Hollow mesoporous silica microsphere, preparation method and application thereof

A technology of mesoporous silica and microspheres, applied in the directions of silica, silica, pharmaceutical formulations, etc., can solve the problems of limiting the application scope and application value of materials, and achieve the expansion of application value, simple preparation method, and high yield. high effect

Inactive Publication Date: 2012-05-02
广州万泽医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Mesopores are too small to limit the entry and exit of large guest molecules and affect the rate of entry and exi

Method used

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  • Hollow mesoporous silica microsphere, preparation method and application thereof
  • Hollow mesoporous silica microsphere, preparation method and application thereof
  • Hollow mesoporous silica microsphere, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The specific preparation process of the hollow mesoporous silica microspheres of this embodiment is as follows:

[0033] (1) Prepare 60ml of an ammonia solution with a pH of 12;

[0034] (2) Add cetyltrimethylammonium bromide to the aqueous ammonia solution of step (1), and the mass percentage concentration of cetyltrimethylammonium bromide in the solution is 0.5% (w / w), Stir to make the solution clear, then add n-heptane, the volume ratio of added n-heptane to ammonia is 0.1;

[0035] (3) Heating the mixed solution in step (2) at a temperature of 40°C, while stirring and emulsifying, the stirring speed is 500 rpm, and the emulsification time is 1 hour;

[0036] (4) Add ethyl orthosilicate to the mixed solution of step (3) while stirring, and the mass ratio of the added ethyl orthosilicate to cetyltrimethylammonium bromide is 1;

[0037] (5) Collect the solid by filtration after 2 hours, wash to neutral and dry;

[0038] (6) The dry powder is not calcined at 550°C for 10 hours to...

Embodiment 2

[0042] The specific preparation process of the hollow mesoporous silica microspheres of this embodiment is as follows:

[0043] (1) Prepare 60ml of ammonia solution with pH 10;

[0044] (2) Add cetyltrimethylammonium bromide to the aqueous ammonia solution of step (1), and the mass percentage concentration of cetyltrimethylammonium bromide in the solution is 0.1% (w / w), Stir to make the solution clear, then add a mixture of isooctane and n-decane, the volume ratio of the added mixture to ammonia is 0.2;

[0045] (3) Heating the mixed solution in step (2) at a temperature of 30°C, while stirring and emulsifying, the stirring speed is 700 rpm, and the emulsification time is 2 hours;

[0046] (4) Add ethyl orthosilicate to the mixed solution of step (3) while stirring, and the mass ratio of the added ethyl orthosilicate to cetyltrimethylammonium bromide is 0.05;

[0047] (5) Collect the solid by filtration after 2 hours, wash to neutral and dry;

[0048] (6) The dry powder is not calcined ...

Embodiment 3

[0051] The specific preparation process of the hollow mesoporous silica microspheres of this embodiment is as follows:

[0052] (1) Prepare 60ml of 0.5M hydrochloric acid solution;

[0053] (2) Add PEO-PPO-PEO triblock copolymer P123 to the hydrochloric acid solution of step (1), and the mass percentage concentration of PEO-PPO-PEO triblock copolymer P123 in the solution is 5.0% (w / w ), stir to make the solution clear, then add a mixture of 1,3,5-trimethylbenzene and isooctane, the volume ratio of the added mixture to ammonia is 0.01;

[0054] (3) Heating the mixed solution in step (2) at a temperature of 80°C, while stirring and emulsifying, the stirring speed is 200 rpm, and the emulsification time is 0.5 hours;

[0055] (4) Add ethyl orthosilicate to the mixed solution of step (3) while stirring, and the mass ratio of the added ethyl orthosilicate to P123 is 0.05;

[0056] (5) Collect the solid by filtration after 2 hours, wash to neutral and dry;

[0057] (6) The dry powder was not ...

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Abstract

The invention discloses a hollow mesoporous silica microsphere with hollow core and adjustable mesopore and penetrating through a shell, preparation method and application thereof. The hollow mesoporous silica microsphere is obtained by the following steps: under the condition of acid or alkaline solution, taking hexadecyl trimethyl ammonium bromide or PEO-PPO-PEO triblock copolymer as template, adding non-polar solvent, stirring at a certain temperature, emulsifying, then adding silica source, after hydrolysis and condensation, filtering, drying, and roasting to remove the template. The preparation method has simple technique and short time, easy operation and low cost, the prepared microsphere comprises both macropore and mesopore structures, the mesopore penetrates through the shell, the aperture thereof is larger than 5nm and is adjustable within the range of 5-20nm, and by relatively large mesopore channel, internal and external transmissions of large guest molecules can be realized. The microsphere can be used as drug carrier, the drug loading amount can exceed 50% (mass percentage), and the drug release can be controlled by adjusting aperture of the mesopore and dissolutionrate of indissolvable drug can be improved.

Description

Technical field [0001] The invention belongs to the field of inorganic material preparation and medical application, and specifically relates to a hollow mesoporous silica microsphere with a mesoporous shell layer and a hollow core, a preparation method thereof, and application as a drug carrier. Background technique [0002] Because of its low density, large specific surface area and high pore volume, porous materials are widely used in various fields such as construction, chemical industry, and medicine. According to the definition of the International Union of Pure and Applied Chemistry (IUPAC), the pore size of porous materials is divided into three categories: pores smaller than 2 nanometers are micropores, pores larger than 50 nanometers are macropores, between 2 Pores up to 50 nanometers are mesopores. The size of the pores determines the purpose of the porous material. Hollow mesoporous microspheres have both mesoporous and macroporous structures in one unit, so that th...

Claims

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Application Information

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IPC IPC(8): C01B33/12A61K47/04
Inventor 吴传斌陈宝王周华权桂兰
Owner 广州万泽医药科技有限公司
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