458 results about "Polylysine" patented technology

The invention discloses a preparation method and application of a composite PVDF-HFP and polylysine nanofiber diaphragm, and belongs to the technical field of lithium batteries. The composite material is prepared by blending polyvinylidene fluoride-hexafluoropropylene (PVDF-HFP) and polylysine and then carrying out an electrostatic spinning process. The PVDF-HFP is utilized to provide excellent mechanical strength and chemical stability, rich polar amino functional groups in a polylysine molecular chain are utilized to improve the lyophilic property of the membrane, and anions in an electrolyte are fixed through an intermolecular acting force, so that the transference number of lithium ions is increased, and the lithium ions are induced to be uniformly deposited. The nanofiber membrane combines the characteristics of PVDF-HFP and polylysine, has high porosity, good thermal stability and excellent interface compatibility, can effectively inhibit the growth of lithium dendrites and prevent the diaphragm from being punctured, and can significantly prolong the cycle life and improve the safety performance of the lithium metal battery when being applied to the lithium metal battery.

The invention relates to epsilon-polylysine epsilon-PL-loaded modified rice bran protein antibacterial nanoparticles as well as a preparation method and application thereof, and belongs to the technical field of preparation of nanoparticles. The preparation method comprises the following steps: extracting rice bran protein from defatted rice bran to prepare a rice bran protein stock solution; under continuous stirring, adding succinic anhydride into the rice bran protein stock solution to obtain acylated rice bran protein; mixing the acylated rice bran protein stock solution, the lactose stock solution and the epsilon-PL stock solution; and centrifuging and freeze-drying to obtain the epsilon-PL-loaded modified rice bran protein antibacterial nanoparticles. The preparation method disclosed by the invention is simple and low in cost, the prepared nanoparticles have smaller particle size and turbidity and higher stability, the hygroscopicity of epsilon-PL can be reduced to a great extent, the bioavailability of epsilon-PL can be improved, and the nanoparticles have an obvious bacteriostatic effect on escherichia coli and staphylococcus aureus.

The present invention relates to a composition (the composition of the invention) comprising a component A consisting of a polylysine component, an XL component and a fibrous component consisting of at least one fibrous element comprising plant fibers, and wherein the fibrous element is free of any other fibers other than plant fibers, and wherein the component A consists of a polylysine component, an XL component, and a fibrous component consisting of at least one fibrous element comprising plant fibers. And the composition does not contain any fibers other than the plant fibers of the fiber component. The invention further relates to a method for obtaining an object from the composition according to the invention. The invention further relates to objects (objects of the invention) obtained by said method, such as sheets, strips, bars, strips, films, cloths, containers, panels, panels, beams, frames, slats, engineered wood, such as fiberboards. The invention further relates to an article (article of the invention) comprising a) a component that is solid at 23 DEG C and 1 atm; and one or both of b) and c) wherein b) is the composition of the invention and c) is the object of the invention. The invention further relates to various uses of any one or any combination of the composition of the invention, the object of the invention and the article of the invention.

The invention provides a wound dressing for diminishing inflammation, easing pain and promoting wound healing and a preparation method thereof. The wound dressing capable of diminishing inflammation, easing pain and promoting wound healing is prepared from the following components in parts by mass: 6 to 10 parts of oxidized sodium alginate, 7 to 9 parts of hydrazide gelatin, 1 to 1.5 parts of tannic acid, 8 to 12 parts of polyethylene glycol, 0.05 to 0.1 part of cannabidiol, 0.05 to 0.1 part of neomycin sulfate, 0.2 to 0.3 part of 2-roots alcohol, 0.02 to 0.04 part of vitamin C palmitate and 0.03 to 0.1 part of epsilon-polylysine. The dressing can achieve excellent effects of diminishing inflammation, easing pain and promoting wound healing through synergistic cooperation of all the components.

The invention provides glycosaminoglycan hydrogel with a physical and chemical double crosslinking mechanism as well as a preparation method and application thereof, and relates to the technical field of biological materials. The glycosaminoglycan hydrogel is prepared from the following raw materials: oxidized sodium hyaluronate, chondroitin sulfate, epsilon-polylysine hydrochloride, a polydopamine-titanium dioxide compound and a stabilizer. The glycosaminoglycan hydrogel is prepared through a physical and chemical double-crosslinking mechanism under the specific raw materials and proportion, the problems of cytotoxicity and the like caused by use of a crosslinking agent or introduction of other solvents are avoided, a stable covalent network is constructed through chemical crosslinking, the gel is endowed with the self-repairing characteristic through physical crosslinking, and the self-repairing performance of the hydrogel is improved. And the viscosity of the product is remarkably improved, so that the hydrogel has stronger mechanical support performance, is suitable for wound repair, wound healing and the like, and has good antibacterial activity and stability.

The present invention relates to a composition (the composition of the invention) comprising a component A consisting of a polylysine component, an XL component and a fibrous component consisting of at least one fibrous element comprising plant fibers, and wherein the fibrous element is free of any other fibers other than plant fibers, and wherein the component A consists of a polylysine component, an XL component, and a fibrous component consisting of at least one fibrous element comprising plant fibers. And the composition does not contain any fibers other than the plant fibers of the fiber component. The invention further relates to a method for obtaining an object from the composition according to the invention. The invention further relates to objects (objects of the invention) obtained by said method, such as sheets, strips, bars, strips, films, cloths, containers, panels, panels, beams, frames, slats, engineered wood, such as fiberboards. The invention further relates to an article (article of the invention) comprising a) a component that is solid at 23 DEG C and 1 atm; and one or both of b) and c) wherein b) is the composition of the invention and c) is the object of the invention. The invention further relates to various uses of any one or any combination of the composition of the invention, the object of the invention and the article of the invention.

The invention discloses a catechol side group-containing polylysine derivative as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) dissolving catechol acid in an organic phase, firstly adding NHS, stirring and dissolving until the materials are uniformly mixed, then adding EDC.HCl, and stirring and reacting to obtain a catechol-NHS intermediate solution; (2) dissolving polylysine or a salt thereof in a water phase, and adjusting the pH value to 6.0-7.0 by using an alkaline solution to obtain a solution of polylysine or a salt thereof; and (3) adding the intermediate solution obtained in the step (1) into the polylysine or the salt solution thereof obtained in the step (2), and maintaining the pH value of the reaction system at 5.0-6.0 by using an alkaline solution to obtain the catechol side group-containing polylysine derivative. The preparation method is short in reaction time and mild in reaction condition, and the obtained product is high in grafting rate and high in raw material conversion rate and has a good application prospect in the aspects of tissue adhesives and the like.

The preparation method comprises the following steps: by taking natural chitosan, epsilon-polylysine and polyphenol as raw materials, firstly, respectively preparing polyphenol modified chitosan and carboxyphenylboronic acid modified polylysine through a carbodiimide coupling method, then, mixing single-component solutions of the polyphenol modified chitosan and the carboxyphenylboronic acid modified polylysine, and then, preparing the antibacterial and antioxidant glycopeptide hydrogel based on the polyphenol. And the antibacterial and antioxidant glycopeptide hydrogel is obtained by virtue of the synergistic effect of the phenolic hydroxyl group-boric acid group dynamic bond and the amino group-carboxyl group. The hydrogel disclosed by the invention has broad-spectrum antibacterial property and glucose response oxidation resistance, has self-healing capability and strong wound adhesion, is excellent in biocompatibility and can be naturally degraded; and the process is simple, convenient and controllable, large-scale production is easy to realize, the hydrogel can be used as a wound dressing for treating chronic difficult-to-heal wounds such as diabetes mellitus in a targeting manner, and integrated nursing of antibiosis, antioxidation, wound adhesion and self-repairing is realized.

The disclosure relates to compositions including a constituent—A, which constituent—A consists of a polylysine component, a XL-component, and a fibrous component which fibrous component consists of at least one fibrous element which fibrous element includes vegetable fibers, and where the fibrous element is free of any fibers other than the vegetable fibers, where and the composition is free of any fibers other than the vegetable fibers of the fibrous component. The disclosure further relates to processes for obtaining an object from the compositions. The disclosure further relates to objects such as sheets, tapes, sticks, strips, films, cloths, containers, boards, panels, beams, frames, planks, engineered wood e.g. fibreboards obtained by said processes.

The invention discloses a gamma delta T cell efficient amplification method and application, and belongs to the technical field of cell biology. The amplification method comprises the following steps: separating PBMC (peripheral blood mononuclear cells) by adopting a density gradient centrifugation method, carrying out initial culture through a polylysine coated container, carrying out three-stage dynamic stimulation, combining with an X-VIVO 15 culture medium of 5-8% autoserum, and finally carrying out anti-gamma delta TCR magnetic bead separation to obtain high-purity cells. Through collaborative optimization of stepped factor combination, staged container coating and a low-serum system, the amplification multiple of the gamma delta T cells reaches 150-180 times, the purity is larger than or equal to 90% after purification, the cytotoxicity and the survival ability are remarkably improved, the gamma delta T cells can be efficiently used for immunotherapy of tumors and infectious diseases, and stable technical support is provided for clinical transformation of the gamma delta T cells.

The invention provides a polyglutamic acid granular fertilizer and a preparation method thereof, and the preparation method comprises the following steps: S1, dissolving lignin in an alkaline solution, and heating until the lignin is dissolved; adding epsilon-polylysine fermentation liquor, mixing, heating, adding a formaldehyde solution, and carrying out grafting reaction to obtain epsilon-polylysine grafted lignin; s2, mixing the epsilon-polylysine grafted lignin solution and the gamma-polyglutamic acid solution, adding N-hydroxysuccinimide, standing at a low temperature, adding 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, and mixing; carrying out gradient temperature reaction to obtain lignin grafted epsilon-polylysine / gamma-polyglutamic acid hydrogel; and S3, homogenizing the lignin-grafted epsilon-polylysine / gamma-polyglutamic acid hydrogel, carrying out normal-temperature high-pressure airflow crushing, and spraying the crushed hydrogel to the surfaces of particles obtained by granulating a basic material through high-pressure electrostatic spraying, so as to obtain the polyglutamic acid granular fertilizer. The obtained polyglutamic acid granular fertilizer has relatively strong water-retaining and slow-release (releasing water, urea and the like) effects.

The invention relates to the technical field of high-performance polyester, and discloses a modified preparation method of functionalized antibacterial polyester fibers, which comprises the following steps: S1, graphene is treated by oxygen-argon mixed plasma to obtain hydroxylated graphene; s2, after hydroxylated graphene is dispersed, cerium nitrate and sodium citrate are added, and cerium-based metallized graphene is obtained; s3, carrying out a reaction on the cerium-based metallized graphene and 3-(2-aminoethylamino) propyltrimethoxysilane, so as to obtain aminated graphene; s4, aminated graphene dicyandiamide, ammonium chloride tetraethoxysilane and hexadecyl trimethyl ammonium bromide are subjected to a reaction, and guanidyl-meso-porous silicon-metal composite graphene is obtained; s5, reacting the product with epsilon-polylysine and polycaprolactone to obtain a modified composite antibacterial agent; s6, treating the polyester fibers with a mixed solution of alkali and a surfactant; s7, the polyester fibers react with a solution containing an antibacterial agent, tetrabutyl titanate, an initiator and a dispersing agent, and a finished product is obtained.

The invention relates to the technical field of fibers, and particularly discloses a skin-friendly fiber, a preparation method of the skin-friendly fiber and a hygienic product with the skin-friendly fiber. The skin-friendly fiber comprises a fiber matrix and a coating layer coating the fiber matrix, and the fiber matrix comprises a core layer and a skin layer coating the core layer; the core layer is prepared from the following raw materials: PET resin, whitening master batch, a flexibilizer, a compatilizer and an antioxidant; the skin layer comprises the following raw materials: PE resin, an initiator, glycidyl methacrylate and tertiary amine; the coating layer comprises the following raw materials: red camellia oil microcapsules and polylysine; the capsule core of the red camellia oil microcapsule is red camellia oil, and the capsule wall of the red camellia oil microcapsule is prepared from the following raw materials: chitosan, hyaluronic acid and a glutaraldehyde solution in a mass ratio of 1: (2-3): (1.5-2). The skin-friendly fiber can be used for manufacturing non-woven fabrics of hygienic products, and has the advantages of being skin-friendly, soft, breathable and high in moisture penetrability.

The present application relates to a kind of pH / H2O2 dual-response drug-loaded hydrogel and its preparation method and application, by ε-polylysine derivative as antitumor active ingredient, with oxidized dextran through Schiff base reaction crosslinking rapid gelation. While using 2-formylphenyl boronic acid covalently package CD73 small molecule inhibitor APCP. ε-polylysine derivative has oncolytic activity, can induce ICD and promote the infiltration of immune cells in tumor cells. CD73 small molecule inhibitor APCP can block extracellular CD39-CD73-adenosine pathway, reduce the level of immunosuppressive metabolite adenosine in tumor tissue, so as to activate the infiltrated immune cells, restore its anti-tumor function. The hydrogel of ε-polylysine derivative and APCP co-delivery synergistically inhibits the effect of tumor growth, and its curative effect is greater than the treatment effect of single drug, and is superior to positive control drug oxaliplatin (OXA). The pH / H2O2 dual-response hydrogel is rapidly gelled, and has good biological safety under mild reaction conditions.

The invention belongs to the technical field of hydrogel dressings, and particularly relates to a high-viscosity antibacterial hydrogel dressing as well as a preparation method and application thereof. The high-viscosity antibacterial hydrogel dressing is prepared from the following raw materials in parts by weight: 4 to 15 parts of oxidized sodium hyaluronate, 2 to 10 parts of chondroitin sulfate, 2.5 to 5 parts of epsilon-polylysine hydrochloride, 1 to 5 parts of hydroxypropyl methyl cellulose and 2 to 4 parts of sodium alginate. The hydrogel dressing prepared by the invention has good effects of inhibiting bacteria, stopping bleeding and promoting wound healing.

The invention discloses a carbon dot, hydrogel containing the carbon dot as well as a preparation method and application of the hydrogel, and relates to the technical field of carbon materials. The carbon dot is prepared from the following raw materials: a hydroxyl-containing flavonoid compound and epsilon-polylysine; the carbon dots contain aniline bonds formed by hydroxyl groups of the hydroxyl-containing flavonoid compounds and amino groups of the epsilon-polylysine. The carbon dot shows higher tumor cell killing property and lower normal cell toxicity than the raw material hydroxyl-containing flavonoid compound at the cellular level, can obviously induce immunogenic death of cancer cells and does not induce up-regulation of extracellular matrix collagen, and also has a better effect of regulating a tumor immune microenvironment.

The invention belongs to the technical field of food fresh-keeping and antibacterial materials, and discloses a preparation method and application of a bamboo cellulose-based sprayable hydrogel fresh-keeping film. According to the system, bamboo cellulose is used as a structural support and cooperates with epsilon-polylysine and bamboo polyphenol, and a hydrogel coating with physical barrier, antibacterial and antioxidant functions is formed on the surfaces of fruits and vegetables through in-situ self-assembly and calcium ion crosslinking. The method comprises the following steps: compounding sodium alginate, carboxymethyl chitosan and a bamboo fiber nano dispersion liquid, and adding epsilon-polylysine and bamboo polyphenol to prepare a functional spray; a calcium chloride solution is sprayed after spraying, and a stable and transparent hydrogel film with high adhesive force is rapidly formed through ionic crosslinking. The technical process is simple and convenient, the film forming speed is high, the components are natural, and industrial spraying is easy. Verified by fruits and vegetables such as bananas and the like, the coating can effectively delay decay, and the application blank of the nano bamboo cellulose in a spray fresh-keeping carrier is filled.

The invention belongs to the technical field of biomedical materials, and discloses a viola philippica exosome-loaded composite hydrogel as well as a preparation method and application thereof, the composite hydrogel is prepared by mixing methacrylated polylysine (PLMA), oxidized dextran (ODex), viola philippica exosome (V-E), a photoinitiator and a physiologically compatible solvent and performing illumination crosslinking; the preparation method comprises the following steps: respectively preparing PLMA and ODex solutions, extracting and purifying V-E, adding a photo-crosslinking agent (LAP), mixing the components to obtain a precursor liquid, and carrying out in-situ curing molding through ultraviolet-visible light irradiation. The composite hydrogel provided by the invention solves the problems that the existing wound dressing is difficult to fit with irregular wounds, is antibacterial and easy to resist drugs, and lacks active anti-inflammatory and efficient healing promotion capabilities, and is suitable for repair treatment of infectious open wounds such as burns, trauma, diabetic foot ulcer and postoperative infected incisions.

This invention relates to the fields of bioengineering and fermentation engineering, and discloses a genetically engineered *Streptomyces albopictus* strain that produces high levels of ε-polylysine and its fermentation production process. This genetically engineered strain uses *Streptomyces albopictus* strains acclimated to ε-polylysine tolerance as a chassis, and its genome integrates... ppc and dapf Through expression box, heterogeneous asd Expression cassettes, containing secretory signal peptides lysp Fusion expression cassettes and D404A / K499A point mutations pls Expression cassette. The fermentation process employs a two-stage pH control strategy, maintaining a neutral environment during the cell growth phase and adjusting to an acidic environment during product synthesis. This invention improves ε-polylysine yield through a synergistic strategy of enhancing precursor supply, constructing efflux detoxification channels, and increasing synthase activity; combined with an acidic fermentation process, it effectively inhibits product degradation, yielding a high-molecular-weight and highly uniform target product suitable for industrial production.

The present application relates to the technical field of biological medicine, and discloses inhalable aptamer modified molybdenum disulfide nanoflower compound and application thereof.The compound comprises a molybdenum disulfide nanoflower core, a dendritic polylysine modification layer attached to the surface of the molybdenum disulfide nanoflower, doxorubicin loaded on the molybdenum disulfide nanoflower and / or the dendritic polylysine modification layer, and AS1411 aptamer combined on the outer surface of the dendritic polylysine modification layer by electrostatic assembly.The compound can be delivered to a lung lesion by atomization inhalation or aerosol inhalation, and undergoes responsive structural change under the action of hydrogen peroxide in a tumor microenvironment, generates active oxygen, and promotes the release of doxorubicin, so as to realize the synergistic antitumor effect of chemotherapy and chemical dynamic therapy.The compound has good colloidal stability, drug loading capacity, active targeting ability and lung local delivery potential, and can be used for preparing inhalation preparations or local administration preparations for treating lung cancer.

The invention relates to absorbent paper as well as a preparation method and application thereof. The method comprises the following steps: pulping plant fiber pulp, adding sodium bicarbonate for pretreatment, and washing to obtain pretreated paper pulp; adding a dispersing agent, a wet strength agent and a composite antibacterial component into the pretreated paper pulp, and uniformly mixing to obtain mixed paper pulp; the composite antibacterial component is prepared from chitosan, polylysine and a modified copper oxide dispersion liquid; feeding the mixed paper pulp into a rotary screen paper machine to produce upper-layer single-layer wrinkling base paper, then compounding the upper-layer single-layer wrinkling base paper with lower-layer single-layer semi-forming base paper on which the macromolecular water-absorbent resin particles are scattered, and then drying to obtain the water-absorbent paper. The antibacterial rate of the absorbent paper on various pathogenic bacteria is larger than or equal to 99.5%, the antibacterial rate is still larger than or equal to 97% after 20 times of water washing, and the absorbent paper is high in water absorption speed, stable in physical performance, safe, environmentally friendly, controllable in cost, capable of being widely applied to the fields of hygienic products, medical dressings, food packaging and the like, simple in preparation process and suitable for industrial production.

This invention discloses a method for preparing mesophase asphalt through quantum dot-targeted hydrogenation heterogeneous nucleation-guided microwave polycondensation, belonging to the fields of petroleum deep processing technology and carbonaceous mesophase materials. It aims to solve the technical bottlenecks of traditional processes, such as random nucleation, poor targeting of feedstock hydrogenation, low polycondensation efficiency, and insufficient product uniformity. This method uses heavy aromatic-rich oil as feedstock. First, a single-atom Fe quantum dot@MOF composite catalyst is prepared. The aromatic molecular structure of the feedstock is selectively optimized through quantum dot-targeted hydrogenation pretreatment, and functional elements are in-situ doped. Then, a "halo benzene core-PNIPAM shell-polylysine arm" intelligent responsive nucleating agent is prepared. Atomic-level dispersion is achieved using supercritical CO2, and the aromatic precursor molecular clusters undergo directional polycondensation in a phased array microwave reactor, inducing ordered molecular stacking. Finally, light components are removed and agglomerates are broken up after molecular distillation and ultrasonic depolymerization. This invention achieves controllable nucleation, efficient condensation, and stable product performance. The prepared mesophase pitch has an anisotropy content of >98%, a softening point of 260~290℃, an H / C atomic ratio of 0.4~0.6, a carbon residue of 82%~92%, and excellent spinnability, providing a new technical route for the large-scale preparation of high-performance mesophase pitch.

The invention provides a nano drug-loaded particle based on gamma-polyglutamic acid and epsilon-polylysine, a composite shell is arranged outside the nano drug-loaded particle, the composite shell is formed through a reaction of gamma-polyglutamic acid and epsilon-polylysine, and a single active component is loaded in the composite shell; the single active component is one of salicylic acid, gallic acid or tea polyphenol. The invention also provides a preparation method and application of the nano drug-loaded particle. According to the nanoparticles, a unified ionic crosslinking process is adopted, and three kinds of nanoparticles with gamma-polyglutamic acid and epsilon-polylysine as composite shells and different single active ingredients loaded on inner cores are prepared respectively. The nanoparticles provided by the invention are stable in structure and good in biocompatibility, and can be used for preparing medicines with anti-aging, antibacterial and anti-inflammatory effects respectively or in combination.

The invention belongs to the field of medicaments, and discloses a nano-medicinal preparation capable of treating diabetes and a preparation method of the nano-medicinal preparation. The preparation method comprises the following steps: carrying out hydrothermal reaction on fructose-1, 6-strontium diphosphate, vanadium pentoxide and ergothioneine to prepare strontium-vanadate organic framework nanoparticles; the strontium-vanadate organic framework nano-particles, dopamine and polylysine are blended, embedding of polydopamine is achieved under the alkaline condition, polylysine-polydopamine co-embedded organic framework nano-particles are formed, and the nano-drug preparation for treating diabetes is obtained. The nano medicinal preparation can release the vanadyl complex and the ergothioneine and improve the blood strontium concentration and the half-life period thereof, so that the blood sugar is controlled, the symptoms of diabetes mellitus are improved, and the symptoms of osteoporosis, arteriosclerosis and the like complicated by diabetes mellitus are improved.

The invention relates to a preparation method and application of nitric oxide gas release hydrogel for chronic wound repair of diabetes mellitus, and belongs to the technical field of biomedical materials. According to the invention, hyaluronic acid is modified by tris (hydroxymethyl) aminomethane with mechanical properties and structural stability, so that the stability of the hydrogel is improved, and the problem that traditional hydrogel is fragile and easy to collapse is solved; the epsilon-polylysine is introduced, so that the hydrogel has a sterilization effect, and infectious bacteria at chronic wounds can be efficiently sterilized; nitric oxide donor small molecules are introduced into hydrogel, and on-demand release in a pathological environment is realized by combining a high active oxygen response mechanism; through dynamic inclusion of the hollow meso-porous silicon-selenium hybrid nanostructure and cyclodextrin, the drug loading efficiency and release stability of the nanoparticles are further improved, and the nanoparticles are endowed with good responsiveness, controllability and synergistic function. The prepared nitric oxide gas release hydrogel can significantly accelerate healing of chronic wound surfaces of diabetes, the preparation process is mild, simple and convenient, and large-scale production is easy.

In specific embodiments, provided is a material for preventing adhesion of membranes in an ophthalmic surgery for treatment of glaucoma or the like without using mitomycin-C or the like. Particularly provided is such material, which is easy to handle and has no risk of histolysis or infections. In a production method of a preferred embodiment, prepared are: aldehyde-modified dextran (first reactant) having weight-average molecular weight of 10,000-5,000,000 and introduced aldehyde group-per-anhydrous glucose unit (mol / AGU) of 0.4-0.7; and succinic anhydride-added poly-L-lysine (second reactant) having weight-average molecular weight of 1000-100,000 and having residual amino group ratio of 80-99%; then, they are mixed together so that aldehyde group-to-amino group molar ratio becomes 0.9-1.1 and are reacted in presence of water so that polymer concentration becomes 8-20%; and a hydrogel produced by the reaction, or a suspension before gelation, is freeze-dried to produce a porous sheet having a thickness of 0.1-0.8 mm.

This invention discloses a method for preparing a polycitric acid-based adhesive composite coating. The method includes the following steps: Step 1: After melting citric acid, polyethylene glycol and 1,8-octanediol are added, acrylic acid is added dropwise and stirred, and the mixture is dissolved, purified by dialysis, and then freeze-dried under vacuum to obtain a double-bonded polycitric acid ester prepolymer; Step 2: Polylysine is mixed with the double-bonded polycitric acid ester prepolymer to obtain a polycitric acid ester composite solution; Step 3: The polycitric acid ester composite solution is dropwise added to the surface of a substrate and thermosetting to obtain a polycitric acid-based adhesive composite coating. This invention also discloses the applications of the polycitric acid-based adhesive composite coating. This invention, by adding acrylic acid to the polycitric acid prepolymer system to generate a double-bonded polycitric acid ester prepolymer, and by adding polylysine to form a polycitric acid ester composite solution, forms a polycitric acid-based adhesive composite coating with strong adhesion after thermosetting, which is applicable to the field of biodegradable biomedical materials technology.

The invention relates to treatment agents for keratin fibers, in particular for hair, for enhancing the fiber structure, containing, in a cosmetically acceptable carrier, the combination of succinic acid and citric acid in selected amounts and weight ratios to each other in combination with at least one active ingredient selected from epsilon-polylysine. The invention also relates to a method for enhancing the fiber structure of keratin fibers using said treatment agents, and to the use of agents containing the combination of succinic acid and citric acid in selected amounts and weight ratios to each other, in combination with at least one active ingredient selected from epsilon-polylysine, for enhancing the fiber structure of keratin fibers.

The application discloses a kind of nanoparticles for tumor sonodynamic combined individualized immunotherapy and its preparation method and application, belong to the field of biological medicine.The nanoparticles for tumor sonodynamic combined individualized immunotherapy are double-shell core structure nanoparticles formed by inner core and shell, and the inner core is formed by self-assembly of TLR3 agonist Poly (I:C), L-arginine and polylysine, and the shell is hyaluronic acid layer HA-Ce6 conjugated with photosensitizer Ce6.It is found through experiment verification that the nanoparticles can target tumor, generate reactive oxygen species to kill tumor cells under the action of ultrasound, promote M1 macrophage polarization and produce NO release at the same time, play the role of antitumor and immune effect, and realize the combined application of sonodynamic and NO gas therapy.The nanoparticles for tumor sonodynamic combined individualized immunotherapy can trigger systemic immune response, inhibit primary tumor, produce immune memory effect, and prevent tumor metastasis and recurrence.

The invention discloses an antibacterial and antioxidant sodium alginate film as well as a preparation method and application thereof, and belongs to the technical field of antibacterial materials. Epsilon-polylysine and tannic acid are synergistically compatible and are loaded on the surface of a sodium alginate matrix by adopting an atomization spraying technology, so that an antibacterial and antioxidant sodium alginate film is formed. The membrane successfully integrates the broad-spectrum antibacterial property of EPL and the strong antioxidant activity of TA, solves the problem of single function in the prior art, and realizes the synergistic interaction of antibacterial property and antioxidant property; secondly, due to the stable combination and slow release characteristics between TA and sodium alginate molecules, the membrane shows remarkable and lasting functionality, for example, the clearance rate of the obtained SA / EPL / TA membrane to DPPH free radicals can still be kept at 90% or above 7 days later, and the DPPH free radicals can be kept at 90% or above. The defect of short efficacy caused by volatilization or rapid migration of a traditional film added with a small-molecule antioxidant (such as plant essential oil) is effectively overcome.