199 results about "Intestinal mucosa" patented technology

The invention discloses a vitamin K2 composite micro-capsule system with stomach protection and intestine slow release functions and a preparation method and application thereof, the vitamin K2 composite micro-capsule system with stomach protection and intestine slow release functions comprises three layers, namely a core layer, a middle layer and an outer layer from inside to outside in sequence; the core layer is formed by coating vitamin K2 with a zein-lac hydrophobic core, the middle layer is a pea protein-pectin electrostatic compound, and the outer layer is sodium alginate and chitosan double-network gel. The micro-capsule system provided by the invention can be tightly combined in a gastric acid environment after being orally taken, the release of active ingredients in the stomach is reduced, and then the micro-capsule system stays at intestinal mucosa for a long time and slowly releases contents, so that the functions of the micro-capsule system are slowly presented outside, the half-life period is prolonged, and the action effect is improved. Vitamin K2 directly or indirectly participates in and regulates various physiological processes related to health, and plays an important role in the aspects of maintaining bone health, preventing cardiovascular diseases, protecting nerves, improving metabolism and the like.

The invention discloses a zinc polyphenol complex suppository as well as a preparation method and application thereof. The preparation process mainly comprises two steps as follows: a, preparation of EGCG-Zn metal polyphenol complex nanoparticles; and b, preparing the nano complex suppository. The method is simple in process, green, environment-friendly and suitable for large-scale preparation. The prepared EGCG-Zn nanoparticles are uniform in particle size and good in stability, and have good antioxidant, anti-inflammatory and tissue repair activity based on a complex network structure formed by self-assembly of EGCG and zinc ions. The nano-particles are firstly treated by adopting a drug pretreatment carrier and then loaded in a suppository matrix to construct a rectal administration type nano-suppository, so that targeted and continuous local drug effect release can be realized. In intervention of radioactive intestinal injury, the suppository not only can relieve oxidative stress and inflammatory response, but also can promote regeneration and repair of intestinal mucosa, and has good treatment potential and clinical application prospect.

The invention discloses a functional probiotic composition and application thereof, and relates to the technical field of microbial engineering. Bifidobacterium longum, lactobacillus acidophilus and enterococcus faecalis are combined to serve as a microbial agent, the microbial agent and active substances of the tea leaves form a composition, then the composition is combined with prebiotics, it is ensured that viable bacteria directly reach the intestinal tract through a microencapsulation technology, and the effect of improving the immune function is achieved; tea polyphenol in the active substances of the tea leaves can serve as a carbon source of prebiotics to stimulate proliferation of the bifidobacterium longum and the lactobacillus acidophilus, so that the acid resistance and intestinal colonization capacity of the microbial inoculum are enhanced, and meanwhile, theanine in the active substances of the tea leaves, the bifidobacterium longum and the lactobacillus acidophilus synergistically promote secretion of gamma-aminobutyric acid, so that the effect of improving the intestinal colonization is achieved. And the tea polyphenol can inhibit the large intestine rod from adhering to the intestinal mucosa, and the probiotic agent secretes antibacterial peptide, so that the integrity of the intestinal barrier is maintained together.

The invention discloses kluyveromyces marxianus KUST3801 for preventing and treating celiac disease, application of the kluyveromyces marxianus KUST3801 and a fruit and vegetable fermented beverage. The preservation number is CGMCC NO. 32767; the Kluyveromyces marxianus strain is classified and named as Kluyveromyces marxianus, and the Kluyveromyces marxianus strain is named as Kluyveromyces marxianus. The strain can be used for effectively preventing and treating celiac disease by protecting intestinal mucosa and intestinal barrier, regulating immunity and relieving inflammation. In addition, in the preparation of the fermented fruit and vegetable juice beverage, the aroma of the beverage can be improved, and the antioxidant activity is enhanced.

The invention belongs to the technical field of drug delivery, and particularly relates to a multi-response colitis disease targeting hydrogel microsphere as well as a preparation method and application thereof. The hydrogel microsphere comprises a calcium ion cross-linked sodium alginate microsphere and HA-Cys / Cur NPs which is encapsulated in the calcium ion cross-linked sodium alginate microsphere, the preparation method comprises the following steps: self-assembling cysteine ethyl ester modified hyaluronic acid and curcumin to form nano-particles, encapsulating HA-Cys / Cur NPs into sodium alginate microspheres by an emulsification method, and carrying out calcium ion crosslinking, so as to obtain the hydrogel. The hydrogel microspheres have pH and GSH response characteristics and hyaluronic acid-mediated active targeting capability, are stable in a gastric acid environment, are accurately released at a colon part and target macrophages at an inflammation part, and NPs disconnects disulfide bonds and releases curcumin in an intracellular high GSH environment, so that synergistic treatment of anti-inflammation, anti-oxidation and intestinal mucosa repair is realized, and the curative effect is good. The medicine has a good application prospect in treatment of ulcerative colitis.

The invention relates to the technical field of antibacterial peptides, and particularly discloses an antibacterial peptide Magainin 2-hEGF fusion protein as well as a preparation method and application thereof. The amino acid sequence of the antibacterial peptide Magainin 2-hEGF fusion protein provided by the invention is as shown in SEQ ID NO. 1. The invention further provides a gene for coding the antibacterial peptide fusion protein, a recombinant vector and a transformant of the gene and application of the gene in the antibacterial field. The antibacterial peptide Magainin 2-hEGF fusion protein prepared by using the technical scheme of the application has a remarkable inhibition effect on escherichia coli and staphylococcus aureus, has good stability in different-pH and different-concentration cholate environments, and can repair intestinal mucosa injury caused by bacterial infection.

The invention discloses a nonapeptide with an immunomodulatory effect as well as preparation and application thereof, and belongs to the technical field of biological medicines. The amino acid sequence of the nonapeptide QT9 is Gln-Pro-Gln-Pro-Pro-Phe-Ser-His-Thr, and the amino acid sequence of the nonapeptide QT9 is shown in the specification. The peptide fragment can be obtained through artificial synthesis or directional enzymolysis of wheat protein. Functional verification shows that the nonapeptide has the effects of promoting immune cell proliferation, improving the immune factor level, improving the immune organ index and improving the immune function of intestinal mucosa. Moreover, the nonapeptide QPQPPFSHT is a natural peptide fragment and is high in biological safety, so that the nonapeptide QPQPPFSHT can be applied to preparation of food or medicines for preventing and improving the undesirable phenomenon of immunosuppression. A new solution is provided for improving the immune function, the requirements of the public for immune health care are met, and good market prospects and application potential are achieved.

The invention relates to the technical field of functional food, in particular to immune regulation type prebiotic syrup with synergy of galactomannan. The active components of the composite solid beverage are prepared from the following raw materials in percentage by weight: 20%-35% of fructo-oligosaccharide, 10%-18% of galactooligosaccharide, 8%-15% of stachyose, 3%-7% of xylooligosaccharide, 5%-12% of lactitol, 5%-10% of galactomannan, 2%-5% of yeast beta-glucan and 1%-3% of N-acetylglucosamine. The composition further comprises 4-8% of inulin and 3-6% of resistant dextrin as a matrix filling and slow-release carrier, and the sum of the weight percentages of all the active ingredients and the carrier is 100%. By remodeling intestinal microecology and inhibiting inflammation pathways, the intestinal inflammation state can be remarkably improved, expression of intestinal mucosa tight junction protein is promoted, and an innovative solution is provided for people suffering from chronic bowel diseases and immune imbalance.

The invention discloses a multi-layer multi-release metagen composition and application thereof in quickly promoting defecation, lubricating intestinal tracts, relieving intestinal problems such as flatulence, stomachache, diarrhea, constipation, irritable bowel syndrome and inflammatory bowel disease, maintaining intestinal flora balance, repairing intestinal tracts, repairing intestinal mucosa health, relieving dyspepsia and improving gastrointestinal functions.

The invention discloses multi-component inulin hydrogel as well as a preparation method and application thereof, and belongs to the technical field of nano materials and medicines.The multi-component inulin hydrogel is characterized in that a medicine L-alanyl-L-glutamine contributing to intestinal mucosa repair is entrapped in the inulin hydrogel; the multi-component inulin hydrogel has the advantages that the multi-component inulin hydrogel is prepared from the inulin and composite nanoparticles (namely mesoporous polydopamine-gallium composite nanoparticles) composed of an active oxygen scavenger polydopamine and an antibacterial agent gallium ions, the repairing capacity on intestinal barriers is further enhanced, and the prepared multi-component inulin hydrogel can be used for effectively treating inflammatory bowel diseases and non-alcoholic steatohepatitis.

The invention provides a preparation method and application of an intestinal adhesion delivery system based on pea 2S albumin. The intestinal adhesion delivery system is a protein-polyphenol compound generated by covalent binding of quinone obtained by oxidizing polyphenol through periodate resin and pea 2S albumin. According to the intestinal adhesion delivery system, cysteine-rich pea 2S albumin is used as a delivery carrier, polyphenol bioactive substances are loaded on the cysteine-rich pea 2S albumin, release of functional components in the digestion process is effectively delayed, and the gastrointestinal stability is improved. The composition is applied to the fields of inflammatory bowel diseases and intestinal infection, can target the diseased region of colitis, and effectively relieves the symptoms of colitis by enhancing the barrier function of intestinal mucosa, regulating intestinal flora and inhibiting inflammatory response. The intestinal adhesion delivery system can also deliver other bioactive substances, is applied to the fields of biological science, functional food and the like, and has good development potential.

The invention discloses a plant lactobacillus PC037 capable of improving intestinal immunity and a fermented product. The plant lactobacillus PC037 is preserved in the China General Microbiological Culture Collection Center on December 13, 2021, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) No. 24096. The plant lactobacillus PC037 can improve the repair speed of the intestinal mucosa and promote the enhancement of the immunity of the intestinal tract. The plant lactobacillus fermented product capable of improving the immunity of the intestinal tract, provided by the invention, can be used for adjusting the exhaust frequency, promoting the enhancement of the immunity of the intestinal tract and reducing the occurrence frequency of diarrhea caused by pathogenic bacteria infection of travelers in a travel process.

The invention belongs to the related technical field of pet prescription food products, and particularly relates to a prescription food for pet dogs with acute intestinal inflammation and a preparation method of the prescription food, the prescription food comprises various components such as rice, barley, chicken powder and corn protein powder, and probiotics are self-made and comprise bifidobacterium, lactobacillus acidophilus and lactobacillus casei. The preparation method comprises the steps of quantitative raw material weighing, auxiliary agent grinding, constant-temperature accurate grinding, adding of specific components for accurate grinding again, heat preservation, deodorization and degassing, drop casting forming, cooling, packaging, sealed storage and the like. Compared with the prior art, the prescription food is high in safety, and feeding tests of healthy dogs have no abnormity; clinical cases show that the leucocyte number and the inflammatory factor content of sick dogs can be reduced; the intestinal barrier can be repaired, so that the intestinal mucosa repair is accelerated; intestinal flora can be improved, and the content of short-chain fatty acid in excrement is increased; the nutrition state can be maintained, and the weight loss range of sick dogs is reduced.

The invention relates to the field of new application of traditional Chinese medicinal materials, and particularly provides application of ash grass root in preparation of medicine for treating ulcerative colitis, DSS-induced mouse colitis model experiments and UC patient control experiments show that ash grass root has remarkable technical effects in treatment of ulcerative colitis, and the application of ash grass root in preparation of medicine for treating ulcerative colitis in preparation of medicine for treating ulcerative colitis in preparation of medicine for treating ulcerative colitis. The gray couchgrass root shows the effect of relieving inflammatory response, tissue damage and immune disorder related to colitis; the intestinal mucosa repair is promoted; the intestinal barrier function is strengthened; the pathological state of colon tissue is improved; the level of inflammatory factors is reduced; and flora metabolism can be adjusted. The invention provides a new natural medicine source for preventing and treating ulcerative colitis, and has good application value and industrial transformation prospect.

The invention relates to the technical field of optical detection, in particular to an intelligent prediction system for an intestinal mucosa antioxidant active peptide purification process, which is characterized in that multi-source spectral data of an ultrafiltration process are acquired, and the multi-source spectral data comprise ultraviolet visible spectral data, fluorescence spectral data and Fourier transform infrared spectral data; performing two-dimensional conversion on the multi-source spectral data to obtain two-dimensional spectral data; fusing the two-dimensional spectral data to obtain multi-channel spectral data; identifying the multi-channel spectral data to obtain activity prediction data; and constructing a parameter optimization model, and performing online rolling optimization solution according to the activity prediction data to obtain ultrafiltration optimization parameters. Purification control is carried out by optically detecting and identifying the activity of the material.

According to the application disclosed by the invention, the new lactobacillus rhamnosus LR159 is found for the first time, and the strain can be used for effectively treating the inflammatory bowel disease by inhibiting the inflammation level, recovering the barrier function of intestinal mucosa and regulating and improving the intestinal microenvironment. Compared with known lactobacillus rhamnosus, the LR159 strain provided by the invention has better intestinal colonization ability, and can realize more lasting anti-inflammatory and mucous membrane repair effects by breaking through the limitation of pathological microenvironment of the inflammatory bowel disease, thereby enhancing the treatment effect of the inflammatory bowel disease. In conclusion, the lactobacillus rhamnosus LR159 has a great application prospect in preventing and treating the inflammatory bowel disease.

The invention discloses a retention enema device, and belongs to the technical field of retention enema. Comprising a three-cavity urinary catheter, an air bag device, a medicine treatment device, a speed adjusting device and a sealing cap, wherein the three-cavity urinary catheter is placed in the anus for flushing, urine drainage and medicine conveying; the air bag device is used for preventing urine from flowing out; the medicine treatment device is used for conveying and treating medicine; according to the device, the bladder of a patient can be flushed through the three-cavity urinary catheter, urine in the bladder can be drained and collected, medicine can be conveyed into the bladder in an injection and infusion mode, the medicine can be injected into the rectum or colon through the anus of the patient, and the treatment purpose is achieved through intestinal mucosa absorption; and in the medicine conveying process, the conveying speed of medicine conveying can be correspondingly adjusted according to the use types of the medicine and the treatment condition of the patient, so that the medicine treatment operation of the patient is more convenient.

The invention provides a neurotransmitter-entrapped ginsenoside liposome and a preparation method thereof, the neurotransmitter-entrapped ginsenoside liposome is prepared from the following raw materials: ginsenoside, neutral phospholipid and acetylcholine, and the mass ratio of ginsenoside to neutral phospholipid to acetylcholine is (6-10): (10-20): (10-15). The lipidosome can effectively inhibit intestinal inflammation reaction, relieve intestinal inflammation damage, repair damaged ENS and improve intestinal functions, is suitable for being used as a treatment or adjuvant treatment mode of IBD, especially for regulation and control of an intestinal mucosa immune system of an IBD patient and protection and repair effects on nerves, improves treatment targeting, and has a good application prospect. The preparation method is simple and convenient, high in safety and excellent in economic benefit and social benefit.

The invention provides a positioning device for an alimentary canal lesion endoscope, and relates to the technical field of alimentary canal endoscopes, the positioning device comprises an endoscope pipeline, an adjusting mechanism facilitating adjustment is arranged on the endoscope pipeline, a supporting mechanism facilitating positioning is arranged on the endoscope pipeline, and the adjusting mechanism comprises a protective hollow column and a mounting column; the supporting mechanism comprises an endoscope probe, a first adjusting pipe and a suction cup, the protective hollow column is slidably mounted at the circumferential end of the endoscope pipeline, and the mounting column is fixedly mounted at the circumferential end of the endoscope pipeline. By arranging the umbrella type supporting structure composed of the first adjusting tube, the second adjusting tube and the universal joint, the actual interior of the digestive tract is not a flat environment, natural wrinkles exist on the stomach wall, the intestinal mucosa fluctuates in a concave-convex mode, and individual differences exist in the forms of the digestive tracts of different patients; the multi-point supporting design of the umbrella type structure enables a plurality of supporting point positions to be respectively attached to mucous membranes at different positions around the focus.

The invention belongs to the technical field of veterinary vaccine adjuvants, and particularly relates to an intestinal tract targeted saccharum alhagi polysaccharide-aluminum adjuvant Pickering emulsion as well as a preparation method and application of the intestinal tract targeted saccharum alhagi polysaccharide-aluminum adjuvant Pickering emulsion. The intestinal tract targeted saccharum alhagi polysaccharide-aluminum adjuvant Pickering emulsion is AHPPE, the AHPPE is formed by mixing an oil phase and a water phase, and the volume ratio of the oil phase to the water phase is 1: (9-13); the oil phase is prepared from the following raw materials: squalene and retinoic acid; the mass ratio of the squalene to the retinoic acid is 1: (0.7-0.8); the water phase is prepared from the following raw materials: saccharum alhagi polysaccharide and aluminum hydroxide; the mass ratio of the saccharum alhagi polysaccharide to the aluminum hydroxide is 1: (10-13). According to the preparation method provided by the invention, the problems that retinoic acid is difficult to dissolve in water and the metabolism speed of saccharum alhagi polysaccharide is high are solved, and meanwhile, an organism can be induced to generate effective systemic immunity and intestinal mucosa immunity by injecting AHPPE.

The present invention provides a salivarius lactobacillus 8-2 strain and an application thereof, wherein the salivarius lactobacillus 8-2 strain has been deposited in the General Microbiology Center of the China Microbiological Culture Collection Administration Committee, and the deposit number is CGMCC NO.30612. The salivarius lactobacillus described in the present invention has good acid resistance, is non-hemolytic, has strong antibacterial ability, can reduce the damage caused by salmonella infection, and can effectively promote the absorption function of intestinal mucosa, improve the production performance of laying hens, has the potential to be developed into a high-quality probiotic preparation for laying hens with both "antibiotic replacement" function and the function of promoting the repair of intestinal mucosal damage, and can be used in the preparation of laying hen antibiotic substitutes, including the application of the fermentation supernatant of the strain in the preparation of laying hen antibiotic substitutes.

The invention discloses a traditional Chinese medicine navel pill for treating constipation, diarrhea and chronic enteritis and a preparation method of the traditional Chinese medicine navel pill, and belongs to the technical field of traditional Chinese medicine. The preparation method comprises the following steps: weighing the raw materials, mixing, crushing and sieving to obtain mixed medicine powder, adding honey into the mixed medicine powder, stirring and kneading until the mixture is sticky, and preparing pills. The navel pill is applied to the navel, two-way conditioning of constipation and diarrhea is achieved through the synergistic effect of traditional Chinese medicine, chronic enteritis can be treated in a targeted mode, intestinal mucosa is effectively repaired, the intestinal inflammation state is improved, the navel pill has the advantages of being safe and convenient to apply, high in bioavailability, mild and free of side effects, stimulation of oral medicine to gastrointestinal tracts is avoided, and the curative effect is good. The food is suitable for digestion function conditioning of different people.

The intestinal canal anastomosis and anastomotic leakage stent system comprises a metal stent, a drainage device and a stent releasing device, the metal stent is arranged in the stent releasing device before being released, the stent releasing device is used for releasing the metal stent, the metal stent is dumbbell-shaped, the two ends of the metal stent are raised, and the middle of the metal stent is a groove section; the drainage device comprises an air cushion and a drainage tube, the air cushion wraps the groove section, the whole air cushion is columnar, and air columns are woven into a net shape; a space is formed between the air cushion and the groove section, and the drainage tube is connected to the metal support and communicated with the space. The air cushion can be filled by injecting gas or water, so that a communicated closed space is formed between the intestinal mucosa and the surface of the metal stent, secretions or blood of the intestinal mucosa, blood vessels and ventage tissues are continuously sucked out through negative pressure, an anastomotic stoma and a ventage are kept clean, and healing of the anastomotic stoma and the ventage is promoted.

The invention discloses a lipidosome composite hydrogel microsphere for repairing damaged intestinal mucosa and a preparation method thereof, LHMs (at) 4-OI is composed of hyaluronic acid modified targeted drug-loaded lipidosome, sodium alginate, hydrochloric acid treated sucralfate and a CaCl cross-linking agent, and rapid gel forming is carried out under the voltage of 11.0 KV through an electrospray technology. The microspheres have pH responsiveness and gastric juice digestion resistance, CD44 receptor targeting is achieved through hyaluronic acid modification, sodium alginate and Ca form an egg box structure to provide a three-dimensional network, and sucralfate enhances adhesion to isolate harmful substances. The preparation method comprises the steps of preparation of the drug-loaded liposome by a film hydration method, hyaluronic acid modification and electrospray crosslinking, is simple to operate and low in cost, and can be used for large-scale production. The microspheres can effectively load an anti-inflammatory drug 4-OI, inhibit expression of inflammatory factors and promote self-repair of damaged intestinal mucosa, and have wide application prospects in the fields of abdominal infection, inflammatory bowel diseases, colorectal cancer and the like.

The present invention addresses the problem of: developing a method capable of noninvasively sampling and analyzing intestinal mucosa bacteria; analyzing the intestinal bacteria, especially intestinal mucosa bacteria on the basis of the method; and developing a therapeutic method for diseases occurring in the intestinal tract for which therapeutic methods have not been established.　The inventors of the present invention have found that bacteria contained in a cotton swab (swab) sample on the feces surface exhibit a bacterial flora composition similar to that of bacteria existing in the intestinal mucosa; and, as a result of analysis based on the finding, have clarified that Adlercreutzia, which has not been reported until now as a mucosa-related bacterium, lives in the large intestinal mucosa layer, produces taurine, which is a strong anti-inflammatory compound, by the action of the bile acid-deconjugating enzyme, and alleviates enteritis, thereby completing the present invention. In other words, the present invention can provide a composition having an anti-inflammatory effect, which includes a bacterium of the genus Adlercreutzia, or a bile acid-deconjugating enzyme that is derived from a bacterium of the genus Adlercreutzia.

The utility model provides a metal support for intestinal canal anastomosis and anastomotic leakage, which relates to the technical field of medical instruments and comprises a metal support, a drainage tube and a support release device, the metal support is arranged in the support release device before being released, and the metal support is dumbbell-shaped after being released and comprises a first raised section, a second raised section and a groove section, the groove section is a double-layer metal net and comprises an inner-layer metal net and an outer-layer metal net, a space is formed between the inner-layer metal net and the outer-layer metal net, the inner face and the outer face of the metal support are both wrapped with silica gel coatings, a plurality of round holes communicated with the space are formed in the silica gel coating of the outer-layer metal net, the drainage tube is connected with the groove section, and the interior of the drainage tube is communicated with the space. After being released, the metal stent can block a digestive tract ventage or support liquid secreted by an anastomotic stoma, intestinal mucosa, blood vessels and ventage tissue, the liquid can enter the space between the two layers of metal stent nets through the round holes in the silica gel coating of the outer-layer metal net and is sucked out by negative pressure, cleanliness of the anastomotic stoma and the ventage can be kept, and healing of the anastomotic stoma and the ventage is promoted.

The invention discloses a piglet anti-diarrhea complete feed formula based on a microecological preparation, and relates to the technical field of animal nutrition and health. The microsphere has a unique three-layer core-shell structure, wherein a core layer is coated with butyric acid producing probiotics and precise prebiotics; the middle layer is a chitosan-gallic acid-vanillin terpolymer with dual functions of strong mucous membrane adsorbability and quorum sensing quenching; and the shell layer is a pH-sensitive slow-release coating and is loaded with an acidifying agent. The structure is constructed through a layer-by-layer coating process, and the technical problems that in the prior art, functional components cannot be delivered in a targeted mode, the synergistic effect is poor, and intestinal barriers cannot be actively repaired are solved. When the microspheres enter animal digestive tracts, the shell layer firstly releases an acidifying agent at the front end to inhibit pathogenic bacteria and clear obstacles for subsequent steps; after entering the small intestine, the middle layer polymer is released, adheres and repairs the damaged intestinal mucosa in the form of a biological bandage, and interferes pathogen communication at the same time.

The invention discloses burdock tea containing low-molecular hyaluronic acid fragments and a preparation method of the burdock tea, and belongs to the technical field of functional tea drinks. The burdock tea comprises the following raw materials in parts by weight: 1 part of a low-molecular hyaluronic acid fragment and 100 parts of burdock, the preparation method comprises the following steps: (1) selecting low-molecular hyaluronic acid fragment dry powder and fresh burdock slices; (2) dissolving the low-molecular hyaluronic acid fragment dry powder in purified water to obtain a hyaluronic acid solution; and (3) uniformly spraying the hyaluronic acid solution on the fresh burdock slices, and baking to obtain the burdock slices. According to the invention, low-molecular hyaluronic acid fragments with specific molecular weight and distribution are organically combined with burdock, and a unique preparation process is adopted, so that a tea beverage with multiple health-care effects is prepared. The burdock tea not only can repair intestinal mucosa and improve gastrointestinal tract discomfort, but also has various effects of moisturizing skin, beautifying, resisting aging, assisting in treating metabolic diseases, relaxing bowel, removing free radicals in the body, enhancing the immunity of the human body and the like.

The invention discloses sea-buckthorn, radix astragali and yeast beta-glucan granules and application thereof, and relates to the technical field of food health care, and the sea-buckthorn, radix astragali and yeast beta-glucan granules are prepared from the following raw materials: sea-buckthorn, radix astragali, yeast beta-glucan, American ginseng, radix salviae miltiorrhizae, fructus lycii, flos sophorae, fructus crataegi, xylitol, erythritol, cordyceps militaris, inonotus obliquus, radix polygonati officinalis, rhizoma dioscoreae, radix ophiopogonis and fructo-oligosaccharide. According to the invention, a three-dimensional efficacy system of immune activation, inflammation inhibition and intestinal repair is constructed through scientific proportioning of raw materials such as sea-buckthorn, astragalus membranaceus, yeast beta-glucan, cordyceps militaris and inonotus obliquus. The core components have a synergistic effect, so that not only can the activity of immune cells be activated and the immunity of the organism be improved, but also the release of inflammatory factors can be inhibited, the inflammatory response can be relieved, and meanwhile, the intestinal beneficial bacteria can be proliferated, the intestinal mucosa can be repaired and the intestinal micro-ecology can be improved. Compared with traditional medicinal and edible granules with a single effect, the product can meet the health requirements of people with different constitutions and is richer in adaptive scene.

The invention relates to a system for intestinal delivery of therapeutic agents. Described herein are systems for enteric delivery of therapeutic agents, and methods of administering therapeutic agents to a patient by oral administration of an enteric delivery system. An intestinal delivery system includes one or more carrier members comprising a carrier polymer and a therapeutic agent, and the system may be configured in a compressed configuration and an expanded configuration, and sized to maintain contact with an intestinal wall of a small intestine by applying an outward pressure to the intestinal wall, and transporting at least a portion of the therapeutic agent across the intestinal mucosa of the small intestine.