quality primary culture, culturing under the conditions of proper temperature, humidity and illumination intensity, and inducing bud germination. The conventional fir wood induction technology is improved, the problems that the explant is subjected to browning and vitrifaction in the fir wood bud induction process and the like are solved, the fir wood bud induction rate, the budding index and the germination and growth conditions are improved, and large-number high-quality buds are obtained, so that the multiplication culture requirement is met, the establishment of a rapid fir wood tissue culture reproductive system is promoted, and the method has high economic benefits and social benefits.

The invention relates to an efficient and rapid propagation technology suitable for southern highbush blueberry. Excellent culture seedlings are obtained by the following steps of a. selecting materials; b, carrying out primary culture to obtain aseptic seedlings; c, optimizing subculture; d, establishing a leaf regeneration system; and e, carrying out rooting culture of tub seedlings. According to the technology, young stems of O'Neil blueberries are used as test materials, a proliferation medium, the leaf regeneration system, a rooting medium and a plantlet medium are optimized, the optimum proliferation culture, the leaf regeneration and the rooting culture are combined, and an efficient seedling survival medium is added, so that excellent tissue culture seedlings can be obtained efficiently, rapidly and continuously.

The invention discloses a traffic operation state sensing method and system based on multi-source data fusion. The method comprises the following steps: acquiring mobile traffic data; obtaining structured first traffic state data from the mobile traffic data; acquiring fixed traffic data; obtaining structured second traffic state data from the fixed traffic data; fusing the first traffic state data and the second traffic state data to obtain target traffic operation state data; obtaining structured road network data from the map data; and matching the position data of the target traffic operation state data with the position data in the road network data to obtain the traffic operation state of the road network. According to the technical scheme provided by the invention, the comprehensiveand accurate traffic operation state in the road network can be obtained, the traffic control and guidance are facilitated, and the traffic passing efficiency in the road network is improved.

The invention discloses a method for preparing a medicine graded sustained-release bone repair body. The method comprises the following steps of: reconstructing a natural cancellous bone micro-computed tomography (micro-CT) scanned image to obtain a three-dimensional model by using Mimics software, and taking positions with uniform pore distribution as stent inner layer and outer layer matrix models through Boolean operation; designing inner layer and outer layer negative models of which the shapes are matched with those of the matrix models by using Magics software, and preparing through fused deposition modeling; and preparing slurry mixed with different medicines, grouting inner layer and outer layer stent matrixes, preparing a stent by a freeze drying process, and thus obtaining a finished bone repair body product. The bone repair body prepared by the method can meet the requirement of a stent material on structural strength and can be loaded with various medicines, the controlled release of the medicines is realized, a sustained-release effect is achieved, and bone repair is well induced and promoted.

The invention relates to the area of medicinal chemistry, pharmacology and medicine and includes description of pharmaceutical compositions and combined medicaments on the base of secretion stimulators and protectors of incretin hormones for treatment of metabolic diseases (among them, diabetes, obesity, metabolic syndrome and the like). The invention consists in that that pharmaceutical composition or combined medicament comprises a derivative of tetrahydrobenzo[f][1,4]oxazepine—either nonsteroidal agonist of bile aids receptor TGR5, or one of endogenous bile acids which stimulate incretin hormones secretion, and also one of the known inhibitors of DPP-IV proteinase. In this case administration of TGR5 agonists is carried out peroral, and administration of endogenous bile acids is exercised rectal in the form of suppository or gel. As proteinase DPP-IV inhibitors could be used Vildagliptin, Saxagliptin, Sitagliptin, Teneligliptin, Linagliptin, Dutogliptin, Alogliptin, Gemigliptin, Carmegliptin and the like. Besides, the invention includes description of novel tetrahydrobenzo[f][1,4]oxazepine derivatives—nonsteroidal agonist of bile aids receptors TGR5, and also methods for their preparation. The invention provides enhancement of therapy effectiveness owing to synergetic action of the components, thus making possible simultaneous treatment of diabetes, and obesity, other metabolic diseases and their cardiovascular and renal complications.

The invention discloses a fish breeding device convenient to clean. The fish breeding device comprises a first breeding pond, a circulation pump and water turbines; heaters are fixedly installed at the lower end of the first breeding pond, and a first drainage pipe penetrates through the lower portion of the surface of the right end of the first breeding pond; a rotating roller is installed in a fixing block, the right end of a connecting shaft penetrates through the fixing block and is connected with a first motor, and the first breeding pond is internally provided with a collecting box; thelower end of a first filtering plate tightly fits a second filtering plate, and support legs are fixedly installed at the front and rear portions of the upper end of the first breeding pond. Accordingto the fish breeding device convenient to clean, the spaces for activities and feeding are separated, breeding ponds are conveniently cleaned and subjected to slag removal, the spreading range of a feeding device is uniform, it can be ensured that fishes of different sizes and body shapes uniformly feed, a screening and automatic fishing device for mature fishes and a temperature and light environment control device are arranged, and the activities of the fishes are better induced.