148 results about "Nitroso" patented technology

The invention discloses a fermentation process for shortening a fermentation period and efficiently synthesizing Ectoine. The fermentation process comprises the following steps: screening and activating high-yield strains, preparing a fermentation culture medium, performing fermentation culture, performing sectional dissolved oxygen regulation and control, performing double-stage pH dynamic regulation and control, performing carbon-nitrogen ratio dynamic regulation based on metabolic flow analysis, performing osmotic pressure gradient induction in the later stage of fermentation, and extracting and purifying a product. According to the fermentation process for shortening the fermentation period and efficiently synthesizing the Ectoin, the expression quantity of key enzymes for synthesizing the Ectoin is increased by 80% or above compared with that of an original strain through the Halomonassp.ECT-09 strain bred through ultraviolet-nitrosoguanidine compound mutation, the basic yield reaches 35 g / L, a foundation is laid for high yield, and the method is suitable for industrial production. A glucose-trehalose mixed carbon source and a yeast extract-ammonium nitrate mixed nitrogen source are adopted, and an L-aspartic acid-L-asparagine mixed precursor is added, so that the metabolic pathway is shortened, and the loss of an intermediate product is reduced.

The invention provides a UPLC-MS / MS (Ultra Performance Liquid Chromatography-Mass Spectrometry / Mass Spectrometry) detection method for N-nitroso landiolol in a landiolol hydrochloride bulk drug. The method comprises the step of carrying out qualitative detection or quantitative analysis on a potential nitrosamine impurity-N-nitroso landiolol in a landiolol hydrochloride bulk drug by adopting an ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS / MS), wherein the structural formula of the N-nitroso landiolol is shown as a formula I in the specification. The detection method disclosed by the invention is high in sensitivity, strong in specificity and good in repeatability, can be used for rapidly and effectively detecting N-nitroso landiolol in the landiolol hydrochloride bulk drug, and has important significance on quality control of the landiolol hydrochloride bulk drug. ; formula I.

This application relates to a rifapentine-containing pharmaceutical composition and its preparation method. The rifapentine-containing granules are prepared by dry granulation, which reduces the content of impurities present in existing pharmaceutical compositions, especially the content of the genotoxic impurity 1-cyclopentan-4-nitrosopiperazine, thereby improving the safety and efficacy of the drug.

The invention provides a sterile, injectable pharmaceutical composition which includes a therapeutically effective amount of ketamine or a pharmaceutically acceptable salt thereof, a nitrite scavenger, a tonicity agent, and water, wherein the composition contains less than about 300 ppb of an N-nitrosoketamine impurity. The invention also provides a pharmaceutical product which includes a container and the composition of the invention aseptically sealed therein. The invention further provides a process for preparing the composition and product of the invention.

The invention discloses a detection method of vitamin K1, and belongs to the technical field of biological detection. The problems that a vitamin K1 detection method is tedious in operation, prone to being influenced by a matrix, low in sensitivity and the like are solved. The detection method comprises the following steps: (1) preparing a standard substance intermediate working solution, an isotope internal standard substance solution and a standard curve working solution of the vitamin K1; (2) treating a serum sample and a standard curve working solution: adding a 2-nitroso pyridine solution to carry out derivatization reaction; and (3) detecting the vitamin K1 by using a high performance liquid chromatography-tandem mass spectrometry method. According to the method, the 2-nitroso pyridine is used as a derivatization reagent, the vitamin K1 and the 2-nitroso pyridine are subjected to a Diels-Alder reaction to generate a new six-membered heterocycle containing N and O, the 2-nitroso pyridine can efficiently and completely react with the vitamin K1 in only 10 minutes at room temperature, the detection steps are simplified, the sample pretreatment time is shortened, and the detection efficiency is improved.

The invention provides a method for continuously and efficiently synthesizing 2, 6-diamino piperazine-1-oxide, which comprises the following steps: S1, preparing an N-nitroso iminodiacetonitrile solution at room temperature, and stirring and dissolving for 5 minutes; s2, sequentially adding hydroxylamine salt and alkali into a solvent, stirring at room temperature for 10-15 minutes for pre-dissolving, adding a proper amount of metal salt catalyst into the obtained solution, and continuously stirring for 5-10 minutes; s3, exhausting the continuous tubular reactor by using a hydroxylamine solution until the continuous tubular reactor is full of the solution; s4, feeding the N-nitrosoiminodiacetonitrile solution and the hydroxylamine solution into a continuous tubular reactor through a mixer according to a certain proportion by adopting a delivery pump, and optimizing the flow velocity and temperature of the reaction solution and the pressure in the continuous tubular reactor; and S5, enabling the reaction liquid to flow out from an outlet of the continuous tubular reactor, performing suction filtration, washing a filter cake with an alcoholic solution, and drying. The method can obviously improve the reaction rate, reduce the generation of impurities and improve the production efficiency.

The invention relates to a method for reducing harmful components in cigarette smoke by using food-grade cyclodextrin metal organic framework materials, which is characterized in that two food-grade cyclodextrin metal organic framework materials CD-MOFs are added into cigarette filters for reducing the harmful components in the cigarette smoke. The unique pore structure and rich hydroxyl functional sites of the gamma-cyclodextrin-KOH and the beta-cyclodextrin-KOH are utilized to efficiently adsorb various harmful components in the mainstream smoke of the cigarette. Compared with a control group without any adsorbent and a control group with only activated carbon as the adsorbent, the CD-MOFs has efficient capturing capability on harmful gases such as carbon monoxide, nitrosonicotine, ammonia gas, benzo [a] pyrene and phenol in the cigarette smoke, and can obviously reduce the cigarette hazard index. The two materials are simple in preparation process, high in cost benefit and good in chemical stability, are food-grade porous materials and have incomparable practical application potential compared with traditional non-food-grade porous materials, and an effective solution is provided for developing novel low-harm cigarette products.

The invention provides a preparation method of high-purity nicotine. The content of nitroso substances in an obtained nicotine finished product is lower than the PPB level, and the content of single heavy metals such as lead, cadmium, mercury and hexavalent chromium is also lower than the PPB level. The low-content nitroso substance concentration and heavy metal concentration can effectively reduce the harm of the synthesized nicotine to the human body, and the method provided by the invention can realize continuous industrial production of nicotine, and fills the blank of the demand of the market for high-purity L-nicotine.

This invention relates to the field of organic synthesis technology, specifically to a method for preparing aryltriazene; comprising the following steps: (1) preparing an aromatic nitroso compound Ar 1 NO is dissolved in the first solvent in the first ratio to obtain solution A; (2) unsymmetrical disubstituted hydrazine R 1 R 2 NNH2 is dissolved in the second solvent in the second ratio to obtain solution B; (3) under stirring, solution A and solution B are mixed and subjected to dehydration condensation reaction for 1-4 hours, and the reaction temperature of dehydration condensation is 10-40℃; after the reaction is completed, aromatic triazine is obtained by separation and purification; the first solvent and the second solvent are aprotic solvents; Ar 1 It is any of the substituted or unsubstituted phenyl, heterocyclic aryl, and fused-ring aryl groups, and the substituents on the ring do not react with hydrazine; R 1 R 2 It is at least one of alkyl and aryl groups. This preparation method is simple to synthesize, produces no unstable diazonium salt intermediates, has mild reaction conditions, and a relatively fast reaction rate.

The application discloses a hydroxylamine hydrochloride detection method in azithromycin dry suspension, and relates to the trace detection field. The method uses isoamyl aldehyde as a derivatizing agent, generates isoamyl aldoxime by performing derivatization treatment on a sample to be measured, and then uses N-nitrosodiisopropylamine as an internal standard substance to quantitatively determine the isoamyl aldoxime by using liquid chromatography-tandem mass spectrometry. The detection method adopts an isoamyl aldehyde derivatizing agent-N-nitrosodiisopropylamine internal standard substance system, can correct detection errors caused by factors such as matrix effect, pretreatment loss and derivatization efficiency fluctuation, and improves the accuracy and sensitivity of the trace hydroxylamine hydrochloride detection result, thereby guaranteeing the safety of the medicine.

This invention provides a nitric oxide generating device and a method for manufacturing the same. [Solution] In an exemplary method, a solution is introduced into the lumen of a nitric oxide permeable polymer object. The solution contains a solvent and S-nitroso-1-adamantanethol dissolved in the solvent. The solution is immersed in the lumen of the nitric oxide permeable polymer object for a maximum of 12 hours. The solution is then removed from the lumen of the nitric oxide permeable polymer object.

The invention discloses a method for preparing p-trifluoromethoxyphenol by adopting a micro-channel reactor, and belongs to the field of fine chemical engineering. 4-trifluoromethoxyaniline and dilute sulphuric acid are pumped into the first micro-channel reactor for a reaction; then introducing inert gas, pumping the nitroso sulfuric acid solution, and carrying out diazotization reaction to obtain a diazonium salt solution; pumping the diazonium salt solution into a second micro-channel reactor, carrying out hydrolysis reaction, adding dichloroethane extract liquor into a rectifying tower after the reaction is ended, and rectifying to obtain p-trifluoromethoxyphenol; porous baffles which are inclined downwards are arranged on the inner wall of the rectifying tower in a crossed manner; a heat-conducting filler layer of 50-100 nm is arranged on the porous baffle plate; the heat-conducting filler layer is a three-dimensional net-shaped material layer which is formed by boron nitride nanosheets / titanium oxide nanorods and has a porous structure. The method is simple in process route, convenient to operate, high in controllability, high in safety, high in reaction efficiency, high in product yield, capable of effectively reducing the solid waste amount in production, energy-saving, environment-friendly and suitable for industrial production.

Systems and methods are provided for non-invasive measurement of endogenous S-nitrosothiols and related measurements thereof. One or more sensors non-invasively measures a set of one or more biometric parameters within a region of interest of a subject to provide a time series of measurements for each of the set of biometric parameters. A medium stores machine-readable instructions that are executable by an associated processor to perform processing comprising receiving the time series of measurements of the biometric parameter, generating, using a predictive model, a value representing an endogenous S-nitrosothiol content of tissue within the region of interest from the time series of measurements of the biometric parameter, and providing, by a user interface, the value representing the endogenous S-nitrosothiol content of tissue within the region of interest to a user.

This invention belongs to the field of biomedical materials and nanotechnology, specifically relating to the synthesis and application of a multifunctional mesoporous nanomaterial. The inventors synthesized a core-shell structured mesoporous nanoparticle using mesoporous silica nanoparticles and dopamine via emulsion epitaxy. The core of the core-shell structured mesoporous nanoparticle is S-nitrosoglutathione supported on mesoporous silica, and the outer shell is pentafluorophenyl chlorophyll supported on mesoporous polydopamine, forming MSN / G@mPDA / F nanoparticles. These nanoparticles rapidly increase in temperature to 45°C under 808 nm laser irradiation. o At temperatures above a certain temperature, S-nitrosoglutathione decomposes to produce nitric oxide. Further irradiation at 750 nm generates a large amount of reactive oxygen species, killing bacteria. This combination of photothermal and photodynamic therapy effectively inhibits bacterial growth. Therefore, this method exhibits excellent antibacterial effects and can play a role in the future treatment of bacterial infections.

In an embodiment, there is provided a varenicline formulation consisting essentially of about 0.85% varenicline tartrate and greater than 1.75% to about 3.0% propyl gallate, wherein the formulation maintains a level of N-nitrosovarenicline (NNV) impurity over the shelf-life of the formulation of not more than 18.5 ppm (37 ng / day) of acceptable daily intake (ADI). In another embodiment, there is provided a varenicline formulation comprising a tablet core comprising about 0.85% varenicline tartrate, about 60.50% microcrystalline cellulose, about 33.33% dibasic calcium phosphate anhydrous, about 2.00% croscarmellose sodium, about 2.57% propyl gallate, and about 0.75% magnesium stearate; and a film coating.

A method includes mixing a liquid carrier and a powder formulation including an S-nitrosothiol (RSNO) powder to form a nitric oxide generating solution; and within a predetermined time of mixing, introducing the nitric oxide generating solution into an inflatable and nitric oxide permeable balloon of a urinary catheter that is inserted in a patient.

The application provides application and synthesis of a water-based polyurethane composition in an environmentally-friendly product capable of long-term air tightness. The composition is used in products that need long-term inflation pressure maintaining and are environmentally-friendly and non-toxic; the long-term inflation pressure maintaining air tightness of the product is that, after being sealed, the product is filled with helium to the size of a mold in a constant temperature and humidity environment (25 DEG C, 50% humidity), the size is maintained for more than 90% of time for greater than or equal to 7*24h; the N-nitroso content in the product is 0-0.5mg / kg. The synthesis method is as follows: a low-boiling-point organic solvent is added to an isocyanate-terminated prepolymer, a dibasic amine chain extender is added, a neutralizing agent is added after chain extension, water dispersion is added under high-speed shearing, the water-based polyurethane coarse emulsion is obtained after the end, and the low-boiling-point organic solvent is removed. The product has excellent long-term air tightness, is environmentally-friendly and non-toxic, and can meet the application requirements in high-performance products with excellent long-term air tightness, environmental friendliness and non-toxicity.

The invention relates to the technical field of compound preparation, in particular to a preparation method of a compound N-nitrosoperindopril. The method specifically comprises the following steps: S1, selecting a first chemical which is prepared from an initial raw material and has the HPLC detection purity of more than or equal to 99.0%, dissolving the first chemical in water, stirring, dissolving, and cooling to obtain a first mixture; s2, adding acid into the first solution to obtain a second mixture; s3, nitrite is added into the second mixture in batches and stirred, white solids are separated out after dissolving clarification, and a third mixture is obtained; s4, after the interior of the third mixture is completely reacted, multiple times of extraction is conducted through dichloromethane, drying and concentration are conducted, and the off-white solid N-nitrosoperindopril is obtained.According to the preparation method of the compound N-nitrosoperindopril, the blank that no standard substance is sold in the market and no literature is used for synthesis report is filled, and the preparation method is suitable for large-scale popularization and application of the compound N-nitrosoperindopril. And help is provided for ensuring that the safety and the quality of medicine products are not influenced.

The application relates to the technical field of pharmaceutical preparations, and particularly discloses a propranolol hydrochloride tablet with low N-nitrosopropylol impurity content and a preparation method thereof. The propranolol hydrochloride tablet with low N-nitrosopropylol impurity content comprises the following components in parts by weight: 0.2-0.3 parts of propranolol hydrochloride, 2.0-2.3 parts of mannitol, 0.2-0.3 parts of glycerin behenate and 0.05-0.1 parts of magnesium stearate. In the application, mannitol, glycerin behenate and magnesium stearate are used as excipients, the mannitol, the glycerin behenate and the magnesium stearate all have high fluidity, and the glycerin behenate has lubricating and excipient effects, so that the compression of the tablets is facilitated.

To provide a photosensitive resin composition capable of realizing a photosensitive resin layer excellent in desired properties (particularly, sensitivity, resolution, and adhesion). 【Solution means】A photosensitive resin composition containing the following components: (A) an alkali-soluble polymer; (B) a compound having an ethylenically unsaturated bond; (C) a polymerization initiator; and (D) a polymerization inhibitor, wherein the content of component (C) is 3.5% by mass or more based on the total solid content of the photosensitive resin composition, and component (D) is represented by the following general formula (I): JPEG2026060536000018.jpg2250 [In formula (I), R 1 represents a hydrocarbon group which may have a substituent, NHR 4 or NR 4 R 5 where R 4 and R 5 each independently represent a hydrocarbon group which may have a substituent.], a photosensitive resin composition containing a compound having a nitroso structure.

This invention belongs to the field of analytical detection technology and discloses an analytical method for detecting N-nitrosobaricitinib impurities in baricitinib tablets. The method includes solution preparation and detection steps: blank, 0.9 ng / ml reference standard, and test sample solutions are prepared using a 40%–60% acetonitrile aqueous solution as a diluent; an Agilent Poroshell 120 EC-C18 column is used with 0.1% formic acid-methanol gradient elution; mass spectrometry is performed using an AJS ESI ion source in MRM scanning mode; and the content is calculated using the external standard method. This method is simple to operate, rapid in analysis, highly specific, highly sensitive (detection limit 4.30 ppb), and exhibits excellent precision, accuracy, and linearity. It can accurately quantify target impurities, providing reliable technical support for the quality control of baricitinib tablets.

This invention relates to a purity standard for N-nitrosonornicotinamide (NNN), its preparation method, and its uses. The N-nitrosonornicotinamide (NNN) purity standard of this invention has a yellow, oily appearance and a density of 1.3 ± 0.1 g / cm³. 3 The sample is sealed in brown sample vials and has a purity of 99.35%. The purity standard material of this invention has high purity, accurate and traceable values, good homogeneity, and good stability.

The invention belongs to the technical field of biological medicine, and particularly relates to a nanometer drug delivery system with a tumor deep penetration effect and a preparation method and application of the nanometer drug delivery system. The polylactic acid-glycolic acid nano-particles are polylactic acid-glycolic acid copolymer nano-particles entrapped with chemotherapeutic drugs and carbon monoxide donors; the chemotherapeutic drug is monomethyl aurestatin E, and the carbon monoxide donor is S-nitroso-N-acetyl-DL-penicillamine; a lipid layer; the core is coated with the core; the targeting polypeptide is modified on the surface of the lipid layer; the targeting polypeptide is an R4F polypeptide; tumor cells are actively targeted through R4F polypeptide, the polylactic acid-glycolic acid copolymer nanoparticles wrapped by a lipid layer deeply penetrate into tumor tissues, nitric oxide is released through a carbon monoxide donor to degrade an extracellular matrix barrier, and deep penetration of loaded chemotherapeutic drugs and immune cells in the tumor tissues is synergistically promoted; the nano drug delivery system provided by the invention can be applied to preparation of drugs for treating solid tumors and delivery of drugs for targeting extracellular matrixes of the solid tumors.

The invention provides a nitrite quantitative detection method based on surface enhanced Raman spectroscopy, relates to the technical field of surface enhanced Raman spectroscopy, and constructs a self-correcting SERS substrate through a three-phase liquid-liquid interface co-assembly technology. In the experiment process, a sample to be detected is mixed with a thiobarbituric acid solution, the mixture is adjusted to be acidic, NO2 <-> and thiobarbituric acid are subjected to an S-nitrosation reaction, and S-nitroso mercaptan is generated. And then, immersing the self-correcting SERS substrate into a reaction solution, so that the substrate adsorbs the generated S-nitroso mercaptan, and further, a Raman signal is enhanced. After soaking is completed, the substrate is taken out and dried, finally, a Raman signal is collected through a Raman spectrometer, and the concentration of NO2 <-> is accurately analyzed through the change of the signal intensity. According to the technical scheme, rapid and high-sensitivity detection of NO2 <-> is achieved, good selectivity and anti-interference capacity are achieved, and the method is widely suitable for detection requirements of multiple fields such as environment monitoring and food safety.

This invention relates to the production of nickel tetracarbonyl and cobalt tricarbonyl nitrosyl from mixed metal hydroxide precipitate (MHP) comprising nickel, cobalt, and manganese.

This invention provides an alkali-generating agent and a curable resin composition that exhibit excellent storage stability in a liquid, high catalytic activity at the desired curing temperature, and induce a curing reaction in a short time. An alkali-generating agent comprises a pyridinium cation and an anionic residue of an organic or inorganic acid, and is represented by the following formula (a). (In formula (a), A represents a divalent hydrocarbon group with 1 to 8 carbon atoms that may contain heteroatoms; R1 to R5 independently represent hydrogen atoms or electron-donating groups; R1 and R2, R2 and R3, R3 and R4, and R4 and R5 can be bonded to form a ring structure. R6 to R5...) 10 Each of the following groups independently represents a hydrogen atom, halogen atom, hydroxyl group, alkoxy group, mercapto group, sulfide group, silyl group, silanol group, nitro group, nitroso group, cyano group, sulfinic acid group, sulfonyl group, sulfonic acid group, phosphono group, oxophosphono group, phosphonyl group, phosphonate group, amino group, or ammonium group, R6 and R7, R7 and R8, R8 and R9, R9 and R 10 They can be bonded separately to form a ring structure.

This invention discloses a bifunctional catalyst, its preparation method, and its applications. The preparation method includes: firstly, loading alumina onto SBA-15 via impregnation, followed by drying and calcination to obtain a composite support Al2O3-SBA-15; then, loading the noble metal Rh onto the composite support using a precipitation deposition method, followed by solid-liquid separation, washing, drying, calcination, and reduction treatment to obtain the Rh / Al2O3-SBA-15 bifunctional catalyst. In the catalyst prepared by this invention, the modification with Al2O3 enhances the metal-support interaction, improving the dispersion and stability of Rh. The catalyst of this invention exhibits excellent bifunctional catalytic performance, capable of efficiently catalyzing the hydrolysis of ammonia borane to produce hydrogen, and effectively reducing N-nitrosodimethylamine in water using in-situ generated hydrogen, achieving an integrated treatment process of "in-situ hydrogen production-simultaneous reduction." The preparation process of this invention is simple, convenient to operate, and operates under mild reaction conditions. The obtained catalyst has broad application prospects in the field of ammonia borane-assisted water pollutant treatment.

This application relates to the field of denitrification technology, and discloses a denitrification device for nitrifying sulfuric acid and a flue gas acid production system. The denitrification device includes: a denitrification reactor, which includes: a denitrification reactor body, which is provided with a nitrifying sulfuric acid inlet, a sulfur dioxide inlet, and a waste gas outlet, and the denitrification reactor body defines a reaction space; the reaction space is used to carry out a denitrification reaction on a mixture including nitrifying sulfuric acid and sulfur dioxide to remove nitrosylsulfuric acid from the nitrifying sulfuric acid to obtain first sulfuric acid, wherein the mass concentration of sulfuric acid in the mixture is 93% to 98%; a heater is disposed inside the denitrification reactor body for heating the mixture. Using this denitrification device to treat nitrifying sulfuric acid is low-cost and environmentally friendly.

Provided are a base generator, a curable resin composition, and a printed wiring board, which have excellent storage stability in a one-component form and exhibit high catalytic activity at a desired curing temperature to cause a curing reaction in a short time. A base generator represented by the following formula (a), which comprises an imidazolium cation and an anion residue of an organic acid or an inorganic acid. [Formula 1] TIFF0007819427000026.tif22170In formula (a), A represents a divalent group of 1 to 8 carbon atoms which may contain a heteroatom, R1 to R4 each independently represent a hydrogen atom, an alkyl group of 1 to 8 carbon atoms which may have a substituent, an aryl group of 6 to 20 carbon atoms which may have a substituent, or an alkylaryl group of 7 to 20 carbon atoms which may have a substituent, and R1 and R2, R2 and R3, and R3 and R4 may each bond to form a ring structure. R5 to R9 each independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms which may have a substituent, a halogen atom, a hydroxyl group, an alkoxy group, a mercapto group, a sulfide group, a silyl group, a silanol group, a nitro group, a nitroso group, a cyano group, a sulfino group, a sulfo group, a sulfonato group, a phosphino group, a phosphinyl group, a phosphono group, a phosphonato group, an amino group, or an ammonio group, and R5 and R6, R6 and R7, R7 and R8, and R8 and R9 may each bond to form a ring structure. - is the anionic residue of an organic or inorganic acid.