280 results about "Bone healing" patented technology

The invention relates to the technical field of bone implantation, and discloses a biomechanical evaluation method and system for a bone defect repair implant, and the method comprises the steps: constructing a human muscle-bone system biomechanical model and a three-dimensional digital model of the bone defect repair implant; through a finite element analysis method, the stress conditions of the bone defect repair implant in different gaits and movement modes are calculated, and the stress conditions of the implant in the actual service process are simulated; and calculating the performance of the implant under the simulated stress, and adjusting the design parameters of the implant. By combining dynamics calculation, bone regeneration process simulation, nano computed tomography image three-dimensional reconstruction and structure optimization, a bone repair implant biomechanical adaptability evaluation mechanism is established, and a comprehensive evaluation system integrating system dynamics calculation and bone healing process analysis is designed. The bone repair and regeneration process and the acting force change process are simulated, the effect of mechanical stimulation on bone regeneration is revealed, and comprehensive evaluation of the structure, the mechanical property, the environmental adaptability and the service life of the implant is achieved.

The invention discloses a spinal surgery postoperative patient rehabilitation intelligent management system and method, and relates to the technical field of spinal surgery postoperative rehabilitation management, and the system can carry out real-time analysis on implant displacement characteristics, and can carry out early warning on potential deviation of an implant in advance. The first analysis module can calculate the risk index Fx of the implant, so that timely correction or adjustment is promoted, the risk of implant deviation is reduced, and the occurrence rate of postoperative complications is reduced. And the second analysis module is specially used for extracting wear characteristics of the implant, constructing an implant wear index Ms, and helping a doctor to intervene in time by monitoring the wear condition of the implant in real time so as to avoid dysfunction or risk caused by wear of the implant. And the third analysis module calculates a comprehensive fusion index ZRh by extracting bone grafting area change characteristics, bone mineral density and rehabilitation bone healing information, so that a doctor can know bone mineral density change and rehabilitation conditions of a patient, a treatment scheme is adjusted, and a rehabilitation effect is improved.

The invention discloses a cranio-maxillofacial dissimilar metal bone implant with an antibacterial property and a preparation method thereof, and relates to the technical field of medical implant prostheses, the preparation method comprises the following steps: step 1, preparing a nano-silver-antibacterial peptide GL13K composite peptide solution with the antibacterial property; 2, based on the selective laser melting technology, titanium alloy powder is prepared into a porous framework; 3, melting zinc powder, and filling pores of the porous skeleton with the molten zinc powder to obtain a semi-finished heterogeneous metal bone implant; step 4, depositing the nano-silver-antibacterial peptide GL13K composite peptide solution prepared in the step 1 on the surface of the semi-finished heterogeneous metal bone implant prepared in the step 3 through a pulse electrodeposition method to obtain a finished heterogeneous metal bone implant; the prepared finished heterogeneous metal bone implant has a remarkable antibacterial effect, the postoperative infection risk can be reduced, and the nano-silver-antibacterial peptide GL13K composite peptide can further promote osteoblast attachment and proliferation and accelerate the bone healing process.

The invention discloses functional injection type bionic hydrogel for promoting bone healing and a preparation method thereof, and relates to the technical field of medical instruments. The hydrogel has good functional characteristics, is a biomimetic material prepared on the basis of methacrylated gelatin, and aims to regulate and control the degradation rate, the drug release mechanism and diversified synergistic treatment and promote bone repair and regeneration; according to the hydrogel, matching of the degradation rate and the bone regeneration rate is achieved through reasonable matching, stem cell osteogenic differentiation and angiogenesis are promoted, ultrasonic controlled-release drug release and synergistic controlled-release of active factors are achieved, inflammation is reduced, and the bone repair process is promoted; the calcium phosphate bone cement provides biocompatibility and bone conductivity, and the nano clay releases active ions to improve the microenvironment and promote bone repair; in addition, the magnetic nanoparticles and a static magnetic field have synergistic interaction, the bone healing process is further accelerated, and treatment effect monitoring is enhanced through magnetic resonance imaging.

The invention discloses a modeling method and system for regulating and controlling bone healing through dynamic stress stimulation, which are applied to the technical field of bone healing, and the method comprises the following steps: establishing a geometric model of a fracture part; performing mesh generation on the geometric model to generate finite element models of bones and callus; assigning values to the material attributes in the callus at the initial moment; applying dynamic load constraint to the top end of the cortical bone based on the finite element model, and establishing a bone healing model; calculating attributes of new materials in tissue cells, and judging whether the attributes of the new materials reach a preset healing standard or not through the bone healing model; if the preset healing standard is reached, simulation is completed, otherwise, iterative simulation is carried out by dynamically adjusting mechanical parameters until the preset healing standard is reached, and final bone healing data are output. Through the bone healing model, loading parameters are adjusted in real time according to simulation data, and the accuracy and reliability of bone healing simulation are improved.

A tissue scaffold for use in a tendon and / or ligament is provided, which includes a weave formed by interlacing warp yarns and weft yarns, wherein the warp yarns include a plurality of fibers with an alternative shaped cross section structure, and the weave includes: a main body area with a bioactive component formed on the fiber surface, and a fixed area comprises the weft yarn having a bioceramic material. The tissue scaffold prepared in the present disclosure has the characteristics of stimulating the growth of tissues and inducing tissue repair, effectively improving the ability of tissue regeneration and bone healing, and is beneficial to the reconstruction of the tendon and / or ligament.

Devices and methods for treating bone fractures involving a micromotional unit (6) that produces reciprocating displacement between two fracture fragments (1) to thereby apply controllable micromotion to a fracture site.

An orthopedic staple system and orthopedic staple are configured to facilitate bone healing through dynamic and adjustable compression. The system comprises the orthopedic staple having a bridge portion and one or more legs that anchor into bone structure. The bridge portion is configurable to include compression features, comprising a pre-compressed chevron, an “S” shaped deformable path, or other suitable geometries to enable active post-operative compression. The staple can be configured to accommodate a single screw or multiple screws, which interact with the bridge to apply targeted compressive forces. Screws can be seated in either fixed or translatable pockets within the bridge, facilitating variable angle adjustments and bone remodeling. This system is optimized for minimally invasive surgical applications, promoting healing and integration, and enhancing overall patient outcomes.

The invention relates to the field of image processing, in particular to an artificial intelligence auxiliary analysis system based on orthopedic images, which comprises an image acquisition module, a grade determination module, a fracture detection module, a treatment detection module and a processing module. The fracture degree and the corresponding healing condition can be more accurately judged by comprehensively analyzing the initial bone image and the post-treatment bone image in combination with factors such as the age and the gender of a patient, the diagnosis accuracy is greatly improved, the bone healing rate is obtained by comparing the initial bone fracture proportion and the post-treatment bone fracture proportion, and the diagnosis accuracy is improved. Reliable data support is provided for evaluating the treatment effect, diagnosis and evaluation time can be greatly shortened, the overall treatment efficiency can be improved, whether the treatment effect is good or not is judged according to clinical data, suggestions about whether an operation needs to be conducted again or rehabilitation guidance needs to be given, the risk of human judgment errors can be reduced, and the treatment efficiency is improved. And the accuracy of diagnosis and treatment decisions is improved.

The invention discloses a high-strength low-immunoreaction bone bonding material and a preparation and application method thereof. The bone binding material comprises tetracalcium phosphate, serine phosphate, magnesium phosphate and a sodium citrate solution. According to the preparation method, tetracalcium phosphate, phosphoserine, magnesium phosphate powder and a sodium citrate solution are fully mixed and reacted by utilizing a hedging device consisting of a screw injector and a connecting pipe. And extruding the mixed liquid material through a filter membrane to complete the preparation of the bone adhesive material. The bone binding material can be used for preparing bionic sclerotin, binding broken bones in comminuted fractures or smearing the bone binding material to bone gaps, and in the decomposition process, the bone binding material can continuously release magnesium ions, so that the immune environment of early bone repair is regulated and controlled, the bone repair process is accelerated, and bone healing is promoted. Meanwhile, experimental data prove that the bone adhesive material provided by the invention can provide stable supporting strength, has no potential toxicity to fibroblasts, and is good in biocompatibility.

The invention belongs to the technical field of drug sustained release, and particularly relates to a preparation method and application of a BMP-2 controllable sustained-release flocculent body based on lysozyme self-regulation. The preparation method comprises the following steps: preparing a chitosan solution; sequentially adding a protein stabilizer and glycerol into the chitosan solution obtained in the step A1 to prepare a chitosan composite solution; obtaining a non-specific binding solution; preparing BMP-2 / chitosan solid particles by adopting a freeze drying method; the preparation method comprises the following steps: preparing a PLGA / PEG composite solution to obtain a suspension, and carrying out post-treatment on the suspension to form the BMP-2 controllable slow-release flocculent. The carrier in the BMP-2 controllable slow-release flocculent body prepared by the preparation method can be specifically degraded by lysozyme in a human body, so that the release amount and the release speed of BMP-2 can be automatically adjusted according to a bone healing process, and long-time continuous release of the BMP-2 controllable slow-release flocculent body is realized. The problems that in the prior art, the slow release effect of a hydrophilic material on BMP-2 is poor, sudden release of factors is easily formed, and the slow release time and the slow release dosage are not controllable are solved.

The invention discloses a bone healing time sequence evaluation method, system and device and a medium, and the method comprises the steps: obtaining a multi-time-point CT image data set through an image preprocessing and data enhancement method; performing feature extraction on the CT image at each time point by using a convolutional neural network to obtain spatial features of bone healing; and inputting the extracted features into an LSTM network, capturing time sequence changes between different periods, and finally outputting an evaluation result of the bone healing state through a full connection layer. According to the method, the limitation of single-time-point image analysis in the prior art can be overcome, more accurate and reliable bone healing evaluation is provided, and important decision support is provided for clinicians.

The invention discloses a lumbar interbody fusion cage and an implementation method thereof.The lumbar interbody fusion cage comprises a base body, the base body comprises an upper end plate and a lower end plate, and the surface curvature of the upper end plate and the surface curvature of the lower end plate are matched with the lumbar interbody curvature of the human body; the porous coatings comprise a single coating and a multi-coating, the porous coatings cover the outer surfaces of the upper end plate and the lower end plate, the porous coatings are made of biological materials, the multi-coating is composed of a plurality of different biological material layers, and each layer of the multi-coating has different porosity and biocompatibility; the supporting structure comprises a flexible hinge, a through hole is formed in the inner side of the base body, the through hole penetrates through the left side and the right side of the base body, and the flexible hinge is matched with the through hole to enable the base body to be bent to a certain extent when the base body is subjected to external force. According to the lumbar interbody fusion cage, through optimization design, the biomechanical suitability, the biocompatibility and the bone healing effect are remarkably improved.

The invention discloses a polyaryletherketone composite implant material and a preparation method and application thereof, and belongs to the technical field of medical materials.The preparation method of the polyaryletherketone composite implant material comprises the following steps that a carbon fiber reinforced polyaryletherketone substrate with the surface provided with a groove structure and conductivity is prepared; based on a precipitation method, a calcium compound, a magnesium compound and a phosphoric acid aqueous solution are used for preparing white calcium stone; the preparation method comprises the following steps: carrying out surface modification on the white calcium phosphate by utilizing polydopamine, so as to obtain modified white calcium phosphate; adding the modified white calcium phosphate and a degradable piezoelectric polymer into a solvent, and mixing to obtain a mixed solution; and coating a carbon fiber reinforced polyaryletherketone substrate with the mixed solution, and performing drying and annealing treatment to form a coating, thereby obtaining the polyaryletherketone composite implant material. According to the invention, the degradable piezoelectric composite coating doped with the white phosphorus calcium stone, which has piezoelectric characteristics and ion release capability, is constructed, so that double biomimetic effects of an electric signal and a chemical signal in a bone healing microenvironment are realized.

The disclosure features methods for treating at least one symptom of neurofibromatosis type 1, treating at least one symptom of dystrophic scoliosis, or inducing bone healing by administering a soluble alkaline phosphatase (sALP) to the patient.

The invention discloses a design method of a structural mechanical gradient regulation and control interbody fusion cage for end plate defects. The design method comprises the following steps of data acquisition and model construction; analyzing the shape of the defective end plate; carrying out interface mechanical adaptation design on the defect end plate and the structural gradient fusion cage; performing multi-objective optimization; the invention relates to a 3D printing defect endplate mechanical and biological adaptive spinal fusion cage. The individual end plate defect model can be established according to the difference of different patients, the local elastic modulus of the fusion cage is dynamically adjusted through morphological analysis and typing, the stress conduction height matching with the defect end plate is realized, the settlement risk is reduced, and the fusion effect is improved; by combining the biological adaptation design of the end plate, the pore structure and material characteristics of the fusion cage are optimized, and bone healing is promoted; through the scheme of image analysis, digital design, intelligent optimization and precise manufacturing, a mechanical and biological dual-adaptive fusion cage system solution is provided for a patient with the defect of the end plate.

The invention discloses a livestock limp detection and correction supporting device, and belongs to the technical field of livestock breeding, the livestock limp detection and correction supporting device comprises a horizontally arranged detection base, and a mesh fence is arranged on the detection base; a limping detection mechanism and a limping correction supporting mechanism are arranged on the detection base, the limping detection mechanism is in sliding fit with the detection base, the limping detection mechanism comprises four pressure sensing modules and a motion posture monitoring module, and the four pressure sensing modules are arranged on the detection base. The four pressure sensing modules are used for respectively detecting four limbs of livestock, and the motion posture monitoring module is positioned at the end part of the detection base; the limp correction supporting mechanism comprises two front leg correction mechanisms and two rear leg correction mechanisms, and the two front leg correction mechanisms and the two rear leg correction mechanisms are symmetrically arranged on the two sides of the detection base respectively. According to the invention, the affected limb and hoof part of the livestock can be adjusted to a proper angle, so that the fracture part can be better fixed and supported, and bone healing is facilitated.

The utility model relates to the field of medical instruments, in particular to a memory alloy rib prosthesis fixator. The two ends of the memory alloy rib prosthesis are respectively sleeved with a memory alloy rib fixator, each memory alloy rib fixator comprises a bone fracture plate body, a bone fracture plate cross beam, bone fracture plate embracing arms and bone fracture plate end teeth, the bone fracture plate body is composed of the bone fracture plate cross beam and the bone fracture plate embracing arms, the bone fracture plate cross beam is provided with a plurality of groups of bone fracture plate embracing arms, and the bone fracture plate end teeth are arranged on the bone fracture plate embracing arms. The multiple sets of bone fracture plate embracing arms are connected with the memory alloy rib prosthesis and an affected bone in an embracing mode respectively, bone fracture plate end teeth are arranged at the two ends of the bone fracture plate cross beam, the bone fracture plate end teeth at one end buckle the memory alloy rib prosthesis, and the bone fracture plate end teeth at the other end buckle the affected bone. After the memory alloy rib bone fracture plate is implanted into a human body, the memory alloy rib bone fracture plate continuously embraces and pressurizes at the body temperature, looseness caused by bone healing is avoided, and the phenomenon that human bones are hurt when a thread structure is implanted into or screwed into the bones can be avoided through the design without screw matching.

The invention belongs to the technical field of orthopaedic orthopaedics, and particularly discloses a reduction and fixation orthopaedic orthopaedic device for orthopaedics, the upper side and the lower side of a positioning part are slidably connected with sliding rods, the side, close to the sliding rods, of the positioning part is fixedly connected with an adjusting part, and the positioning part comprises two positioning frames. According to the reduction and fixation orthopedic equipment for the orthopedics department, the positioning component is arranged, and a cooling mechanism is arranged in the middle of the inner side of the positioning frame, so that ice compress detumescence can be directly carried out on a bruise position, local swelling and pain caused by fracture or correction operation of a patient are relieved in time, local blood circulation is promoted, and favorable conditions are created for bone healing; when the positioning frame is worn for a long time, the contact mechanism can massage and relieve the corresponding part of the patient, muscle stiffness and discomfort caused by long-time fixation are relieved, the wearing comfort of the patient is improved, and the patient can better cooperate with treatment.

The invention concerns a method, in particular a computer-implemented method, for performing scaffold design optimization (h) towards enhanced bone healing, the method comprising the steps of a) Inputting a set of parameters comprising information about a geometry and a material of a scaffold (3) to a computational model, the computational model comprising a finite element model and a mechano-biological computational model, wherein the finite element model determines and provides a set of mechanical information data for the set of parameters to the mechano-biological computational model, wherein the mechano-biological computational model determines from the set of mechanical information data a regenerated bone volume; b) Determining a plurality of regenerated bone volumes for a plurality of sets of parameters according to step a), such as to generate a scaffold bone data associating the regenerated bone volume with the corresponding set of parameters; c) Determining a computational surrogate model consisting of an analytical expression configured to associate the regenerated bone volumes with the sets of parameters from the scaffold bone data; and d) Determining from the computational surrogate model an optimum set of parameters for which the computational surrogate model puts out a maximum regenerated bone volume. The invention also concerns a computer program and a method to manufacture a scaffold (3).

Knee arthroplasty implants, instruments, systems, and methods of implanting the same. The knee arthroplasty implants may include a femoral implant and a tibial tray implant, each with trabecular surfaces configured to contact bone to provide a scaffold for bone healing and interdigitation. The implants may also include fixation pegs with bulleted profiles to increase the surface area for bone ingrowth. An inserter instrument may include a sliding rack, which is incrementally extended with a rotatable shaft, thereby allowing for quick lock and release of various tibia trays.

The invention discloses a titanium-magnesium hollow screw system capable of promoting fracture healing and a manufacturing method. The titanium-magnesium hollow screw system comprises a titanium-based supporting structure and a magnesium filling layer. The titanium-based supporting structure comprises a main body part, the surface of the main body part is provided with an imitated bone trabecula part, and a plurality of bone gaps are formed in the imitated bone trabecula part; wherein bone gaps are filled with the magnesium filling layer, and the magnesium filling layer is combined with the titanium-based supporting structure in a physical embedding mode; the titanium-based supporting structure bears and maintains initial fixation and long-term bearing, so that the strength and the stability of the screw are ensured; the surface imitated bone trabecula and the communicated bone gaps increase the surface area and provide a physical channel for vascularization and bone tissue ingrowth, so that synostosis is promoted; the magnesium filling layer releases magnesium ions after being locally controllably degraded, so that osteogenesis and angiogenesis are favorably stimulated, the local biological environment is improved, instant mechanical support after an operation is ensured, bone healing is promoted through local biological activity release and structural orientation, the healing time is favorably shortened, and the healing quality is favorably improved.

The invention discloses an anti-inflammatory osteogenesis-promoting titanium-based implant which comprises a titanium base material, a TiO2 nanotube array layer is constructed on the surface of the titanium substrate in situ; iL-4 is loaded in the TiO2 nanotube array layer, and the surface of the TiO2 nanotube array layer is grafted with a gate molecule mPEG2000-PLGLAL-(PEG4)-C. The invention further discloses a preparation method of the TiO2 nanotube array. The anti-inflammatory osteogenesis-promoting titanium-based implant can respond to MMP concentration change of a surrounding microenvironment so as to regulate and control the release rate of IL-4, in the early stage of bone healing, IL-4 is slowly released, M1 macrophages are dominant, a short and moderate inflammatory reaction is kept, along with response to MMP in the microenvironment, IL-4 is rapidly released, M1 polarization is inhibited, and the osteogenesis-promoting titanium-based implant has the advantages of being good in anti-inflammatory effect and capable of promoting osteogenesis. And inflammation is eliminated in time, M2 polarization is promoted, wound repair is accelerated, osseointegration is further promoted, dynamic regulation of immune response is realized, and a new strategy is provided for promoting bone tissue regeneration through immune regulation.

The invention belongs to the technical field of biological medicine, and provides a multifunctional fusion peptide modified 3D printing Ti implant constructed by a fusion peptide platform and a preparation method and application thereof. The antibacterial peptide KR-12 and the adhesion peptide GFOGER are simultaneously loaded on the surface of the 3D printing titanium implant through the specific targeting peptide minTBP-1. The sequence of the fusion peptide platform is divided into four main components: bioactive polypeptide sequences KR-12 and GFOGER; a connection unit (Linker); a lysine residue; a specific anchoring group minTBP-1; the composite material has specific loading and slow release capabilities, and utilizes synergistic antibacterial and osteogenesis functions to cope with continuous challenges of implant infection and insufficient osseointegration in biomedical equipment. Meanwhile, sterilization and bone regeneration promotion are achieved, and the method is of great importance to bone healing and enhancement of bone combination around the implant. In addition to the antibacterial effect, the synergistic effect of the antibacterial peptide KR-12 and the adhesive peptide GFOGER can significantly promote osteogenesis of the BMSCs.

The invention provides moldable hemostatic putty as well as a preparation method and application thereof. The hemostatic putty comprises hemostatic powder and a solvent, wherein the hemostatic powder comprises gelatin particles and a polysaccharide compound containing an aldehyde group or a succinimide ester group, and the gelatin particles are cross-linked gelatin particles coated with an active substance. The hemostatic putty disclosed by the invention has good flexibility, moldability, adhesion plugging property and degradability, can be kneaded and molded into any shape to be filled at a bleeding part of a bone wound surface, and forms adhesion plugging on the bleeding part, so that a good plugging hemostatic effect is realized. Active substances are wrapped in a network structure of crosslinked gelatin to form a stable core-shell structure, so that the active substances can be prevented from influencing the adhesion plugging property and hemostatic effect of a final product, and the active substances can be slowly released along with degradation of the gelatin, so that generation of new callus is induced or accelerated, and bone healing is accelerated.

The invention relates to the field of orthopedic surgery risk assessment, in particular to an orthopedic surgery risk assessment method and system. The method comprises the following steps: acquiring preoperative data and intra-operative data of an orthopedic surgery of a patient, performing data preprocessing on the preoperative data and the intra-operative data, and extracting bone microstructure spatial features in initial orthopedic surgery data by using a cascade feature extraction network; calculating an association weight of the image data and the biological signal through a cross-modal attention mechanism, and constructing a patient specific skeleton model based on finite element analysis to perform real-time scene simulation on the characteristic orthopedic surgery data; the influence of joint contact stress distribution under different osteotomy angles, a bone implant interface micro-motion threshold after implantation of an internal fixation instrument and hemodynamic changes on a bone healing microenvironment is simulated in real time, complications caused by misoperation are remarkably reduced, and the success rate of an operation is increased.

The utility model discloses a positioning and depth-setting line passing instrument for two angled communicated bone blind sidewalks, which solves the problems that consumable-free fixation cannot be realized and line passing cannot be completed in angled communicated blind sidewalks in the existing tail line fixing mode, and comprises a tool main frame, a depth-setting opening, an angle fixer, a depth-setting hollow guide sleeve and an angle-setting hollow guide sleeve, the depth setting opening is formed in one end of the tool main frame, sliding ways are arranged on the two sides of the tool main frame, the angle fixator is in an inverted U shape, sliding grooves are formed in the two sides of the angle fixator, the angle fixator can slide on the tool main frame conveniently through matching of the sliding grooves and the sliding ways, and the angle setting opening is formed in the upper portion of the angle fixator. The depth-keeping hollow guide sleeve is installed in the depth-keeping opening, and the angle-keeping hollow guide sleeve is installed in the angle-keeping opening. According to the application principle and scene, suture auxiliary fixing is achieved, the depth and the position of a hole channel are defined, and muscle-bone healing is promoted.

The invention discloses hydrogel for remodeling an aging microenvironment and promoting rotator cuff injury repair and a preparation method of the hydrogel. The hydrogel comprises ordered hydroxyapatite super-long nanowire / gelatin-hyaluronic acid composite hydrogel and quercetin loaded in the ordered hydroxyapatite super-long nanowire / gelatin-hyaluronic acid composite hydrogel. According to the ordered hydroxyapatite ultra-long nanowire (AHNW) / gelatin-hyaluronic acid (GH) hydrogel compound loaded with Quercetin, the repairing capacity of bone marrow-derived mesenchymal stem cells (BMSCs) and tendon-derived stem cells (TDSCs) is improved by remodeling an aging microenvironment, so that tendon-bone healing is promoted, the integration effect is improved, and the application prospect is wide. A new treatment strategy is provided for the patient with the rotator cuff injury, especially the patient with the osteoporosis.

This invention relates to the field of orthopedic surgical risk assessment, and in particular to a method and system for orthopedic surgical risk assessment. By acquiring preoperative and intraoperative data of a patient's orthopedic surgery, the method preprocesses the preoperative and intraoperative data, extracts the spatial features of bone microstructure from the initial orthopedic surgical data using a cascaded feature extraction network, calculates the correlation weights between imaging data and biological signals through a cross-modal attention mechanism, and constructs a patient-specific bone model based on finite element analysis to simulate the characteristic orthopedic surgical data in real time. The method simulates the distribution of joint contact stress at different osteotomy angles, the impact of micromotion thresholds at the bone implant interface and hemodynamic changes on the bone healing microenvironment after internal fixation device implantation, significantly reducing complications caused by improper operation and improving the surgical success rate.

The invention relates to a traumatic injury pill and a preparation method thereof. The twenty traditional Chinese medicinal materials are selected, the production method is optimized according to different characteristics of the traditional Chinese medicinal materials, the Chinese angelica, the divaricate saposhnikovia root and the cassia twig contain volatile components and cannot be treated at a high temperature, temperature-controlled crushing needs to be performed preferentially, and the fried frankincense, the fried myrrh and the catechu are easy to soften in the crushing process, are adhered to a crusher and are not easy to crush, so that the traditional Chinese medicinal materials are difficult to crush. And finally, the powder is mixed and crushed with other medicinal powder, so that the crushing effect can be effectively improved. The obtained traumatic injury pill has the effects of promoting blood circulation to remove blood stasis, relieving swelling and pain and promoting reunion of fractured tendons and bones, and can be used for traumatic injury, tendon fracture and blood stasis swelling and pain.