30results about How to "Good monodispersity" patented technology

The invention discloses a method for preparing single-solid-core solid-water oil droplets based on droplet splitting, which comprises the following steps: preparing a T-shaped through microchannel and Y-shaped microchannel composite micro-fluidic chip, inserting stainless steel capillary tubes into an inlet and an outlet of the composite micro-fluidic chip, and sealing by using AB glue; preparing a dispersed phase and a continuous phase; the method comprises the following steps: constructing a composite microfluidic platform, controlling the flow rates of a dispersed phase and a continuous phase by using an injection pump, continuously generating double-solid-core water-solid oil drops at a T-shaped microchannel, and splitting the double-solid-core water-solid oil drops into two single-solid-core water-solid oil drops at a Y-shaped microchannel. High-flux preparation of the single-solid-core water-fixing oil droplets is realized by adopting a composite channel of a T-shaped micro-channel and a Y-shaped micro-channel, the T-shaped micro-channel is used for preparing the double-solid-core water-fixing oil droplets, the Y-shaped micro-channel is used for splitting the double-solid-core water-fixing oil droplets, and two single-solid-core water-fixing oil droplets with uniform sizes are obtained after splitting.

The invention relates to the technical field of biological medicines, in particular to a preparation method of protein cross-linked nano affinity microspheres, which comprises the following steps: preparing carboxylated silicon dioxide nano microspheres with the particle size of 500nm by adopting a sol-gel method, mixing tetraethoxysilane and ammonia water according to the volume ratio of 1: (3 + / -1), reacting in an ethanol solution at 40 DEG C for 6 hours, filtering, washing, and drying to obtain the protein cross-linked nano affinity microspheres. And centrifuging to obtain a microsphere precipitate, washing with deionized water for three times to finally obtain a nano microsphere suspension of which the surface is rich in carboxyl, and controlling the solid content to be 10 + / -0.5 mg / mL. The capturing efficiency of the finally prepared protein cross-linked nano affinity microspheres for exosomes reaches 95.0%, the binding capacity reaches 28.5 mu g / mg, the purity of the extracted exosomes is higher than that of an ultracentrifugation method, the biological activity and structural integrity of animal cell exosomes and plant cell exosomes are completely kept, and the protein cross-linked nano affinity microspheres are suitable for large-scale industrial production. The problems that in a traditional exosome extraction method, the recovery rate is low, impurity pollution is serious, exosome activity is damaged, and the application range is limited are solved.

The application provides a quantum dot microsphere fluorescent immunochromatography test paper for combined detection of ASFV antibodies and nucleic acids and an application thereof, and belongs to the technical field of veterinary biological diagnosis products. The quantum dot microsphere fluorescent immunochromatography test paper for combined detection of ASFV antibodies and nucleic acids comprises a base plate, on the base plate, a sample pad, a combination pad, a nitrocellulose membrane and a water absorption pad are sequentially connected in a head-to-tail mode, from the combination pad to the water absorption pad, the nitrocellulose membrane is sequentially provided with an antibody detection line, a nucleic acid detection line and a quality control line, the antibody detection line is coated with a goat anti-pig IgG-Fc antibody, the nucleic acid detection line is coated with streptavidin, and the quality control line is coated with a rabbit anti-sheep IgG antibody; the combination pad is coated with a quantum dot microsphere labeled recombinant protein P22 and a quantum dot microsphere labeled sheep anti-digoxin antibody. The test paper can rapidly, highly specifically and highly sensitively detect ASFV antibodies and nucleic acids.

This invention discloses a method for controllable preparation of nanoparticles using a multi-channel microreactor. The method utilizes a microchannel reactor to segment droplets and prepare quantitatively synthesized nanoparticles with controllable particle size. The invention employs capillary action to draw the reaction solution into the microchannel, segmenting one or more droplets (each droplet into 10-100 portions). By changing the width of the microchannel, controllable preparation of nanoparticles within a small range (±3 nm) can be achieved; by changing the length of the microchannel, controllable preparation of nanoparticles within a large range (±10-30 nm) can be achieved. Furthermore, the reactor structure of this invention is simple, enabling highly precise and quantitative synthesis of various nanoparticles. Compared to large-scale reactors, the miniaturization of the synthesis reaction in this invention effectively reduces energy waste and safety hazards, making it highly valuable for applications in safe chemical engineering, green chemical engineering, high-efficiency chemical engineering, microchemical engineering, and precise reaction monitoring.

The invention discloses a high-strength impact-resistant glass product and a preparation method of the high-strength impact-resistant glass product in the field of glass, and the high-strength impact-resistant glass product comprises the following raw materials in parts by weight: 50-60 parts of SiO2; 10 to 15 parts of Al2O3; 5 to 8 parts of Li2O; 1 to 3 parts of Na2O; 0.5 to 1.5 parts of K2O; 2 to 5 parts of P2O5; 2 to 4 parts of ZrO2; 1 to 3 parts of TiO2; 1 to 2 parts of B2O3; 0.5 to 2 parts of rare earth oxide; 4 to 12 parts of modified SiC particles; and 1 to 3 parts of modified MoAlB particles. The modified SiC particles and the modified MoAlB particles are adopted as a double-phase reinforcing system, the thermal matching performance with a glass matrix is enhanced, and the strength and toughness of the final glass product are greatly improved under the assistance of the structural densification effect of the rare earth oxide.

The invention relates to the technical field of colloidal quantum dot manufacturing, in particular to a method for preparing HgTe quantum dots based on ODT-assisted synthesis, which comprises the following steps: adding oleylamine into a single-mouth bottle, sequentially adding HgCl2 and ODT into the bottle, adding a TOP-Te solution, finally injecting tetrachloroethylene, trimercaptopropionic acid and isopropanol into the solution, centrifuging to obtain a precipitate, dispersing the precipitate in n-octane, and drying to obtain the HgTe quantum dots. The HgTe quantum dot solution is obtained. According to the method, ODT-assisted synthesis is adopted, and the HgTe CQDs are excellent in monodispersity and exciton absorption characteristic; the HgTe quantum dot film prepared from the synthesized HgTe quantum dots is flat and uniform, and has low roughness.

The invention discloses a multi-channel micro-fluidic chip and a preparation method of monodisperse chitosan microspheres in the multi-channel micro-fluidic chip, and belongs to the technical field of chitosan microsphere preparation, the multi-channel micro-fluidic chip comprises an upper layer substrate, a middle layer substrate and a lower layer substrate, and further comprises a continuous phase channel assembly, a disperse phase channel assembly and a microsphere collection assembly, the upper-layer substrate, the middle-layer substrate and the lower-layer substrate are fixedly connected in sequence from top to bottom, the upper-layer substrate is connected with a continuous phase channel assembly, the middle-layer substrate is connected with a dispersed phase channel assembly, the lower-layer substrate is connected with a microsphere collecting assembly, and the continuous phase channel assembly, the dispersed phase channel assembly and the microsphere collecting assembly are connected with one another. Through the mode, the monodisperse chitosan microspheres with uniform size and controllable morphology can be prepared.

The invention belongs to the field of preparation of inorganic flame-retardant materials, and particularly relates to a preparation method and application of nitrogen-phosphorus-silicon co-doped flame-retardant fluorescent carbon quantum dots. The nitrogen-silicon co-doped carbon quantum dots are prepared by adding a carbon source compound, a nitrogen source compound and a silanization reagent in the hydrothermal synthesis process, meanwhile, the surfaces of the carbon quantum dots contain rich amino groups, one hydrogen atom in the amino groups is substituted by a phosphorus source compound spiro phosphate diacyl chloride, and the nitrogen-silicon co-doped carbon quantum dots are obtained. According to the nitrogen-phosphorus-silicon co-doped carbon quantum dot, nitrogen, phosphorus and silicon elements can improve the fluorescence yield and the flame retardant property of the carbon quantum dot. Moreover, the nitrogen-phosphorus-silicon co-doped flame-retardant fluorescent carbon quantum dot prepared by the method has a spiral ring structure on the surface, is sprayed on the surface of a fabric in a post-finishing form, is subjected to ring-opening crosslinking under the action of a photoinitiator and UV light, and can be effectively combined with a fiber base material, so that the problem of falling in the subsequent washing and using processes is solved.

The utility model relates to titanium dioxide preparation device technical field especially relates to a device and preparation nanometer titanium dioxide of preparation titanogel. Include: reaction container, stirring mechanism, vortex disperser, set up in reaction container bottom, including turbine, perforated screen and umbrella -like diffusion head, for dispersing into liquid alkali and even injection titanyl sulfate solution in fine flow, interface, with vortex disperser connects, for conveying liquid alkali, through the vortex disperser of reaction container bottom realizes the even injection of liquid alkali, avoids local concentration too high, improves mixing efficiency, reduces particle agglomeration, ensures that titanogel particle size distribution is even, and further ensures that nanometer titanium dioxide particle size distribution is even, the core innovation of the utility model lies in the traditional top drop -wise mixing mode is innovated as bottom vortex injection mode, and the mixing dynamics characteristics of reaction liquid are fundamentally changed.

The present invention relates to a microsphere, a radioactive microsphere, a preparation method and an application. The microsphere is a polyimide dioxime-based microsphere, and the polyimide dioxime-based microsphere has a specific coordination and chelation effect on radioactive metal nuclides. The present invention also provides a method for preparing microspheres, comprising the following steps: grafting a functional monomer onto a base microsphere to obtain a microsphere containing a polyacrylonitrile group; subjecting the microsphere containing a polyacrylonitrile group to an ammoximation reaction and a deprotonation cyclization reaction to obtain a polyimide dioxime-based microsphere. The present invention also provides a radioactive microsphere, comprising the polyimide dioxime-based microsphere described in the present invention and a radioactive nuclide coordinated and chelated with the polyimide dioxime-based microsphere. The present invention also provides an application of a radioactive microsphere in a drug for tumor diagnosis and treatment. The present invention provides a new tumor drug, which provides a new option for the treatment of tumors.

The invention discloses an InSb quantum dot and a preparation method thereof, and the preparation method comprises the following steps: dispersing indium nanocrystals and antimony nanocrystals in an organic solvent, uniformly mixing, heating to 60-300 DEG C in the presence of a ligand, and reacting for 0.1-120 minutes to obtain the InSb quantum dot. The invention also provides an application of the InSb quantum dot in preparation of a colloidal quantum dot infrared detector, a solar cell or a luminescent device. The indium antimonide quantum dot is prepared by taking the antimony nanocrystal and the indium nanocrystal as precursors, the preparation method of the antimony nanocrystal and the indium nanocrystal is simple, the required initial raw materials are cheap and easy to obtain, and the preparation cost of the indium antimonide quantum dot is reduced.

This invention discloses a magnetic nano-adsorbent material, which is a magnetic composite nanosphere modified with silane on its surface. The magnetic nano-adsorbent material has a core-shell structure, and the silane modification includes hydrophilic and lipophilic groups. The hydrophilic and lipophilic groups modified with silane exhibit excellent synergistic effects in improving the adsorption rate of drugs, especially tetrahydrocannabinol (THC-COOH), NKET, and 6-AM, demonstrating a significant improvement in adsorption efficiency. This allows for efficient and selective enrichment and purification of multiple illicit drugs in water. Furthermore, the magnetic nano-adsorbent material of this invention possesses strong magnetism, allowing for rapid separation of the adsorbent material using a magnet, achieving rapid solid-liquid separation, and enabling material recycling and regeneration. This invention employs a sol-gel method to prepare the magnetic nano-adsorbent material, which has simple synthesis conditions, a short one-pot synthesis time, and results in magnetic nano-adsorbent materials with good monodispersity and uniform particle size.

The invention relates to a poly-L-lactic acid microsphere used for a drug delivery system and having a controllable degradation rate and a preparation method and application thereof.The preparation method comprises the steps that an oil-phase organic solution is added into an emulsifier aqueous solution through an SPG film to be stirred for a reaction, and a poly-L-lactic acid microsphere crude product is obtained; sequentially mixing and reacting the L-polylactic acid microsphere crude product with a sodium hydroxide solution and a polylysine solution, washing and freeze-drying to obtain L-polylactic acid microspheres; a solute in the oil-phase organic solution comprises poly-L-lactic acid and a lactic acid-glycolic acid-polyvinyl alcohol block copolymer. The poly-L-lactic acid microsphere material obtained through a specific preparation process has good stability and biocompatibility, is controllable in degradation rate, and is suitable for preparing a drug delivery system, so that the drug curative effect is improved, and the drug administration frequency is reduced.

The invention discloses porous polycaprolactone microspheres for tissue filling and a preparation method of the porous polycaprolactone microspheres, and relates to the field of biomedical materials. The microsphere is composed of polycaprolactone, the diameter of the microsphere is 40-70 [mu] m, the dispersion coefficient of the microsphere is less than 5%, the porosity of the microsphere is 55-85%, and the surface of the microsphere is provided with a uniform open pore structure formed by tridecane. According to the preparation method, a microfluidic technology is adopted, a tridecane-containing polycaprolactone dichloromethane solution is taken as a dispersion phase, a polyvinyl alcohol aqueous solution is taken as a continuous phase, an oil-in-water emulsion is formed through microchannel shearing, and curing, washing and freeze-drying are performed to obtain the tridecane-containing polycaprolactone / polyvinyl alcohol composite material. The microspheres disclosed by the invention have excellent monodispersity and a porous structure, and can remarkably promote fibroblast proliferation and collagen secretion and induce moderate inflammatory response to activate tissue regeneration. The process is simple and controllable, and the obtained microspheres have injectability and a tissue repair promoting function and have application prospects in the field of soft tissue repair.

The invention relates to the field of coatings, and particularly discloses an environment-friendly anti-radiation coating for buildings and a preparation method thereof.Renewable vegetable fat is used as an epoxy resin modifier and compounded with acrylic acid to generate bio-based acrylic resin, and the bio-based acrylic resin is combined with an organosilicon polymer; spherical hollow nano titanium dioxide prepared by taking a nano carbon sphere template as a template is subjected to surface carboxylation modification and then is combined with graphene oxide to cooperate with multiple anti-radiation components, so that the defects that an anti-radiation coating is easy to decompose and migrate and is non-uniform in dispersion are effectively overcome, and the anti-radiation performance of the coating can be remarkably improved; meanwhile, the heat resistance and the strength are excellent, the service life is not prone to being shortened even if the cable is exposed in the natural environment, and the preparation method is simple and suitable for large-scale application and popularization.

The invention discloses an up-conversion fluorescent microsphere and a preparation method thereof, and relates to the field of up-conversion fluorescent microspheres. The method comprises the following steps: preparing a first surfactant aqueous solution, and taking the first surfactant aqueous solution as a continuous phase; the preparation method comprises the following steps: mixing up-conversion nanoparticles, a high-molecular polymer and an organic solution to obtain an up-conversion nanoparticle-high-molecular polymer organic solution, and taking the up-conversion nanoparticle-high-molecular polymer organic solution as a dispersion phase; preparing a second surfactant aqueous solution, and taking the second surfactant aqueous solution as a collection phase; the method comprises the following steps: introducing a continuous phase and a dispersed phase into a micro-fluidic chip, cutting the dispersed phase into tiny dispersed liquid drops under the action of interfacial tension and flow shear force to obtain up-conversion fluorescent microspheres, and collecting the obtained up-conversion fluorescent microspheres by using a collection phase positioned at an outlet of the micro-fluidic chip. According to the method, the fluorescence intensity of the up-conversion fluorescent microspheres can be controlled, and the obtained up-conversion fluorescent microspheres are uniform in fluorescence intensity distribution and stable in fluorescence performance.

The invention provides nano-micron particles of a metal-carbon skeleton structure and a preparation method of the nano-micron particles, and belongs to the field of nano material preparation, and the nano-micron particles of the metal-carbon skeleton structure are prepared from preparation raw materials through solvothermal reaction; the preparation raw materials comprise, by mass, 3%-15% of a polymerizable monomer, 0.05%-1.5% of an initiator, 0.01%-1.5% of a metal salt and the balance a solvent; active functional groups of the polymerizable monomer comprise nitrogen and / or oxygen; the metal salt comprises at least one of aluminum salt, zirconium salt, chromium salt and zinc salt. According to the preparation method, metal ions and an organic precursor containing active groups are taken as raw materials, and controllable adjustment of the particle size of nano-micron particles within the range of 1-5000 nanometers is realized through metal crosslinking, induced nucleation and in-situ carbonization processes. The preparation process is simple and controllable, and the obtained nano-micron particles are uniform in size, stable in structure and high in temperature resistance and salt resistance and can be widely applied to the fields of catalysis, sensing or oil displacement and the like.

The invention discloses silver particles with holes in the surface and a preparation method and application of the silver particles. Holes exist in the surfaces of the silver particles, and the maximum diameter or the diagonal distance of the holes is smaller than 500 nm. The surfaces of the silver particles are modified with nanometer hole structures, and the sintering activity of the silver particles is improved by means of the high diffusion rate after nearby defective atoms are heated. According to the preparation method, surface holes are formed in the synthesis process of silver particles by using a template method, and the monodispersity of the silver particles in the growth process is improved by taking nano-silver as a seed crystal and combining the use of a protective agent.

The application discloses monodisperse smooth spherical silver powder, a preparation method and application thereof, wherein the silver powder has a particle size distribution parameter D100 of less than or equal to 4.0 microns, a sphericity ratio range of 0.85 to 1.15, and a specific surface area range of 0.60 to 0.75 m 2 / g. In view of the trend of narrow line width of the metalized printing of the crystalline silicon solar cell, the silver powder as the conductive phase of the silver paste needs to have a smaller D100 value and higher monodispersity. The application realizes high sphericity of the silver particles by constructing high supersaturation, inhibits agglomeration by combining two types of surface adsorbents with adsorption effect, and then adjusts the D100 value and optimizes the smoothness of the surface by Ostwald ripening process, so as to obtain the silver powder with excellent monodispersity, small D100 value, high sphericity and smooth surface, which effectively meets the high-precision requirement of the narrow line width printing of the photovoltaic cell, and is suitable for the field of high-performance conductive paste preparation.

The application relates to the field of oil and gas field fracturing technology, and particularly discloses an ultra-low-density micro-nano proppant for unconventional reservoir fracturing and a preparation method thereof. The proppant is prepared from a mixture containing 30-60 wt% of a vinyl monomer, 10-25 wt% of an acrylic ester monomer and 25-50 wt% of an unsaturated resin, emulsified into micro-nano scale droplets through a compounded emulsifier system, and then solidified. The preparation method comprises the following steps: mixing the resin composition with the emulsifier to form a uniform oil phase, dispersing the oil phase into an aqueous phase under high-speed shearing to form a micro-nano emulsion; and then realizing complete solidification of the droplets under mild conditions through an oxidation-reduction solidification system. The proppant has ultra-low density and micro-nano scale particle size, can effectively enter and support a super-remote complex micro-nano scale fracture network in an unconventional reservoir, and greatly improves the oil and gas recovery rate. The proppant has a complete structure under a 60MPa closed pressure, and can significantly improve the fracture conductivity.

This invention discloses a modified organic black dye and its preparation method, relating to the field of dye modification technology. The preparation method includes the following steps: (1) chemically modifying the organic black dye with a linker to obtain a modified black dye; (2) preparing polymer microspheres using a soap-free emulsion polymerization method; (3) chemically bonding the modified black dye obtained in step (1) with the polymer microspheres obtained in step (2) to obtain a spherical modified organic black dye. The preparation method of this invention combines the organic black dye with polymer microspheres through chemical bonds to form a spherical dye, improving the dye morphology and enhancing its flowability and dispersion uniformity. Furthermore, the polymer microspheres prepared using the soap-free emulsion polymerization technology of this invention have controllable particle size and good monodispersity, resulting in uniform particle size of the final dye particles, making them suitable for applications with strict particle size requirements.

The present invention discloses a Janus Pd-AuPd melon seed-shaped nanomaterial and a one-step preparation method and application thereof. + An auxiliary agent, a reducing agent and a coating agent are dispersed in water and stirred to obtain a mixed solution; under a protective atmosphere with an initial pressure of 1.0-1.2 MPa, the mixed solution is placed at 170-190°C for reaction for 8-12 hours, and the product is cooled, centrifuged and washed to obtain a Janus Pd-AuPd melon seed-shaped nanomaterial. The two components of the Janus structure of the present invention are AuPd alloy and Pd single metal, respectively. The present invention realizes the one-step synthesis of Janus Pd-AuPd melon seed-shaped nanomaterials, and the synthesis method has good stability and reproducibility. The nanomaterial prepared by the present invention exhibits good ORR catalytic performance and has application prospects in the field of fuel cells.

The invention relates to the technical field of nano material preparation, and discloses a high-dispersion zinc oxide preparation method based on high-speed shearing, which comprises the following steps: mixing 4.1829-32.7715 g of a zinc source precursor, 100 m l of an organic solvent and 0-1 m l of laboratory self-made ultrapure water, and carrying out high-speed shearing at 50-70 DEG C for 5-30 minutes; maintaining the temperature and shearing, quickly adding 10-50ml of alkali liquor, and reacting for 5-30 minutes; maintaining the temperature and shearing, quickly adding 2-20m l of laboratory self-made ultrapure water, and reacting for 5-30 minutes; and standing, centrifugally washing and drying the product. According to the preparation method disclosed by the invention, micro-mixing is enhanced through full-process high-strength shearing, explosive nucleation is induced, soft agglomeration among particles can be destroyed by continuous shearing force, and particle growth is inhibited, so that zinc oxide with small particle size and high dispersity is prepared.

The invention relates to a phase change capsule with a strengthened and toughened shell and a preparation method thereof, and the method comprises the following steps: adding sodium alginate into a polyvinyl alcohol solution, and fully dissolving to serve as an external phase fluid; heating the phase change material needing to be wrapped to be molten to serve as an internal phase fluid; respectively pumping the external phase fluid and the internal phase fluid into a flow focusing type micro-fluidic chip by using an injection pump, and generating a composite emulsion precursor at an outlet of a chip channel; taking a calcium chloride solution as a collecting solution, collecting a composite emulsion precursor, and curing the shell through chemical reaction to complete the preparation of the phase change capsule; the prepared phase change capsule is frozen and thawed by liquid nitrogen for three times. According to the invention, a microfluidic technology is adopted, polyvinyl alcohol is introduced into a calcium alginate shell, and polyvinyl alcohol and calcium alginate cross-linked crystals are formed by taking polyvinyl alcohol crystals as cross-linking points through repeated freezing and thawing, so that the compression strength and toughness of the phase change capsule can be greatly improved; and the leakage risk of the inner core phase change material in the using process is obviously reduced.

The invention discloses a polyacetimide magnetic nanoparticle with a core-shell structure, wherein the magnetic nanoparticle has Fe3O4 as a core, SiO2 as a shell, and the shell surface modification material is polyacetimide. The preparation method comprises: synthesizing oil-soluble magnetic nanoparticles by thermal decomposition; treating the synthesized oil-soluble magnetic nanoparticles with a surfactant to obtain magnetic nanoparticles dispersed in water; coating the surface of the obtained magnetic nanoparticles dispersed in water with a layer of SiO2 shell layer to obtain Fe3O4@SiO2 magnetic nanoparticles dispersed in water; adding an alcohol solution containing polyacetimide to the Fe3O4@SiO2 magnetic nanoparticles to obtain Fe3O4@SiO2@PEI magnetic nanoparticles. The oil-soluble magnetic nanoparticles obtained by thermal decomposition can be surface modified by the invention, and the surface of the magnetic nanoparticles after surface modification has a large number of amino groups and good dispersibility in water.

A particle size and doping regulation and control method of high-quality Ag2Se colloidal quantum dots (CQDs) relates to a quantum dot control technology, and comprises the following steps: injecting AgNO3 containing an Ag source and a TOP-Se precursor solution containing an Se source into a three-necked round-bottom flask filled with an oleylamine solution, and carrying out reaction, nucleation and growth in vacuum and inert gas atmosphere to finally form Ag2Se CQDs. And the particle size, the morphology and the absorption are changed by changing the precursor proportion and the reaction time. The method is low in cost, simple to operate and easy to implement.

The present invention relates to a composite microsphere for copper CMP with a mesoporous core-shell structure, a preparation method thereof, a chemical mechanical polishing liquid and an application thereof. The composite microsphere has mesoporous SiO2 as a core and CeO2 as a shell. During preparation, a template agent and a silicon source are first used to prepare mesoporous SiO2 microspheres by a template method as the core of the core-shell structure; then a cerium source and a precipitant are used to disperse and synthesize SiO2 / CeO2 composite microspheres for copper CMP with a mesoporous core-shell structure. The chemical mechanical polishing liquid comprises SiO2 / CeO2 composite microspheres for copper CMP with a mesoporous core-shell structure, a corrosion inhibitor, an oxidant and a complexing agent. The polishing liquid is applied to copper chemical mechanical polishing. Compared with the prior art, the composite microspheres prepared by the present invention have uniform surface coating, good monodispersity, simple preparation process, and can be used in the fields of copper sheet chemical mechanical polishing.

This invention provides a method for preparing high-sphericity gold powder, relating to the field of nanomaterial preparation technology. The method involves sequentially adding a multi-ligand stabilizer solution and an acidic solution to a chloroauric acid solution, adjusting the pH of the reaction system to 4.0-5.0 to obtain solution A. Then, a dispersant solution is rapidly added to solution A for a first-stage mixing, followed by the rapid addition of a reducing agent solution for a second-stage mixing. Subsequently, a morphology-optimizing agent solution is added dropwise to the reaction system, and after sufficient reaction, the precipitate is collected to obtain high-sphericity gold powder. This invention achieves precise control of gold powder morphology through the competitive adsorption between ligands by adding a multi-ligand stabilizer to the chloroauric acid solution. Furthermore, the addition of an acidic solution to the chloroauric acid solution further consolidates the morphology control of the gold powder. The acidic pH of the solution after adjustment further slows down the reduction rate, resulting in better dispersibility and more uniform size of the gold powder.

The invention discloses a 3D hepatotoxicity test monodisperse microgel preparation method, a 3D hepatotoxicity test monodisperse microgel preparation system and a medium, and belongs to the technical field of 3D cell culture and drug screening. The system comprises a preparation module, a statistical analysis module, a material processing module and a control system, the method comprises the following steps: collecting historical data to train an adaptive neural network, and establishing a mapping relation between control parameters and microgel quality indexes; a neural network is used as a prediction model, and optimal control input is solved through a model prediction controller; performing microgel preparation; acquiring images in real time to obtain and feed back actual particle sizes and variation coefficients; applying the new data to incremental updating of the neural network; and performing iteration to form a closed-loop optimization process. According to the method, multi-parameter self-adaptive optimization is realized through an artificial intelligence algorithm, the problem of manual exploration of parameters of different hydrogel materials is solved, the monodispersity and consistency of microgel are improved, and full-process automation is realized.

The application discloses a rare earth up-conversion red-green-blue fluorescent coding microsphere, adopts a modified olefin-norbornene copolymer as a matrix material, and adopts red, blue or green rare earth up-conversion luminescent nanocrystals as a fluorescent coding material. The application further discloses a preparation method of the rare earth up-conversion red-green-blue fluorescent coding microsphere. The modified olefin-norbornene copolymer is blended with the up-conversion luminescent nanocrystals to obtain a uniform blend, and the blend is hot-pressed into a rod-shaped core layer which is inserted into a cladding material to form a preform rod, and then the preform rod is hot-drawn into a fiber, and then heat treatment is carried out to obtain a polymer fluorescent microsphere with a coding function. The method can control the fluorescent type and intensity of the fluorescent coding microsphere and the particle size of the microsphere according to requirements, the preparation process is simple, the method is suitable for large-scale production, the fluorescent performance is stable, and the method can be used for detecting cells, proteins or other molecules in biological samples.