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154 results about "Bone healing" patented technology

Bone healing, or fracture healing, is a proliferative physiological process in which the body facilitates the repair of a bone fracture. Generally bone fracture treatment consists of a doctor reducing (pushing) displaced bones back into place via relocation with or without anaesthetic, stabilizing their position to aid union, and then waiting for the bone's natural healing process to occur.

Lumbar interbody fusion cage and implementation method thereof

The invention discloses a lumbar interbody fusion cage and an implementation method thereof.The lumbar interbody fusion cage comprises a base body, the base body comprises an upper end plate and a lower end plate, and the surface curvature of the upper end plate and the surface curvature of the lower end plate are matched with the lumbar interbody curvature of the human body; the porous coatings comprise a single coating and a multi-coating, the porous coatings cover the outer surfaces of the upper end plate and the lower end plate, the porous coatings are made of biological materials, the multi-coating is composed of a plurality of different biological material layers, and each layer of the multi-coating has different porosity and biocompatibility; the supporting structure comprises a flexible hinge, a through hole is formed in the inner side of the base body, the through hole penetrates through the left side and the right side of the base body, and the flexible hinge is matched with the through hole to enable the base body to be bent to a certain extent when the base body is subjected to external force. According to the lumbar interbody fusion cage, through optimization design, the biomechanical suitability, the biocompatibility and the bone healing effect are remarkably improved.
Owner:SUZHOU SINOMED BIOMATERIALS CO LTD

Polyaryletherketone composite implant material as well as preparation method and application thereof

The invention discloses a polyaryletherketone composite implant material and a preparation method and application thereof, and belongs to the technical field of medical materials.The preparation method of the polyaryletherketone composite implant material comprises the following steps that a carbon fiber reinforced polyaryletherketone substrate with the surface provided with a groove structure and conductivity is prepared; based on a precipitation method, a calcium compound, a magnesium compound and a phosphoric acid aqueous solution are used for preparing white calcium stone; the preparation method comprises the following steps: carrying out surface modification on the white calcium phosphate by utilizing polydopamine, so as to obtain modified white calcium phosphate; adding the modified white calcium phosphate and a degradable piezoelectric polymer into a solvent, and mixing to obtain a mixed solution; and coating a carbon fiber reinforced polyaryletherketone substrate with the mixed solution, and performing drying and annealing treatment to form a coating, thereby obtaining the polyaryletherketone composite implant material. According to the invention, the degradable piezoelectric composite coating doped with the white phosphorus calcium stone, which has piezoelectric characteristics and ion release capability, is constructed, so that double biomimetic effects of an electric signal and a chemical signal in a bone healing microenvironment are realized.
Owner:JILIN UNIVERSITY

Resetting and fixing orthopedic equipment for orthopedics department

InactiveCN120616878ARoller massageFractureOrthopedic departmentLocalized swelling
The invention belongs to the technical field of orthopaedic orthopaedics, and particularly discloses a reduction and fixation orthopaedic orthopaedic device for orthopaedics, the upper side and the lower side of a positioning part are slidably connected with sliding rods, the side, close to the sliding rods, of the positioning part is fixedly connected with an adjusting part, and the positioning part comprises two positioning frames. According to the reduction and fixation orthopedic equipment for the orthopedics department, the positioning component is arranged, and a cooling mechanism is arranged in the middle of the inner side of the positioning frame, so that ice compress detumescence can be directly carried out on a bruise position, local swelling and pain caused by fracture or correction operation of a patient are relieved in time, local blood circulation is promoted, and favorable conditions are created for bone healing; when the positioning frame is worn for a long time, the contact mechanism can massage and relieve the corresponding part of the patient, muscle stiffness and discomfort caused by long-time fixation are relieved, the wearing comfort of the patient is improved, and the patient can better cooperate with treatment.
Owner:NO 2 PEOPLES HOSPITAL HUAIAN CITY

Knee replacement implants and instruments

Knee arthroplasty implants, instruments, systems, and methods of implanting the same. The knee arthroplasty implants may include a femoral implant and a tibial tray implant, each with trabecular surfaces configured to contact bone to provide a scaffold for bone healing and interdigitation. The implants may also include fixation pegs with bulleted profiles to increase the surface area for bone ingrowth. An inserter instrument may include a sliding rack, which is incrementally extended with a rotatable shaft, thereby allowing for quick lock and release of various tibia trays.
Owner:GLOBUS MEDICAL INC

Titanium-magnesium hollow screw system capable of promoting fracture healing

The invention discloses a titanium-magnesium hollow screw system capable of promoting fracture healing and a manufacturing method. The titanium-magnesium hollow screw system comprises a titanium-based supporting structure and a magnesium filling layer. The titanium-based supporting structure comprises a main body part, the surface of the main body part is provided with an imitated bone trabecula part, and a plurality of bone gaps are formed in the imitated bone trabecula part; wherein bone gaps are filled with the magnesium filling layer, and the magnesium filling layer is combined with the titanium-based supporting structure in a physical embedding mode; the titanium-based supporting structure bears and maintains initial fixation and long-term bearing, so that the strength and the stability of the screw are ensured; the surface imitated bone trabecula and the communicated bone gaps increase the surface area and provide a physical channel for vascularization and bone tissue ingrowth, so that synostosis is promoted; the magnesium filling layer releases magnesium ions after being locally controllably degraded, so that osteogenesis and angiogenesis are favorably stimulated, the local biological environment is improved, instant mechanical support after an operation is ensured, bone healing is promoted through local biological activity release and structural orientation, the healing time is favorably shortened, and the healing quality is favorably improved.
Owner:BEIJING LUHE HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV

Orthopedic surgery risk assessment method and system

The invention relates to the field of orthopedic surgery risk assessment, in particular to an orthopedic surgery risk assessment method and system. The method comprises the following steps: acquiring preoperative data and intra-operative data of an orthopedic surgery of a patient, performing data preprocessing on the preoperative data and the intra-operative data, and extracting bone microstructure spatial features in initial orthopedic surgery data by using a cascade feature extraction network; calculating an association weight of the image data and the biological signal through a cross-modal attention mechanism, and constructing a patient specific skeleton model based on finite element analysis to perform real-time scene simulation on the characteristic orthopedic surgery data; the influence of joint contact stress distribution under different osteotomy angles, a bone implant interface micro-motion threshold after implantation of an internal fixation instrument and hemodynamic changes on a bone healing microenvironment is simulated in real time, complications caused by misoperation are remarkably reduced, and the success rate of an operation is increased.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY

A method and system for risk assessment in orthopedic surgery

This invention relates to the field of orthopedic surgical risk assessment, and in particular to a method and system for orthopedic surgical risk assessment. By acquiring preoperative and intraoperative data of a patient's orthopedic surgery, the method preprocesses the preoperative and intraoperative data, extracts the spatial features of bone microstructure from the initial orthopedic surgical data using a cascaded feature extraction network, calculates the correlation weights between imaging data and biological signals through a cross-modal attention mechanism, and constructs a patient-specific bone model based on finite element analysis to simulate the characteristic orthopedic surgical data in real time. The method simulates the distribution of joint contact stress at different osteotomy angles, the impact of micromotion thresholds at the bone implant interface and hemodynamic changes on the bone healing microenvironment after internal fixation device implantation, significantly reducing complications caused by improper operation and improving the surgical success rate.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY

Traumatic injury pill and preparation method thereof

The invention relates to a traumatic injury pill and a preparation method thereof. The twenty traditional Chinese medicinal materials are selected, the production method is optimized according to different characteristics of the traditional Chinese medicinal materials, the Chinese angelica, the divaricate saposhnikovia root and the cassia twig contain volatile components and cannot be treated at a high temperature, temperature-controlled crushing needs to be performed preferentially, and the fried frankincense, the fried myrrh and the catechu are easy to soften in the crushing process, are adhered to a crusher and are not easy to crush, so that the traditional Chinese medicinal materials are difficult to crush. And finally, the powder is mixed and crushed with other medicinal powder, so that the crushing effect can be effectively improved. The obtained traumatic injury pill has the effects of promoting blood circulation to remove blood stasis, relieving swelling and pain and promoting reunion of fractured tendons and bones, and can be used for traumatic injury, tendon fracture and blood stasis swelling and pain.
Owner:HARBIN XIAS ORTHOPEDICS HOSPITAL CO LTD

Gradient degradation type personalized absorbable sternum fracture fixing plate and preparation process

The invention discloses a gradient degradation type personalized absorbable sternum fracture fixing plate and a preparation process, and belongs to the technical field of medical implant materials. Comprising an anatomical adaptive plate body and an integrated locking assembly, the plate body is of a partitioned structure of a middle supporting area and an edge buffering area, a gradient pore array penetrating through the thickness direction is formed in the surface of the plate body, and a hydroxyapatite-collagen composite coating is loaded on the inner wall of a pore; the plate body is made of a composite absorbable material through 3D printing forming and hot pressing post-treatment, and the composite absorbable material comprises, by weight, 60%-70% of polylactic acid-glycolic acid copolymer (PLGA, LA / GA = 75 / 25), 15%-20% of silanized magnesium alloy microwires, 5%-10% of hydroxyapatite nano-particles and 5%-10% of polycaprolactone (PCL). Space-time matching of the degradation rate and the bone healing process is achieved through the partition gradient structure, the magnesium alloy microwires enhance the mechanical property and release active ions to promote osteogenesis, and the method has the advantages of personalized adaptation, gradient degradation, bone regeneration promotion and the like.
Owner:ZHANGZHOU HOSPITAL OF TRADITIONAL CHINESE MEDICINE FUJIAN PROVINCE

Swim bladder-based bioactive patch for rotator cuff tendon repair and preparation method of swim bladder-based bioactive patch

The invention provides a swim bladder-based bioactive patch for rotator cuff tendon repair and a preparation method thereof, and relates to the technical field of biological materials.The swim bladder-based bioactive patch is composed of a swim bladder substrate and a metal-phenol toughening network component, has good tensile strength and biological activity and can be used for repairing rotator cuff tendons. The compound can support cell adhesion and proliferation, stimulate differentiation and phenotype maintenance of various cells derived from tendon-bone tissue, and is expected to be used for repairing rotator cuff tendon injury and promoting tendon-bone healing. Besides, the invention provides a preparation method of the swim bladder-based rotator cuff patch, a special microstructure of directionally arranged nano-matrix fibers is reserved, and a metal-phenol network further plays roles in toughening the patch and enhancing the biological activity of the material. Particularly, the metal-network has an active oxygen free radical response function, excessive free radicals at the shoulder joint part can be removed, and metal ions are released, so that the patch has the effects of resisting bacteria, resisting inflammation, resisting oxidation and improving healing.
Owner:AFFILIATED HOSPITAL OF NANTONG UNIV

Fracture fixing device

The invention relates to the field of medical apparatus and instruments, and discloses a fracture fixing device, comprising: a screw comprising a rod body and a screw head connected to one end of the rod body, the rod body being of a hollow structure, the screw head being provided with an opening communicating with the inside of the rod body, the outer side of the rod body being provided with a communicating hole communicating with the inside of the rod body; the degradable part is arranged in the rod body, and the degradable part is right opposite to the communicating hole; a mounting hole is formed in the fixing plate, and the end, away from the screw head, of the rod body penetrates through the mounting hole. After the screw is implanted into a bone, needed mechanical support can be provided, connection and fixation of a fracture part are facilitated, and factors beneficial to bone repair and healing and bacteriostasis and anti-inflammation are released through the degradable part; therefore, bone healing and rehabilitation are better promoted, and the fracture rehabilitation effect is improved.
Owner:HUAMEI MEDICAL TECHNOLOGY (SUZHOU) CO LTD

A medicinal wine for treating sprains and bruises and promoting tendon and bone healing, and its preparation method.

This invention discloses a medicinal wine for treating sprains and bruises, promoting tendon and bone healing, and its preparation method. It belongs to the technical field of bone-healing medicinal wines. This bone-healing wine is made from the following raw materials in parts by weight: 1 part small sprain bone, 1 part large sprain bone, 1 part white crane lingzhi, 1 part moha han, and 10 parts baijiu (Chinese liquor) with an alcohol content of 50 degrees or higher. The preparation method includes: cutting the fresh or dried leaves and branches of small sprain bone, large sprain bone, white crane lingzhi, and moha han into sections, and then soaking the medicinal materials in baijiu with an alcohol content of 50 degrees or higher to obtain this product. This formula can treat sprains and bruises. This invention, as an external medicinal wine for treating sprains and bruises, promotes tendon and bone healing, and has the effects of promoting blood circulation, dispelling wind and dampness, dispersing blood stasis, promoting tendon and bone healing, clearing meridians and collaterals, reducing swelling, promoting blood circulation and removing blood stasis, dispelling wind and relieving pain, tonifying fire and strengthening the body, strengthening tendons and bones, and promoting fracture healing.
Owner:蔡梓豪

A method of depositing hydroxyapatite in a three-dimensional porous sample

PendingCN122272903ABone implantHydroxylapatite
This invention discloses a method for depositing hydroxyapatite in a three-dimensional porous sample, comprising: S1, pretreatment of the three-dimensional porous sample; S2, placing the three-dimensional porous sample in an O... 2 In a plasma spraying apparatus; S3, prepare SBF1, immerse the sample treated in step S2 into SBF1, seal the container tightly, and place it in an incubator. After immersion in SBF1, remove the sample, wash and dry it. SBF1 contains the following components: CaCl2, MgCl2·6H2O, NaHCO3, K2HPO4·3H2O, Na2SO4, KCl, and NaCl; S4, prepare SBF2, immerse the sample treated in step S3 into SBF2, seal the container tightly, and place it in an incubator at 37°C. SBF2 contains the following components: NaCl, CaCl2, and K2HPO4·3H2O; S5, remove the sample, wash and dry it to obtain a three-dimensional porous sample with deposited hydroxyapatite. The method provided by this invention uniformly deposits HA in the porous three-dimensional void surface, and the composite interface can accelerate early bone healing, increase the integration of the bone implant surface with the bone, and promote the early stability of the implant.
Owner:SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

Orthopedic surgery visualization method, device and equipment and storage medium

The invention relates to the technical field of medical image processing, in particular to an orthopedic surgery visualization method and device, equipment and a storage medium. Through multi-angle shooting of an operation area, providing of rich information, reduction of single-view-angle missing and accurate presentation of an actual situation, elastic imaging data reflects tissue elastic features, in the aspects of feature extraction and model construction, key information of shooting data and a three-dimensional point cloud coordinate set are extracted by using an accelerated robust feature algorithm, and a three-dimensional point cloud coordinate set is obtained. Constructing a rendering elastic model to visually display tissue elastic distribution; meanwhile, relevant data are acquired from a preset database, a skeleton healing evaluation model is constructed by using a clustering analysis algorithm, and the skeleton healing condition is scientifically evaluated; in a data analysis and result application stage, elastic imaging data are analyzed based on the two models to obtain visual data, and doctors are assisted to formulate a reasonable treatment scheme, so that the doctors can comprehensively understand an operation area and make a decision accurately and quickly, and the operation efficiency and quality are improved.
Owner:GUANGZHOU YINGHUIXING TECH CO LTD

A PP-BST 3-x Implant and its preparation method and application

The present invention discloses a PP-BST 3‑x The invention relates to an implant and its preparation method and application, which belongs to the field of medical material technology. The invention constructs oxygen vacancies (BST) on the surface of strontium ion-doped barium titanate. 3‑x ), under ultrasonic conditions, the internal electron movement of the material is enhanced, making the electron-hole separation easier, thereby accelerating the reaction of electrons with surrounding substances and improving the efficiency of ROS generation. And the PP-BST prepared by the present invention 3‑x On the one hand, the implant can polarize macrophages through electrical potential and inhibit inflammation; on the other hand, it can regulate Sr release through ultrasound, thereby inhibiting osteoclast differentiation in an infected environment, achieving dual-pathway osteogenesis, and improving the high osteoclast environment brought about by the bacterial microenvironment while inhibiting bacteria, thereby promoting bone regeneration, accelerating bone healing ability, and reducing patient recovery time.
Owner:WEST CHINA HOSPITAL SICHUAN UNIV

Zinc-based alloy guided bone regeneration barrier membrane as well as preparation method and application thereof

The invention belongs to the technical field of biomedical materials, and particularly discloses a zinc-based alloy guided bone regeneration barrier membrane as well as a preparation method and application thereof. Based on Zn, Cu, Li and Mg element selection, by reasonably setting the proportion of each alloy component, the degradable zinc-based guided bone regeneration membrane which has excellent biocompatibility, proper degradation speed, mechanical property, bone healing promotion, bone regeneration capability and antibacterial property is preferably selected; and meanwhile, adverse effects on bone regeneration caused by over-high degradation rate of other metal films such as magnesium alloy and hydrogen generated in the release process of the metal films are also avoided. The Zn-2Cu-0.8 Li-0.2 Mg alloy film is optimally selected from the comprehensive aspects of degradation speed, mechanical property, biocompatibility, guided bone regeneration performance, antibacterial performance and the like, and a high-quality guided bone regeneration material is provided for repairing bone defects such as alveolar bones.
Owner:SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

Sternotomy closure technique using polymeric cable

ActiveUS12408961B2Internal osteosythesisDiagnosticsPolymer scienceSternum incision
A sternotomy closure technique is suitably carried out with a cerclage mechanism, which is capable of maintaining proper bony compression (within a desired range) across the sternum cut, in spite of a range of external forces and significant lateral distraction due to these external forces. The sternum fragments are aligned in apposition disposed around a longitudinal seam and secured with a resilient element. The resilient element is tensioned to a desired tension to compress the sternum to a desired compression range. The resilient element is then elongated and contracted while accepting multiple cycles of physiological distracting forces across the sternum while maintaining contact pressure across the longitudinal seam within a desired range for a length of time sufficient for bony healing. The resilient element is preferably a polymer cable comprising an elongated elastic polymeric core coaxially surrounded by a sheath woven from ultra-high molecular weight polyethylene strands.
Owner:KINAMED INC

Non-osteoconductive inorganic device for bone formation, bone reshaping or healing of bone

PendingUS20260248595A1Oral maxillofacial surgeryBone forming
The invention relates to a device for bone formation, bone reshaping or healing of bone in dental, oral and maxillofacial applications, specifically in connection with installation of dental implants. The device comprises a sheet structure made of an inert material, wherein the sheet structure has an inner surface intended to be directed towards the bone and an outer surface intended to be directed away from the bone. The geometrical features of the cavity formed between the inner surface of the device and the initial bone surface when the device is installed at the intended location is further used to improve and plan the treatment. The device is customized by means of digital planning based on the initial and the optimal bone volume for the intended treatment. Modifications of the device can be introduced to facilitate a combined installation of dental implants with the device.
Owner:MEDCER AB

Shape memory nano-short fiber stent with self-adaptive capability and preparation and application of shape memory nano-short fiber stent

The invention provides a shape memory nano short fiber stent with self-adaptive capacity and preparation and application thereof, and belongs to the technical field of tissue engineering materials. The preparation method comprises the following steps: firstly, preparing flexible polylactic acid-fullerol composite nanofibers containing uniformly dispersed fullerol nanocrystals by utilizing an electrospinning technology, then dividing the flexible polylactic acid-fullerol composite nanofibers into short fibers by virtue of homogenization and freeze-drying processes, and assembling the short fibers into a three-dimensional porous scaffold by taking chitosan as an adhesive. The porous scaffold material disclosed by the invention has excellent biological characteristics and a water-triggered shape memory effect, and due to the fact that chitosan has excellent antioxidant activity and inherent bone induction characteristics, the nanofiber scaffold with the controllable and recoverable shape developed by the invention is expected to effectively promote osteoporotic bone healing.
Owner:RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

Bone trabecula bionic implant

The invention discloses a bone trabecular bionic implant, and relates to the field of bone trabecular bionic planting, the bone trabecular bionic implant comprises a bone trabecular bionic body, the lower end of the bone trabecular bionic body is fixedly connected with a fixed threaded part, and a reserved filling cavity is formed in the bone trabecular bionic body; an external threaded piece is arranged at the lower end of the bone trabecula bionic body. According to the bone trabecular bionic implant, the whole bone trabecular bionic body is made of a tantalum metal material, the tantalum metal has bone healing force and supporting strength, and the surface of the bone trabecular bionic body is of a porous structure, so that attachment and ingrowth of muscle fulcrums are facilitated, fulcrums are provided for long-term stability of nodules and muscles, exertion of muscle force is facilitated, and the bone trabecular bionic implant has a good application prospect. The bone trabecula bionic body is filled with gel biological factor substances through a reserved filling cavity, the bone trabecula bionic body is mainly applied to implant operation after femoral head necrosis in early and middle stages and drilling decompression, and other drugs can be plugged into micropores in the surface of the bone trabecula bionic body and are slowly released.
Owner:THE PEOPLES HOSPITAL WEIFANG CITY CN0

Accurate cutting equipment for allogeneic bone processing

The invention discloses precise cutting equipment for allogeneic bone machining, which comprises an ultrasonic osteotome and an allogeneic bone clamping piece, the ultrasonic osteotome comprises a replaceable cutting tool bit, and an ultrasonic vibration generator acting on the cutting tool bit is arranged in the ultrasonic osteotome; a runner pipe is embedded in the upper portion of one side of the ultrasonic osteotome, electrode connectors are arranged at the two ends of the runner pipe respectively, and quantitative liquid expansion metal is contained in the runner pipe. Bone tissue is stably clamped through clamping jaws of the allogeneic bone clamping piece under the action of a pressing disc and a spring piece, a rotating sleeve drives a threaded disc to rotate under pushing of liquid, the extending length of an adjusting fan blade of an adjusting mechanism changes along with changes of centrifugal force, and the clamping force is enhanced when high-density bones are cut in cooperation with changes of the flow speed of the liquid; meanwhile, the bone residues are taken away from the cutting area by the liquid expanding the flowing direction, so that the bone residues are prevented from being sucked away during cutting, the bone residues are prevented from being embedded into bone gaps, the inflammatory reaction risk is reduced, and the bone healing efficiency is improved.
Owner:NANJING LONGDE BIOTECHNOLOGY CO LTD +1

Methods for promoting post-surgical healing and devices for same

Systems, devices and methods are provided for transcutaneously delivering energy impulses to bodily tissues for therapeutic purposes, such as for enhancing the body's bone healing process in spinal fusion patients. A therapeutic stimulator system comprises a housing for an energy source and a signal generator. The system further includes one or more electrodes coupled to the signal generator. A processor is coupled to the housing and configured to determine usage levels of the signal generator and / or motion data of the housing. The system may include a mobile device that allows the patient to input user status data, such as pain levels, and compare the user status data with the usage levels and / or the motion data, thereby improving patient compliance with a prescribed therapy regimen.
Owner:THERAGEN INC

Dual-regulation nano drug delivery system based on near-infrared light response and application thereof

The invention provides a near-infrared light NIR response-based dual-regulation nano drug delivery system and application thereof, the nano drug delivery system takes mesoporous silica as a carrier, and alendronate sodium is coupled on the surface of the carrier to increase bone targeting; mesopores in the carrier are blocked by rhodamine RH, nitric oxide NO can be consumed to generate rhodamine B, and bioactive drugs in the carrier are released. The invention constructs a systemic drug carrier with bone targeting and diabetic bone microenvironment response release, and solves the problems that the bone healing ability of diabetic patients is significantly reduced, and traditional local treatment is difficult to effectively improve systemic bone microenvironment disorder; the problems that an existing local drug system cannot be released according to needs, local NO and NO in bone marrow are difficult to efficiently remove, and macrophages are difficult to transform to repair-promoting M2 type are solved.
Owner:XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV

A polyaryletherketone composite implant material and a preparation method and application thereof

ActiveCN121570638BRealize dual bionicsImprove bone repair abilityPharmaceutical delivery mechanismTissue regenerationFiberO-Phosphoric Acid
The application discloses a kind of polyaryletherketone composite implant materials and preparation method and application, and belongs to medical material technical field, wherein, the preparation method of the polyaryletherketone composite implant material includes the following steps: preparation surface has recess structure and the carbon fiber reinforced polyaryletherketone base of conductivity;Based on precipitation method, white brushite is prepared using calcium compound, magnesium compound and phosphoric acid aqueous solution;White brushite is surface modified using polydopamine, to obtain modified white brushite;Modified white brushite is mixed with degradable piezoelectric polymer into solvent, to obtain mixed solution;Mixed solution is coated on carbon fiber reinforced polyaryletherketone base, after drying, annealing treatment, form coating, to obtain polyaryletherketone composite implant material.The application constructs white brushite doped degradable piezoelectric composite coating with piezoelectric characteristics and ion release capacity simultaneously, realizes the dual bionics of electric signal and chemical signal in bone healing microenvironment.
Owner:JILIN UNIVERSITY

Recombinant humanized type III collagen-hydroxyapatite composite bone repair material and its application

The present invention relates to a recombinant humanized type III collagen-hydroxyapatite composite bone repair material and its preparation method and application. At present, the industry has always expected to achieve efficient production of macromolecular humanized collagen or whole human collagen, which is a technical difficulty that is difficult to completely break through. The molecular weight of the recombinant humanized type III collagen of the present invention is close to that of natural collagen; at the same time, its encoding gene is optimized to achieve efficient and secretory expression of recombinant collagen with high yield. The composite bone repair material prepared with the collagen of the present invention has a more uniform microstructure than the products prepared with commercially available natural collagen or type III human collagen, and achieves the combination of hydroxyapatite grains and collagen fibers at the nanoscale. At the same time, there is a multi-scale pore structure inside the material, which achieves the purpose of better biomimetic natural bone composite material preparation. Therefore, this product can be widely used in dental (jaw) bone defects, as well as dental or bone surgery such as filling and repair of bone defects, nonunion, delayed bone healing or nonunion caused by various reasons, so that more patients can benefit from it.
Owner:GENSUN INSTITUTE OF BIOMEDICINE CO LTD

Computational mechanical analysis system for evaluating bone growth induced by bone healing scaffold

The invention discloses a computational mechanical analysis system for evaluating bone growth induced by a bone healing scaffold, and relates to the technical field of bone healing evaluation, and the computational mechanical analysis system is specifically characterized in that under unified external load and time gating, quantitative indexes such as a regional average osteogenesis rate curve, an accumulated bone mass, time for reaching a preset healing threshold value, a cross section bridging rate and the like are used for evaluating bone growth induced by a bone healing scaffold; the induction osteogenesis effects of different stent structures are fairly compared, shape scoring and subjective weight are avoided, reproducibility and calibration are emphasized, the method can be used for preoperative structure screening and parameter sensitivity analysis and can also be in butt joint with follow-up images and experimental data, online calibration and treatment course optimization of individualized digital twinning are further supported, and the method is suitable for popularization and application. According to the method, the period boundary, the time-varying supply gating and the multi-physics field coupling of the RVE can be unified into the same calculation framework, and the defects of the prior art in microscopic geometric maintenance, time rhythm expression and biomechanical closed loop are effectively overcome.
Owner:FIRST HOSPITAL AFFILIATED TO GENERAL HOSPITAL OF PLA

In-situ lubrication 3D printing Janus bone cartilage repair scaffold and preparation method thereof

The invention relates to an in-situ lubrication 3D printing Janus bone cartilage repair scaffold and a preparation method thereof.The scaffold is prepared through 3D printing and comprises a subchondral bone layer and a cartilage layer, the subchondral bone layer is prepared from GelMA and NAGA loaded nHA, and bone healing is promoted; the cartilage layer is provided with zwitterionic monomers, and in-situ lubrication is achieved. In-situ lubrication can be realized through lubrication modification of the cartilage layer scaffold structure, and bone healing is promoted by loading hydroxyapatite on the subchondral bone layer scaffold.
Owner:BEIJING UNIV OF TECH

External traditional Chinese medicinal liquor for treating bone diseases as well as preparation method and application of external traditional Chinese medicinal liquor

The invention discloses traditional Chinese medicine external medicinal liquor for treating bone diseases and a preparation method and application thereof. The medicinal liquor is prepared from, by weight, 30 g of ginseng under forest, 60 g of raw radix astragali, 90 g of dragon's blood, 60 g of sargentgloryvine stem, 30 g of radix clematidis, 60 g of radix angelicae, 30 g of scorpion, 60 g of lumbricus, 60 g of dried river crab, 30 g of silkworm larva, 60 g of ground beetle, 30 g of frankincense, 30 g of myrrh, 60 g of teasel root and 60 g of rhizoma drynariae. The traditional Chinese medicine is prepared from 60 g of native copper, 30 g of amber, 30 g of pericarpium zanthoxyli, 25 g of radix aconiti, 25 g of radix aconiti agrestis, 60 g of caulis spatholobi, 30 g of cortex erythrinae, 45 g of semen strychni, 15 g of musk and 30 g of borneol. The medicinal liquor achieves the effects of rapidly relieving swelling and pain, promoting bone healing, dispelling wind and eliminating dampness and the like through the synergistic effect of multiple targets, is especially suitable for arthralgia type osteoarticular diseases and traumatic injuries, and has remarkable curative effects on osteoproliferation, fracture recovery and the like and high safety according to clinical cases.
Owner:王先平

Single-arm orthopedic external fixation supporting device and adjusting method thereof

The invention relates to a single-arm orthopedic external fixing and supporting device and an adjusting method thereof, belongs to the technical field of traction equipment, and solves the technical problem of rapid growth of bone tissue in the later stage of fracture healing The single-arm orthopedic external fixing and supporting device comprises a fixing pressurization module, a fine adjustment pressurization assembly and a universal spherical hinge module which are fixedly arranged on corresponding sliding bases respectively, the fixed pressurization module and the universal spherical hinge module are movably connected through the movable connection module, and the fine adjustment pressurization assembly accurately adjusts the distance between the fixed pressurization module and the universal spherical hinge module. According to the device, firm fixation and bone tissue passive stress stimulation are realized in the early stage of bone healing, and the basic functions of a conventional single-arm orthopedic external fixation support frame are met; in the later stage of fracture healing (unscrewing a locking bolt), the fixing and pressurizing module and the universal spherical hinge module can slide back and forth relative to the movable connecting module, stress stimulation of the fixing and pressurizing module and the universal spherical hinge module is stably achieved, bone tissue healing is promoted, and the fracture healing period is shortened.
Owner:SHANXI GUSHU MEDICAL TECH CO LTD