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1426 results about "Biological macromolecule" patented technology

Anatomical structure which has as its parts one or more ordered aggregates of nucleotide, amino acid fatty acid or sugar molecules bonded to one another. Examples: collagen, DNA, neurotransmitter receptor, troponin.

Diffraction grating-based encoded element having a substance disposed thereon

The present invention generally provides multicomponent articles of manufacture and methods of making them. In its broadest aspect, the invention provides a multicomponent article that includes a diffraction grating-based encoded element, wherein the encoded element includes an optical substrate having at least one surface, and an optical coding element; and a substance disposed on at least a portion of the surface of the substrate. The optical substrate may be made from a wide variety of materials. Importantly the multicomponent article may be a reagent particle wherein the substance includes a reagent. The reagent may be chosen from a wide range of biological macromolecules and oligomeric molecules, from any organic chemical or inorganic chemical compound including pharmaceutical agents and candidate pharmaceutical agents, modifications of any of them, and from any microbiological entity, a cell, and similar entities. In another aspect the invention provides a coded reagent library including a plurality of reagent particles described herein the preceding paragraphs. In another aspect the invention provides a method of preparing a multicomponent article including the steps of providing a diffraction grating-based encoded element, and binding a substance to a surface of said optical substrate. The invention also provides a method of preparing a coded reagent library. Additionally the invention provides a method of synthesizing a polynucleotide reagent on a multicomponent article.

Super macroporous polymer microspheres and preparation method thereof

The invention provides super macroporous polymer microspheres and a preparation method thereof. The preparation method comprises the following steps of: firstly, preparing an oil-in-water in-water composite emulsion as a template for super macroporous microspheres through a two-step emulsion process; then, solidifying an oil phase by using a solvent removal method to form super macroporous microspheres provided with inner-outer through pore passages; and finally, after molding the microspheres, further crosslinking microsphere skeleton molecules to obtain microspheres with rigid resin structures. The microspheres prepared by the method have a through pore passage structure, the controllable particle size range is 0.1-300 microns, the controllable pore size range is 0.09-90 microns, and the controllable porosity range is 10-90%. Super macroporous structures are beneficial for biological macromolecules to penetrate through and enter the microspheres, the mass transfer by convection in the microspheres can be realized, and the rigid structure can tolerate higher pressure and higher flow velocity. The super macroporous polymer microspheres can be used as stationary phase fillers for chromatographic separation, immobilized carriers of enzymes, cell culture micro-carriers, tissue engineering micro scaffold materials, adsorbing materials and the like.

Polymer micro-needle array chip, and preparation method and application thereof

The invention discloses a polymer micro-needle array chip. The chip comprises a micro-needle array and a substrate used for the standing of the micro-needle array; and the matrix material of the micro-needle array is a polyacrylamide polymer. The invention also discloses a preparation method of the polymer micro-needle array chip, a micro-needle transdermal drug delivery patch prepared through utilizing the polymer micro-needle array chip, and a preparation method of the patch. The micro-needle of the polymer micro-needle array chip has a high mechanical strength and a sharp needle point, so the skin cuticle can be easily pierced; the preparation method avoids a high-temperature processing treatment step, and is in favor of maintaining the activities of biomacromolecules comprising polypeptides, proteins and the like; the polyacrylamide polymer can easily dissolve or swell after meeting with the water-containing environment, and is in favor the sustained release of drugs in skins; and the preparation method of the polymer micro-needle array chip based transdermal drug delivery patch is simple, so the batch produced can be realized through utilizing present manure processing technologies.

Electrospraying method for fabrication of particles and coatings and treatment methods thereof

Electrospray systems and modified electrospray systems for the fabrication of core-shell particles for controlled-release and/or sustained-release treatment and delivery are herein disclosed. The electrospray system may include between one and a plurality of co-axially situated tubes. Each tube may be electrically connected to a power supply wherein a voltage may be applied thereto. Core-shell particles may be collected on a collection target, which may be a wet or dry collector, and electrically connected to the power supply. Core-shell particles and methods of manufacture are also disclosed. The precursors of the core-shell particles may be polymer- or biomacromolecule-based solutions and may include at least one treatment agent incorporated therein. The number of “core” particle(s) within the “shell” may vary and may provide different treatment agent release profiles depending on the material and/or chemical characteristics of the polymer and/or biomacromolecule used. Methods of treating a condition are also disclosed. A treatment may include delivery of a plurality of core-shell particles which include a treatment agent to a treatment site. Delivery may be performed by a surgical procedure or by a non-invasive procedure such as catheter delivery.

Method for preparing NCC/CS/PVA composite nano-membrane

The invention relates to a method for preparing an NCC/CS/PVA composite nanofiber membrane. NCC is rod-shaped particles, wherein the diameter of each particle ranges from 20 nm to 60 nm, and the particles are highly crystallized. The method comprises the steps that (1) an NCC/CS solution is prepared, wherein the concentration of the NCC, by weight, ranges from 0.09% to 0.21%; (2) an NCC/PVA solution is prepared, wherein the concentration of the NCC, by weight, ranges from 0.4% to 0.8%; (3) an acetic acid solution, tetraethyl orthosilicate, the NCC/CS solution obtained in the step (1) and processed through ultrasound, and the NCC/PVA solution obtained in the step (2) and processed through ultrasound are mixed to obtain a spinning solution, and the nanofiber membrane is obtained through the electrospinning technology, wherein the mass ratio of the acetic acid solution to the tetraethyl orthosilicate to the NCC/CS solution to the NCC/PVA solution is (2.5-3.5):(1.5-2.5):5:5; (4) the obtained nanofiber membrane is immersed in an alkaline solution for 2-6 hours at the normal temperature, and the membrane structure can be stable. The method for preparing the NCC/CS/PVA composite nanofiber membrane has the advantages that the nanofiber material preparation process is simple, the preparation process is environmentally friendly and free of pollution, nanofibers are excellent in mechanical performance, the surface of the nanofiber membrane is rich in modifiable functional groups, and the nanofiber membrane has a remarkable affinity effect on biomacromolecule.

Graphene matrix and application of graphene matrix in matrix-assisted laser desorption/ionization-time of flight-mass spectrometry detection

InactiveCN102426187AUnique physical propertiesUnique chemical propertiesPreparing sample for investigationMaterial analysis by electric/magnetic meansMetaboliteNucleotide
The present invention discloses a graphene matrix and an application of the graphene matrix in matrix-assisted laser desorption/ionization-time of flight-mass spectrometry (MALDI-TOF-MS) detection. According to the present invention, in the MALDI-TOF-MS, the graphene is adopted as an assisted matrix, such that the analysis and the detection of the materials including from the small molecule compounds to the biological macromolecules can be efficiently and rapidly achieved; importantly the background interference of the molecular ion peak of the traditional organic matrix can be effectively eliminated so as to achieve the analysis and the detections of amino acids, lipid compounds, peptides, proteins, oligonucleotides, and other structural molecules; the MALDI-TOF-MS adopting the graphene as the matrix is the desorption ionization method, which does not require addition of any organic matrixes, such that the decomposition of the analyte can be avoided, and good reproducibility and high salt tolerance are provided; the efficient and rapid detection method is provided for the natural products and the biological metabolites; the method further can be used for the detection of the common biological macromolecules, and can be popularized and applied in all the MALDI-TOF mass spectrometry so as to achieve the deep application of the graphene.

Magnetic fluorescent microspheres and preparation method thereof

The invention relates to magnetic fluorescent microspheres and a preparation method thereof. The particle size of the magnetic fluorescent microspheres is 5-10 mu m, the fluorescence excitation wavelength range is 400-700nm, and the fluorescence intensity is not reduced within 24h. The prepration method comprises the following steps: adding a swelling agent into monodisperse carboxylated polystyrene microspheres, and adding magnetic nano microparticles into a swelling system; shaking on a decolorization shaker for 12-48h; using mixed solution of cyclohexane and ethanol for cleaning sediment, and sequentially carrying out ultrasonic dispersion and centrifugal separation till supernatant liquid is colorless under an ultraviolet lamp; and saving a final sediment product in 1ml of liquor. Compared with the existing magnetic fluorescent microspheres, the magnetic fluorescent microspheres have the advantages of uniform and controllable diameter, good fluorescence stability, simple preparation process, multiple types of fluorescence codes and the like, and can not only carry out fast separation and purification on reactants by being applied in the biological macromolecular detection, but also simultaneously detect a plurality of target molecules in a sample to be detected in a reaction tube and a hole, thereby being widely applied in the fields of immunoassay, nucleic acid hybridization, genotype analysis and the like.

Micro-needle array chip, percutaneous administration device, percutaneous administration patch and preparation method thereof

The invention relates to a micro-needle array chip, a transdermal delivery device, a transdermal delivery patch and a preparation method thereof, wherein a micro-needle is obliquely fixed on a substrate at a set angle, the upper surface of the needle is an elliptic plane parallel to the substrate or obliquely provided with an acute angle, the needle is further treated to have more edge angles, a metal wire bar or tube penetrates a non-metallic material substrate such as polymer and the like along a certain angle, and then a nick of the metal wire bar or tube on the substrate is grinded and polished; and photosensitive resist patterns are formed nearby the nick at one end by adopting photoetching and etching technology, then the metal wire bar or tube is subjected to chemical or electrochemical corrosion to form a needle point and the photosensitive resist is removed, the surface of the manufactured solid micro-needle array chip can be covered with drugs, and the manufactured solid micro-needle array chip can deliver liquid medicine or extract body fluid. The method avoids the skin plugging a transfusion hole, is easy to adjust and control the maximum penetrating depth of the micro-needle, and is suitable for percutaneous transportation of biological macromolecular drugs and cosmetics and skincare and new percutaneous preparation of the prior drugs.
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