172 results about "Mesoporous silica" patented technology

This invention belongs to the field of electrocatalytic hydrogen evolution catalyst technology, and particularly relates to an ultrasmall intermetallic compound confined in mesoporous carbon interstices and its preparation method. Using mesoporous silica SBA-15 as a hard template, sulfur-containing amino acids are filled into the SBA-15 channels via capillary action as a carbon source. Simultaneously, potassium chloroplatinate and a transition metal source are also filled into the SBA-15 channels along with the sulfur-containing amino acids. The mass ratio of potassium chloroplatinate, SBA-15, and sulfur-containing amino acids is 1:5–10:20–30, and the metal mass is consistent with the atomic ratio in the formed Pt-based intermetallic compound. The reaction also includes a solvent and water. This invention uses electrocatalytic hydrogen evolution as a model reaction to investigate the catalytic activity and stability of this PtFe ultrasmall nanoparticle embedded in a mesoporous carbon support. Electrocatalytic results show that it exhibits excellent activity and stability, meeting the requirements of related applications and development.

This invention relates to diselenylene-bridged mesoporous silica nanoparticles loaded with baicalin and their applications. The invention constructs a ROS-responsive, microglia-inspired Ba@Se-MSN&BV2 nanoplatform targeting the secondary phase of spinal cord injury. The BV2 cell membrane-mediated enrichment at the injury site, combined with the diselenylene-triggered, on-demand release of baicalin, enables targeted intervention in a highly oxidative and pro-inflammatory microenvironment. In vitro and in vivo studies show that Ba@Se-MSN&BV2 can alleviate oxidative stress and mitochondrial dysfunction, inhibit apoptosis, promote axonal and neuronal survival, and improve motor circuit function. This invention provides a new therapeutic target and research direction for neuroinflammatory injuries driven by redox homeostasis disruption, with significant clinical application prospects and social value.

The application discloses a preparation of isosorbide catalyst and its preparation method and application. The catalyst is an organic / inorganic hybrid material, wherein the organic component comprises a functional group containing two or more N atoms and a hydrophobic group without nitrogen, and the inorganic component is a mesoporous silica material. The catalyst provided by the application is applied to the reaction of sorbitol and dimethyl carbonate to prepare isosorbide, and has high catalytic performance.

A nasal pharmaceutical composition comprising a porous excipient and an active agent, wherein the active agent is loaded onto a surface of the porous excipient located within pores of the porous excipient, wherein the porous excipient is an inorganic porous material selected from colloidal silicon dioxide, mesoporous silica, microporous silica and macroporous silica, and wherein the loaded porous excipient is dispersed in a gel, the gel comprising a vehicle comprising an oil or a mixture of oils, and wherein the composition is designed for nasal administration.

This invention relates to a multifunctional composite membrane containing a natural antibacterial agent and a biomimetic hydrophilic carrier, and pertains to the field of separation membrane manufacturing technology for water treatment applications. The membrane is prepared by blending MCM-41 type honeycomb-structured mesoporous silica modified with tea tree oil (TTO) with a PVDF membrane, aiming to enhance the membrane's antibacterial and antifouling capabilities. TTO, with its excellent antibacterial properties, effectively alleviates biofouling problems, while MCM-41 possesses a high specific surface area and good chemical stability, offering multiple benefits including improved membrane hydrophilicity, reduced fouling, and enhanced essential oil dispersion. The combination of tea tree oil and MCM-41 simultaneously addresses both organic and biofouling issues in PVDF membranes, achieving a synergistic improvement in both material and membrane performance.

The application discloses a kind of bionic transmembrane protein affinity chromatography column and its preparation method and application.The system (iSTAC) realizes the in-situ construction of transmembrane protein in highly bionic dynamic microenvironment by integrating cell-free protein synthesis, functional mesoporous silica modification and amphiphilic (AH) peptide stabilized planar lipid bilayer technology.The core is to use long-chain PEG-24 crosslinking agent to retain lipid bilayer on the surface of silica gel, provide sufficient conformational dynamic space for multi-transmembrane protein, and introduce AH peptide to repair membrane defects, ensure that the receptor realizes directional embedding while maintaining natural functional attributes.The preparation cycle is shortened from 168 hours to 5 hours, which significantly improves the efficiency of targeted drug screening and in-situ analysis of binding sites.Using this platform, 5-HT 1A Receptor agonists crocin I and crocin II with anti-insomnia and neuroprotective effects are successfully screened from saffron, and the action site is accurately depicted.

A single-cell transcriptome-guided multimodal synergistic injectable magnetically responsive biomimetic hydrogel system, its preparation method, and its application are described. This hydrogel platform is a three-level composite system of "matrix-microsphere-nanoparticle": the primary structure is a photocrosslinked methacryloyl hyaluronic acid three-dimensional network matrix; the secondary structure is GelMA microspheres loaded with MTPT nanoparticles prepared by microfluidic control; and the tertiary structure consists of bevacizumab and magnetite nanoparticles dispersed in the HAMA matrix. The MTPT nanoparticles have a mesoporous silica core, which is sequentially coated with temozolomide, a polydopamine coating, and a T7 targeting peptide. Under the activation of an alternating magnetic field, Fe3O4 generates a magnetothermal effect, which not only achieves local hyperthermia but also accelerates the time-sequential release of bevacizumab and MTPT, synergistically exerting the effects of chemotherapy, anti-angiogenic therapy, and hyperthermia.

The application discloses silica nano composite fertilizer, a preparation method and application thereof, and belongs to the field of nanobiotechnology. The silica nano composite fertilizer is prepared by taking modified dendritic mesoporous silica as a carrier and loading ionic compounds. The silica nanoparticles prepared by the application have excellent nanometer size, and the formed nano organic fertilizer can better help the transportation of element ions in plants. After modification, the loading and penetration guiding effect of the silica nanoparticles is improved, so that the yield and quality of vegetables are improved, the transportation performance of various elements in the vegetables is improved, and the utilization rate of element fertilizers is improved.

The present application provides the use of a nanocomposite with a core-shell structure. Specifically, the present application provides the use of a nanocomposite with a core-shell structure in the preparation of a drug for preventing and / or treating Clostridium difficile infection and recurrent diseases caused thereby, wherein the nanocomposite comprises: ZnO nanoparticles as a core; mesoporous silica as a shell coated on the surface of the ZnO nanoparticles; an antibiotic loaded in the pore channel of the mesoporous silica; hyperbranched polylysine modified on the surface of the mesoporous silica; and a pH-responsive coating material as the outermost layer. The nanocomposite provided by the present application can achieve precise targeted release of the drug in the colon, and through the sequential and synergistic mechanism of "membrane breaking-sterilization-spore inhibition-repair", it can simultaneously solve multiple factors leading to CDI recurrence such as biofilm protection, spore storage, bacterial population destruction, mucosal damage, etc., and improve the treatment effect.

The application provides a fluorescent structural color anti-counterfeiting material and a preparation method thereof, and the preparation method comprises the following steps: preparing composite fluorescent particles of mesoporous silica microsphere loaded halogen perovskite fluorescent particles CsPbX3, wherein X is Br, Cl or I; mixing the composite fluorescent particles with monodisperse silica nanoparticles, resin, a solvent, an initiator and an additive to obtain a mixture, wherein the volume percentage of each component in the mixture is as follows: 25-65% of the nanoparticles, 35-75% of the resin, 0.01-10% of the initiator, and 5-90% of the solvent, and the mass of the composite fluorescent particles is 0.01-3% of the mass of the silica nanoparticles; performing rotary evaporation on the mixture under vacuum to obtain concentrated paint, and after photocuring or thermal curing, the anti-counterfeiting material is obtained. The anti-counterfeiting material of the technical scheme has the dual anti-counterfeiting effects of structural color anti-counterfeiting under natural light and fluorescent anti-counterfeiting under ultraviolet excitation.

The present application relates to a kind of for CO2 hydrogenation methanol hydrophobic core-shell catalyst and its preparation method and application, belong to catalyst preparation technical field.Zirconium-based metal organic framework UiO-66 is core body, outer layer constructs hydrophobic mesoporous silica shell layer to form core-shell structure carrier.The carrier is pre-wetted with solvent before metal introduction, and copper, zinc nitrate precursor is introduced under the condition, and its wetting, penetration and migration process in channel are controlled, so that it can penetrate hydrophobic mesoporous shell layer and transport to core-shell interface and UiO-66 core surface.Subsequently, by adjusting metal deposition kinetics, copper zinc species is selectively deposited and forms active component enrichment at interface.Preferably, by controlling metal loading process, copper zinc active component is enriched and controllably distributed in hydrophobic core-shell structure, so as to improve the stability and catalytic performance of catalyst in CO2 hydrogenation methanol reaction.

This invention belongs to the field of biomedical materials and nanotechnology, specifically relating to the synthesis and application of a multifunctional mesoporous nanomaterial. The inventors synthesized a core-shell structured mesoporous nanoparticle using mesoporous silica nanoparticles and dopamine via emulsion epitaxy. The core of the core-shell structured mesoporous nanoparticle is S-nitrosoglutathione supported on mesoporous silica, and the outer shell is pentafluorophenyl chlorophyll supported on mesoporous polydopamine, forming MSN / G@mPDA / F nanoparticles. These nanoparticles rapidly increase in temperature to 45°C under 808 nm laser irradiation. o At temperatures above a certain temperature, S-nitrosoglutathione decomposes to produce nitric oxide. Further irradiation at 750 nm generates a large amount of reactive oxygen species, killing bacteria. This combination of photothermal and photodynamic therapy effectively inhibits bacterial growth. Therefore, this method exhibits excellent antibacterial effects and can play a role in the future treatment of bacterial infections.

The present application relates to the technical field of biological agents, and discloses a kind of M cell targeted peptide and chitosan modified dendritic mesoporous silica oral adjuvant and application thereof.The oral adjuvant includes dendritic mesoporous silica (DFNSs), and M cell targeted peptide (CKS9) modified chitosan (CS), the dendritic mesoporous silica is mixed with M cell targeted peptide modified chitosan at mass ratio 4-6:1, and is made into CKS9-CS-DFNSs oral nano adjuvant.The CKS9-CS-DFNSs oral nano adjuvant provided in the present application has good stability and safety, can effectively induce mucosal immune response and humoral immune response by oral immunization, improve the effect of oral vaccine immunization, and can be widely used in the preparation of animal inactivated vaccine, recombinant protein vaccine and polypeptide vaccine.The oral nano adjuvant preparation has low cost, simple process and is easy to mass-produce.

This invention proposes a long-term low-conductivity composite treatment method for the inner cavity of a hydrogen fuel cell stack heat sink core. The method includes pre-treating the surface of the heat sink core, coating it with a slurry, curing it, and cleaning it. The slurry comprises pH-responsive slow-release microcapsules, which, from the inside out, consist of an ion trapping agent and mesoporous silica grafted with polyacrylic acid. A coating is formed on the surface of the heat sink core by coating and curing the slurry. This slurry integrates the atomic-level physical barrier function of graphene with the intelligent chemical trapping function of the pH-responsive microcapsules, achieving multi-layered protection of "physical barrier as the main component, chemical trapping as a supplement, and intelligent response." This allows the coolant conductivity to be stably controlled below 5 μS / cm under dynamic operating conditions for thousands of hours.

The application belongs to the field of chemical separation and functional materials, and provides an industrial hemp metabolite extraction method based on dynamic borate reversible reaction. The application adopts a core-shell mesoporous functional adsorbent design. The adsorbent comprises a mesoporous silica core and an organic shell layer containing a pincer-type double-boron recognition cavity. The distance from boron to the boron center is 0.32-0.50 nm. The selective adsorption of ortho-diphenol type industrial hemp metabolites is realized under the condition that the volume fraction of ethanol is 85-96 vol%, and the temperature is 30-40 DEG C. The borate bond is reversibly broken by reducing the acidity and / or introducing a glycol competitive agent to complete mild desorption, realizing the performance of a selectivity coefficient of greater than or equal to 100, a recovery rate of greater than or equal to 95%, an activity retention rate of greater than or equal to 90% after 100-200 cycles, and a boron leaching amount of less than or equal to 1 ppm. The triple contradiction between the shell layer cross-linking and recognition cavity accessibility, high liquid hourly space velocity and ethanol-water microenvironment regulation, mild regeneration and site chemical integrity is solved, and the application has wide application value.

This invention belongs to the field of medical technology, specifically relating to a tandem controlled-release nucleic acid nanoprobe composite hydrogel and its application in the diagnosis and treatment of wound infections. First, the invention modifies the surface of gold nanoparticles with nucleic acid sequences via Au-S bonds to prepare a DNA-gold nanoparticle probe (NAFP), achieving highly specific detection of sulfides, a wound infection marker. Then, using mesoporous silica as a carrier, an antibacterial drug is loaded, constructing mesoporous silica D@MSNs loaded with a double-stranded DNA molecule valve-type bactericide. Subsequently, the NAFP and D@MSNs are formulated into a gel to obtain a therapeutic dressing. This dressing can trigger conformational changes in nucleic acids through infection markers, achieving precise matching of drug release to the degree of infection, thereby enabling in-situ detection of bacteria. It also possesses highly efficient antibacterial activity, physical protection, and moisturizing functions. The dressing is easy to operate, has low clinical translation costs, and is suitable for the diagnosis and treatment of acute and chronic wound infections, showing broad application prospects.

This invention provides a nanocomposite material with a core-shell structure. The nanocomposite material comprises: ZnO nanoparticles as the core; mesoporous silica as the shell coating the surface of the ZnO nanoparticles; an antibiotic loaded within the pores of the mesoporous silica; hyperbranched polylysine modified on the surface of the mesoporous silica; and a pH-responsive coating material as the outermost layer. The nanocomposite material provided by this invention enables precise targeted drug release in the colon, simultaneously addressing multiple factors leading to CDI recurrence, such as biofilm protection, spore storage, microbial disruption, and mucosal damage, through a sequential synergistic mechanism of "membrane disruption-bactericidal-spore inhibition-repair," thereby improving treatment efficacy.

This invention discloses a mesoporous silica-based composite material with phosphotungstic acid simultaneously immobilized with titanium oxide and its cellulose hydrolysis method, belonging to the field of biomass catalytic conversion technology. This invention aims to solve the problems of easy desorption of active components, low catalytic efficiency, and poor cycle stability in existing solid acid catalysts during cellulose hydrolysis. This method uses an ionic liquid as the reaction medium and a titanium-silicon-supported phosphotungstic acid composite material with a two-dimensional hexagonal ordered mesoporous structure prepared by a one-step hydrothermal synthesis as the solid acid catalyst, catalyzing the hydrolysis of cellulose to reduce sugars in the presence of water. This invention achieves highly efficient cellulose conversion through the synergistic catalytic effect of the two acid sites combined with the good solubility of cellulose in the ionic liquid. The catalyst exhibits excellent recyclability, the process conditions are well-defined, it meets the requirements of green chemistry, and it is applicable to the field of biomass resource utilization.

The present invention provides a solid dispersion comprising lurasidone or a pharmaceutically acceptable salt thereof and a carrier. The carrier material includes polyvinyl acetate phthalate (PVAP), polyvinyl alcohol (PVA), cellulose acetate phthalate (CAP), mesoporous silica, hydroxypropyl methylcellulose (HPMC), polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, acrylic resin, hydroxypropyl cellulose (HPC), povidone, copovidone, ethylcellulose, polyoxyethylene glycol, hypromellose acetate succinate (HPMCAS), hypromellose phthalate (HPMCP), or a combination thereof.

An antireflection member comprising: a resin base; and a particle layer that is disposed on the surface of the resin base and that includes mesoporous silica nanoparticles, wherein a portion of the nanoparticles is directly fixed to the surface of the resin base, at least a portion of the nanoparticles directly fixed to the surface of the resin base is embedded in the surface of the resin base, at least two layers of the nanoparticles are disposed to form the particle layer, the thickness of the particle layer is 2-10 times the average particle size of the nanoparticles, and the proportion of the area occupied by the particle layer including the nanoparticles with respect to the total surface area of the resin base is at least 95%.

The application discloses a kind of photovoltaic glass self-cleaning nano coating and its processing method, for crosslinking grafting on the surface of photovoltaic glass to control water contact angle less than 0.3 °, it is related to photovoltaic maintenance technical field, the photovoltaic glass self-cleaning nano coating includes mesoporous silica, epoxy group polyether, dimethyl diallyl ammonium chloride, enamine, ethyl chloroacetate, crosslinking agent, initiator, silane coupling agent.The application has the photovoltaic glass self-cleaning nano coating of water contact angle less than 0.3 ° formed on the surface of photovoltaic glass, so that water film spread on the surface of photovoltaic glass is separated from the photovoltaic glass self-cleaning nano coating by contaminant, and then the effect of removing contaminant is carried out by using gravity and / or wind power to drive water film to move.

This invention relates to a deodorant, its preparation method, and its application, belonging to the field of deodorization technology. The invention provides a deodorant preparation method, specifically involving the following steps: a mineral-based deodorizing carrier, anhydrous calcium chloride, magnesium stearate, calcium peroxide, ferrous sulfate, basic copper carbonate, zinc oxide, and mesoporous silica are orderly mixed to obtain a composite powder. This powder is then mixed with a sodium silicate aqueous solution, kneaded, pressed into shape, and cured to obtain a raw blank. The raw blank is then immersed in a composite treatment solution containing silica sol, a silane coupling agent, and nano-titanium dioxide. After removal, it is dried and heat-treated to obtain the deodorant. The deodorant prepared by this invention can be applied to kitchens, bathrooms, and shoe cabinets, exhibiting excellent deodorizing effects.

This application relates to the field of water pollution control technology and discloses a method for preparing a sediment microecological reconstruction and pollutant-targeted immobilization conditioner. The method includes: modifying mesoporous silica with amino- and thiolated compounds and mixing it with biochar to obtain an adsorbent material; dispersing ferrous sulfate, sodium thiosulfate, and hydroxyapatite with the adsorbent material in a sodium alginate solution and adding it dropwise to a calcium chloride solution for cross-linking and chitosan coating to obtain microcapsules; compounding riboflavin, humic acid, carbon source nutrients, and adding signaling molecules to obtain a metabolic enhancer; compounding metalloenzyme inhibitors and activating them with microorganisms to obtain an activator; granulating and coating calcium carbonate, magnesium hydroxide, ferrous sulfate, sulfur powder, calcium peroxide, and sodium lactate to obtain buffer particles; mixing the adsorbent material, microcapsules, and buffer particles, spraying, adding the metabolic enhancer and activator, adding binders and pore-forming agents, granulating, drying, sieving, and spraying a protective film to obtain the conditioner. This application solves the technical problems of existing sediment conditioners, such as single function, uncontrolled release, and microecological imbalance.

The application discloses an amino-functionalized magnetic mesoporous nanomaterial and a preparation method and application thereof, and the nanomaterial is Fe3O4@nSiO2@TiO2@mSiO2-NH2; from inside to outside, the nanomaterial comprises a magnetite magnetic core, a dense silica layer, a titanium dioxide layer and an amino-functionalized mesoporous silica layer. The magnetic core is synthesized by a solvothermal method, the dense silica layer and the titanium dioxide layer are coated by adopting a sol-gel method in sequence, and finally the amino-functionalized mesoporous silica layer is modified by a co-condensation method. The material can protonate the surface amino group to form a local alkaline microenvironment under an acidic condition, can maintain trypsin activity, realizes synchronous performance of rapid enzymolysis of proteins and in-situ enrichment of phosphorylated peptides, and significantly shortens the enzymolysis time. The application has excellent enrichment selectivity for the phosphorylated peptides, the sensitivity reaches 10 fmol / μL, the enrichment capacity is about 100 mg / g, and is suitable for high-throughput quantitative analysis of phosphorylated proteins in complex biological samples.

This invention relates to the field of bio-breeding technology and discloses a molecular marker-assisted breeding method for bitter gourd resistant to powdery mildew and high-altitude leaf spot disease. The method includes constructing powdery mildew-resistant target-response probes and high-altitude leaf spot-resistant target-response probes; preparing mesoporous silica nanoparticles with a surface covalently coupled to a fluorescent internal reference molecule and a plant cell-penetrating peptide; loading the powdery mildew-resistant and high-altitude leaf spot-resistant target-response probes into the mesoporous channels to obtain a self-calibrated in-situ living nanoprobe complex; infiltrating the self-calibrated in-situ living nanoprobe complex into the living tissue of a single bitter gourd plant; collecting the total fluorescence intensity and spontaneous background fluorescence intensity and calculating the standardized resistance index; comparing the standardized resistance index with a judgment threshold to screen out dual-resistant living plants. This invention eliminates the physical error caused by fluctuations in the absolute amount of vector infiltration, achieving in-situ, non-destructive, and accurate identification of dual-resistant genotypes in living plants.

The application discloses a polymer-coated mesoporous silica supported ruthenium catalyst and a preparation method and application thereof. The catalyst has a polymer-coated mesoporous silica inner core, wherein the surface of the silica inner core is grafted with triethoxysilane having an alkenyl group; the alkenyl group of the triethoxysilane serves as an active site; the polymer is formed by polymerization of a polymer monomer through the alkenyl group; and the catalyst is formed by further coordination of metal Ru. The particle size of the catalyst is between 400 nm and 600 nm. The supported ruthenium catalyst provided by the application can catalyze hydrogen transfer reduction of carbonyl compounds at a high yield (up to 99%) and high enantiomeric selectivity (up to 99%), can be recycled for 8 times through simple recovery, and is easy to be industrialized, and can reduce catalyst cost and pollution.

The application provides a method for improving the stability of water-soluble active substances. The method comprises mixing a solution containing water-soluble active substances, ethanol, ammonia, cetyltrimethylammonium bromide, tetraethyl orthosilicate and a reducing agent, performing hydrophobic treatment after reaction, and then dispersing in an oil phase for storage. The water-soluble active substances are wrapped in mesoporous silica by a specific process, the surface and mesoporous channels of the silica are modified by hydrophobic treatment, and then the silica is dispersed in an oil phase, so that the water-soluble active substances can avoid contact with external stimulating factors such as water molecules, oxygen and metal ions, thereby effectively improving the stability of the water-soluble active substances in long-term storage and further widening the application range of the water-soluble active substances.

This invention discloses a mesoporous silica nanocarrier for enhancing oral intestinal retention, its preparation method, and its application, belonging to the field of nanomedicine delivery technology. The preparation method of the mesoporous silica nanocarrier includes the following steps: dissolving a template agent and an alkaline catalyst in an ethanol-water solution, adding a silica source material, reacting at 100±50 rpm, and then calcining at high temperature to obtain the mesoporous silica nanocarrier. This invention successfully prepared helical mesoporous silica nanoparticles by controlling the stirring rate during the nanoparticle synthesis process. Due to their unique geometric structure, these nanoparticles exhibit optimal in vitro mucus permeability and intestinal retention characteristics, significantly enhancing the therapeutic effect of loaded drugs and improving drug bioavailability in the intestine. This invention provides a new strategy for constructing efficient oral targeted drug delivery systems and achieving precision treatment of IBD.

A method for preparing bimodal nanocapsules includes: preparing a solution of mesoporous silica and deionized water, adding chloroauric acid solution and stirring, then adding sodium borohydride solution under ice bath stirring conditions to obtain gold nanoparticle-modified mesoporous silica; preparing a solvent of ultrapure water and gold nanoparticle-modified mesoporous silica, then sequentially adding a fluorescence quencher, a fluorescent molecule, and 4-mercaptophenylboronic acid to react separately to obtain bimolecularly modified nanoprobes; and mixing an adenosine-5′-triphosphate nucleic acid aptamer solution with the nanoprobes using ultrapure water as a solvent to obtain nucleic acid aptamer-encapsulated bimodal nanocapsules. This invention provides a simple, mild, environmentally friendly, and low-cost preparation method. The bimodal nanocapsules prepared by this invention can simultaneously monitor the levels of hydrogen peroxide and adenosine-5′-triphosphate (ATP) in cells using fluorescence and surface-enhanced Raman scattering (SERS) techniques, which can be used for early disease monitoring.

To provide an anti-reflective material having high light transmittance in the near-infrared wavelength range (800-2500 nm). [Solution] The system comprises a resin substrate and a particle layer made of mesoporous silica nanoparticles arranged on the surface of the resin substrate. Some of the aforementioned nanoparticles are directly immobilized on the surface of the resin substrate, and At least a portion of the nanoparticles directly immobilized on the surface of the resin substrate are embedded in the surface of the resin substrate. The aforementioned nanoparticles are arranged in two or more layers to form the particle layer, The thickness of the particle layer is 2 to 10 times the average particle diameter of the nanoparticles. The area occupied by the particle layer made of nanoparticles is 95% or more of the total surface area of ​​the resin substrate. An anti-reflective member characterized by the following features.