503 results about "Vitamin k" patented technology

Vitamin K is effective in counteracting cardiovascular disorders such as the reduction in arterial elasticity normally associated with the aging process. A pharmaceutical composition or nutritional formulation comprising vitamin K can be used to combat age-related stiffening of the arteries, and the consequences thereof, namely pulmonary congestion, hypertension, left ventricular hypertrophy, congestive (right sided) heart failure, left sided or left ventricular failure, chronic cardiac failure, angina pectoris, myocardial infarction, Mönckeberg's sclerosis and stroke. In various embodiments, vitamin K can also be used to reduce or reverse calcification of a blood vessel in pre-existing cardiovascular disorders such as arteriosclerosis.

The invention provides feed for improving growth performances of broiler chickens. The feed comprises a main feed ingredient, bone meal, rapeseed meal, monocalcium phosphate, vitamin E, vitamin K, pantothenic acid, lysine, methionine, threonine, sodium butanoate, enzyme additives, probiotics additives, microelement additives and Chinese medicinal herb additives. The feed can well solve the problem that the feed digestion capability of the broiler chickens is poor, effectively controls pathogenic microorganisms, promotes digestion and immunity of the broiler chickens in the growing process, improves growth performances of the broiler chickens, reduces morbidity and mortality of the broiler chickens and reduces medicine residue rate of antibiotics and chemical synthesis medicines in the broiler chickens.

Methods of treating, preventing or suppressing symptoms associated with mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), dominant optic atrophy (DOA); mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), Leigh syndrome or Kearns-Sayre Syndrome (KSS) with vitamin K are disclosed.

The invention provides a nano nutrient microemulsion and a preparation method thereof. The nano nutrient microemulsion comprises active components, auxiliary materials and a solvent, wherein the active components comprise vitamins and amino acid, and the auxiliary materials comprise an emulsifier and an assistant emulsifier. According to parts by weight, the active components particularly comprise 5-50 parts of vitamin A, 1-10 parts of vitamin D3, 1-10 parts of vitamin E, 1-5 parts of vitamin B1, 1-5 parts of vitamin B 6, 0.01-0.5 part of vitamin B12, 1-10 parts of vitamin C, 1-10 parts of vitamin K, 1-10 parts of D-calcium pantothenate, 0.5-5.0 parts of L-lysine, 0.5-5.0 parts of DL-methionine and 0.5-5.0 parts of L-arginine. The invention further provides the preparation method for the nano nutrient microemulsion, which prepares the oil-in-water microemulsion by uniformly mixing an oil phase with an aqueous phase. With stable thermodynamic property, high bioavailability, simple preparation method and easy operation, the nano nutrient microemulsion can be widely used in such industries as feed, cosmetics, medicine, beverages, health care products and the like.

The invention discloses formula milk powder assisting development of height of children. The formula milk powder consists of the following components of raw milk or whole milk powder, desalinated wheypowder, skimmed milk powder, solid corn syrup ( or maltodextrin ), whey protein powder, crystallized fructose, vegetable oil, fructo-oligosaccharide, anhydrous butter, galactooligosaccharide, docosa-hexaenoic, bovine coloctrum powder, milk mineral salt, hydrolyzed dried egg yolk, lactoferrin, phosphatide, vitamin A, vitamin D, vitamin E, vitamin K, vitamin B1, vitamin B2, vitamin B6, vitamin B12,vitamin C, magnesium, calcium, iron, zinc, selenium and the like. According to the formula milk powder assisting the development of the height of the children and a production method disclosed by theinvention, the products have the characteristics of ''supplementing, promoting and improving'', namely supplementing nutrition required by growth and development of Chinese children, promoting absorption of key nutrition for the development of the height, and improving immunity of the children, so that the height of the Chinese children is assisted to quickly grow.

A skin care active complex in accordance with an embodiment of the invention comprises a combination of (1) from about 0.001% to about 10% by weight, preferably from about 0.001% to about 5% by weight, of a vitamin A derivative; (2) from about 0.00001% to about 10% by weight of a hydroxamate derivative; (3) from about 0.01% to about 5% by weight of an anti-inflammatory natural compound; and optionally, (1) from about 0.001% to about 10% by weight of vitamin K.

The invention provides feed for improving the digestive and immunologic ability of chicken, which comprises a feed carrier, choline chloride, lysine hydrochloride, phenylalanine dihydrochloride, pantothenic acid, clostridium butyricum, lactobacillus plantarum, sodium butyrate, stone powder, folic acid, riboflavin, vitamin E, vitamin K, glucolase, amylase, sodium selenate, magnesium sulfate and a Chinese herbal medicine composition additive. The feed has the beneficial effect that a digestion system and an immune system of the chicken can be improved, so that the feeding management and epidemic prevention works during the brooding period are better improved.

To provide medicinal compositions containing an active ingredient which has a low molecular weight, is free from any side effects and has an effect of potentiating nerve growth factor activity and utilization thereof for treating diseases associated with dementia, medicinal preparations containing an effective amount of vitamin K and/or its derivative showing an effect of potentiating nerve growth factor activity are provided.

The invention discloses a fine feed for rhizomys in a rearing period. The fine feed comprises the following raw materials in percentage by weight: 20%-42% of corn, 12%-18% of soybean meal, 30%-50% of rice bran, 10%-23% of bran, 1%-3% of fish meal, 2% of calcium hydrophosphate, 0.5% of stone dust, 1% of common salt and 1% of premix. One kilogram of premix provides 88 million IU (international units) of VA (vitamin A), 60,000 IU of VE (vitamin E), 325 million IU of VD (vitamin D), 310g of VK (vitamin K), 110g of VB (vitamin B), 220g of VB, 65g of VB, 1220g of VB, 50g of pantothenic acid, 10g of nicotinic acid, 800mg of folic acid, 10g of biotin, 30g of Lys (lysine), 60g of Met (methionine), 30g of potassium, sodium, zinc and the like, and 30g of VC (vitamin C); and the main nutritional levels of the obtained fine feed are that the digestible energy is 2.85-3.01 Mcal/kg, and crude protein is 15.52%-18.07%. The fine feed disclosed by the invention can meet the nutritional requirements of the rhizomys sinensis in the rearing period, has a reasonable formula, and can ensure the rapid growth, robust physique, low disease incidence and low mortality rate of the rhizomys.

The present invention relates to a host organism containing recombinant nucleic acids coding for the vitamin K reductase complex subunit 1 (VKORC1) and recombinant nucleic acids coding for a vitamin K dependent (VKD) protein, wherein both the recombinant VKORC1 and the recombinant VKD protein are expressed in said host organism. Further, the present invention relates to a cell culture system comprising cells which contain said recombinant nucleic acids and to methods for improving the productivity of recombinant VKD protein expression in a host organism being cultured in suitable systems.

The invention provides a process for preparing a composition of vitamins and minerals, which contains the following components in each 1,000 tablets: 1 to 5 x 10<6>IU of vitamin A, 0 to 2 grams of beta-carotene, 0.75 to 4 x 10<5>IU of vitamin D, 0 to 30 milligrams of vitamin K, 0.5 to 5 grams of vitamin B1, 0.5 to 5 grams of vitamin B2, 0.25 to 1 gram of vitamin B6, 0.5 to 2 milligrams of vitamin B12, 25 to 100 grams of vitamin C, 0 to 0.4 grams of folic acid, 0 to 30 milligrams of biotin, 5 to 15 grams of vitamin E, 5 to 15 grams of nicotinamide, 2.5 to 10 grams of calcium pantothenate, 0 to 50 grams of heavy choline bitartrate, 0 to 100 milligrams of iodine, 0 to 25 grams of L-lysine salt, 0 to 50 grams of inositol, 5 to 10 grams of potassium, 5 to 15 grams of iron, 0.5 to 1 grams of copper, 0 to 50 milligrams of selenium, 0 to 120 grams of magnesium, 0 to 2 grams of manganese, 0.25 to 15 grams of zinc, 0 to 20 milligrams of chromium, 0 to 25 milligrams of molybdenum, 163 to 558 grams of bicalcium phosphate, 0 to 600 grams of calcium carbonate, 50 to 100 grams of starch, 30 to 60 grams of lactose, 100 to 200 grams of microcrystalline cellulose, 20 to 50 grams of dextrin, 15 to 50 grams of cross-linked sodium carboxymethyl cellulose, 0 to 30 grams of low substituted hydroxypropyl cellulose, 8 to 16 grams of tartaric acid, 5 to 20 grams of talcum powder, 8 to 12 grams of superfine silica gel powder, and 6 to 10 grams of magnesium stearate. The process is characterized in that the vitamin C adopts powder coating, and the coating material is methyl acrylate copolymer, preferably a mixture of a methacrylic acid/ethyl acrylate (1 to 1) copolymer and an ethyl acrylate/methyl methacrylate (2 to 1) copolymer, wherien the weight ratio of mixture is between 1 to 4 and 4 to 1. The composition of the vitamins and the minerals has simple preparation process and convenient operation, and can improve the stability of the vitamins.

The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.

The invention of this application relates to compositions and methods for the treatment and/or prevention of osteoporosis; improving and/or enhancing bone formation; and prevention and/or reducing bone mineral density loss. More particularly, the invention relates to a composition comprising vitamin K, in any form and betacryptoxanthin. A further aspect of this invention is a composition comprising vitamin K, in any form, betacryptoxanthin, and/or vitamin D and/or calcium.

The invention belongs to the field of feed premixes, and especially relates to a weaning sow health-care premix and a producing method thereof. The premix is characterized by comprising the following components: lysine sulphate, methionine, tryptophan, threonine, arginine, folic acid, vitamin E, carotene, vitamin B6, vitamin B2, vitamin K, biotin, biotin C, niacin, selenium yeast, chromium yeast, soy isoflavones, nucleotide, betaine, sweetener, flavoring agent, ball-milled mixture of rice chaff and husk, and the like. The premix disclosed by the invention is applied to weaning sows, and can quickly restore the body conditions of sows, effectively shorten the estrous interval of weaning sows, promote the oestrus of sows, improve the conception rate of sow mating, and increase the litter size of sows.

The invention discloses fruit and vegetable health-care flour which is prepared from raw materials in parts by weight as follows: 50-60 parts of barley, 30-40 parts of sticky rice, 30-35 parts of wheat starch, 15-20 parts of white sesame seeds, 20-25 parts of loofahs, 15-20 parts of Chinese yam, 20-30 parts of figs, 25-30 parts of lotus roots, 15-20 parts of dried longan, 30-40 parts of grape wine, 12-18 parts of black fungi, 9-11 parts of osmanthus fragrans, 2-3 parts of ginkgo leaves, 1-2 parts of Chinese wolfberries, 1-2 parts of prepared rehmannia roots, 2-3 parts of honey flowers, 1-2 parts of a food additive and an appropriate amount of water. According to the flour, barley, sticky rice, wheat starch and the like are taken as main raw materials and have the efficacy of relieving thirst, removing heat toxin, tonifying qi, regulating middle energizer, nourishing consumptive disease, tonifying spleen, nourishing stomach and stopping abnormal sweating. Besides, added loofahs have the efficacy of resisting scurvy, strengthening brain, resisting virus and allergy, curing nasosinusitis and sphagitis, beautifying features, resisting aging and the like. Figs are rich in various substances such as dietary fiber, calcium, copper, magnesium, manganese, potassium and vitamin K which are beneficial to human bodies, contain various antioxidants, flavone and polyphenol and have the efficacy of tonifying spleen, nourishing stomach and lubricating intestines.

The invention discloses premixed feed for improving the growth speed and the nutrient substance digestion rate of minks at a breeding period. The premixed feed per one kilogram comprises the following raw material components: 265g-300g of corn protein powder, 15g-20g of compound vitamin B, 25g-35g of a complex enzyme preparation, 250000-300000 IU of vitamin A, 12g-15g of vitamin C, 2000-2500 IU of vitamin E, 50000-80000 IU of vitamin D, 0.6g-1g of vitamin K, 25g-28g of methionine, 15g-18g of lysine, 0.5g-1g of biotin, 55g-70g of choline chloride, 7g-9g of ferrous sulfate monohydrate, 9g-12g of copper sulfate pentahydrate, 10g-12.5g of manganese sulfate, 16g-20g of zinc sulphate monohydrate, 5g-6g of sodium selenite, 6g-8g of cobalt chloride, 5g-6g of potassium iodate, 10g-15g of yeast, 0.5g-0.6g of pantothenic acid, 3g-5g of nicotinamide, 0.5g-0.6g of folic acid, 140g-150g of calcium hydrogen phosphate, 30g-40g of table salt and 260g-300g of puffed corn powder. The premixed feed can be used for effectively improving the daily gain and the digestion rate of proteins, fat and carbohydrates of the minks at a breeding period, reducing the diarrhea rate of the minks and improving the culture benefits of the minks.

Methods of isolating highly sialylated recombinant vitamin K dependent proteins, particularly Factor IX, by chromatographic methods are described. The highly sialylated recombinant proteins are characterized. The improved Factor IX has at least 62% N-glycosylation with 3 or 4 sialic acid residues and improved bioavailability and pharmokinetic properties.

The present invention provides a medicine composition with analgesic and anti-inflammatory functions, which belongs to medicine technology field. The medicine composition contains 1-25 parts extract of curcuma, 1-25 parts glucosamine hydrochloride, 1-10 parts beta-sitosterol. The medicine also can add other nutrition compositions such as vitamin C, vitamin E, vitamin K, chondroitin sulfate, vitamin A, vitamin D, immunoglobulin etc. The medicine is processed to various oral agent with acceptable carrier or excipient as substrate in medicine by conventional process. It was verified by animal experiment that the medicine has functions of analgesic and anti-inflammatory, and can be used to prepare medicine and food for preventing chest rib twinging, dysmenorrhea, shoulder and arm pain, injuries from impacts, gout, rheumatoid arthritis etc.

The invention relates to a preparation method of a microcapsule of vitamin K. The vitamin K has the problems of instability and easy metamorphism. In the method, the salt of the vitamin K is used as core material, and xanthan or arabic gum or guar gum or isinglass is used as wall material to prepare the microcapsule of the vitamin K. The detailed preparation method is as follows: the aqueous liquid of the wall material and the aqueous liquid of the core material are respectively prepared; then the two are fully mixed; an the obtained mixture is pre-frozen, frozen, dried, crashed and screened in turn, thus being prepared into the product of the microcapsule of the vitamin K with excellent organoleptic attributes. The product has excellent thermal stability and optical stability, can be used as a food accessory to be applied to food processing to enhance the content of the vitamin K in the food.

The invention relates to a compound for preventing osteoporosis and osteoarthrosis. The compound relates to a compound for preventing osteonosuses. The compound for preventing osteoporosis and osteoarthrosis solves the problem that: the prior calcium replenishing agent can purely replenish calcium, while the replenished calcium cannot be fully absorbed and utilized by the human body. The compound for preventing osteoporosis and osteoarthrosis comprises the following components by weight portion: 10 to 90 portions of glucosamine, 10 to 90 portions of calcium agent, 0.1 to 40 portions of casein phosphopeptide, 0.1 to 40 portions of drynaria rhizome extract, 0.0001 to 0.09 portion of vitamin K and 0.81 to 208 portions of supplementary materials. The compound for preventing osteoporosis and osteoarthrosis can obviously improve the bone calcium content and bone density; and the replenished calcium agent can be fully absorbed and utilized.

The invention provides vitamin k-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.

The invention relates to a novel poultry micro-ecological preparation and a preparation method of the novel poultry micro-ecological preparation. The preparation comprises following components in part by weight: 0.8-3.5 parts of vitamin A, 0.2-0.8 part of vitamin D, 2-8 parts of vitamin E, 0.2-1.2 parts of vitamin K, 0.1-0.9 part of vitamin B1, 0.2-0.8 part of vitamin B2, 0.1-0.7 part of vitamin B6, 0.08-0.5 part of vitamin B12, 2-5 parts of nicotinamide, 0.8-3.5 parts of calcium pantothenate, 0.02-0.4 part of folic acid, 0.2-1.2 parts of biotin, 0.02-2 parts of vitamin C, 1.3-32 parts of enterococcus faecium, 27-155 parts of bacillus subtilis, 75-210 parts of oligosaccharide, 150-400 parts of pine needle meal and 400-600 parts of bentonite. The novel poultry micro-ecological preparation can improve daily gain, feed intake, feed conversation efficiency of young poultry, reduces death and culling rate of the young poultry, and improves reproductive performance of breeding poultry, laying rate, fertilization rate of hatching eggs, hatching rate, and healthy rate of the young poultry. According to the invention, as double-layer shallow coating is performed to enterococcus faecium, the stress resistance of enterococcus faecium is improved.