49results about How to "Good monodispersity" patented technology

The invention relates to a montmorillonite-probiotic microsphere preparation as well as a preparation method and application thereof, the microsphere preparation comprises montmorillonite, a probiotic biofilm and functional small molecules, and microspheres of the microsphere preparation are prepared by crosslinking sodium alginate in a collection solution based on a microfluidic technology. The microsphere preparation is mainly used for oral delivery of montmorillonite-probiotic biofilms and functional small molecules, so as to treat intestinal diseases. Compared with the prior art, the microsphere preparation provided by the invention has the advantages of gastric acid invasion resistance, intestinal responsive release and the like, and can effectively treat intestinal inflammation. In addition, the probiotic biofilm wrapped by the microspheres can enhance the interaction with the intestinal mucosa and prolong the residence time in the intestinal tract. Meanwhile, the used functional small molecules have excellent anti-inflammatory and intestinal barrier repairing effects, and can cooperate with the probiotics to regulate and control intestinal flora, so that the intestinal health is further improved.

The invention discloses a preparation method of size-controllable monodisperse indium antimonide colloidal quantum dots, which comprises the following steps: (1) preparing a precursor solution containing an indium precursor and an antimony precursor, and heating the precursor solution at 50-300 DEG C for 1-20 minutes; (2) in an inert atmosphere, raising the temperature of a solvent to a reaction temperature, injecting a reducing agent, then injecting the heated precursor solution, maintaining the reaction temperature for 10s-30min, and then stopping the reaction to obtain monodisperse indium antimonide colloidal quantum dots; the reaction temperature is 250 to 300 DEG C; in the reaction system in the step (2), the concentration of the indium precursor and the concentration of the antimony precursor are independently 0.4-8 mmol / L; the size of the monodisperse indium antimonide colloidal quantum dot is regulated and controlled by regulating and controlling the concentration of a precursor in a reaction system, the injection mode of a precursor solution and the growth time. According to the preparation method disclosed by the invention, accurate regulation and control on the size of the indium antimonide colloidal quantum dot can be realized without the help of a complex size selective precipitation technology.

The invention discloses a pH and temperature dual-responsive Pickering emulsion resistant to high temperature and an acid-base environment, which is characterized in that N-vinylcaprolactam (VCL) and sodium alginate (SA) are used as raw materials, flexible P (VCL-co-SA) microgel solid particles with pH and temperature dual-responsiveness are synthesized through a precipitation polymerization method, and the flexible P (VCL-co-SA) microgel solid particles are used for stabilizing the pH and temperature dual-responsive Pickering emulsion with water as a continuous phase and the pH and temperature dual-responsive Pickering emulsion. The O / W type Pickering emulsion is an O / W type Pickering emulsion with a water phase and dodecane and the like as a dispersed phase, and the stability of the emulsion is enhanced by adding Ca < 2 + > into the water phase. The Pickering emulsion disclosed by the invention has pH and temperature responsiveness and excellent stability, and can be stable not only at normal temperature but also at high temperature in strong acid (pH = 3) and strong alkali (pH = 9) environments. The preparation method of the emulsion is simple, the reaction condition is mild, the dosage of raw materials for preparing the microgel is small, the cost is low, and the prepared microgel and emulsion have good biocompatibility and have wide application prospects in the fields of food, medicine, cosmetics, petrochemical engineering and the like.

The invention discloses a method for preparing single-solid-core solid-water oil droplets based on droplet splitting, which comprises the following steps: preparing a T-shaped through microchannel and Y-shaped microchannel composite micro-fluidic chip, inserting stainless steel capillary tubes into an inlet and an outlet of the composite micro-fluidic chip, and sealing by using AB glue; preparing a dispersed phase and a continuous phase; the method comprises the following steps: constructing a composite microfluidic platform, controlling the flow rates of a dispersed phase and a continuous phase by using an injection pump, continuously generating double-solid-core water-solid oil drops at a T-shaped microchannel, and splitting the double-solid-core water-solid oil drops into two single-solid-core water-solid oil drops at a Y-shaped microchannel. High-flux preparation of the single-solid-core water-fixing oil droplets is realized by adopting a composite channel of a T-shaped micro-channel and a Y-shaped micro-channel, the T-shaped micro-channel is used for preparing the double-solid-core water-fixing oil droplets, the Y-shaped micro-channel is used for splitting the double-solid-core water-fixing oil droplets, and two single-solid-core water-fixing oil droplets with uniform sizes are obtained after splitting.

The invention discloses an AIE fluorescence immunochromatography test strip for detecting a toxoplasma gondii antibody as well as a preparation method and application of the AIE fluorescence immunochromatography test strip, and belongs to the technical field of production of veterinary biological diagnosis products. The test strip provided by the invention comprises a bottom plate, a sample pad, a combination pad, a nitrocellulose membrane and a water absorption pad, wherein the sample pad, the combination pad, the nitrocellulose membrane and the water absorption pad are bonded on the bottom plate in an end-to-end connection manner; the combination pad is coated with AIE microsphere labeled protein; the nitrocellulose membrane contains a detection line T and a quality control line C; the test strip prepared by adopting a double-antigen sandwich antibody detection method can be used for detecting serum antibodies in animal bodies such as pigs, cats and the like. Compared with a colloidal gold test strip on the market, the colloidal gold test strip has the advantages that the sensitivity is improved by 32 times, the batch-to-batch difference is less than 5%, the test performed by adopting 40 parts of pig serum and 30 parts of cat serum shows that the specificity, the stability and the accuracy are excellent, the operation is simple, the cost is low, and an accurate result can be obtained only in 10 minutes; and a rapid and effective detection method is provided for epidemiological investigation and disease diagnosis.

The invention discloses a bionic vascularized iPSC (induced pluripotent stem cell)-hepatocyte sphere for liver regeneration and a preparation method of the bionic vascularized iPSC-hepatocyte sphere. The bionic vascularized iPSC-hepatocyte sphere is a microcapsule which takes porous methacrylated hyaluronic acid as a shell and takes a human induced pluripotent stem cell derived hepatocyte sphere as an inner phase, human umbilical vein endothelial cells are adhered to the surface of the shell. According to the bionic vascularized iPSC-hepatocyte sphere, effective communication between hiPSC-heps and HUVECs is promoted, barrier protection is provided for the packaged hiPSC-hep sphere, attack of an immune system is avoided, and compared with dispersed cells, communication between cells is improved through interaction between the cells in the cell sphere, so that the service life of the hiPSC-heps and the HUVECs is prolonged, and the service life of the hiPSC-heps and the HUVECs is prolonged. The simulation of a physiological heterogeneity structure and a cell microenvironment of the liver is facilitated, and the acute failure liver can be more effectively repaired.

The invention provides a preparation method of SSZ-39 molecular sieve nanosheets, and belongs to the technical field of zeolite molecular sieve preparation. The preparation method comprises the following steps: uniformly mixing and stirring a silicon source, an aluminum source, a USY molecular sieve, a template agent, sodium hydroxide and water, stirring and aging to obtain gel, adding SSZ-39 molecular sieve seed crystal, drying, grinding and crushing to obtain dry gel, crystallizing, and removing the template agent. The SSZ-39 molecular sieve nanosheet synthesized by the method disclosed by the invention has the characteristics of good monodispersity and ultra-thinness, the thickness of the crystal can be reduced to 30 nm, and the mass transfer length can be effectively shortened. The key point of the invention is to control the low water content in the reaction gel, and to add the SSZ-39 molecular sieve as a seed crystal for induction. The SSZ-39 molecular sieve nanosheet synthesized by the method has relatively high specific surface area and micropore volume, and can be used in the fields of gas adsorption, catalytic reaction and the like.

The invention relates to the technical field of biological medicines, in particular to a preparation method of protein cross-linked nano affinity microspheres, which comprises the following steps: preparing carboxylated silicon dioxide nano microspheres with the particle size of 500nm by adopting a sol-gel method, mixing tetraethoxysilane and ammonia water according to the volume ratio of 1: (3 + / -1), reacting in an ethanol solution at 40 DEG C for 6 hours, filtering, washing, and drying to obtain the protein cross-linked nano affinity microspheres. And centrifuging to obtain a microsphere precipitate, washing with deionized water for three times to finally obtain a nano microsphere suspension of which the surface is rich in carboxyl, and controlling the solid content to be 10 + / -0.5 mg / mL. The capturing efficiency of the finally prepared protein cross-linked nano affinity microspheres for exosomes reaches 95.0%, the binding capacity reaches 28.5 mu g / mg, the purity of the extracted exosomes is higher than that of an ultracentrifugation method, the biological activity and structural integrity of animal cell exosomes and plant cell exosomes are completely kept, and the protein cross-linked nano affinity microspheres are suitable for large-scale industrial production. The problems that in a traditional exosome extraction method, the recovery rate is low, impurity pollution is serious, exosome activity is damaged, and the application range is limited are solved.

The application provides a quantum dot microsphere fluorescent immunochromatography test paper for combined detection of ASFV antibodies and nucleic acids and an application thereof, and belongs to the technical field of veterinary biological diagnosis products. The quantum dot microsphere fluorescent immunochromatography test paper for combined detection of ASFV antibodies and nucleic acids comprises a base plate, on the base plate, a sample pad, a combination pad, a nitrocellulose membrane and a water absorption pad are sequentially connected in a head-to-tail mode, from the combination pad to the water absorption pad, the nitrocellulose membrane is sequentially provided with an antibody detection line, a nucleic acid detection line and a quality control line, the antibody detection line is coated with a goat anti-pig IgG-Fc antibody, the nucleic acid detection line is coated with streptavidin, and the quality control line is coated with a rabbit anti-sheep IgG antibody; the combination pad is coated with a quantum dot microsphere labeled recombinant protein P22 and a quantum dot microsphere labeled sheep anti-digoxin antibody. The test paper can rapidly, highly specifically and highly sensitively detect ASFV antibodies and nucleic acids.

The invention provides a rare earth complex fluorescent microsphere and a preparation method and application thereof. The preparation method comprises: (1) preparing a rare earth complex from thenoyltrifluoroacetone, europium ions, other lanthanide metal ions, sodium hydroxide, phenanthroline and an ethanol solution; (2) dissolving the obtained rare earth complex and polystyrene microspheres in dichloromethane to further prepare the rare earth complex fluorescent microspheres. The rare earth complex fluorescent microspheres synthesized by the preparation method can encapsulate tens of thousands of rare earth complex fluorescent molecules in the microspheres, and can achieve a fluorescence signal amplification effect without dissociation enhancement. The obtained microspheres have a controllable particle size range, good uniformity, monodispersity, stability and repeatability, and have important application value.

This invention discloses a method for controllable preparation of nanoparticles using a multi-channel microreactor. The method utilizes a microchannel reactor to segment droplets and prepare quantitatively synthesized nanoparticles with controllable particle size. The invention employs capillary action to draw the reaction solution into the microchannel, segmenting one or more droplets (each droplet into 10-100 portions). By changing the width of the microchannel, controllable preparation of nanoparticles within a small range (±3 nm) can be achieved; by changing the length of the microchannel, controllable preparation of nanoparticles within a large range (±10-30 nm) can be achieved. Furthermore, the reactor structure of this invention is simple, enabling highly precise and quantitative synthesis of various nanoparticles. Compared to large-scale reactors, the miniaturization of the synthesis reaction in this invention effectively reduces energy waste and safety hazards, making it highly valuable for applications in safe chemical engineering, green chemical engineering, high-efficiency chemical engineering, microchemical engineering, and precise reaction monitoring.

The invention discloses a high-strength impact-resistant glass product and a preparation method of the high-strength impact-resistant glass product in the field of glass, and the high-strength impact-resistant glass product comprises the following raw materials in parts by weight: 50-60 parts of SiO2; 10 to 15 parts of Al2O3; 5 to 8 parts of Li2O; 1 to 3 parts of Na2O; 0.5 to 1.5 parts of K2O; 2 to 5 parts of P2O5; 2 to 4 parts of ZrO2; 1 to 3 parts of TiO2; 1 to 2 parts of B2O3; 0.5 to 2 parts of rare earth oxide; 4 to 12 parts of modified SiC particles; and 1 to 3 parts of modified MoAlB particles. The modified SiC particles and the modified MoAlB particles are adopted as a double-phase reinforcing system, the thermal matching performance with a glass matrix is enhanced, and the strength and toughness of the final glass product are greatly improved under the assistance of the structural densification effect of the rare earth oxide.

According to the microreactor device and system and the application of the microreactor device and system in preparation of the liquid crystal colloidal particles, by designing the special structures of the microreactor device and system, liquid crystal topological defects can be used as a programmable nano template for directional assembly and synthesis of the polymer colloidal particles; a liquid crystal center defect point formed in a limited closed system is utilized to assemble a high polymer material into the microspheres with controllable particle size. According to the invention, the characteristics of a single assembly can be researched, or the single assembly can be used as a functional material, such as application in the fields of intelligent photoelectric display, optoelectronic devices, sensing and the like.

The invention relates to the technical field of colloidal quantum dot manufacturing, in particular to a method for preparing HgTe quantum dots based on ODT-assisted synthesis, which comprises the following steps: adding oleylamine into a single-mouth bottle, sequentially adding HgCl2 and ODT into the bottle, adding a TOP-Te solution, finally injecting tetrachloroethylene, trimercaptopropionic acid and isopropanol into the solution, centrifuging to obtain a precipitate, dispersing the precipitate in n-octane, and drying to obtain the HgTe quantum dots. The HgTe quantum dot solution is obtained. According to the method, ODT-assisted synthesis is adopted, and the HgTe CQDs are excellent in monodispersity and exciton absorption characteristic; the HgTe quantum dot film prepared from the synthesized HgTe quantum dots is flat and uniform, and has low roughness.

The invention discloses a multi-channel micro-fluidic chip and a preparation method of monodisperse chitosan microspheres in the multi-channel micro-fluidic chip, and belongs to the technical field of chitosan microsphere preparation, the multi-channel micro-fluidic chip comprises an upper layer substrate, a middle layer substrate and a lower layer substrate, and further comprises a continuous phase channel assembly, a disperse phase channel assembly and a microsphere collection assembly, the upper-layer substrate, the middle-layer substrate and the lower-layer substrate are fixedly connected in sequence from top to bottom, the upper-layer substrate is connected with a continuous phase channel assembly, the middle-layer substrate is connected with a dispersed phase channel assembly, the lower-layer substrate is connected with a microsphere collecting assembly, and the continuous phase channel assembly, the dispersed phase channel assembly and the microsphere collecting assembly are connected with one another. Through the mode, the monodisperse chitosan microspheres with uniform size and controllable morphology can be prepared.

The present invention belongs to the field of fluorescent microsphere coding technology, and specifically relates to a method for preparing functionalized fluorescent protein multicolor coded microspheres. Fluorescent protein is used instead of organic fluorescent dyes and nanomaterials, and the fluorescent protein is assembled on the surface of the microsphere by chemical coupling. The protein type, concentration and microsphere particle size are used as coding elements to obtain single-color and multicolor fluorescent microspheres with ultra-large coding capacity; the surface of the fluorescent microsphere is modified by biotin to fix streptavidin to the surface of the microsphere, and combined with biotin-labeled capture probes to achieve high-throughput rapid analysis of multiple target molecules. The preparation process of the present invention is simple, the coding capacity is large, the performance is stable, and it has strong versatility and is environmentally friendly. The microspheres of the present invention can be applied to disease diagnosis, food safety, environmental protection, proteomics, genomics and drug screening.

The invention belongs to the field of preparation of inorganic flame-retardant materials, and particularly relates to a preparation method and application of nitrogen-phosphorus-silicon co-doped flame-retardant fluorescent carbon quantum dots. The nitrogen-silicon co-doped carbon quantum dots are prepared by adding a carbon source compound, a nitrogen source compound and a silanization reagent in the hydrothermal synthesis process, meanwhile, the surfaces of the carbon quantum dots contain rich amino groups, one hydrogen atom in the amino groups is substituted by a phosphorus source compound spiro phosphate diacyl chloride, and the nitrogen-silicon co-doped carbon quantum dots are obtained. According to the nitrogen-phosphorus-silicon co-doped carbon quantum dot, nitrogen, phosphorus and silicon elements can improve the fluorescence yield and the flame retardant property of the carbon quantum dot. Moreover, the nitrogen-phosphorus-silicon co-doped flame-retardant fluorescent carbon quantum dot prepared by the method has a spiral ring structure on the surface, is sprayed on the surface of a fabric in a post-finishing form, is subjected to ring-opening crosslinking under the action of a photoinitiator and UV light, and can be effectively combined with a fiber base material, so that the problem of falling in the subsequent washing and using processes is solved.

The utility model relates to titanium dioxide preparation device technical field especially relates to a device and preparation nanometer titanium dioxide of preparation titanogel. Include: reaction container, stirring mechanism, vortex disperser, set up in reaction container bottom, including turbine, perforated screen and umbrella -like diffusion head, for dispersing into liquid alkali and even injection titanyl sulfate solution in fine flow, interface, with vortex disperser connects, for conveying liquid alkali, through the vortex disperser of reaction container bottom realizes the even injection of liquid alkali, avoids local concentration too high, improves mixing efficiency, reduces particle agglomeration, ensures that titanogel particle size distribution is even, and further ensures that nanometer titanium dioxide particle size distribution is even, the core innovation of the utility model lies in the traditional top drop -wise mixing mode is innovated as bottom vortex injection mode, and the mixing dynamics characteristics of reaction liquid are fundamentally changed.

The present invention relates to a microsphere, a radioactive microsphere, a preparation method and an application. The microsphere is a polyimide dioxime-based microsphere, and the polyimide dioxime-based microsphere has a specific coordination and chelation effect on radioactive metal nuclides. The present invention also provides a method for preparing microspheres, comprising the following steps: grafting a functional monomer onto a base microsphere to obtain a microsphere containing a polyacrylonitrile group; subjecting the microsphere containing a polyacrylonitrile group to an ammoximation reaction and a deprotonation cyclization reaction to obtain a polyimide dioxime-based microsphere. The present invention also provides a radioactive microsphere, comprising the polyimide dioxime-based microsphere described in the present invention and a radioactive nuclide coordinated and chelated with the polyimide dioxime-based microsphere. The present invention also provides an application of a radioactive microsphere in a drug for tumor diagnosis and treatment. The present invention provides a new tumor drug, which provides a new option for the treatment of tumors.

The invention discloses an InSb quantum dot and a preparation method thereof, and the preparation method comprises the following steps: dispersing indium nanocrystals and antimony nanocrystals in an organic solvent, uniformly mixing, heating to 60-300 DEG C in the presence of a ligand, and reacting for 0.1-120 minutes to obtain the InSb quantum dot. The invention also provides an application of the InSb quantum dot in preparation of a colloidal quantum dot infrared detector, a solar cell or a luminescent device. The indium antimonide quantum dot is prepared by taking the antimony nanocrystal and the indium nanocrystal as precursors, the preparation method of the antimony nanocrystal and the indium nanocrystal is simple, the required initial raw materials are cheap and easy to obtain, and the preparation cost of the indium antimonide quantum dot is reduced.

This invention discloses a magnetic nano-adsorbent material, which is a magnetic composite nanosphere modified with silane on its surface. The magnetic nano-adsorbent material has a core-shell structure, and the silane modification includes hydrophilic and lipophilic groups. The hydrophilic and lipophilic groups modified with silane exhibit excellent synergistic effects in improving the adsorption rate of drugs, especially tetrahydrocannabinol (THC-COOH), NKET, and 6-AM, demonstrating a significant improvement in adsorption efficiency. This allows for efficient and selective enrichment and purification of multiple illicit drugs in water. Furthermore, the magnetic nano-adsorbent material of this invention possesses strong magnetism, allowing for rapid separation of the adsorbent material using a magnet, achieving rapid solid-liquid separation, and enabling material recycling and regeneration. This invention employs a sol-gel method to prepare the magnetic nano-adsorbent material, which has simple synthesis conditions, a short one-pot synthesis time, and results in magnetic nano-adsorbent materials with good monodispersity and uniform particle size.

The invention relates to a poly-L-lactic acid microsphere used for a drug delivery system and having a controllable degradation rate and a preparation method and application thereof.The preparation method comprises the steps that an oil-phase organic solution is added into an emulsifier aqueous solution through an SPG film to be stirred for a reaction, and a poly-L-lactic acid microsphere crude product is obtained; sequentially mixing and reacting the L-polylactic acid microsphere crude product with a sodium hydroxide solution and a polylysine solution, washing and freeze-drying to obtain L-polylactic acid microspheres; a solute in the oil-phase organic solution comprises poly-L-lactic acid and a lactic acid-glycolic acid-polyvinyl alcohol block copolymer. The poly-L-lactic acid microsphere material obtained through a specific preparation process has good stability and biocompatibility, is controllable in degradation rate, and is suitable for preparing a drug delivery system, so that the drug curative effect is improved, and the drug administration frequency is reduced.

The invention discloses porous polycaprolactone microspheres for tissue filling and a preparation method of the porous polycaprolactone microspheres, and relates to the field of biomedical materials. The microsphere is composed of polycaprolactone, the diameter of the microsphere is 40-70 [mu] m, the dispersion coefficient of the microsphere is less than 5%, the porosity of the microsphere is 55-85%, and the surface of the microsphere is provided with a uniform open pore structure formed by tridecane. According to the preparation method, a microfluidic technology is adopted, a tridecane-containing polycaprolactone dichloromethane solution is taken as a dispersion phase, a polyvinyl alcohol aqueous solution is taken as a continuous phase, an oil-in-water emulsion is formed through microchannel shearing, and curing, washing and freeze-drying are performed to obtain the tridecane-containing polycaprolactone / polyvinyl alcohol composite material. The microspheres disclosed by the invention have excellent monodispersity and a porous structure, and can remarkably promote fibroblast proliferation and collagen secretion and induce moderate inflammatory response to activate tissue regeneration. The process is simple and controllable, and the obtained microspheres have injectability and a tissue repair promoting function and have application prospects in the field of soft tissue repair.

The invention relates to the field of coatings, and particularly discloses an environment-friendly anti-radiation coating for buildings and a preparation method thereof.Renewable vegetable fat is used as an epoxy resin modifier and compounded with acrylic acid to generate bio-based acrylic resin, and the bio-based acrylic resin is combined with an organosilicon polymer; spherical hollow nano titanium dioxide prepared by taking a nano carbon sphere template as a template is subjected to surface carboxylation modification and then is combined with graphene oxide to cooperate with multiple anti-radiation components, so that the defects that an anti-radiation coating is easy to decompose and migrate and is non-uniform in dispersion are effectively overcome, and the anti-radiation performance of the coating can be remarkably improved; meanwhile, the heat resistance and the strength are excellent, the service life is not prone to being shortened even if the cable is exposed in the natural environment, and the preparation method is simple and suitable for large-scale application and popularization.

The invention discloses an up-conversion fluorescent microsphere and a preparation method thereof, and relates to the field of up-conversion fluorescent microspheres. The method comprises the following steps: preparing a first surfactant aqueous solution, and taking the first surfactant aqueous solution as a continuous phase; the preparation method comprises the following steps: mixing up-conversion nanoparticles, a high-molecular polymer and an organic solution to obtain an up-conversion nanoparticle-high-molecular polymer organic solution, and taking the up-conversion nanoparticle-high-molecular polymer organic solution as a dispersion phase; preparing a second surfactant aqueous solution, and taking the second surfactant aqueous solution as a collection phase; the method comprises the following steps: introducing a continuous phase and a dispersed phase into a micro-fluidic chip, cutting the dispersed phase into tiny dispersed liquid drops under the action of interfacial tension and flow shear force to obtain up-conversion fluorescent microspheres, and collecting the obtained up-conversion fluorescent microspheres by using a collection phase positioned at an outlet of the micro-fluidic chip. According to the method, the fluorescence intensity of the up-conversion fluorescent microspheres can be controlled, and the obtained up-conversion fluorescent microspheres are uniform in fluorescence intensity distribution and stable in fluorescence performance.

The invention provides nano-micron particles of a metal-carbon skeleton structure and a preparation method of the nano-micron particles, and belongs to the field of nano material preparation, and the nano-micron particles of the metal-carbon skeleton structure are prepared from preparation raw materials through solvothermal reaction; the preparation raw materials comprise, by mass, 3%-15% of a polymerizable monomer, 0.05%-1.5% of an initiator, 0.01%-1.5% of a metal salt and the balance a solvent; active functional groups of the polymerizable monomer comprise nitrogen and / or oxygen; the metal salt comprises at least one of aluminum salt, zirconium salt, chromium salt and zinc salt. According to the preparation method, metal ions and an organic precursor containing active groups are taken as raw materials, and controllable adjustment of the particle size of nano-micron particles within the range of 1-5000 nanometers is realized through metal crosslinking, induced nucleation and in-situ carbonization processes. The preparation process is simple and controllable, and the obtained nano-micron particles are uniform in size, stable in structure and high in temperature resistance and salt resistance and can be widely applied to the fields of catalysis, sensing or oil displacement and the like.

The invention belongs to the technical field of high polymer materials, and discloses monodisperse submicron polyurethane microspheres as well as a preparation method and application thereof. According to the method, a mixed solvent of an organic solvent and water is used as a good solvent, polyurethane prepared from raw materials including polyisocyanate and dihydric alcohol or polyhydric alcohol containing carboxylic acid, sulfonic acid and the like is dissolved in the good solvent, then water is used as a poor solvent, the flow speed of the water is controlled, the water is added into the polyurethane, and through the interaction of the polyurethane and the good solvent / poor solvent, the polyurethane is prepared. The preparation method comprises the following steps: carrying out nano precipitation at room temperature and under stirring conditions in a short time to obtain a product, namely, submicron monodisperse polyurethane spheres, and then carrying out multiple times of centrifugal separation, washing and drying on the product to obtain the monodisperse submicron polyurethane microspheres. Moreover, the polyurethane photonic crystal with bright structural color can be assembled by methods such as centrifugation and vertical deposition.

The invention discloses silver particles with holes in the surface and a preparation method and application of the silver particles. Holes exist in the surfaces of the silver particles, and the maximum diameter or the diagonal distance of the holes is smaller than 500 nm. The surfaces of the silver particles are modified with nanometer hole structures, and the sintering activity of the silver particles is improved by means of the high diffusion rate after nearby defective atoms are heated. According to the preparation method, surface holes are formed in the synthesis process of silver particles by using a template method, and the monodispersity of the silver particles in the growth process is improved by taking nano-silver as a seed crystal and combining the use of a protective agent.

The application discloses monodisperse smooth spherical silver powder, a preparation method and application thereof, wherein the silver powder has a particle size distribution parameter D100 of less than or equal to 4.0 microns, a sphericity ratio range of 0.85 to 1.15, and a specific surface area range of 0.60 to 0.75 m 2 / g. In view of the trend of narrow line width of the metalized printing of the crystalline silicon solar cell, the silver powder as the conductive phase of the silver paste needs to have a smaller D100 value and higher monodispersity. The application realizes high sphericity of the silver particles by constructing high supersaturation, inhibits agglomeration by combining two types of surface adsorbents with adsorption effect, and then adjusts the D100 value and optimizes the smoothness of the surface by Ostwald ripening process, so as to obtain the silver powder with excellent monodispersity, small D100 value, high sphericity and smooth surface, which effectively meets the high-precision requirement of the narrow line width printing of the photovoltaic cell, and is suitable for the field of high-performance conductive paste preparation.

The invention discloses a rare earth up-conversion red-green-blue fluorescence coding microsphere, which adopts a modified olefin-norbornene copolymer as a matrix material and adopts red, blue or green rare earth up-conversion luminescence nanocrystals as a fluorescence coding material. The invention also discloses a preparation method of the rare earth up-conversion red-green-blue fluorescence coding microspheres, which comprises the following steps: modifying an olefin-norbornene copolymer, and blending the modified olefin-norbornene copolymer with up-conversion luminescence nanocrystals to obtain a uniform blend; the core layer is inserted into a cladding material to prepare a prefabricated rod, and then the prefabricated rod is subjected to hot drawing to prepare fibers; and then, the fibers are subjected to heat treatment to obtain the polymer fluorescent microspheres with the coding function. According to the method disclosed by the invention, the fluorescence type and intensity of the fluorescence coding microspheres and the particle size of the microspheres can be controlled as required, the preparation process is simple, the method is suitable for large-scale production, the fluorescence performance is stable, and the method can be used for detecting cells, proteins or other molecules in biological samples.