252 results about "Intestinal mucosa" patented technology

The invention discloses a vitamin K2 composite micro-capsule system with stomach protection and intestine slow release functions and a preparation method and application thereof, the vitamin K2 composite micro-capsule system with stomach protection and intestine slow release functions comprises three layers, namely a core layer, a middle layer and an outer layer from inside to outside in sequence; the core layer is formed by coating vitamin K2 with a zein-lac hydrophobic core, the middle layer is a pea protein-pectin electrostatic compound, and the outer layer is sodium alginate and chitosan double-network gel. The micro-capsule system provided by the invention can be tightly combined in a gastric acid environment after being orally taken, the release of active ingredients in the stomach is reduced, and then the micro-capsule system stays at intestinal mucosa for a long time and slowly releases contents, so that the functions of the micro-capsule system are slowly presented outside, the half-life period is prolonged, and the action effect is improved. Vitamin K2 directly or indirectly participates in and regulates various physiological processes related to health, and plays an important role in the aspects of maintaining bone health, preventing cardiovascular diseases, protecting nerves, improving metabolism and the like.

The invention discloses an anti-digestion polysaccharide-based food colon simulated glycolysis and multi-dimensional online analysis system, and belongs to the technical field of food. According to the method, glycolysis simulation of each colon part is completely carried out according to a human body digestion and glycolysis process and a physiological environment, and intestinal mucosa pellets are added to simulate a human body intestinal mucosa environment, so that the degradation process of partial microorganisms of the human body colon for resisting digestion of polysaccharide-based food is simulated under an in-vitro condition; and the glycolysis condition of the digested polysaccharide-based food entering the colon can be observed on line, and the device fits the real physiological environment of people.

The invention discloses a zinc polyphenol complex suppository as well as a preparation method and application thereof. The preparation process mainly comprises two steps as follows: a, preparation of EGCG-Zn metal polyphenol complex nanoparticles; and b, preparing the nano complex suppository. The method is simple in process, green, environment-friendly and suitable for large-scale preparation. The prepared EGCG-Zn nanoparticles are uniform in particle size and good in stability, and have good antioxidant, anti-inflammatory and tissue repair activity based on a complex network structure formed by self-assembly of EGCG and zinc ions. The nano-particles are firstly treated by adopting a drug pretreatment carrier and then loaded in a suppository matrix to construct a rectal administration type nano-suppository, so that targeted and continuous local drug effect release can be realized. In intervention of radioactive intestinal injury, the suppository not only can relieve oxidative stress and inflammatory response, but also can promote regeneration and repair of intestinal mucosa, and has good treatment potential and clinical application prospect.

The invention belongs to the technical field of medicines, and provides application of Nintedanib and a plant-derived cyclic peptide and radix pseudostellariae cyclic peptide B combined medicine in preparation of a medicine for treating pulmonary fibrosis, the Nintedanib and the plant-derived cyclic peptide and radix pseudostellariae cyclic peptide B combined medicine can play a synergistic effect, and the inhibition effect on the pulmonary fibrosis process is remarkably improved. The toxic and side effects of diarrhea and intestinal mucosa injury caused by nintedanib are reduced, and a good choice is provided for clinical treatment of pulmonary fibrosis.

The invention provides plant prebiotics, a composition and application, and belongs to the technical field of biological medicine. The plant prebiotics comprise plantain herb extract, lotus leaf extract, dandelion extract and mulberry extract, the weight ratio of the plantain herb extract to the lotus leaf extract to the dandelion extract to the mulberry extract is (2-4): (2-4): (1-3): (1-3), and the plantain herb extract and the lotus leaf extract are prepared by a synergistic reflux extraction method of alcohol extraction and water extraction in sequence. The dandelion extract and the mulberry extract are prepared by a water extraction method; the composition comprises plant prebiotics and probiotics, and traditional prebiotics can also be added. Each component of the plant prebiotics independently or jointly has the effect of inhibiting the growth of gastrointestinal pathogenic bacteria, and the plant prebiotics not only have the effects of inhibiting the gastrointestinal pathogenic bacteria, protecting the barrier function of intestinal mucosa and inhibiting the inflammatory response of a body, but also can enhance the effects of the probiotics, such as enhancing the effects of regulating the balance of intestinal flora and resisting inflammation of the probiotics.

The invention discloses a functional probiotic composition and application thereof, and relates to the technical field of microbial engineering. Bifidobacterium longum, lactobacillus acidophilus and enterococcus faecalis are combined to serve as a microbial agent, the microbial agent and active substances of the tea leaves form a composition, then the composition is combined with prebiotics, it is ensured that viable bacteria directly reach the intestinal tract through a microencapsulation technology, and the effect of improving the immune function is achieved; tea polyphenol in the active substances of the tea leaves can serve as a carbon source of prebiotics to stimulate proliferation of the bifidobacterium longum and the lactobacillus acidophilus, so that the acid resistance and intestinal colonization capacity of the microbial inoculum are enhanced, and meanwhile, theanine in the active substances of the tea leaves, the bifidobacterium longum and the lactobacillus acidophilus synergistically promote secretion of gamma-aminobutyric acid, so that the effect of improving the intestinal colonization is achieved. And the tea polyphenol can inhibit the large intestine rod from adhering to the intestinal mucosa, and the probiotic agent secretes antibacterial peptide, so that the integrity of the intestinal barrier is maintained together.

The invention discloses kluyveromyces marxianus KUST3801 for preventing and treating celiac disease, application of the kluyveromyces marxianus KUST3801 and a fruit and vegetable fermented beverage. The preservation number is CGMCC NO. 32767; the Kluyveromyces marxianus strain is classified and named as Kluyveromyces marxianus, and the Kluyveromyces marxianus strain is named as Kluyveromyces marxianus. The strain can be used for effectively preventing and treating celiac disease by protecting intestinal mucosa and intestinal barrier, regulating immunity and relieving inflammation. In addition, in the preparation of the fermented fruit and vegetable juice beverage, the aroma of the beverage can be improved, and the antioxidant activity is enhanced.

The invention relates to a montmorillonite-probiotic microsphere preparation as well as a preparation method and application thereof, the microsphere preparation comprises montmorillonite, a probiotic biofilm and functional small molecules, and microspheres of the microsphere preparation are prepared by crosslinking sodium alginate in a collection solution based on a microfluidic technology. The microsphere preparation is mainly used for oral delivery of montmorillonite-probiotic biofilms and functional small molecules, so as to treat intestinal diseases. Compared with the prior art, the microsphere preparation provided by the invention has the advantages of gastric acid invasion resistance, intestinal responsive release and the like, and can effectively treat intestinal inflammation. In addition, the probiotic biofilm wrapped by the microspheres can enhance the interaction with the intestinal mucosa and prolong the residence time in the intestinal tract. Meanwhile, the used functional small molecules have excellent anti-inflammatory and intestinal barrier repairing effects, and can cooperate with the probiotics to regulate and control intestinal flora, so that the intestinal health is further improved.

The invention belongs to the technical field of drug delivery, and particularly relates to a multi-response colitis disease targeting hydrogel microsphere as well as a preparation method and application thereof. The hydrogel microsphere comprises a calcium ion cross-linked sodium alginate microsphere and HA-Cys / Cur NPs which is encapsulated in the calcium ion cross-linked sodium alginate microsphere, the preparation method comprises the following steps: self-assembling cysteine ethyl ester modified hyaluronic acid and curcumin to form nano-particles, encapsulating HA-Cys / Cur NPs into sodium alginate microspheres by an emulsification method, and carrying out calcium ion crosslinking, so as to obtain the hydrogel. The hydrogel microspheres have pH and GSH response characteristics and hyaluronic acid-mediated active targeting capability, are stable in a gastric acid environment, are accurately released at a colon part and target macrophages at an inflammation part, and NPs disconnects disulfide bonds and releases curcumin in an intracellular high GSH environment, so that synergistic treatment of anti-inflammation, anti-oxidation and intestinal mucosa repair is realized, and the curative effect is good. The medicine has a good application prospect in treatment of ulcerative colitis.

The invention relates to the technical field of antibacterial peptides, and particularly discloses an antibacterial peptide Magainin 2-hEGF fusion protein as well as a preparation method and application thereof. The amino acid sequence of the antibacterial peptide Magainin 2-hEGF fusion protein provided by the invention is as shown in SEQ ID NO. 1. The invention further provides a gene for coding the antibacterial peptide fusion protein, a recombinant vector and a transformant of the gene and application of the gene in the antibacterial field. The antibacterial peptide Magainin 2-hEGF fusion protein prepared by using the technical scheme of the application has a remarkable inhibition effect on escherichia coli and staphylococcus aureus, has good stability in different-pH and different-concentration cholate environments, and can repair intestinal mucosa injury caused by bacterial infection.

The invention discloses a nonapeptide with an immunomodulatory effect as well as preparation and application thereof, and belongs to the technical field of biological medicines. The amino acid sequence of the nonapeptide QT9 is Gln-Pro-Gln-Pro-Pro-Phe-Ser-His-Thr, and the amino acid sequence of the nonapeptide QT9 is shown in the specification. The peptide fragment can be obtained through artificial synthesis or directional enzymolysis of wheat protein. Functional verification shows that the nonapeptide has the effects of promoting immune cell proliferation, improving the immune factor level, improving the immune organ index and improving the immune function of intestinal mucosa. Moreover, the nonapeptide QPQPPFSHT is a natural peptide fragment and is high in biological safety, so that the nonapeptide QPQPPFSHT can be applied to preparation of food or medicines for preventing and improving the undesirable phenomenon of immunosuppression. A new solution is provided for improving the immune function, the requirements of the public for immune health care are met, and good market prospects and application potential are achieved.

The invention relates to the technical field of functional food, in particular to immune regulation type prebiotic syrup with synergy of galactomannan. The active components of the composite solid beverage are prepared from the following raw materials in percentage by weight: 20%-35% of fructo-oligosaccharide, 10%-18% of galactooligosaccharide, 8%-15% of stachyose, 3%-7% of xylooligosaccharide, 5%-12% of lactitol, 5%-10% of galactomannan, 2%-5% of yeast beta-glucan and 1%-3% of N-acetylglucosamine. The composition further comprises 4-8% of inulin and 3-6% of resistant dextrin as a matrix filling and slow-release carrier, and the sum of the weight percentages of all the active ingredients and the carrier is 100%. By remodeling intestinal microecology and inhibiting inflammation pathways, the intestinal inflammation state can be remarkably improved, expression of intestinal mucosa tight junction protein is promoted, and an innovative solution is provided for people suffering from chronic bowel diseases and immune imbalance.

The invention discloses a multi-layer multi-release metagen composition and application thereof in quickly promoting defecation, lubricating intestinal tracts, relieving intestinal problems such as flatulence, stomachache, diarrhea, constipation, irritable bowel syndrome and inflammatory bowel disease, maintaining intestinal flora balance, repairing intestinal tracts, repairing intestinal mucosa health, relieving dyspepsia and improving gastrointestinal functions.

The invention discloses multi-component inulin hydrogel as well as a preparation method and application thereof, and belongs to the technical field of nano materials and medicines.The multi-component inulin hydrogel is characterized in that a medicine L-alanyl-L-glutamine contributing to intestinal mucosa repair is entrapped in the inulin hydrogel; the multi-component inulin hydrogel has the advantages that the multi-component inulin hydrogel is prepared from the inulin and composite nanoparticles (namely mesoporous polydopamine-gallium composite nanoparticles) composed of an active oxygen scavenger polydopamine and an antibacterial agent gallium ions, the repairing capacity on intestinal barriers is further enhanced, and the prepared multi-component inulin hydrogel can be used for effectively treating inflammatory bowel diseases and non-alcoholic steatohepatitis.

The invention provides a preparation method and application of an intestinal adhesion delivery system based on pea 2S albumin. The intestinal adhesion delivery system is a protein-polyphenol compound generated by covalent binding of quinone obtained by oxidizing polyphenol through periodate resin and pea 2S albumin. According to the intestinal adhesion delivery system, cysteine-rich pea 2S albumin is used as a delivery carrier, polyphenol bioactive substances are loaded on the cysteine-rich pea 2S albumin, release of functional components in the digestion process is effectively delayed, and the gastrointestinal stability is improved. The composition is applied to the fields of inflammatory bowel diseases and intestinal infection, can target the diseased region of colitis, and effectively relieves the symptoms of colitis by enhancing the barrier function of intestinal mucosa, regulating intestinal flora and inhibiting inflammatory response. The intestinal adhesion delivery system can also deliver other bioactive substances, is applied to the fields of biological science, functional food and the like, and has good development potential.

The invention discloses a plant lactobacillus PC037 capable of improving intestinal immunity and a fermented product. The plant lactobacillus PC037 is preserved in the China General Microbiological Culture Collection Center on December 13, 2021, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) No. 24096. The plant lactobacillus PC037 can improve the repair speed of the intestinal mucosa and promote the enhancement of the immunity of the intestinal tract. The plant lactobacillus fermented product capable of improving the immunity of the intestinal tract, provided by the invention, can be used for adjusting the exhaust frequency, promoting the enhancement of the immunity of the intestinal tract and reducing the occurrence frequency of diarrhea caused by pathogenic bacteria infection of travelers in a travel process.

The invention provides a combined lactobacillus salivarius strain 8-2 and an application of the combined lactobacillus salivarius strain 8-2. The combined lactobacillus salivarius strain 8-2 is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number of the combined lactobacillus salivarius strain 8-2 is CGMCC NO.30612. The invention further provides a preparation method of the combined lactobacillus salivarius strain 8-2. The lactobacillus salivarius disclosed by the invention has the advantages of good acid resistance, no hemolysis and relatively strong antibacterial ability, can relieve injury caused by salmonella infection, can effectively promote the absorption function of intestinal mucosa, improves the production performance of laying hens, and improves the production efficiency of the laying hens. The strain has the potential of being developed into a laying hen high-quality probiotic preparation with an anti-replacement function and a function of promoting intestinal mucosal injury repair, and can be applied to preparation of laying hen antibiotic substitutes, including application of strain fermentation supernatant in preparation of laying hen antibiotic substitutes.

The invention belongs to the related technical field of pet prescription food products, and particularly relates to a prescription food for pet dogs with acute intestinal inflammation and a preparation method of the prescription food, the prescription food comprises various components such as rice, barley, chicken powder and corn protein powder, and probiotics are self-made and comprise bifidobacterium, lactobacillus acidophilus and lactobacillus casei. The preparation method comprises the steps of quantitative raw material weighing, auxiliary agent grinding, constant-temperature accurate grinding, adding of specific components for accurate grinding again, heat preservation, deodorization and degassing, drop casting forming, cooling, packaging, sealed storage and the like. Compared with the prior art, the prescription food is high in safety, and feeding tests of healthy dogs have no abnormity; clinical cases show that the leucocyte number and the inflammatory factor content of sick dogs can be reduced; the intestinal barrier can be repaired, so that the intestinal mucosa repair is accelerated; intestinal flora can be improved, and the content of short-chain fatty acid in excrement is increased; the nutrition state can be maintained, and the weight loss range of sick dogs is reduced.

The invention relates to the field of new application of traditional Chinese medicinal materials, and particularly provides application of ash grass root in preparation of medicine for treating ulcerative colitis, DSS-induced mouse colitis model experiments and UC patient control experiments show that ash grass root has remarkable technical effects in treatment of ulcerative colitis, and the application of ash grass root in preparation of medicine for treating ulcerative colitis in preparation of medicine for treating ulcerative colitis in preparation of medicine for treating ulcerative colitis. The gray couchgrass root shows the effect of relieving inflammatory response, tissue damage and immune disorder related to colitis; the intestinal mucosa repair is promoted; the intestinal barrier function is strengthened; the pathological state of colon tissue is improved; the level of inflammatory factors is reduced; and flora metabolism can be adjusted. The invention provides a new natural medicine source for preventing and treating ulcerative colitis, and has good application value and industrial transformation prospect.

The invention relates to the technical field of optical detection, in particular to an intelligent prediction system for an intestinal mucosa antioxidant active peptide purification process, which is characterized in that multi-source spectral data of an ultrafiltration process are acquired, and the multi-source spectral data comprise ultraviolet visible spectral data, fluorescence spectral data and Fourier transform infrared spectral data; performing two-dimensional conversion on the multi-source spectral data to obtain two-dimensional spectral data; fusing the two-dimensional spectral data to obtain multi-channel spectral data; identifying the multi-channel spectral data to obtain activity prediction data; and constructing a parameter optimization model, and performing online rolling optimization solution according to the activity prediction data to obtain ultrafiltration optimization parameters. Purification control is carried out by optically detecting and identifying the activity of the material.

According to the probiotic gel microspheres disclosed by the invention, probiotics are wrapped by the gel microspheres, so that the probiotics are protected from being absorbed or the influence of gastric acid and intestinal digestive juice is reduced, and the release of the probiotics in intestinal tracts is promoted. When the probiotics adopt functional coatings, after the probiotics gel microspheres reach the intestinal tract and release the probiotics, the coating layers on the surfaces of the probiotics can promote the probiotics to adhere to the intestinal mucosa, and the problem that traditional probiotics are difficult to colonize in the intestinal tract is solved. The probiotic gel microspheres disclosed by the invention have an obvious radiation injury protection effect after being orally taken, and can be used for relieving whole-body radiation injury or local radiation injury (such as radioactive intestinal injury) caused by whole-body radiation or local radiation (such as abdominal radiotherapy).

According to the application disclosed by the invention, the new lactobacillus rhamnosus LR159 is found for the first time, and the strain can be used for effectively treating the inflammatory bowel disease by inhibiting the inflammation level, recovering the barrier function of intestinal mucosa and regulating and improving the intestinal microenvironment. Compared with known lactobacillus rhamnosus, the LR159 strain provided by the invention has better intestinal colonization ability, and can realize more lasting anti-inflammatory and mucous membrane repair effects by breaking through the limitation of pathological microenvironment of the inflammatory bowel disease, thereby enhancing the treatment effect of the inflammatory bowel disease. In conclusion, the lactobacillus rhamnosus LR159 has a great application prospect in preventing and treating the inflammatory bowel disease.

The invention relates to a composite probiotic postbiotic capable of improving intestinal health and application of the composite probiotic postbiotic, and belongs to the technical field of microorganisms, the composite probiotic postbiotic comprises inactivated thalli and / or metabolites of a probiotic composition; the probiotic composition is prepared from the following components: the lactobacillus casei Zhang, the plant lactobacillus P8 and the bifidobacterium animalis subsp. Lactis V9. The preparation method comprises the following steps: preparing the probiotic composition from the lactobacillus casei Zhang, the plant lactobacillus P8 and the bifidobacterium animalis subsp. Lactis V9; researches show that the content of the metabolite of the complex probiotics, such as L-phenylalanyl-L-glutamic acid, glutamic acid-isoleucine, proline-histidine, L-isoleucine-L-arginine, prolyl glutamine, chrysophanol, crocin, tributyric acid and campsis grandiflora saponin C, is remarkably increased, and the content of the metabolite of the complex probiotics is remarkably increased; therefore, the composite probiotic metagen has the effects of enhancing the intestinal barrier function, regulating cellular immunity and intestinal mucosa immunity, resisting inflammation and resisting oxidation.

The invention discloses a retention enema device, and belongs to the technical field of retention enema. Comprising a three-cavity urinary catheter, an air bag device, a medicine treatment device, a speed adjusting device and a sealing cap, wherein the three-cavity urinary catheter is placed in the anus for flushing, urine drainage and medicine conveying; the air bag device is used for preventing urine from flowing out; the medicine treatment device is used for conveying and treating medicine; according to the device, the bladder of a patient can be flushed through the three-cavity urinary catheter, urine in the bladder can be drained and collected, medicine can be conveyed into the bladder in an injection and infusion mode, the medicine can be injected into the rectum or colon through the anus of the patient, and the treatment purpose is achieved through intestinal mucosa absorption; and in the medicine conveying process, the conveying speed of medicine conveying can be correspondingly adjusted according to the use types of the medicine and the treatment condition of the patient, so that the medicine treatment operation of the patient is more convenient.

The invention belongs to the technical field of biological medicines, and discloses application of Weissella cibaria ZMC030 and exopolysaccharides thereof in prevention and treatment of colitis. The preservation number of the Weissella sinus ZMC030 is CCTCC (China Center for Type Culture Collection) NO: M 20241261, and the Weissella sinus ZMC030 is preserved in the China Center for Type Culture Collection. The Weissella cibaria ZMC030 can secrete exopolysaccharide, and the secreted exopolysaccharide can relieve intestinal injury, reduce apoptosis of intestinal epithelial cells, effectively protect intestinal mucosa barriers and reduce the inflammation level; moreover, intestinal microorganisms and metabolites thereof can be regulated and controlled, the level of pro-inflammatory microorganisms is reduced, the level of anti-inflammatory microorganisms and short-chain fatty acid is increased, and ulcerative colitis symptoms of mice are finally relieved; in addition, the exopolysaccharide has no influence on the weight and the growth state of the mouse, has no damage to important visceral organs, and is high in safety. Therefore, the Weissella cibaria ZMC030 and the exopolysaccharide secreted by the Weissella cibaria ZMC030 can be used for preparing the medicine for relieving or / and treating the colitis.

The invention relates to application of microalgae polysaccharide in improving intestinal immunity of dairy cows, belongs to the technical field of feeds, and the microalgae polysaccharide prepared by the invention is used for improving the secretion volume of intestinal mucosa to lgA, lgG and lgM. Kelp buds, dunaliella salina and haematococcus pluvialis are compounded and mixed according to a specific proportion, trypsin and nattokinase are adopted for pre-enzymolysis within a certain period of time, then hemicellulase and pectinase are adopted for enzymolysis within a certain period of time, and the enzymolysis effect is good. The obtained microalgae polysaccharide product has an excellent effect of promoting the intestinal tract of the dairy cow to secrete immune globulin, the content of IgA, IgG and IgM in the intestinal tract of the dairy cow can be greatly increased, the immunity of the intestinal tract of the dairy cow is further improved, and the microalgae polysaccharide product can be used as a substitute component for efficiently improving the immune function of the intestinal tract of the dairy cow.

The invention provides a neurotransmitter-entrapped ginsenoside liposome and a preparation method thereof, the neurotransmitter-entrapped ginsenoside liposome is prepared from the following raw materials: ginsenoside, neutral phospholipid and acetylcholine, and the mass ratio of ginsenoside to neutral phospholipid to acetylcholine is (6-10): (10-20): (10-15). The lipidosome can effectively inhibit intestinal inflammation reaction, relieve intestinal inflammation damage, repair damaged ENS and improve intestinal functions, is suitable for being used as a treatment or adjuvant treatment mode of IBD, especially for regulation and control of an intestinal mucosa immune system of an IBD patient and protection and repair effects on nerves, improves treatment targeting, and has a good application prospect. The preparation method is simple and convenient, high in safety and excellent in economic benefit and social benefit.

The invention provides a positioning device for an alimentary canal lesion endoscope, and relates to the technical field of alimentary canal endoscopes, the positioning device comprises an endoscope pipeline, an adjusting mechanism facilitating adjustment is arranged on the endoscope pipeline, a supporting mechanism facilitating positioning is arranged on the endoscope pipeline, and the adjusting mechanism comprises a protective hollow column and a mounting column; the supporting mechanism comprises an endoscope probe, a first adjusting pipe and a suction cup, the protective hollow column is slidably mounted at the circumferential end of the endoscope pipeline, and the mounting column is fixedly mounted at the circumferential end of the endoscope pipeline. By arranging the umbrella type supporting structure composed of the first adjusting tube, the second adjusting tube and the universal joint, the actual interior of the digestive tract is not a flat environment, natural wrinkles exist on the stomach wall, the intestinal mucosa fluctuates in a concave-convex mode, and individual differences exist in the forms of the digestive tracts of different patients; the multi-point supporting design of the umbrella type structure enables a plurality of supporting point positions to be respectively attached to mucous membranes at different positions around the focus.

The invention relates to the technical field of preparation of traditional Chinese medicines for relaxing bowel, in particular to a traditional Chinese medicine formula for relaxing bowel, which comprises the following components in parts by weight: 20-40 parts of black sesame, 10-20 parts of oil angelica sinensis, 10-15 parts of fructus cannabis, 10-20 parts of bunge cherry seed, 10-20 parts of radix rehmanniae, 10-15 parts of radix scrophulariae, 10-30 parts of radix ophiopogonis, 5-15 parts of immature bitter orange, 10-30 parts of bighead atractylodes rhizome, 5-10 parts of liquorice, 10-20 parts of peach kernel, 10-20 parts of almond, 10-20 parts of snakegourd seed, 10-20 parts of mangnolia officinalis, 5-15 parts of rheum officinale, 5-10 parts of mirabilite and 20-30 parts of raw honey. The traditional Chinese medicine is prepared from 0-30 parts of mulberry, 0-40 parts of radish leaves, 0-15 parts of herba cistanche and the balance of water. The traditional Chinese medicine composition can enhance peristalsis of intestinal tracts, accelerate movement of excrement in the intestinal tracts, facilitate defecation, nourish components of intestinal mucosa, and help to protect health of the intestinal tracts and reduce constipation.

The invention belongs to the technical field of veterinary vaccine adjuvants, and particularly relates to an intestinal tract targeted saccharum alhagi polysaccharide-aluminum adjuvant Pickering emulsion as well as a preparation method and application of the intestinal tract targeted saccharum alhagi polysaccharide-aluminum adjuvant Pickering emulsion. The intestinal tract targeted saccharum alhagi polysaccharide-aluminum adjuvant Pickering emulsion is AHPPE, the AHPPE is formed by mixing an oil phase and a water phase, and the volume ratio of the oil phase to the water phase is 1: (9-13); the oil phase is prepared from the following raw materials: squalene and retinoic acid; the mass ratio of the squalene to the retinoic acid is 1: (0.7-0.8); the water phase is prepared from the following raw materials: saccharum alhagi polysaccharide and aluminum hydroxide; the mass ratio of the saccharum alhagi polysaccharide to the aluminum hydroxide is 1: (10-13). According to the preparation method provided by the invention, the problems that retinoic acid is difficult to dissolve in water and the metabolism speed of saccharum alhagi polysaccharide is high are solved, and meanwhile, an organism can be induced to generate effective systemic immunity and intestinal mucosa immunity by injecting AHPPE.