1227 results about "Collagen peptide" patented technology

The invention relates to the field of biological medicines, in particular to a facial anti-aging collagen peptide, a composition and an application of the facial anti-aging collagen peptide, and particularly relates to a 21-type recombinant humanized collagen peptide (ColpepA1 21) and an application of a composition of the 21-type recombinant humanized collagen peptide in anti-aging treatment and skin care. The recombinant collagen provided by the invention can effectively promote the repair process after skin injury, enhance the hydration state and barrier function of the skin, reduce fine lines and wrinkles, and improve the compactness and elasticity of the skin.

The invention provides a composition for improving bone joint health as well as a preparation method and application thereof, and relates to the technical field of bone joint health products. The composition for improving bone joint health is prepared from the following components in parts by mass: 0.5 to 5 parts of collagen peptide, 5 to 30 parts of mangosteen extract, 0.5 to 3 parts of non-denatured II type collagen peptide, 0.1 to 2 parts of milk mineral salt, 0.3 to 3 parts of bone collagen peptide, 0.1 to 2 parts of cartilage extract, 0.1 to 2 parts of N-acetylglucosamine, 0.1 to 2 parts of sodium hyaluronate and 0.3 to 3 parts of turmeric extract. The composition obtained by repeatedly compounding the mangosteen extract, the turmeric extract, the cartilage extract and the sodium hyaluronate has the advantages of low cost and high safety, and has a better effect on preventing or improving osteoarthrosis.

The invention discloses a preparation method of cod skin collagen peptide with high ACE (angiotensin converting enzyme) inhibitory activity, which comprises the following steps: firstly, scaling cod skin, cleaning, cutting into small pieces, pretreating with NaOH and n-butyl alcohol to remove impure protein and certain lipid substances, preparing cod skin gelatin by a hot water extraction method, and then adding the cod skin gelatin into the cod skin collagen peptide to obtain cod skin collagen peptide; the cod skin collagen peptide with high ACE inhibitory activity is prepared by using cod skin collagen as a raw material, performing enzymolysis on the cod skin collagen peptide sequentially by using a double-enzyme distribution enzymolysis method, performing enzyme deactivation and centrifugal treatment after enzymolysis, and performing membrane separation on enzymolysis supernate. The whole enzymolysis process is more thorough by adopting a double-enzyme distribution enzymolysis method, more small molecule peptides can be obtained, cod skin collagen peptide with high ACE inhibitory activity can be further enriched by combining a membrane separation method, the utilization degree of cod skin resources is effectively improved, and the cod skin collagen peptide has a relatively wide application prospect.

The invention relates to the technical field of food, in particular to a composition and a product with effects of maintaining beauty and keeping young as well as a preparation method and application of the composition. The composition is prepared from the following components in parts by weight: 5 to 12 parts of fish collagen peptide, 0.1 to 0.5 part of III type collagen peptide, 0.1 to 0.5 part of ray collagen peptide, 1 to 3 parts of collagen tripeptide, 0.1 to 0.5 part of cubilose peptide, 0.1 to 0.3 part of casein peptide, 0.1 to 0.5 part of fish maw oligopeptide and 0.01 to 0.05 part of red currant and black currant mixed powder. The skin care product has the advantages of good skin moisture and elasticity improving and wrinkle removing effects and high safety.

The present disclosure provides a preparation method of a yak hide-derived oligopeptide ferrous chelate with a high antioxidant activity. The preparation method includes preparing a yak hide-derived oligomeric collagen peptide and subjecting the yak hide-derived oligomeric collagen peptide as a protein source to chelation with an iron source in water. A pretreated yak hide is subjected to enzymatic hydrolysis under a pH value of 7 at 50° C. for 4 h with an amount of an enzyme added at 2% to obtain a yak skin-derived collagen with a molecular weight of less than 2 kDa; the chelation is conducted in a peptide-to-iron mass ratio of 1:1 to 5:1 with a peptide concentration of 1% to 5% at 30° C. to 70° C. for 20 min to 60 min under a pH value of 3 to 8; and an iron chelating capacity is 42.72 mg / g under optimal preparation conditions.

The invention belongs to the technical field of health-care food, and provides a composition containing ergothioneine and having sleep-aiding, whitening, anti-aging and anti-inflammatory effects and application thereof. The ergothioneine composition disclosed by the invention is prepared from ergothioneine, collagen peptide, carnosine, nicotinamide, an olive leaf extract and a chamomile extract. The components in the composition are matched for use, the synergistic effect is obvious, the whitening, anti-aging and anti-inflammatory effects are obviously improved, meanwhile, the composition also has a sleep-aiding effect, and the comprehensive performance is excellent.

The invention relates to the field of cosmetics, and discloses an anti-wrinkle composition containing recombinant collagen as well as a preparation method and application of the anti-wrinkle composition. The anti-wrinkle composition is prepared by compounding I-type collagen peptide nano-micelles, recombinant humanized III-type collagen, recombinant humanized XVII-type collagen, glycosylglycerol and ceramide. The skin care composition has the advantages that multiple synergistic effects are achieved, collagen generation is promoted, the skin moisturizing capacity is enhanced, and the skin barrier is repaired, so that the elasticity, compactness and smoothness of the skin are remarkably improved. The product disclosed by the invention has the effects of skin barrier repair, anti-aging care, collagen protection, collagen generation promotion, water locking and moisturizing and the like, and is suitable for research, development and application of skin care products for resisting wrinkles, tightening and delaying senescence.

The invention provides anti-aging collagen peptide mask liquid and a preparation method thereof. The mask liquid is prepared from the following components in percentage by mass: 1 to 2 percent of tremella polysaccharide, 3 to 4 percent of herba portulacae extract, 2 to 3 percent of radix gentianae extract, 0.3 to 0.8 percent of nicotinamide, 1.2 to 1.6 percent of alpha-arbutin, 0.2 to 0.6 percent of chrysanthellum indicum extract, 0.7 to 1.5 percent of geranium flower / leaf / stem extract, 0.4 to 0.8 percent of aloe barbadensis extract, 0.7 to 1.3 percent of radix sophorae flavescentis extract, 0.3 to 0.9 percent of herba houttuyniae extract, 1.2 to 1.7 percent of herba centellae extract and the balance of water. The traditional Chinese medicine composition is prepared from the following raw materials in percentage by weight: 0.2 to 0.6 percent of fructus hippophae extract, 0.02 to 0.06 percent of peony root bark extract, 0.06 to 0.09 percent of scutellaria baicalensis root extract, 0.04 to 0.08 percent of rosemary extract, 0.01 to 0.04 percent of pearl powder and the like. The mask liquid prepared by the invention has an anti-aging effect.

The invention relates to a composition containing ceramide and collagen tripeptide and a preparation method thereof, and belongs to the technical field of health care products. The invention discloses a composition containing ceramide and collagen tripeptide. The composition is prepared from the following raw materials: collagen tripeptide, rice bran oil powder, a herba houttuyniae extract, pineapple powder, konjaku flour, a grape seed extract, olive fruit powder, carnosine, pomegranate concentrated powder and a whey fermentation product. The grape seed extract, the olive fruit powder, the carnosine and the pomegranate concentrated powder inhibit the Maillard reaction of the collagen peptide and improve the utilization rate of collagen tripeptide; ceramide rich in the rice bran oil powder is a natural skin moisturizing factor, and is matched with the pineapple powder and the konjaku flour which have a keratin metabolism effect to maintain the health of cuticles; the herba houttuyniae extract and the whey fermentation product are matched to have an excellent anti-inflammatory effect, so that the components enhance the skin barrier in multiple dimensions through collagen synthesis, cuticle maintenance, anti-inflammatory and anti-oxidation.

The invention discloses a collagenase mutant, a gene segment, a recombinant plasmid, a recombinant expression system, a collagen peptide, and a preparation method and application thereof, and belongs to the field of gene engineering and fermentation engineering. The collagenase mutant KT513 with high specific activity is obtained through recombinant expression in a trichoderma reesei host, and the enzyme activity of the collagenase mutant KT513 reaches 7423.18 U / mL. The optimum action pH of the enzyme is 3.0, the red snapper scale collagen can be subjected to enzymolysis in the pH range of 3.0-5.0, and the enzyme has excellent enzymolysis activity. After the collagenase mutant KT513 is subjected to enzymolysis at 40 DEG C for 4 hours, the extraction rate of fish scale collagen reaches 80.09%, and the prepared collagen peptide has good antioxidant activity. When the addition concentration is 10 mg / mL, the in-vitro scavenging activity of the prepared collagen peptide on hydroxyl radicals reaches 99.26% and is equivalent to that of ascorbic acid, and the collagen peptide has a wide application prospect in preparation of antioxidant preparations.

The invention relates to method for obtaining collagen from animal sources such as fresh or saltwater fish, chicken, eggs or from parts of these animal sources that can be considered waste, and to a collagen hydrolysate obtained as a result of this method.

The invention belongs to the technical field of extraction equipment, and particularly relates to collagen peptide protein extraction equipment which comprises an enzymolysis tank, supporting legs are fixedly mounted at the bottom of the enzymolysis tank, a driving motor is fixedly mounted at the top of the enzymolysis tank, a rotating rod is arranged in the enzymolysis tank, a limiting ring is fixedly mounted in the rotating rod, and two rotating shafts are arranged in the limiting ring. Limiting grooves are formed in the rotating shafts, square plates are fixedly installed on the rotating shafts, gears are fixedly connected to one ends of the rotating shafts, and a driving wheel is arranged on one rotating shaft. According to the collagen peptide protein extraction equipment, the mixing efficiency of an enzyme liquid and an extract in the collagen peptide protein extraction equipment is conveniently improved through a rotating shaft and a square plate which are mounted, a driving motor works to drive a gear to rotate, the gear rotates to drive the rotating shaft to rotate, and the rotating shaft rotates to drive the square plate to rotate; the materials at the bottom of the enzymolysis tank can flow upwards, so that the efficiency of mixed reaction with enzyme liquid can be improved, and the materials are effectively prevented from being accumulated at the bottom of the enzymolysis tank.

The invention belongs to the field of biomedical materials, and particularly relates to a preparation method of collagen tripeptide and an obtained product. Compared with the prior art, the method has the advantages that by adding alkali to soak the cowhide particles and combining treatment means such as denaturation and enzymolysis, the destroy denaturation of a triple helix structure of collagen in the cowhide can be promoted, the collagen can be thoroughly subjected to enzymolysis, so that the yield of collagen tripeptide is higher, the molecular weight is small and concentrated, and meanwhile, the foreign flavor in the cowhide can be effectively removed; subsequently, mixed enzymes jointly act on collagen peptide bonds, so that generation of collagen tripeptide is facilitated; in the operation process of the method, acid or alkali does not need to be added for multiple times to adjust the pH, and the generated collagen tripeptide is low in ash content; after suction filtration and impurity removal, impurities in the collagen tripeptide are reduced, and the yield of the obtained collagen tripeptide freeze-dried product is high; under the synergistic effect of all the treatment processes, the prepared product is fine and smooth in component, free of fishy smell and foreign flavor and good in water solubility.

The invention belongs to the technical field of functional foods, and particularly relates to a peptide-containing composition with a function of improving qi and blood as well as a preparation method and application of the peptide-containing composition. The peptide-containing composition comprises ginseng oligopeptide, donkey-hide gelatin peptide, bovine blood peptide, wolfberry peptide, fish collagen peptide, American ginseng peptide, lily extract, licorice extract, sea buckthorn fruit powder, polydextrose and xanthan gum. According to the peptide-containing composition, a plurality of small-molecule active peptides are innovatively used as core components, and plant extracts, dietary fibers and fruit powder which have a synergistic effect are matched; the traditional Chinese medicine composition not only has advantages in absorption and utilization of components, but also is more comprehensive and deep in effect and action mechanism of improving qi and blood. Through the synergistic effect of a plurality of peptide components, generation of qi and blood can be promoted from a plurality of aspects, running of qi and blood can be regulated, meanwhile, immunity and oxidation resistance of the body are enhanced, and a more effective solution is provided for improving qi and blood.

The invention belongs to the field of preparation of sedation maintaining agents, and particularly relates to a sedation maintaining agent administrated through oral mucosa and a preparation method of the sedation maintaining agent. Bamboo leaf polysaccharide and pigskin collagen peptide are heated and mixed with chlorogenic acid and butyl acetate under the catalytic action of lanthanum nitrate, and the obtained moisturizing adhesive has biocompatibility, can be stably adhered to oral mucosa and can promote salivary secretion of children; nanoparticles obtained through freeze spray drying are uniformly dispersed in a copolymer solution containing sodium salicylate and polyacrylate, and the obtained nervous system regulator can balance excitability of sympathetic nerves and parasympathetic nerves of children; the emotion relieving composition contains modified felwort powder obtained through esterification reaction, the modified felwort powder is mixed with a moisturizing adhesive and a nervous system regulator, and the prepared sedation maintaining medicament administrated through the oral mucosa protects oral health of children in the oral operation anesthesia process, is free of irritation, improves anxiety emotion and does not affect postoperative awakening.

The invention relates to the field of artificial intelligence, in particular to a collagen peptide absorptivity prediction method. Comprising the following steps: acquiring a collagen peptide sample data matrix, and constructing a convolutional neural network and a recurrent neural network to obtain a molecular structure feature vector and a time sequence feature vector; constructing a prediction neural network, inputting the molecular structure feature vector and the time sequence feature vector into an interactive feature fusion layer, and obtaining a fused feature vector by using an interactive feature fusion algorithm; inputting the fused feature vector into a self-adaptive decoupling layer, and calculating by using a self-adaptive feature decoupling algorithm to obtain a decoupled feature vector; and inputting the decoupled feature vector into an output layer to obtain a predicted value of the collagen peptide absorptivity. The technical problems that the molecular structure feature extraction capacity is insufficient, the complex interaction relation between local molecular structures cannot be flexibly captured, feature extraction is not deep enough, and the accuracy of collagen peptide absorptivity prediction is affected are solved.

The invention relates to the technical field of exosomes, in particular to an exosome compound preparation with a hair growing effect and a preparation method of the exosome compound preparation. Comprising 12 to 22 parts of ginsenoside Rb1, 15 to 12 parts of biotin tripeptide-15, 8 to 15 parts of diammonium glycyrrhizinate, 50 to 70 parts of fish collagen peptide, 10 to 20 parts of soybean peptide, 0.5 to 4.5 parts of SHH protein, 0.5 to 2.5 parts of SMO inhibitor, 0.5 to 1.5 parts of HhSP protein, 5 to 10 parts of N-acetyl tyrosine, 0.1 to 2 parts of hyaluronic acid, 0.1 to 1 part of melatonin, 0.1 to 1 part of quercetin, 0.1 to 1 part of kaempferol, 0.1 to 1 part of tanshinone, 0.1 to 1 part of biotin and 0.1 to 1 part of vitamin A. The compound preparation is combined with exosomes from various sources, so that the hair papilla cell function is synergistically enhanced, and the damaged hair follicle structure is repaired.

The invention relates to the technical field of functional product preparation, and provides a rhizoma polygonati and saussurea involucrata bone marrow peptide tablet as well as a preparation method and application thereof. The rhizoma polygonati and saussurea involucrata bone marrow peptide tablet is prepared from the following components: collagen peptide powder, L-isoleucine, a compound nutrient supplement, rhizoma polygonati, sorbitol, yak bone marrow peptide powder, fructus phyllanthi, fructus alpiniae oxyphyllae, mulberry powder, a saussurea involucrata culture and magnesium stearate. All the components of the rhizoma polygonati and saussurea involucrata bone marrow peptide tablet disclosed by the invention have a synergistic effect, so that the effects of conditioning sub-health, maintaining joints and assisting in treating diseases can be achieved.

The invention discloses a bullfrog extracted biological collagen composition and a preparation method thereof in the technical field of collagen. The bullfrog extracted biological collagen composition comprises the following components in parts by weight: 1-1.5 parts of hydrophobic bullfrog source collagen peptide, 0.6-0.8 part of hydrophobic bullfrog source elastin peptide, 1-1.5 parts of polyglutamic acid and 1-1.5 parts of polylysine. Collagen and elastin in bullfrog skin and bullfrog cartilage are extracted in a combined mode through a three-enzyme co-production method, and after bullfrog source collagen peptide and bullfrog source elastin peptide are subjected to hydrophobic modification, polyglutamic acid and polylysine are added to form a collagen combination. The stability, the medicine carrying capacity and the slow release capacity of the composition can be improved.

The invention discloses an anti-oxidation fiber mask containing tremella aurantialba polysaccharide. The anti-oxidation fiber mask containing the tremella aurantialba polysaccharide is prepared from the following components in parts by weight: 6 to 30 parts of the tremella aurantialba polysaccharide, 10 to 45 parts of micromolecular collagen peptide and 30 to 80 parts of deionized water. The tremella aurantialba polysaccharide mask is prepared from the tremella aurantialba polysaccharide and the small-molecule collagen peptide according to a specific proportion, the tremella aurantialba polysaccharide serves as an exogenous antioxidant nutrient of an organism and can play a role in scavenging free radicals, and in addition, the tremella aurantialba polysaccharide has good biocompatibility and can be better attached to a mask, so that the mask is free of toxic and side effects. The anti-oxidation mask provides required nutrition for skin while resisting oxidation, and plays a positive role in regulating skin micro-ecology.

The invention relates to the technical field of collagen peptide extraction, and particularly discloses aquatic collagen tripeptide and a processing technology thereof, and the processing technology comprises the following steps: step S1, fish skin pretreatment; step S2, performing enzymolysis; step S3, fermentation; step S4, separation and purification; starting from three aspects, firstly, a modified degreasing agent is added in the degreasing treatment process, the modified degreasing agent takes 1-ethyl-3-methylimidazole acetate, zinc phytate and calcium citrate as main components according to a specific mass ratio, and secondly, gel emulsion is added in the enzymolysis process, so that the modified degreasing agent is prepared. The gel emulsion has an oil gel structure, grape seed oil and sodium lignin sulfonate, and 3, a composite strain is added in the fermentation process, the composite strain is prepared by mixing bacillus natto and lactobacillus plantarum according to a specific proportion, and the purity and the extraction rate of the aquatic collagen tripeptide are improved through the synergistic effect of all the procedures.

The invention provides an enzyme response type supramolecular PDRN-mini ECM liposome and a preparation method and application thereof.The enzyme response type supramolecular PDRN-mini ECM liposome comprises phospholipid, a membrane stabilizer, a supramolecular compound and an emulsifier, a water phase formed by the supramolecular compound and the emulsifier serves as an inner core, and the supramolecular compound is formed by PDRN and mini ECM through intermolecular acting force; the mini ECM is formed by self-assembly of collagen peptide, elastin and hyaluronic acid. The supramolecular PDRN-mini ECM liposome with uniform particle size and good stability is obtained through a microfluidic technology, the process is simple, the controllability is high, and amplification is easy.

The invention belongs to the technical field of functional foods and health foods, and particularly relates to an anti-saccharification and anti-aging aronia melanocarpa fruit composition and a preparation method thereof. The composition is prepared from the following raw materials in parts by weight: 150 to 400 parts of aronia melanocarpa fruit fermentation liquor, 10 to 80 parts of lycium ruthenicum, 10 to 80 parts of ginseng, 0.5 to 2.5 parts of grape seed extract, 10 to 70 parts of collagen peptide, 0.5 to 4 parts of sodium hyaluronate, 0.1 to 0.8 part of resveratrol and 0.03 to 0.3 part of yeast extract. The content of type I collagen peptide in the skin is increased, the generation of in-vitro anti-glycation end products is inhibited, and the anti-glycation and anti-aging effects are achieved.

The invention discloses a composition for promoting cartilage repair and maintaining joint health as well as a preparation process and application thereof, and relates to the technical field of functional foods. The composition is prepared from the following components in parts by weight: 21.1 to 90 parts of a multi-protein complex, 0.1 to 3 parts of cherry powder, 0.01 to 2 parts of N-acetylglucosamine, 0.01 to 2 parts of radix puerariae powder, 0.1 to 1.5 parts of a calcium compound and 0.01 to 0.2 part of rhizoma curcumae longae, the multi-protein compound is prepared from 0.1 to 10 parts of ray collagen peptide, 1 to 30 parts of bone collagen peptide powder and 20 to 50 parts of fish collagen peptide. The composition provided by the invention can promote cartilage repair, achieves the purpose of daily maintenance of joint health, and has a good application prospect.

The invention provides a fish collagen peptide with skin brightening and freckle removing effects as well as a preparation method and application thereof, and belongs to the technical field of protein peptides. The preparation method comprises the following steps: by taking fish skin and / or fish scales as raw materials, performing degreasing and fishy smell removal treatment, and then sequentially performing heat treatment, homogenization treatment, enzymolysis treatment and enzyme deactivation refining to obtain the fish collagen peptide. In the fish collagen peptide prepared by the invention, the proportion of polypeptide with the molecular weight of 189-3000Da is more than 90%, and the protein content is more than 99.23%. Experiments show that the fish collagen peptide can effectively reduce the skin color spot area proportion of a subject and improve the skin L value and ITA value of the subject at the same time. Therefore, the fish collagen peptide prepared by the invention has good skin brightening and freckle removing effects, and a new way is provided for preparing related products.

The invention discloses antioxidant salmon collagen peptide and a preparation method thereof, and belongs to the technical field of processing of salmon collagen peptide. The preparation method comprises the following steps: firstly, carrying out enzymolysis on the salmon material by using phospholipase A2, hydrolyzing abundant membrane phospholipids in the salmon material, destroying fat cell structures and releasing wrapped triglyceride, then carrying out secondary enzymolysis by using aspergillus oryzae lipase, hydrolyzing macromolecular lipids into free fatty acids which are easily dissolved in supercritical carbon dioxide, and carrying out secondary enzymolysis by using aspergillus oryzae lipase. The degreased salmon material is obtained by means of supercritical carbon dioxide extraction, the lipid removal rate is greatly increased, and the antioxidant salmon collagen peptide which is small in molecular weight and high in oxidation resistance is obtained through subsequent collagen extraction and enzymolysis.

The invention relates to the technical field of biological products, and discloses a mesenchymal stem cell hair growth liquid and a preparation method thereof, and the mesenchymal stem cell hair growth liquid comprises the following components: hair follicle mesenchymal stem cells; a hair follicle mesenchymal stem cell exosome; growth factors: a vascular endothelial growth factor (VEGF), a fibroblast growth factor (FGFs), a keratinocyte growth factor (KGF-7) and interleukin-10 (IL-10); vitamins: vitamin E, vitamin B5, vitamin B2, vitamin B6, vitamin C and biotin; the plant extracts comprise a cacumen biotae extract, a polygonum multiflorum extract, a ginseng extract, a peppermint extract, a purslane extract and a rhodiola rosea extract; other active ingredients: tripeptide and digoxin; the auxiliary material is a hyaluronic acid-collagen peptide graft copolymer; and the balance of a phosphate buffer solution.

The invention provides a composition containing elastin peptide as well as a preparation method and application thereof, and relates to the technical field of food. The composition containing the elastin peptide is prepared from the following components in parts by weight: 5 to 10 parts of fish collagen peptide, 3 to 10 parts of tremella polysaccharide, 0.1 to 0.5 part of elastin peptide, 0.01 to 0.1 part of skipjack elastin peptide, 1 to 2 parts of hydrolyzed II-type collagen, 0.01 to 0.05 part of vitamin C, 1 to 5 parts of pomegranate concentrated powder, 1 to 5 parts of cranberry concentrated powder, 5 to 15 parts of lily powder and 1 to 3 parts of blueberry juice powder. The composition containing the elastin peptide is high in safety, and meanwhile, the effects of improving skin elasticity, improving skin moisture, delaying generation of wrinkles and resisting aging are achieved by remodeling internal skin tissues, increasing skin moisture, improving oxidation resistance and the like.

The invention discloses a process method for preparing fish collagen tripeptide and application of the fish collagen tripeptide, and belongs to the technical field of collagen peptide preparation processes. According to the method, the raw material fish skin is subjected to pretreatment and pretreatment, and then the pretreated fish skin is subjected to two times of enzymolysis treatment, so that efficient hydrolysis of fish skin collagen is realized, and a collagen peptide product with small molecular weight is obtained. Firstly, neutral protease and papain are used for carrying out primary enzymolysis on fish skin, then a microbial fermentation agent and an activity accelerant are used for carrying out deep fermentation enzymolysis treatment, peptide fragments can be effectively further cut, the yield of small molecule peptide fragments is increased, and the biological activity is improved. The method is simple, the process is easy to control, environmental pollution is avoided, the enzymolysis time is short, the enzymolysis speed and the extraction rate of the collagen peptide can be increased, and the collagen peptide obtained through the method is low in molecular weight, good in biological activity and easier to popularize and apply.

The invention relates to the technical field of foods and medicines, and discloses a composition of medicinal and edible food extracts for treating insomnia, which comprises the following components in percentage by weight: 8.92%-9.9% of gamma-aminobutyric acid (GABA), 2.97%-3.96% of phosphatidylserine, 29.7%-39.64% of spina date seed extract, 29.7%-39.64% of poria cocos extract, 0.59%-0.79% of tea leaf theanine extract and 5.95%-6.94% of fish collagen peptide. The mask comprises the following components in percentage by weight: 5.95%-6.94% of honey, 0.59%-0.79% of collagen tripeptide, 0.59%-0.79% of sodium hyaluronate, 0.59%-0.79% of rice bran oil powder, 0.59%-0.79% of haematococcus pluvialis, 0.59%-0.79% of acerola cherry extract, 0.01% of nicotinamide and 0.59%-0.79% of grape seed extract. The composition for treating insomnia based on the concept of homology of medicine and food not only overcomes the limitation of the existing therapy, but also has higher safety, wide adaptability and good user acceptability, and has positive significance for improving the life quality of insomnia people, improving the overall health level and improving the skin elasticity and luster.