4877 results about "Dry powder" patented technology

The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-freeze drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry 10 powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.

The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.

The present invention provides an inhaler comprising a housing which contains a blister strip having a plurality of blisters which contain powdered medicament for inhalation, a mouthpiece mounted to the housing through which the medicament is inhaled by a user, an indexing and opening mechanism for indexing the blister strip and for opening the blisters which is operated by an actuator, wherein the blister strip is indexed by forward motion of the actuator from a first position to a second position, such as by opening a cover, and is also indexed in the same direction by reverse motion of the actuator from the second positon to the first position, such as by closing the cover.

The present invention provides an inhaler comprising a housing which contains a blister strip having a plurality of blisters which contain powdered medicament for inhalation; a mouthpiece through which the medicament is inhaled by a user; an indexing wheel for indexing the blister strip; an opening mechanism for opening the blisters; an actuator which is movable between a first position and a second position in order to operate the indexing wheel and the opening mechanism; and a coupling mechanism for coupling the actuator to the indexing wheel so that the indexing wheel rotates together with the actuator during part of the motion of the actuator; characterized in that the coupling mechanism comprises a shuttle that rotates on the same axis as, and translates axially relative to, the indexing wheel.

The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.

The present disclosure provides water-soluble film packages composed of a water-soluble film, where the packages include: one or more compartment(s) including dehydrated microbes. The disclosure further provides methods of production of the water-soluble film packages, and methods of application thereof. The water-soluble packages of the disclosure enable convenient and accurate application of microbial dry powders to plants, promote uniform dispersion of powdered microbes, enhance microbial shelf life, and enhance the survival of microbes on seed, while being environmentally sustainable.

The invention discloses solid-waste-based fluid-state solidified soil and a preparation method thereof, and belongs to the technical field of solid waste resource utilization. Raw soil is used as a base material, a curing agent composed of steel slag, granulated blast-furnace slag, gypsum, fly ash, aluminate and other industrial solid waste, a flocculating agent, a conditioning agent, a modifying agent, a stabilizing agent and a soil modifying agent are doped, and then the solid-waste-based fluid-state solidified soil is prepared. Adding water and stirring to form premixed flow-state solidified soil; comprising dry powder and water, and the mass ratio of the water to the dry powder is 0.65-0.75; the dry powder comprises the following components in parts by mass: 80-85 parts of raw soil, 10-15 parts of a curing agent, 2-5 parts of a flocculating agent, 0.5-1.5 parts of a conditioning agent, 1-3 parts of a modifying agent, 0.2-0.4 part of a stabilizing agent and 3-5 parts of a soil modifying agent. The solid-waste-based fluid-state solidified soil prepared by the method has the characteristics of high fluidity, high strength, relatively good water stability, low cost and the like, is beneficial to actual production, and conforms to a green development mode.

The invention discloses carboxymethyl chitosan-hyaluronic acid-stem cell exosome eye drops as well as a preparation method and application thereof, and relates to the technical field of eye drops and medical biogel. The carboxymethyl chitosan-hyaluronic acid-stem cell exosome eye drops are prepared from tannic acid modified carboxymethyl chitosan and adipose tissue-derived stromal cell exosome freeze-dried powder, the carboxymethyl chitosan-hyaluronic acid-stem cell exosome eye drops provided by the invention can effectively treat xerophthalmia, and are stable in components, safe and reliable. The three components including the tannic acid modified carboxymethyl chitosan, the hyaluronic acid and the adipose tissue-derived stromal cell exosome coexist, so that the functions of all the components can be fully played, a synergistic effect is achieved, and a better treatment effect on xerophthalmia is achieved.

The invention relates to the technical field of pharmaceutical preparations, and discloses a composition with liver protection and antioxidation effects and a preparation method thereof.The composition is prepared from galactosamine modified astragalus membranaceus exosome, schisandra chinensis nanocrystals, liquorice-chitosan nanoparticles, lactobacillus acidophilus freeze-dried powder, beta-(1, 3) / (1, 3, 4-tetramethyl-1, 3-pentanediol monoisobutyrate) sourced from saccharomyces cerevisiae, and beta-(1, 3, 4-tetramethyl-1, 3-pentanediol monoisobutyrate). And (6) a dextran, grape exosome-curcumin hybrid vesicle freeze-dried powder, a curcumin-mitochondrial targeting peptide compound, a resveratrol-hydroxypropyl-beta-cyclodextrin inclusion compound and reduced panthenol. According to the liver-protecting and anti-oxidation composition disclosed by the invention, multi-dimensional intervention on liver protection is realized through an elaborately designed ternary system. The system is composed of a traditional Chinese medicine extract, a microorganism-plant exosome combination and a high-bioavailability antioxidant, all the parts have a synergistic effect, and the liver protection effect is remarkably improved.

Provided herein are dry powder formulations comprising epinephrine alone or in combination with at least one enabling agent suitable for nasal application. Also provided are unit dose forms and devices comprising such formulations and methods of using such formulations for the treatment of various conditions including anaphylaxis, anaphylactoid reaction, respiratory conditions, hemodynamic collapse, and for administration during cardiopulmonary arrest and other life-threatening conditions.

The utility model belongs to the technical field of concrete stirring equipment, and discloses a concrete stirring and mixing device with an automatic additive adding function, which comprises a rack and a stirring assembly arranged on the rack, the stirring assembly comprises a material storage barrel arranged on the rack; one end of the driving shaft is rotationally connected with the storage barrel, and the free end of the driving shaft penetrates through the top of the storage barrel; the crushing blade is arranged in the storage barrel, and the crushing blade is coaxially and fixedly connected with the driving shaft; the output end of the driving motor is fixedly connected with the driving shaft; according to the scheme, the driving motor drives the driving shaft and the crushing blades to rotate in the material storage barrel, and the shearing force generated by the blades of the crushing blades is utilized to crush and scatter agglomerated dry powder additives, so that the situation that a part of areas are not coagulated for a long time or the overall strength deviation is too large due to uneven dispersion of the retarders agglomerated with damp is avoided; the utility model solves the problem that the concrete additive is affected with damp and agglomerated.

The mixing device comprises a powder hopper, a pre-mixing pipe, a high-pressure water pipe, a high-pressure pump, a machine body and a shearing emulsification pump, the powder hopper is connected with the pre-mixing pipe, the pre-mixing pipe is connected with the shearing emulsification pump, and the outlet side of the shearing emulsification pump is connected with a finished product output pipe; the water outlet end of the high-pressure water pipe is nested in the premixing pipe to form an annular powder channel, and the water inlet end of the high-pressure water pipe is connected with the high-pressure pump; a powder channel on-off mechanism is arranged outside the high-pressure water pipe; a kinetic energy collecting and stirring mechanism is arranged in the lower end of the high-pressure water pipe. The invention also comprises a mixing method of S1-S6. An annular powder channel is formed between the high-pressure water pipe and the pre-mixing pipe, dry powder can be annularly and uniformly distributed in the circumferential direction of the high-pressure water pipe through the annular powder channel, the dry powder is continuously and circumferentially sucked in through the Venturi effect generated when high-pressure water passes through the tail end of the high-pressure water pipe, the contact between the dry powder and water is larger, caking is more likely to be generated, and the dry powder is more stable. The online dry powder mixing device has a better online dry powder mixing effect.

The invention relates to the technical field of cosmetics, and provides a composition containing a dendrobium officinale enzymolysis extract, which is prepared from the following components in percentage by mass: 18 to 22 percent of dendrobium officinale enzymolysis extract, 9 to 11 percent of chitosan oligosaccharide, 6.5 to 7.5 percent of bionic moisturizing enhancer, 0.1 to 0.2 percent of sodium alginate, 0.05 to 0.15 percent of citric acid / sodium citrate buffer pair and 60.4 to 65.4 percent of solvent matrix. By combining low-temperature enzymolysis with a biological purification process, efficient extraction of dendrobium candidum polysaccharides and phenolic substances is realized, dendrophenol oxidation inactivation caused by high temperature can be effectively avoided, hydrochloric acid residues in chitosan oligosaccharide preparation are effectively removed, formula irritation is remarkably reduced, and the dendrobium candidum extract is more suitable for sensitive skin care; the components in the composition have a synergistic effect, the dendrobium officinale enzymolysis extract and the enzymolysis chitosan oligosaccharide form a composite moisturizing network, the moisturizing rate is remarkably increased, the oxidation resistance is remarkably improved, and the composition can be applied to products such as essence, masks and freeze-dried powder.

The invention relates to the technical field of electrode processing, and provides a dry electrode rolling device with a controllable pressure roll gap, which comprises at least two compression rollers with inner cavities, and a rolling gap is arranged between the two compression rollers; the first touch piece is arranged in the inner cavity, the first touch piece and the pressing roller are arranged in a split mode, the first touch piece is provided with a first touch part, the first touch part makes contact with the inner wall of the inner cavity, and the first touch part and the rolling seam are located on the inner side and the outer side of the roller wall of the pressing roller respectively. According to the technical scheme, the problems that in the prior art, dry powder materials are not uniformly distributed, so that the compression rollers deform, the gap between the adjacent compression rollers is reduced, the quality of the formed electrode diaphragm is influenced, the thickness is not uniform, the surface is not flat and the like are solved.

The invention relates to the technical field of biological medicine, and discloses a pharmaceutical composition of paclitaxel dimer prodrug nanoparticles and a traditional Chinese medicine compound and application of the pharmaceutical composition, and the pharmaceutical composition is composed of Qiyuansanlong prescription freeze-dried powder and paclitaxel dimer prodrug nanoparticles; wherein the paclitaxel dimer prodrug nanoparticles comprise one of NQO1 response type PTX dimer prodrug nanoparticles (PTX-Q-PTX NPs) or GSH (glutathione) response type PTX dimer prodrug nanoparticles (PTX-SeSe-PTXNPs), and the paclitaxel dimer prodrug nanoparticles comprise one of NQO1 response type PTX dimer prodrug nanoparticles (PTX-Q-PTX NPs) and GSH response type PTX dimer prodrug nanoparticles (PTX-SeSe-PTXNPs). According to the pharmaceutical composition disclosed by the invention, a traditional Chinese and western medicine synergistic treatment system is innovatively constructed, and the advantage of multi-dimensional synergistic interaction is shown. Firstly, an NQO1 / GSH double-response type intelligent release system is adopted, and a biomarker highly expressed by tumor tissue can be specifically responded to realize precise drug release, so that the PTX concentration in tumors is improved compared with that of a traditional dosage form, and meanwhile, the drug circulation time is prolonged. Secondly, the active ingredients in the Qiyuansanlong prescription freeze-dried powder can significantly down-regulate the PD-L1 expression level, synergistically enhance CD4 + T and CD8 + T cell infiltration, and form chemical-immune dual killing effects.

The invention discloses a method for improving the performance of a resistance reducing agent based on cyclodextrin solubilization modification and application, and belongs to the technical field of fracturing fluids. The method comprises the following steps: S1, preparing a mixed liquid from hydrophobic associated polymer dry powder and cyclodextrin; s2, stirring the mixed liquid, testing the particle size of the mixed liquid at the same time interval, and ending stirring after the particle size is reduced to a stable size, so as to obtain the hydrophobic associated polymer solution. The cyclodextrin polymer not only has a high-molecular effect, but also retains the inclusion ability of a cyclodextrin cavity, and has better inclusion performance under the condition of larger guest molecules. The hydrophobic association polymer is modified through a host-guest inclusion technology, the solubility of the hydrophobic association polymer is improved on the basis of guaranteeing the resistance reducing effect of the hydrophobic association polymer, and the prepared hydrophobic association polymer resistance reducing agent has the advantages of being fast in dissolution and good in shear resistance and resistance reducing effect.

The invention relates to a preparation method of a flexible solid hydrogen storage bed body, which comprises the following steps: S1, mixing 74-90% by mass of hydrogen storage alloy powder and 3-16% by mass of carbon-based heat conduction material for 20-50 minutes in a mechanical stirring manner to obtain a dry powder mixture; s2, adding an organic silicon material with the mass fraction of 5-16%, and continuously mechanically stirring for 1-5 hours to obtain a non-dry powder mixture; and S3, carrying out vacuum drying on the non-dry powder mixture in the S2 at 60-100 DEG C for 8-20 hours, and naturally cooling to room temperature to obtain the required novel non-dry powdery hydrogen storage bed body. Through the synergistic effect of the hydrogen storage alloy, the expanded graphite and the double-liquid silica gel, the flexible solid hydrogen storage material is formed on the basis of optimizing the material ratio and the process sequence. The synergistic effect of the materials breaks through the defect that a traditional hydrogen storage bed body is too high in rigidity or in a loose powder state, and finally the hydrogen storage bed body has high hydrogen storage efficiency, stable cycle life and excellent safety performance.

The present invention provides a dry powder inhaler comprising: one or more doses of powdered medication; an outlet through which a user may inhale a dose of medication; an airway, and a mixing element located in the airway When a user inhales on the outlet, medication is entrained in an air flow and flows through the airway and out through the outlet. The mixing element is in the form of three generally orthogonal generally circular discs with a common centre.

The invention provides an ultrasonic-assisted red pomelo polyphenol extraction method and application. The polyphenol component in the red pomelo is extracted through the following steps: firstly, performing activation pretreatment on red pomelo dry powder by adopting a low-temperature plasma device, and destroying a cell wall structure so as to improve the accessibility of combined polyphenol; then cellulase, pectinase, hemicellulase and beta-glucosidase are added into a biodegradable deep eutectic solvent to synergistically hydrolyze the cell wall polysaccharide, and combined polyphenol is released; then applying pulse type ultrasonic wave to assist extraction under a low-temperature condition, so that polyphenol is fully dissolved out and enters the eutectic solvent; and finally, carrying out solid-liquid separation to obtain the red pomelo polyphenol extract. Compared with a conventional heat extraction method, the method has the advantages that the extraction rate of the polyphenol of the red pomelo is remarkably increased at a lower temperature, the degradation of the polyphenol is effectively avoided, and the content of the total polyphenol and the antioxidant activity are increased; the method is green and environment-friendly, and can be applied to the health industry as an antioxidant.

The invention provides a fermentation medium for efficiently producing lipopeptide by bacillus subtilis as well as application and a method of the fermentation medium. Each liter of the fermentation medium comprises 20-60g of a carbon source; 5-10 g of a nitrogen source; 1-5g of corn steep liquor dry powder; 1 to 5g of monopotassium phosphate; 1 to 5g of disodium hydrogen phosphate; 0.1 to 0.5 g of magnesium sulfate; 5 to 10 mg of calcium chloride; 5 to 10 mg of manganese sulfate; 5 to 10 mg of ferrous sulfate; and vegetable oil with a volume fraction of 1-5%. The carbon source is selected from at least one of glucose, maltodextrin and brown sugar; the nitrogen source is selected from at least one of diammonium hydrogen phosphate, sodium nitrate and urea; the vegetable oil is selected from at least one of soybean oil and corn oil. Bacillus subtilis with the volume fraction of 1-5% is inoculated into a fermentation culture medium for fermentation and fed-batch culture, and the yield of lipopeptide reaches 48.58 g / L. The method improves the lipopeptide production capability of the bacillus subtilis while eliminating foam, and is suitable for large-scale production and application.

The present invention provides a dry powder formulation of 5-MeO-DMT or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable carriers or excipients. The formulations described herein may be used to treat a disease or condition, such as depression or alcohol use disorder in a subject in need thereof.

The invention belongs to the technical field of oil field well cementation cement paste, and particularly relates to thixotropic cement paste and a preparation method thereof. The thixotropic cement paste provided by the invention comprises water, a dry powder material, modified silica sol, a polymer fluid loss agent and other additives. The cement paste disclosed by the invention has the characteristics of viscoelasticity, no dispersion under water, thixotropy and leaking stoppage.

The application provides a lactobacillus rhamnosus GS044 and a lyophilized powder and a probiotic of the lactobacillus rhamnosus GS044 in application to promoting growth and development and improving immunity, and belongs to the technical field of microorganisms.The application provides a lactobacillus rhamnosus GS044 with a preservation number of CGMCC No.33713.The application further provides a method for preparing gamma-aminobutyric acid by using the lactobacillus rhamnosus GS044, and a lyophilized powder prepared by using the lactobacillus rhamnosus GS044, a probiotic and application of the lyophilized powder and the probiotic.The lyophilized powder and the probiotic prepared by the application can effectively promote growth and development and improve immunity.

The present invention discloses a fire-resistant cable, which includes a conductor. A conductor shielding layer is arranged outside the conductor. An insulating layer is arranged outside the conductor shielding layer. An insulating shielding layer is arranged outside the insulating layer. A semiconductive buffer tape layer is arranged outside the insulating shielding layer. A composite copper tape shielding layer is arranged outside the semiconductive buffer tape layer. The composite copper tape shielding layer includes an inner shaped copper tape winding layer and an outer flat copper tape covering layer. The shaped copper tape winding layer is formed by winding copper tapes with a T-shaped cross-section, and adjacent winding turns overlap a part of each other. There are cavities between the T-shaped copper tapes and both the inner semiconductive buffer tape layer and the outer flat copper tape covering layer, and the cavities are filled with dry powder. The outside of several cable cores is a cable skin, and an insulating filling layer is arranged between the cable skin and the cable cores; through the formation of a composite fire-resistant structure, the cable can achieve the effect of layered heat insulation; the composite copper tape shielding layer forms cavities for accommodating dry powder, which can improve the heat preservation and heat insulation effect.

The invention discloses a primer group and a kit for simultaneously detecting nucleic acids of various respiratory pathogens based on twenty-six PCR (Polymerase Chain Reaction). The kit comprises primer pool freeze-dried powder of influenza A virus (FluA), influenza B virus (FluB), respiratory syncytial virus (RSV), human parainfluenza virus (hPIV), mycoplasma pneumoniae (MP), novel coronavirus (SARS-CoV-2), human respiratory adenovirus (HADV), human respiratory nose / enterovirus (HRV / HEV), bordetella pertussis (BP), human coronavirus (HCoV), human bocavirus (HBoV) and chlamydia pneumoniae (CP), PCR (polymerase chain reaction) freeze-dried powder and a buffer solution. According to the kit, primer system optimization is carried out on various pathogens, brand new primers and probe pools are designed, clinical sensitivity and specificity can be achieved, and meanwhile, the kit is matched with a fully-closed full-automatic detection card box integrating sample treatment and amplification and is suitable for rapid detection of respiratory tract pathogens.

The invention discloses closed type polymer dry powder conveying equipment for fracturing, and belongs to the technical field of conveying equipment, the closed type polymer dry powder conveying equipment comprises a positive and negative pressure conversion assembly, the positive and negative pressure conversion assembly comprises a powder conveying pipe, the powder conveying pipe is communicated with a Roots blower, the air inlet end and the air outlet end of the Roots blower are both communicated with a valve shell, and a valve element is rotationally connected into the valve shell; according to the device, under the condition that the powder conveying pipe is blocked, part of polymer dry powder is pumped into the filter cloth bag through negative pressure generated by air pumping of the Roots blower, dry powder accumulation in the powder conveying pipe is remarkably reduced in the process, then, pipelines of the pipe replacing assembly are switched, and therefore the powder conveying pipe can be replaced, and the powder conveying pipe can be replaced conveniently. By means of the Roots blower blowing mode, residual dry powder in the powder conveying pipe is effectively blown, so that the conveying effect of wind power is improved, the dry powder in the powder conveying pipe is blown twice, the automatic unblocking function is achieved, and efficient operation of equipment is guaranteed.

The invention provides a 25-hydroxyvitamin D dissociation and detection kit and a detection method thereof. By screening and optimizing formulas of a dissociation agent and antibody dry powder, automatic uniform mixing and dissociation of a sample are realized, the method is not influenced by human factors and does not depend on any uniform mixing equipment, and sufficient reaction of a 25-hydroxyvitamin D antibody and an object to be detected is ensured; meanwhile, the operation process of an immunochromatography method is improved, the dissociation process of a sample and the binding process of the 25-hydroxyvitamin D antibody and a to-be-detected substance are both completed in one reaction tube and are completely separated from a test strip, after the reaction is completed, the test strip is adopted for sample injection detection, meanwhile, a specific quality control line is arranged, and the detection accuracy is improved. The accuracy and the sensitivity of portable detection of the 25-hydroxy vitamin D by the immunochromatography are remarkably improved, and the detection sensitivity of the 25-hydroxy vitamin D reaches 1ng / mL.

The present invention provides a dry powder formulation of 5-MeO-DMT or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable carriers or excipients. The formulations described herein may be used to treat a disease or condition, such as depression or alcohol use disorder in a subject in need thereof.

The invention discloses a flash and top blowing coupled molten pool tin smelting device and method, and belongs to the technical field of pyrogenic smelting of crude tin. Tin concentrate, fuming enriched tin middling and powdery tin smoke dust are subjected to ore blending with a flux and then are smelted; adding a carbonaceous reducing agent into the molten pool, and reducing to form a CO reducing atmosphere layer at the upper part of the slag layer; and blowing fluidized bed furnace roasting dry powder to the upper part of the CO reducing atmosphere layer, carrying out flash reduction smelting on the fluidized bed furnace roasting dry powder, enabling the fluidized bed furnace roasting dry powder which is not subjected to flash reduction smelting to enter a molten pool, and continuing to carry out a reduction stage in top-blowing molten pool smelting, so that flash and top-blowing coupling is realized, and crude tin is prepared. According to the invention, flash melting pool smelting and top-blowing melting pool smelting are effectively coupled together, fuel consumption can be reduced by about 20%, and the bed capacity is obviously improved.

The invention discloses an unattended tertiary oil recovery injection allocation system. A produced water treatment module receives oil well produced water, treats the oil well produced water and then provides softened water for a system; the dry powder dispersing, dissolving and curing module is used for mixing polymer dry powder with softened water treated by the produced water treatment module to form a polymer mother solution and curing the polymer mother solution; the liquid medicament storage and feeding module is used for storing, preparing and accurately adding liquid medicaments such as surfactants and bactericides; the mother liquor feeding and watering module conveys the polymer mother liquor to the injection module at a constant pressure, and meanwhile, softened water and a surfactant target solution in a set proportion are doped; the injection module mixes a polymer solution, water and an agent provided by the mother liquor feeding and watering module and then injects the mixture into the stratum at constant pressure; and the monitoring communication module controls the injection allocation system through the PLC. The system has the beneficial effects that the whole production process is automatically operated under the scheduling of the monitoring communication module, the operation state of corresponding equipment can be timely adjusted in case of special situations, the management efficiency is improved, and the maintenance cost is reduced.