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88 results about "Nano complex" patented technology

Preparation method and application of multifunctional membrane-controlled targeting nano-carrier integrating tracing and targeted drug delivery effects

The invention belongs to the technical fields of preparation and applications of nano-carriers, and in particular discloses a preparation method and an application of a multifunctional membrane-controlled targeting nano-carrier integrating tracing and targeted drug delivery effects. With nano mesoporous silica (MSN) as a drug 'warehouse', a positively charged high molecular material and a negatively charged high molecular material as preparation materials of a gating membrane, and adriamycin (DOX), cis-platinum, imatinib, taxol and the like as model anti-cancer drugs, research contents mainlyinclude optimization and improvement of natural materials, construction and process optimization of the gating membrane, structural characterization of a nano complex, drug release kinetic characteristics of drug molecules under the control of the gating membrane, and the like. Meanwhile, in the combination with the tracing imaging function of a fluorescent quantum dot, drug delivery behaviors andanti-tumor effectiveness of the membrane-controlled nano drug delivery system undergo preliminary evaluation through in-vitro experiments. Based upon research results, references are provided for thedesign and preparation of the novel membrane-controlled nano drug delivery system.
Owner:SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES

Novel mesoporous silicon sphere co-loaded medicine nano-complex and preparation method thereof

The invention discloses a novel mesoporous silicon sphere co-loaded medicine nano-complex and a preparation method thereof. The novel mesoporous silicon sphere co-loaded medicine nano-complex is Ce6@MMSN / DOX / Ko143@PAsp-b-PEG-FA; the preparation method comprises the following steps: selecting TEOS (Tetraethyl Orthosilicate) as a silicon source, CTAB (Cetyltrimethyl Ammonium Bromide) as a template agent and n-hexane as a pore expanding agent and synthesizing mesoporous silicon dioxide nanoparticles with a double-pore-channel core-shell structure; carrying out amination modification on the mesoporous silicon dioxide nanoparticles; synthesizing Fe3O4 nanoparticles by adopting an LSS (Liquid-Solid-Solution) phase transfer method and ligand exchange reaction; modifying and embedding superparamagnetic iron oxide nanoparticles on the surface of aminated MSN through nucleophilic substitution, so as to construct magnetic mesoporous silicon dioxide nanoparticles; taking DCC (Dicyclollexyl Carbodiimide) as a condensation agent and covalently binding a photosensitizer Ce6 through amidation; meanwhile, loading a BCRP (Breast Cancer Resistance Protein) inhibitor Ko143; then crossly linking a copolymer FA-PEG-b-PAsp; finally, loading an anti-tumor medicine DOX.
Owner:SECOND AFFILIATED HOSPITAL SECOND MILITARY MEDICAL UNIV

SiC-ZrC-ZrB2 nano complex phase ceramic modified C/C composite material and preparation method thereof

The invention relates to a SiC-ZrC-ZrB2 nano complex phase ceramic modified C/C composite material and a preparation method thereof. A technical scheme adopted by the invention is that the preparation method of the SiC-ZrC-ZrB2 nano complex phase ceramic modified C/C composite material comprises the following steps: mixing 1-5wt% of organic boron, 5-10wt% of organic silicon, 10-20wt% of a ZrC precusor and 65-84wt% of an asphalt methylbenzene soluble component, adding a solvent to dissolve the mixture, reacting the obtained solution for 1-4 hours at 300-450 DEG C to obtain boron-silicon-zirconium-doped asphalt; dipping a carbon fiber prefabricated body with the boron-silicon-zirconium-doped asphalt, and then carrying out pyrolysis treatment to obtain a SiC-ZrC-ZrB2 nano complex phase ceramic modified C/C perform body; and repeatedly dipping and carrying out pyrolysis treatment on the SiC-ZrC-ZrB2 nano complex phase ceramic modified C/C perform body until the density is 1.9-2.5g/cm<3> to obtain the SiC-ZrC-ZrB2 nano complex phase ceramic modified C/C composite material. The composite material prepared by the preparation method has good mechanical performance, self-healing antioxidant ability and superhigh temperature ablation resistance within a wider temperature range.
Owner:WUHAN UNIV OF SCI & TECH

Nano-gold/manganese dioxide/graphene-carbon nanotube three-dimensional structural nano complex and hydrogen peroxide sensor prepared by using complex

The invention relates to a preparation method for a nanogold/manganese dioxide/graphene-carbon nanotube three-dimensional structural nano complex. The method specifically comprises the following steps: firstly carbon nanotubes are oxidized by a strong acid, and graphene oxide is stripped from the surfaces of the carbon nanotubes in the oxidation process, so that a graphene oxide-carbon nanotube three-dimensional carbon structure is formed; then KMnO4 is added to make manganese dioxide deposited on the surface of the carbon material, and the graphene oxide can be reduced to graphene through high-temperature heating; and manganese dioxide/graphene-carbon nanotubes are subjected to amination treatment, negatively-charged colloidal gold nanoparticles are immobilized on the surfaces of the aminated carbon nanotubes by utilizing electrostatic interaction, and therefore the complex is obtained. The preparation method provided by the invention is simple, and sandwich design of the manganese dioxide solves the problems of conductivity and stability of a manganese dioxide material and expands the application range of the manganese dioxide material; and a sensor prepared by using the complexrealizes rapid, sensitive and high-selectivity detection on hydrogen peroxide, and has potential application prospects.
Owner:ANYANG NORMAL UNIV

Preparation method of novel liquid-state nano complex flocculant

The invention belongs to the technical field of sewage treatment and particularly relates to a preparation method of a novel liquid-state nano complex flocculant. The preparation method comprises thefollowing steps: step 1, taking waste liquid containing hydrochloric acid, corroded aluminum and oxidized ferric, discharged in production processes, as raw materials, and performing stirring treatment for reacting to generate an aluminum chloride and ferric chloride mixture solution; step 2: adding the aluminum chloride and ferric chloride mixture solution generated in the reaction to a sodium hydroxide solution, adjusting the solution to a certain pH value, and standing the solution for a period of time to obtain a polymeric aluminum ferric chloride (PAFC) solution; and step 3, adding the obtained PAFC solution to an organic cation polymer product to generate a nano flocculant. The nano complex flocculant prepared by the preparation method provided by the invention has the beneficial effects that the nano complex flocculant belongs to an efficient complex variety, and pesticide wastes are used as raw materials, so that waste utilization is realized, ecological environment protectionis realized, and green cyclic development of agriculture is promoted; and compared with a traditional solid-state product, the nano complex flocculant has the advantages of high reaction speed, full reaction, uniform concentration and greatly improved treatment efficiency.
Owner:渤海今日(天津)科技有限公司
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