11594 results about "Sodium alginate" patented technology

Compositions comprising a glycosaminoglycan (e.g., a hyaluronan, hyaluronic acid, hyaluronate, sodium hyaluronate, dermatan sulfate, karatan sulfate, chondroitin 6-sulfate, heparin, etc.) in combination with at least one component selected from; i) polyglycols (e.g., polyethylene glycol), ii) long chain hydroxy polyanionic polysaccharides (e.g., dextran, sodium alginate, alginic acid, propylene glycol alginate, carboxymethyl cellulose and carboxyethyl cellulose, hydroxyl ethyl starch, hydroxyl propyl methyl cellulose, hydroxy propyl ethyl cellulose, hydroxy propyl cellulose, methyl cellulose, polylysine, polyhistidine, polyhydroxy proline, poly ornithine, polyvinyl pyrolidone, polyvinyl alcohol, chitosan, etc.) and iii) long chain Nitrogen containing polymers (e.g., Polylysine, Polyvinylpyrrolidone, and polyvinyl alcohol). The invention also includes methods for using such compositions (e.g., as substance delivery materials, tissue fillers or bulking agents, as moistening or hydrating agents, etc.)

A cartridge for an e-vaping device includes an ethanol-free gel formulation. The ethanol-free gel formulation includes a vapor former, water, and a biopolymer. The biopolymer may be included in an amount ranging from about 0.01% by weight based on the weight of the ethanol-free gel formulation to about 2.0% by weight based on the weight of the ethanol-free gel formulation. The biopolymer may be one or more of agar, kappa carrageenan, gelatin, sodium alginate, gellan gum, pectin, and combinations thereof. The cartridge also includes a heater configured to heat liquid from the gel formulation to a temperature sufficient to release a liquid / semi-liquid component from the gel, which component thereupon forms a vapor.

The invention discloses an enteric-solubility multilayer encysted bacterium microcapsule and making method in the biological agent technical domain, which is characterized by the following: adopting sodium alginate, calcium chloride and chitose as clad material of microcapsule; making lactic acid bacteria or bifidobacteria as core-clad material; proceeding ionic exchange for sodium alginate and calcium chloride; forming second clad on the surface of calcium alginate through different isoelectric points of calcium alginate and chitose; freezing at low temperature to obtain the product.

The invention discloses a sodium alginate oligosaccharide coated slow-release fertilizer. Coated materials of the slow-release fertilizer contain sodium alginate oligosaccharide and an auxiliary coated material, wherein sodium alginate oligosaccharide is composed of two structural units, namely a-L-mannuronic acid and b-D-guluronic acid. The two structural units are linked in three ways by 1,4-glucosidic bond, so as to form a unbranched linear segmented copolymer. The coated slow-release fertilizer is mainly applied in commercial crops, fruit and vegetable crops, grain crops, economic forest, flowers and plants, traditional Chinese medicinal materials, lawn and the like. By introducing organism-derived sodium alginate oligosaccharide into the coated materials of the slow-release fertilizer, nutritive elements required by plant growth and development can be supplemented by a slow-release approach, and the plant growth promoting effect of sodium alginate oligosaccharide also can be performed so as to finally achieve the yield-increasing effect. In addition, a medicament prepared by using sodium alginate oligosaccharide as the main coated material composition is safe and nontoxic and has advantages of low cost, small application amount and the like.

The invention discloses a sodium alginate-acrylamide composite aquagel. The preparation method comprises the following steps: 1) proportionally dissolving sodium alginate and acrylamide in water, and uniformly mixing; 2) sequentially adding a crosslinking agent and an initiator, carrying out vacuum degassing treatment, and adding a catalyst; and 3) transferring the obtained mixed solution into a glass mold, and heating to react, thereby obtaining the sodium alginate-acrylamide composite aquagel. The sodium alginate-acrylamide composite aquagel has favorable multivalent ion adsorption capacity and biocompatibility. By combining the polyacrylamide network with the graft copolymerization action of the sodium alginate and acrylamide, the mechanical properties of the aquagel are effectively enhanced. The aquagel is sensitive under the condition of different pH values, can generate intermolecular interactions with multiple cationic dyes and heavy metal ions, and is applicable to the fields of chemical substance adsorptive separation, sewage treatment and the like.

The invention relates to a biocolloid hemostatic prepared by aldehyde-modified sodium alginate and amine-modified gelatine. Sodium alginate and gelatine as raw materials; according to ratio, aldehyde-modified sodium alginate solution with the concentration of 5-25% and the same volume of amine-modified gelatine solution with the concentration of 5-40% are mixed; sodium alginate is modified by aldehyde through sodium periodate oxidation; and then gel is obtained by mixing with gelatine modified by ethanediamine. The adopted gelatine and sodium alginate are safe and stable, have good biocompatibility and can be absorbed and degraded by organism. Gel is rapidly formed through Schiff base reaction of aldehyde-modified sodium alginate and amine-modified gelatine, and the gel has the same gel-forming time as fibrin glue but better adhesion property and adhesion strength, can be acted on any part of body through simple local spraying or injection, and can be used as substitute product of fibrin glue.

Comestible products, for example beverage products, are disclosed containing encapsulated probiotic bacteria having resistance to subjection to at least thermal and acidic conditions. Beverage products include at least one aqueous liquid and capsules comprising a gelled mixture of alginate and denatured protein, and probiotic bacteria entrapped within the gelled mixture. The average particle size of the capsules is optionally less than 1000 microns (μm) in diameter, such as less than 500 μm in diameter. Methods are provided for making such encapsulated probiotics by providing a mixture comprising sodium alginate, denatured protein and active probiotic cells, and combining the mixture with a divalent cation to initiate cold gelation of the sodium alginate and denatured protein to form a second mixture. The second mixture is passed through an opening having a diameter of less than 1000 μm to form capsules. The weight ratio of protein to alginate is from 1:1 to 9:1.

The invention relates to a method for preparing a sodium alginate-chitosan nano-grade medical dressing, and belongs to the field of natural biological polymer materials. The method comprises the following steps: dispersing sodium alginate and synthesized polymer in an ethanol solution; and preparing a chitosan solution containing a crosslinking agent to serve as a receiving liquid, wherein fibers are cross-linked by the crosslinking agent after the sodium alginate fibers are received in the chitosan solution, the electrolyte property of the chitosan is adsorbed to the surfaces of the sodium alginate fibers due to the electrostatic effect, and the prepared sodium alginate-chitosan composite nano-fibers have good air permeability and antibacterial and hemostasis effects, is advantageous to wound tissue growth and regeneration when being applied to a wound dressing, and can be used for accelerating wound healing. The method adopts a natural polymer matrix as a raw material, and the medical dressing has low cost, no toxicity and good biocompatibility.

The invention discloses a heating-non-burning cigarette fuming granular material and a preparation method thereof. The granular material includes a heating-non-burning granular material carrier, fuming agents, a surface coating agent and a perfuming extract. The heating-non-burning granular material carrier includes juncus roemerianus, gramineous plant granules, radix puerariae, eupatorium adenophorum, tobacco powder, tobacco stem powder, hydroxypropyl methyl cellulose, beta cyclodextrin, gelatin, sodium alginate, diatom ooze, chitosan, methylcellulose, lignin and other natural plant granules.The preparation method of the granular material includes the following step of preparing the heating-non-burning granular material carrier at first, wherein the carrier is preferably selected from domestic high-quality granules or natural mineral compound granules and powder thereof for pelleting or compounding. The fuming granules are integrally loaded according to volume and then sealed, finished products of a fuming unit are mixed with the fuming agents of perfuming groups different in taste, and the problems that cigarette containers in the heating-non-burning field are monotonous in typeand processing technologies are cumbersome are solved.

The invention provides self-expanding ice-cream and a production method thereof. The self-expanding ice-cream comprises, by total weight, 35%-80% of light cream, 0.1-5% of thickener, and 0.1%-5% of super absorbent polymer, wherein the thickener is from one or a plurality of gelatin, sodium alginate and carrageen, and the super absorbent polymer is from one or a plurality of locust bean gum, xanthan gum, gellan gum and guar gum. In addition, milk fat content of the ice-cream is 15%-25%. The production method of the self-expanding ice-cream includes: whipping light cream of the ice-cream ingredients until expansion rate of the light cream reaches 60%-85%; mixing the light cream with other ingredients to make ice-cream liquid; and pouring the ice-cream liquid into a mould prior freezing into the finished ice-cream. The ice-cream can have certain expansion rate and good organization and taste with no coagulating needed in production of the self-expanding ice-cream, and the ice-cream is excellent in forming performance, oral thawing performance and thawing resistance.

Enteric film coating systems for orally ingestible substrates such as pharmaceutical tablets and dietary supplements are disclosed. In preferred aspects, the enteric film coatings include an ethylcellulose dispersion and a substantially gastro-insoluble pore former such as sodium alginate.

The invention discloses a water capsule for a three-layer cigarette and a preparation method of the water capsule. Water-soluble essence serves as an inner layer in the capsule, water serving as a solvent dilutes the essence, a middle layer is a sodium alginate complex to wrap the water and the essence, and a third layer is a waxy material to prevent the water from permeating in the capsule. An additive can endow the cigarette with special fragrance and taste or can lower content of harmful chemical components in smoke of the cigarette. The preparation method is simple and easy to implement in process, simple in equipment, capable of being directly used for cigarette processing and convenient for popularization and application. Used raw materials are extensive in source and low in cost.

The invention discloses yacon ice cream and a manufacturing method thereof, wherein, the yacon ice cream comprises whole milk powders accounting for 12 to 15 percent, unsweetened evaporated milk accounting for 6 to 9 percent, cream accounting for 7 to 9 percent, white granulated sugar accounting for 3 to 4 percent, starch syrup accounting for 1 to 1.5 percent, sodium alginate accounting for 0.15 to 0.2 percent, monoglyceride accounting for 0.15 to 0.2 percent, yacon granules accounting for 20 to 25 percent and appropriate drinking water. The manufacturing method of the yacon ice cream comprises the steps of yacon granule preparation, raw material mixing preparation, sterilization, homogenizing, cooling, ageing, congealing, filling, rigidification and the like; the yacon ice cream contains yacon granules, achieves cool and delicious taste, achieves double functions of nourishment and health care, and further achieves the nourishment and health care effects of reducing temperature, relieving summer-heat, clearing intestines and stomach, resolving liver toxicity, reducing blood fat, reducing blood pressure, helping digestion, preventing oxidation, preventing constipation and the like compared with the traditional ice cream.

The invention discloses a method for producing instant straw mushroom chips by adopting a vacuum low-temperature dehydration technology, and belongs to the technical field of deep processing of agricultural products. The method for producing the instant straw mushroom chips comprises the following main processes of: performing pretreatments such as conventional picking, cleaning, segmenting, blanching, non-sulfur color protecting, ultrasonic aid impregnating, sodium alginate film coating and the like on fresh straw mushrooms, and then, performing hot air and vacuum frying combined dehydrating, centrifugal oil removing, seasoning and packing. By adopting the new processes of non-sulfur color protecting, ultrasonic aid impregnating, sodium alginate film coating and hot air and vacuum fryingcombined dehydrating, the oil content of the product is remarkably reduced while the sensory quality of the product is improved and the impregnating efficiency is increased. In the method, necessary freezing treatment in the conventional fruit and vegetable chip frying process is not needed, so that the processing time is greatly reduced, and the production period of the product is effectively shortened. The product obtained by using the method has the characteristics of high puffing rate, low oil content, good sensory quality and the like; and a feasible new path is provided for deep processing utilization of the straw mushrooms.

The invention relates to a preparation method of injectable natural polysaccharide self-healing hydrogel. The preparation method of the injectable natural polysaccharide self-healing hydrogel comprises the following steps: firstly synthesizing water soluble N-carboxyethyl chitosan by carrying out a Michael addition reaction on acrylic acid and chitosan, carrying out an oxidization reaction on sodium periodate and sodium alginate to obtain oxidized sodium alginate, then carrying out a dehydration condensation reaction on N-carboxyethyl chitosan and oxidized sodium alginate and on adipic dihydrazide and oxidized sodium alginate in a phosphate buffer liquid at the temperature of 37 DEG C, so as to respectively generate invertible imine bond and acylhydrazone bond, and finally preparing injectable natural polysaccharide macromolecular hydrogel with self-healing property. The preparation method of the injectable natural polysaccharide self-healing hydrogel has the advantages that a synthetic process of the injectable self-healing hydrogel is simple and green, reaction conditions are mild, the injectable self-healing hydrogel can form gel in a physiological environment and has self-healing capability, and the injectable self-healing hydrogel has a good application prospect in the fields of drug sustained release and the like.

The invention discloses postoperation anti-adhesion hydrogel and a preparing method thereof. The hydrogel is prepared from sodium alginate powder, chitosan powder, acrylamide monomers, N,N'-methylene bisacrylamide, calcium sulfate, ammonium persulfate and N,N,N',N'-tetramethylethylenediamine. The preparing method of the high-strength high-tenacity chitosan and sodium alginate compound hydrogel is easy to operate, parameters are controllable, the materials are easy to obtain, and the solvent is nontoxic or low in toxicity and safe to treat and use; the method integrates advantages of the two natural biological materials, and the requirement for postoperation adhesion prevention of patients and the requirement for nursing care and treatment of medical workers can be met well. The hydrogel is soft, can be attached to the skin easily, has good flexibility and can effectively prevent wound surface adhesion and be degraded and absorbed, secondary trauma is avoided, and the hydrogel is expected to become a novel postoperation anti-adhesion material.

The invention provides a lactobacillus helveticus microcapsule as well as the preparation and application thereof, pertaining to the embedding technology of lactobacillus helveticus and aiming at microencapsulating the lactobacillus helveticus so as to solve the problems of low embedding efficiency and embedding yield in single-layer or double-layer embedment. The technical proposal adopted by the invention is that isolated soy protein, microporous starch and sodium alginate are respectively taken as the first, the second and the third layers of wall materials for microencapsulation; the three-layer embedment is carried out to the lactobacillus helveticus for the first time, wherein, in the process of preparing bacterial suspension, an orthogonal optimization protective agent is adopted to improve the livability after freeze drying. The microcapsule of the invention has strong heat resistance and acid resistance, solves the inactivation problem caused by gastric acid, digestive enzyme and antibiotic, etc. to active bacillus, is capable of releasing when reaching large intestine, and balances intestinal flora. The reusability of fermented milk is good. The lactobacillus helveticus used by the invention enriches the variety of probiotic bacteria microcapsule and is a good dietary supplement.

The invention discloses an efficient probiotics microcapsule which comprises a core material and a wall material, wherein the core material comprises 90-95wt% of probiotics and 5-10wt% of a protector; the wall material is of a double-layer structure, wherein the inner layer is made from sodium alginate and the outer layer is made from whey protein or gelatin. The invention also discloses a preparation method and application of the efficient probiotics microcapsule. The microcapsule is coated by double layers of the sodium alginate and the gelatin or whey protein, so that the acid resistance, cholate resistance and storage resistance of the probiotics are improved. The microcapsule disclosed by the invention is added into the feed, so that the host intestinal microenvironment equilibrium can be regulated, the harmful bacteria can be restrained and the disease resistance of the host can be improved.

The invention provides a polymeric hydrogel grafted on fibers by calcium ion crosslinking and a preparation method thereof. The polymeric hydrogel comprises the following components in percentage by mass: 3-8% of sodium polyacrylate grafted fiber, 0.96-4% of sodium alginate, 0-2% of water-solubility polymeric additive, 0.96-8% of calcium chloride and 75-95% of deionized water. The preparation method comprises the following steps: grafting polyacrylic acid on fibers by ultraviolet radiation; neutralizing with sodium hydroxide to obtain sodium polyacrylate-grafted fibers; soaking sodium polyacrylate-grafted fibers in an aqueous sodium alginate solution; taking out and scraping off the superabundant adherent viscous solution; and crosslinking in an aqueous calcium chloride solution to obtain the calcium alginate hydrogel grafted on the fibers. The preparation method is simple to operate, and the prepared polymeric hydrogel grafted on fibers has application prospects in the fields of adsorption separation, drug control and release, immobilized enzyme, tissue engineering and the like.

The invention discloses a preparation method of essence microcapsules. The preparation method comprises the following steps: (1) dissolving chitosan in acetum; (2) adding emulsifier and essence into the chitosan acetum for high-speed emulsification and dispersion to obtain the chitosan essence emulsion; (3) adding the mixed solution of sodium alginate and sodium tripolyphosphate dropwise into the chitosan essence emulsion; (4) adjusting the pH value of the system to 5-7 with NaOH solution to obtain the condensed essence microcapsules; and (5) adding cross-linking agent into the condensed essence microcapsule system to perform chemical cross-linking process on the condensed essence microcapsules to obtain the essence microcapsules. For the essence microcapsules prepared according to the method disclosed by the invention, as chemical cross-linking process is implemented on the walls of the capsules, the density of the capsule walls and the resistance to the solution alkalinity / acidity are improved, and the application stability of the essence microcapsules is increased; moreover, with small size, the capsules can easily permeate into textile fiber, and the water-washing resistance of the textile fiber is greatly improved.

The triple composite microsphere preparation consists of mainly model medicine, calcium alginate, chitosan, and diglycolide-lactide copolymer. The preparation process includes W / O emulsification, washing with isopropanol to prepare small calcium alginate microcapsule, coating with chitosan to form compact double-layered alginic acid-chitonsan microcapsule, the subsequent emulsifying and solvent volatilization step to coat the double-layered alginic acid-chitonsan microcapsule into diglycolide-lactide copolymer to form the three-layered composite microsphere. The present invention can protect protein and polypeptide medicine in hydrophilic sodium alginate-chitonsan microcapsule environment to reduce abrupt release and incomplete release, prolong the medicine release time, and regulate the medicine releasing mode via altering PLGA composition.

The invention relates to a nitrogen-sulfur double-doped carbon material difunctional oxygen catalyst, a preparation method thereof and electrocatalysis application of alkaline medium in oxygen. In the catalyst, ocean polysaccharide sodium alginate is used as a carbon source, thiourea is sources of nitrogen and sulfur atoms, and double doping is performed on N and S which have electronegativity by high-temperature calcination in an inertia atmosphere to obtain a nitrogen-sulfur double-doped carbon material electrocatalyst. Since a double-doped crystal structure of heteroatoms is changed, the specific area and the catalyst site of the catalyst are improved, meanwhile, relatively high oxygen evolution (OER) and oxygen reduction (ORR) catalytic activity are achieved, and the overoptential of OER and ORR is effectively reduced; the ORR process is most divided to four electron catalytic mechanisms and is an relatively ideal ORR reaction process, and the catalyst has favorable stability and excellent methyl alcohol resistance; and the used raw material is low in cost, the preparation method is simple and is easy to operate, and mass production is facilitated.

The invention relates to a method for preparing a fish oil ethyl ester microcapsule from fish pomace, which mainly comprises the extraction of fish oil, the preparation of fish fatty acid ethyl ester, the purification of fish oil ethyl ester and the preparation of a fish oil ethyl ester microcapsule, wherein the extraction of fish oil comprising the following steps: eliminating foreign matters from fish viscus, cleaning, mashing, adding pepsin and neutral protease for enzymolysis, then adding anhydrous alcohol, standing to stratify, and centrifuging to obtain the fish oil; the preparation of fish fatty acid ethyl ester comprising the following steps: mixing the fish oil with ethanol, making the mixture to be subject to an esterification reaction under the catalysis of sodium ethylate, vaporizing the ethanol, washing with water, and then centrifuging to obtain the fish oil ethyl ester; in the purification process, supercritical CO2 extraction is adopted, the purified fish oil ethyl ester is a golden yellow transparent liquid, and EPA ethyl ester and DHA ethyl ester contents thereof are more than 50%; and the preparation of a fish oil ethyl ester microcapsule comprises the following steps: mixing sodium alginate, maltodextrin and sodium caseinate, dissolving in water, adding the purified fish oil ethyl ester, and adopting a spray drying method to obtain the powdered fish oil ethyl ester microcapsule which can hide the fishy smell of the fish oil ethyl ester, improve the mouth feel and be beneficial to packaging and storage.

The invention relates to an antibacterial finishing method for textile containing cellulose. The method uses natural polymer chitosan and sodium alginate as wall materials; traditional Chinese medicine extracts are used as a core material and are subjected to encapsulation by a micro capsule technology; then an afterfinishing method is employed to treat the microcapsule to the partially carboxymethylated textile containing cellulose, so as to endow the textile with antibacterial performance and good wash fastness through electrostatic attraction between the carboxyl on cellulose fiber and chitosan, as well as the crosslinking effect of the cross-linking agent. The raw materials employed by the invention are green, environment-friendly, safe and high-efficiency, and the obtained textile has good antibacterial effect on common staphylococcus aureus, Eschierichia coli and bacillus subtilis.

The invention discloses a barley noodle, which comprises the following parts: one or more component from barley noodle, wheat flour, maize starch, manihot starch, sweet potato starch, potato starch and glutelin powder, one or more of glutamine transaminase, xylanase and cellulose enzyme, one or more of guar gum, xanthan gum, sodium polyacrylate, sodium alginate and konjaku flour, one or more of monosodium calcium lactate stearate, diacetyl tartaric acid monoester, soya phosphatide and monoaliphatic acid glyceride, water, salt and egg.

The invention discloses a chemical and ionic cross-linked alginate hydrogel flat membrane for filtration, which is designed and prepared aiming at the problems of poor stability, low mechanical strength, overlarge pores and the like of a pure ionic cross-linked hydrogel filtering membrane. According to the flat membrane, sodium alginate is used as a membrane forming substrate, a water-soluble compound is used as a pore-forming agent, and a chemical cross-linking agent and an ionic cross-linking agent are added, so that the sodium alginate is subjected to covalent bonding and ionic cross-linking to improve the stability of the membrane. The mechanical strength and the pore size of the membrane and the stability in an electrolyte solution are adjusted by changing the types and the proportions of the chemical cross-linking agent and the ionic cross-linking agent. The hydrogel flat membrane is prepared through a simple preparation process and is low in cost; no organic waste liquid is produced; the obtained hydrogel membrane can resist the pressure of 0.2-1 MPa and has a good application prospect in the separation field in which membrane pollution is easy to produce, such as oil-water separation, protein separation and biological sample filtration. The hydrogel flat membrane is directly discarded and can be fully degraded by microorganisms after being used, so that no environmental harm is caused.

The invention relates to injection amphiphilic-microsphere-containing hyaluronic acid mixed gel and a preparation method thereof. The microsphere material relates to amphiphilic materials of PLLA-PEG, PLGA, PLGA-PEG and the like. The molecular weight of PLLA or PLGA is 10,000-500,000, the molecular weight of PEG is 1,000-10,000, and in PLGA, LA / GA=90 / 10-10 / 90. The average grain diameter of the microsphere is 1-200 [mu[m, and the mass percent of the microsphere in the gel is 1-50%; the gel is made from hyaluronic acid, divinyl sulphone crosslinked hyaluronic acid, or glycidyl ether crosslinked hyaluronic acid, the molecular weight of the hyaluronic acid is 100,000-3,000,000, and the mass percent of the hyaluronic acid is 1-50%. The gel can be also made from animal-derived collagen, chitosan, amino acid cellulose and sodium alginate. The microsphere mixed gel is prepared in a sodium chloride solution or a phosphate buffered solution with the osmotic pressure of 250-350 mOsm / L and pH of 6.5-7.5. According to the invention, the amphiphilic microsphere is directly mixed with hyaluronic acid gel, can be uniformly distributed in the gel easily, and is unlikely to aggregate into blocks in the water environment of a human body after being injected.

The invention provides an air refreshing agent of traditional Chinese medicine for dispelling mosquito and sterilizing. The prescription of the invention, which is calculated according to the weight percentage, is 1 percent to 3 percent of essential oil of southernwood, 1 percent to 3 percent of essential oil of eucalyptus leaf, 2 percent to 3 percent of excipient, 1 percent to 3 percent of solubilizer, 0.5 percent to 1 percent of preservative, 0.5 percent to 1 percent of coagulant, 50 percent to 80 percent of solvent, 5 percent to 10 percent of essence and 0.5 percent to 1 percent of pigment, wherein the excipient is sodium alginate, gelatin and agar; the solubilizer is the tween series (40, 60 and 80); the preservative is sodium benzoate and potassium sorbate; the coagulant is calcium carbonate or calcium chloride; the solvent is water. The invention uses the traditional Chinese medicinal materials of the essential oil of southernwood and the essential oil of eucalyptus leaf as the main component for dispelling mosquito and sterilizing to replace a traditional chemical mosquito-dispelling and sterilizing agent with toxic and side effect, and the invention is nontoxic and innoxious to human body and is a green and environmental protective product and can be applied widely.

The invention relates to an alginate-polycationic microcapsule product used for embedding bioactive substance, in particular to an alginate-polycationic microcapsule subjected to graft modification of dopamine. According to the alginate-polycationic microcapsule subjected to graft modification of dopamine, dopamine molecules are in covalent bonding to sodium alginate molecules, the obtained molecules are used for preparing a hydrogel microsphere carrier, the embedded hydrogel microsphere carrier further has film formation reaction with polycations, and thus the dopamine-based alginate / polycationic microcapsule is prepared. The microcapsule has good stability, and does not swell or break in the body fluid environment. The product is mainly used for embedding the bioactive substance, the microcapsule film has the excellent biocompatibility while having the good film strength, and the integrity of the microcapsule film when taken as the histocyte transplantation carrier, the cell carrier of the in-vitro bioartificial liver system, the cell carrier in the cell culture process and the like in the application process is guaranteed.

The present invention relates to preparation process of sodium alginate / chitosan mixture gel capable of being used as biodegradable medicine carrier. The preparation process includes the following steps: 1. forming homogeneous transparent alginate and chitosan solution in 1-5 wt% concentration each with alginate in 5-95 wt% and chitosan in 5-95 wt%, and adding acetic acid; 2. preparing alginate / chitosan mixture sol; 3. dropping the sol into 1.5-3 wt% concentration calcium chloride or sodium sulfate solution; 4. preparing alginate / chitosan-calcium ion-sulfate radical double cross-linked gel grain; and 5. soaking in absolute ethanol for 2-5 min, vacuum drying to obtain alginate / chitosan mixture gel grain of 300-1000 micron grain size. The alginate / chitosan mixture gel grain of the present invention has high pH sensitivity and the preparation process is safe and simple.