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Temperature sensitive type water gel medicine release system and its preparing method

A temperature-sensitive, temperature-sensitive hydrogel technology, applied in the field of medicine, to prolong antigen presentation time, prevent burst release effect, and improve stability

Inactive Publication Date: 2007-01-24
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a solution to the sudden release of drugs caused by water loss caused by dehydration and solidification caused by dehydration and solidification caused by the solution-gel phase transition when the existing temperature-sensitive hydrogel is used as a therapeutic substance carrier. A temperature-sensitive hydrogel drug delivery system and its preparation method can improve the release curve, increase the drug loading capacity, and stably load the drug in the process of preparation, storage and release; at the same time, it can also realize the pulse of vaccine delivery drug release

Method used

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  • Temperature sensitive type water gel medicine release system and its preparing method

Examples

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Embodiment 1

[0043] Preparation of a novel temperature-sensitive hydrogel with BSA supported by polysaccharide polymer particles-temperature-sensitive hydrogel composite method

[0044] Choose BSA as a model drug, prepare a mixed solution of dextran, BSA and a mixed solution of polyethylene glycol and sodium alginate; mix and homogenize the two to obtain a stable emulsion; freeze for 12 hours, vacuum dry for 24 hours, and use the solid sample Wash with dichloromethane, centrifuge, pour to remove the supernatant and wash off polyethylene glycol at night, and evaporate the organic solvent to obtain polysaccharide polymer particles of dextran-sodium alginate. Before use, the temperature-sensitive hydrogel matrix is ​​prepared into a 25% solution, and the polymer polysaccharide particles are added to the compound. In the composition, BSA (0.1%, w / w), dextran (5%, w / w), temperature-sensitive hydrogel matrix (90%, w / w), sodium alginate (4.9%, w / w) . The composition is released in vitro in HEPEs buff...

Embodiment 2

[0046] Polysaccharide-temperature sensitive hydrogel emulsification method to prepare new temperature sensitive hydrogel with BSA

[0047] A mixed solution of dextran, BSA, sodium alginate, and trehalose is prepared, and the temperature-sensitive hydrogel matrix is ​​made into a 25% solution. After mixing the two phases, homogenize to obtain a stable emulsion; freeze for 12 hours, vacuum dry for 24 hours, and the obtained solid sample can be reconstituted before use. In the composition, BSA (30%, w / w), temperature-sensitive hydrogel (29.55%, w / w), dextran (27.5%, w / w), sodium alginate (2.95%, w / w), Trehalose (10%, w / w). The composition is released in vitro in HEPEs buffer at 37°C for 10 days without sudden release and incomplete release, achieving an ideal and stable sustained release effect.

Embodiment 3

[0049] Preparation of a novel temperature-sensitive hydrogel with BSA supported by polysaccharide-temperature-sensitive hydrogel composite method

[0050] A mixed solution of dextran, BSA, and trehalose is prepared, and the temperature-sensitive hydrogel matrix is ​​made into a 25% solution. After mixing the two phases, homogenize to obtain a suspension, ready to use. In the composition, BSA (25%, w / w), temperature-sensitive hydrogel (20%, w / w), dextran (50%, w / w), trehalose (5%, w / w) (poly Electrolyte). The composition is released in vitro in HEPEs buffer at 37°C for 10 days without sudden release and incomplete release, achieving an ideal and stable sustained release effect.

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Abstract

The temperature sensitive hydro gel medicine releasing system and its preparation process belongs to the field of medicine technology. The medicine releasing system consists of carried medicine 0.1-30 wt%, temperature sensitive hydro gel 20-90 wt%, and high molecular weight polysaccharide 5-50 wt%. The medicine releasing system is prepared through a polysaccharide-temperature sensitive hydro gel compounding process, a polysaccharide-temperature sensitive hydro gel hydrophilic emulsifying process or a polysaccharide-temperature sensitive hydro gel emulsifying process. Owing to the retarding diffusion effect during solution-gel conversion, the present invention has raised medicine carrying amount, and improved medicine stability. The present invention provides simple and practical technological scheme for the controllable conveyance of biological macro molecular medicine and other treating components and the improvement of carried medicine release.

Description

Technical field [0001] The invention relates to a composition in the technical field of medicine and a preparation method thereof, in particular to a temperature-sensitive hydrogel drug release system and a preparation method thereof. Background technique [0002] Temperature-sensitive hydrogel is a polymer hydrogel whose volume changes with temperature. The so-called temperature sensitivity refers to a sudden change in the amount of water (or solvent) absorbed by the hydrogel at a certain temperature. That is, the swelling ratio (the ratio of the amount of absorbed water or solvent to the weight of the dry gel) will suddenly change at a certain temperature, and this temperature is called the sensitive temperature. Near the critical temperature, the hydrogel whose swelling rate will suddenly increase as the temperature increases is called "thermal swelling" hydrogel (with a high critical dissolution temperature UCST); on the contrary, the swelling rate increases as the temperatur...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/36A61K47/38A61K47/34A61K47/32A61K47/10
Inventor 金拓吴飞
Owner SHANGHAI JIAO TONG UNIV
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