Preparation and application of quadruple-responding nano composite

A nanocomposite and responsive technology, which can be used in medical preparations containing non-active ingredients, medical preparations containing active ingredients, drug delivery, etc., and can solve problems such as leakage of loaded object molecules

Inactive Publication Date: 2017-07-04
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of mesoporous silica as a carrier for the release of guest molecules has the advantages of good biocompatibility, easy surface modification, and large loading capacity, but pure mesoporous silica materials cannot meet the controllability requirements of guest molecule release. , and there is a problem of premature leakage of loaded guest molecules
[0003] In addition, most of the nanocarriers currently used for controlled release are single-responsive, such as sensitive to pH, temperature, light, reducing agents, etc., but in the face of complex and changeable environments, nanocarriers that respond to single stimuli have been unable to meet the requirements. Realistic needs limit its application, and nanocarriers responding to multiple stimuli can better and more play the role of controlled release

Method used

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  • Preparation and application of quadruple-responding nano composite
  • Preparation and application of quadruple-responding nano composite
  • Preparation and application of quadruple-responding nano composite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A preparation method of a fourfold responsive nanocomposite is as follows:

[0042] Step 1. Preparation of reduced graphene oxide-mesoporous silica composite: adopt improved Hummer's method to prepare graphene oxide: 1 gram of natural graphite flakes is mixed with 60 grams of sodium chloride and ground in a grinder, and then mixed with Mix 1 to 2 liters of water and filter with suction after the sodium chloride is dissolved, and dry the obtained graphite in a vacuum at 80 to 90°C overnight; mix the dried graphite flakes with 23 ml of 98% H2SO2 and stir at room temperature for 8 to 12 hours. Slowly add 3 grams of potassium permanganate under bath conditions, then stir in an oil bath at 38-42°C for 30 minutes, heat to 70-80°C for 45 minutes, then add 3 ml of deionized water, and then heat to 100- Add 3ml of deionized water after 105°C for 5 minutes, add 40ml of deionized water after 5 minutes, keep the temperature at 100-105°C, add 140ml of deionized water and 10ml of 30%...

Embodiment 2

[0049] Step 1. Preparation of reduced graphene oxide-mesoporous silica composite: graphene oxide was prepared by the improved Hummer's method, and the obtained graphene oxide was ultrasonically crushed in a 600W ultrasonic machine for 2 hours; 60mg of the crushed Graphene oxide was dispersed in 100 ml of alkaline water with pH=11, stirred in an oil bath at 85°C for 12 hours for reduction, then added 2.0 g of cetyltrimethylammonium bromide and adjusted to pH=11.8 and stirred for 30 minutes, and finally added 850 The microliter tetraethyl orthosilicate was continuously stirred in an 85°C oil bath for 24 hours, and the reduced graphene oxide-mesoporous silica composite was obtained after centrifugation.

[0050] Step 2. Surface functionalization of the reduced graphene oxide-mesoporous silica composite: disperse 270 mg of the composite obtained in step 1 into 50 ml of toluene and stir in an oil bath at 85°C for 30 minutes, then dropwise add 3.0 Milliliters of isocyanatopropyltrie...

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Abstract

The invention relates to a quadruple-responding nano composite. With a reductive-ruptured disulfide bond as a connection point, the nano composite is prepared by polymerizing dimethylaminoethyl methacrylate on surface of a reduced graphene oxide-mesoporous silicon dioxide composite through an atom transfer radical polymerization reaction. The nano composite has temperature, pH value and reduction responding properties, has near-infrared light response, and has wide application prospect in the field of controlled release.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and relates to the preparation and application of a four-fold responsive nanocomposite to near-infrared light, temperature, pH and reduction. Background technique [0002] In recent years, various nanocarriers have been developed for controlled release, especially mesoporous silica. The use of mesoporous silica as a carrier for the release of guest molecules has the advantages of good biocompatibility, easy surface modification, and large loading capacity, but pure mesoporous silica materials cannot meet the controllability requirements of guest molecule release. , and there is a problem of premature leakage of loaded guest molecules. [0003] In addition, most of the nanocarriers currently used for controlled release are single-responsive, such as sensitive to pH, temperature, light, reducing agents, etc., but in the face of complex and changeable environments, nanocarriers that respo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F292/00C08F220/34A61K47/69A61K31/352
CPCC08F292/00A61K9/0009A61K31/352C08F220/34
Inventor 王国杰王潘俊陈硕曹自权
Owner UNIV OF SCI & TECH BEIJING
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