Patents
Literature
18results about How to "Avoid clearing" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
Microenvironment detection device for environmental toxicology research and use method of microenvironment detection device
ActiveCN119574548AImprove observation effectEfficient removalMaterial analysis by optical meansCleaning using liquidsEnvironmental toxicologyHazardous substance
The invention relates to the technical field of toxicology microenvironment detection, and discloses a microenvironment detection device for environmental toxicology research and a use method thereof.The microenvironment detection device comprises a detection table, the top of the detection table is fixedly connected with a microscope, the bottom of the detection table is fixedly connected with an electric telescopic rod, and the top of the detection table is slidably connected with a placement plate; when a microscope needs to be cleaned, an electric telescopic rod is started to stretch out, a liquid storage tank ascends, a lens of the microscope is soaked in cleaning liquid, meanwhile, a first connecting rod and a second connecting rod make contact with a rotating plate in the ascending process of an annular plate, the first connecting rod jacks up the rotating plate, the rotating plate extrudes the second connecting rod to descend, and a spring pushes a plate to descend; and the extrusion rod descends to extrude the cleaning liquid entering the communicating hole, and the cleaning liquid is sprayed out towards the periphery of the lens through the top of the communicating hole, so that harmful substances adhered to the surface of the lens are effectively removed, and the situation that the definition of the lens is reduced due to the harmful substances adhered to the surface of the lens is avoided.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY
Defrosting control method and system for air source heat pump unit
ActiveCN119468564AGuaranteed uptimeImprove stabilityHeat pumpsCorrosion preventionProcess engineeringHeat exchanger temperature
The invention discloses a defrosting control method and system for an air source heat pump unit, and relates to the technical field of air source heat pumps. The frosting rate, the frosting thickness and the heat exchange efficiency reduction rate are calculated respectively, the frosting degree index is further calculated, a preset threshold value is compared, and whether the air source heat pump unit needs to be defrosted or not is judged; total defrosting heat is calculated, defrosting time is calculated based on the total defrosting heat, and then the temperature change rate of the outdoor heat exchanger is calculated; a defrosting effect index is calculated based on the outdoor heat exchanger temperature change rate; a preset threshold value is compared and whether defrosting is completed or not is judged; according to the method, the defrosting process can be monitored in real time and accurately controlled, and it is ensured that defrosting operation is timely, appropriate and efficient.
Owner:JIANGSU SHINCO CENT AIR CONDITIONING
Tumor cell exosome, anti-tumor immune drug delivery system and preparation method and application of anti-tumor immune drug delivery system
PendingCN119639677Apromote infiltrationImprove targetingMammal material medical ingredientsPharmaceutical non-active ingredientsPharmaceutical SubstancesTumor cells
The invention provides a tumor cell exosome, an anti-tumor immune drug delivery system and a preparation method and application of the anti-tumor immune drug delivery system, the tumor cell exosome is derived from starved and stimulated tumor cells, the tumor cell exosome is coated with nano drug particles for delivery, and the exosome has the effects of enhancing immune cell infiltration and remodeling an immune microenvironment; due to the homing effect of the exosome, the medicine and the exosome are more easily accumulated in the tumor, and the targeting property is improved; due to coating and camouflage of the biological membrane of the exosome membrane, the exosome membrane is prevented from being recognized, attacked and removed by an organism, and the biological safety is improved, so that the exosome and the nano-drug act on the tumor together to achieve a synergistic effect.
Owner:SUN YAT SEN UNIVERSITY CANCER CENTER (CANCER HOSPITAL AFFILIATED TO SUN YAT SEN UNIVERSITY CANCER RESEARCH INSTITUTE OF SUN YAT SEN UNIVERSITY)
Monitoring and tracing mechanism for train skin excess material cleaning
PendingCN119456504AImprove cleanlinessEfficient scrapingDispersed particle filtrationTransportation and packagingStructural engineeringToughened glass
The invention belongs to the technical field of automation and intelligent monitoring, and discloses a monitoring and tracing mechanism for train skin excess material cleaning, which comprises a shell, a rectangular protective shell is fixedly mounted on the front surface of the shell, a monitoring and tracing device is fixedly mounted in the rectangular protective shell, and a cleaning mechanism is arranged in the shell; the cleaning mechanism comprises a power assembly and a cleaning assembly, the cleaning assembly comprises two sliding rails fixedly installed on the inner wall of the shell, and sliding blocks are slidably installed on the outer walls of the two sliding rails correspondingly. The sliding block slides to drive the C-shaped cleaning scraping strip to move, when the C-shaped cleaning scraping strip is tightly attached to tempered glass, dust and dirt attached to the surface of the tempered glass can be effectively scraped away, and therefore pollutants can be thoroughly removed, and compared with a traditional cleaning mode, the design achieves automation of cleaning work and improves the cleaning efficiency. And the cleaning task can be executed regularly, and it is ensured that the outer wall of the tempered glass always keeps high cleanliness.
Owner:HUBEI XIANGYANG POWER GENERATION CO LTD
Die
Owner:CHINA CONSTR SCI & IND CORP LTD
Steel billet slag scraping structure of continuous casting machine
The utility model discloses a steel billet slag scraping structure of a continuous casting machine, which belongs to the technical field of metallurgical equipment and comprises a terminal roller way, a steel pusher, a water spraying unit and a scraping unit. The steel pushing machine is arranged between rollers of a terminal roller way and pushes the steel billet limited by the collision plate to move in the axial direction of the rollers; the water spraying unit and the scraping unit are sequentially arranged on the line along which steel is driven by a steel pusher to move, the water spraying unit is provided with a spray head for spraying water to the front end face of a steel billet, and the scraping unit is provided with a steel brush for scraping the front end face of the steel billet. The device is compact in structure, rapid cooling and efficient slag scraping treatment of the end face of a steel billet can be achieved, the adhesive force and definition of spray marks are remarkably improved, and the problem of furnace number confusion caused by spray mark falling is solved. The device is high in automation degree and stable in operation, can be seamlessly integrated with an existing continuous casting production line, and has good practicability and popularization value.
Owner:TIANJIN TIANGANG UNITED SPECIAL STEEL CO LTD
Conical flow type anti-blocking electric regulating valve for heat pipe network
This utility model belongs to the field of valve technology, specifically disclosing a conical flow-guiding anti-clogging electric regulating valve for thermal pipeline networks. The utility model includes a valve body with a connecting seat on one side. Filter components are located on both sides of the valve body, and a flow regulating component is located on one side of the connecting seat. The filter components achieve staged filtration through two filter screens with different mesh sizes. The larger mesh screen first intercepts large impurities, preventing them from impacting and scratching subsequent components, while the smaller mesh screen filters out finer impurities, achieving comprehensive removal of impurities from the medium. Combined with the conical flow channel's characteristic of reducing impurity retention, this significantly reduces the risk of valve clogging. Furthermore, the filter screens can be installed and removed without tools, ensuring stable operation under medium impact, continuously guaranteeing the efficient and safe operation of the valve and thermal pipeline network, and extending equipment lifespan.
Owner:SHANDONG PUBLIC THERMAL POWER GROUP (QINGCHENG) THERMAL POWER CO LTD
Lotus root slicing device for lotus root processing
The embodiment of the present disclosure provides a lotus root slicing device for lotus root processing, which comprises a conveying roller for conveying lotus roots to a cutting area; a cutting cutter disc arranged above the conveying roller and forming a clamping channel with the conveying roller; a cleaning scraper located on one side of the cutting cutter disc, one side of the cleaning scraper being in close contact with the cutting cutter disc, a flow guide groove being arranged below the cleaning scraper and being communicated to a waste collecting device; wherein the cleaning scraper is provided with a first protruding part, the first protruding part being located at the leading edge of the cleaning scraper and extending towards the cutting cutter disc; the cleaning scraper is provided with a second recessed part, the second recessed part being arranged at the middle part of the cleaning scraper and forming a gap with the outer periphery of the cutting cutter disc; and the cleaning scraper is provided with a third fixing block. Through the scheme of the embodiment of the present disclosure, lotus root juice residues adhered to the surface of the cutter blade can be removed without stopping the machine.
Owner:HUBEI HONGRUN ECOLOGICAL AGRI DEV CO LTD
Central air conditioner condenser automatic pickling integrated machine
ActiveCN224650409Ugood user interfaceflexible call
The utility model discloses a central air conditioning condenser automatic pickling integrated machine, including small trolley, the pickling tank of being evenly arranged on small trolley, pickling agent tank, acid -resistant pump, control mechanism, and the whole pickling tank is "L" type, and acid -resistant pump and pickling tank horizontal section outside side -by -side arrangement, and pickling agent tank is arranged on the horizontal section of pickling tank, and control mechanism is located acid -resistant pump top, and pickling agent tank top surface is equipped with pickling agent injection port, and bottom front side is equipped with pickling agent outlet, and acid -resistant pump bottom front side is equipped with acid -resistant pump pumping outlet, and bottom rear side is equipped with acid -resistant pump water outlet, and pickling tank water outlet, acid -resistant pump pumping outlet, pickling agent outlet are connected through the three -way pipeline of being equipped with three -way valve, and acid -resistant pump water outlet, pickling tank backwater all are equipped with pH value concentration sensor, the utility model has the advantages of nimble and timely call, integrated space layout is reasonable, accurate pickling agent amount adds, operation step is simple and fast, and work safety is improved.
Owner:CHONGQING BLUEHORIZON ENERGY-SAVING TECH CO LTD
Nasal mucosa microneedle vaccine delivery system capable of inducing mucosal immunity as well as preparation method and application of nasal mucosa microneedle vaccine delivery system
PendingCN119499529AHigh mechanical strengthImprove dissolution efficiencySsRNA viruses negative-senseViral antigen ingredientsTGE VACCINERespiratory tract infections
The invention discloses a nasal mucosa microneedle vaccine delivery system capable of inducing mucosa immunity and a preparation method and application of the nasal mucosa microneedle vaccine delivery system. The administration mode of vaccines is nasal mucosa microneedle vaccine delivery. The soluble layered microneedle is characterized in that a needle body is inspired by a hunting claw, a leopard-claw-shaped needle tip is designed, and the needle tip is bent; the strategy is proved to be capable of inducing potent antigen-specific immune response in mucous membrane tissues. The technology can be widely applied to research and development of novel mucosal vaccines for preventing respiratory tract infection pathogens (such as influenza viruses and the like).
Owner:SHENZHEN CENTER FOR DISEASE CONTROL AND PREVENTION (SHENZHEN HEALTH INSPECTION CENTER SHENZHEN INSTITUTE OF PREVENTIVE MEDICINE) +1
Preparation method of size-adaptive bismuth-based nanoreactor with antibacterial effect as well as product and application of size-adaptive bismuth-based nanoreactor
PendingCN119424363AImprove permeabilityavoid clearingAntibacterial agentsInorganic active ingredientsDiseaseBismuth sulfide
The invention relates to a preparation method of a size-adaptive bismuth-based nanoreactor with an antibacterial effect as well as a product and application of the size-adaptive bismuth-based nanoreactor. The bismuth-based nano-reactor comprises bismuth sulfide cross-linked nano-particles, a nitric oxide donor loaded in the bismuth sulfide cross-linked nano-particles and a neutrophile granulocyte membrane wrapping the outer layers of the bismuth sulfide cross-linked nano-particles. The outer layer of the bismuth-based nano-reactor is coated with a neutrophile granulocyte membrane, and the bismuth-based nano-reactor has the capacity of targeting an inflammation infection part and also has pH responsiveness, so that ultra-small bismuth sulfide particles are in a dynamic allosteric state in a body and are prevented from being quickly cleared by kidneys during body fluid circulation, and meanwhile, dissociated particles are easier to permeate into a bacterial biofilm, so that the biological activity of the ultra-small bismuth sulfide particles is improved. And the effectiveness of the medicine on an infected part is improved. According to the bismuth-based nano reactor, the photothermal effect and the NO antibacterial effect are combined, the two effects cooperate with each other, the antibacterial effect is enhanced, and the bismuth-based nano reactor is suitable for treatment of refractory bacterial infection diseases.
Owner:THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
Vexin-probucol self-assembled nanoparticles as well as preparation method and application of vitexin-probucol self-assembled nanoparticles
PendingCN122075472AAchieve precise enrichmentEfficient and safe treatmentPowder deliverySulfur/selenium/tellurium active ingredientsEfficacyTherapeutic effect
The invention belongs to the technical field of biological medicines, and particularly relates to vitexin-probucol self-assembled nanoparticles as well as a preparation method and application thereof. The nanoparticle is formed by self-assembly of vitexin and probucol, and the mass ratio of vitexin to probucol is 2: (1-5). The nano particles are prepared by adopting a nano precipitation method, and the method specifically comprises the following steps: mixing vitexin and probucol, and dissolving and dispersing in a good solvent to obtain a mixed solution; and adding the obtained mixed solution into a poor solvent, and promoting the vitexin and probucol to be self-assembled to form the nanoparticles by utilizing a solvent replacement effect. The nanoparticles have the advantages of high drug loading capacity, synergistic anti-inflammation and anti-oxidation, long-acting circulation and the like, and can effectively treat atherosclerosis, reduce side effects and improve the treatment effect and safety.
Owner:CHONGQING UNIV
Bromine-doped carbon dots, nano-micelle assembly of bromine-doped carbon dots, preparation method of nano-micelle assembly and application of nano-micelle assembly
ActiveCN119410365Aavoid clearingquick clearAntibacterial agentsNervous disorderPhotodynamic therapyNear infrared absorption
The invention provides a bromine-doped carbon dot, a nano-micelle assembly of the bromine-doped carbon dot, a preparation method and application of the nano-micelle assembly, and belongs to the technical field of nanotechnology. According to the present invention, 1, 7-dibromo-3, 4, 9, 10-perylene tetracarboxylic anhydride and urea are adopted as raw materials to prepare the novel bromine-doped carbon dot, and the carbon dot has characteristics of near-infrared absorption and emission, and efficient I-type / II-type active oxygen generation ability; according to the invention, bromine-doped carbon dots are embedded into DSPE-PEG2000 micelles to prepare a nano-micelle assembly, so that the water solubility and biocompatibility of the nano-micelle assembly are improved, the circulation time of the nano-micelle assembly in blood is prolonged, and rapid kidney clearance is prevented. The carbon dot and nano-micelle assembly can effectively generate I-type / II-type active oxygen, overcomes environmental limitation, has very high photodynamic efficiency in antibacterial and anti-tumor application, realizes efficient photodynamic therapy by using a near-infrared emission bromine-doped carbon dot nano-material in a complex microenvironment for the first time, and has a good application prospect.
Owner:SICHUAN UNIV
Stem cell gel line, compound containing stem cell gel line, catgut embedding needle and application
The invention belongs to the technical field of biology, and particularly relates to a stem cell gel line, a compound containing the stem cell gel line, a catgut embedding needle and application. The stem cell gel line is prepared according to the following steps: preparing a suspension from mesenchymal stem cells, and adding a sodium alginate solution to obtain a stem cell-sodium alginate gel solution; sucking the stem cell-sodium alginate gel liquid, extruding the stem cell-sodium alginate gel liquid into a calcium chloride solution with a relative flow rate in a linear manner at a constant speed, and removing the calcium chloride solution to obtain a stem cell gel line; wherein in the stem cell-sodium alginate gel solution, the final concentration of stem cells is (3-6) * 10 < 6 > / mL, and the final concentration of sodium alginate is 1.5-3wt%. The stem cell gel line provided by the invention can remarkably prolong the activity preservation time of stem cells, can be stored in a line embedding needle, and is convenient to apply.
Owner:SHAANXI ZHONGHONG KERUI REGENERATIVE MEDICINE RES INST CO LTD
Wafer positioning equipment for gluing developing machine
ActiveCN119472175Aavoid replacementeasy to useFinal product manufactureSemiconductor/solid-state device manufacturingWaferMachine
The invention belongs to the technical field of gluing and developing auxiliary equipment, and discloses wafer positioning equipment for a gluing and developing machine, the wafer positioning equipment comprises a carrier plate and a positioning operation arm, a main clamping assembly is fixedly arranged in the carrier plate, and mounting plates are fixedly arranged at the two ends of the main clamping assembly. According to the invention, the two-side extruding and pushing assemblies extrude and push along the two sides of the back of the adjustable clamping part, control the deformation of the elastic metal sheet and the thermal stress sheet, and fit along the outer side surface of the wafer to adapt to the arc surface of the outer side of the wafer so as to realize sufficient tight fit and clamping, thereby adapting to clamping of wafers of different sizes, and improving the clamping efficiency. The bending radian is rapidly adjusted to adapt to the outer side arc surface of the wafer, the use range of experience positioning is greatly widened, replacement of a positioning clamping mold is avoided, meanwhile, the adjusting process can be adjusted in real time according to the wafer size, the bending temperature can be maintained after adjustment, continuous and rapid use after one-time adjustment is achieved for the wafers of the same size, the comprehensive use effect is good, and the production efficiency is high. Adaptive adjustment is simple and fast, and the use effect is good.
Owner:YUHONGYAN TECH (SUZHOU) CO LTD
Multifunctional smell diffusion prevention type conveying device for chili processing
InactiveCN119408927Aprevent proliferationImprove cleanlinessCleaningDrying gas arrangementsProcess engineeringMechanical engineering
The invention discloses a multifunctional smell diffusion prevention type conveying device for chili processing, and relates to the field of chili processing, the multifunctional smell diffusion prevention type conveying device comprises a sealing box, a conveying mechanism and a purifying mechanism are arranged in the sealing box, and a discharging groove and an overhauling groove are formed in the left side face of the sealing box at the same time; the bottom ends of the front side face and the rear side face of the discharging groove are rotationally connected with the opposite ends of two supporting shafts through bearings correspondingly. The conveying mechanism is arranged in the sealing box, and the purifying mechanism is arranged on the sealing box, so that when the conveying mechanism is used for conveying crushed chili sections, the sealing box can be used for sealing the conveyed chili sections to avoid diffusion of spicy smell of chili; air in the sealing box can be sucked out through the purification mechanism, and then spicy smell is filtered and adsorbed through the multiple purification rings in the purification cylinder, so that the situation that the production environment is influenced by diffusion of the spicy smell in a production workshop during chili processing, processing workers are uncomfortable, and the processing efficiency is influenced is avoided.
Owner:QINGDAO KAIZHONG FOOD CO LTD
Mesenchymal stem cell exosome composition for repairing wounds and method of preparing the same
The present application relates to the technical field of biological medicine, in particular to a mesenchymal stem cell exosome composition for repairing wound and a preparation method thereof.The preparation raw material of the exosome composition comprises the following components in parts by weight: mesenchymal stem cell exosome 0.15-0.2 parts, modified hyaluronic acid 3-5 parts, modified dandelion extract 5-8 parts, and carboxymethyl chitosan 2-3 parts.The exosome composition prepared by the present application can effectively promote wound repair.
Owner:SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
Exosome composition for reducing side effects of chemotherapy treatment and method of preparing the same
ActiveCN120501841BGrowth inhibitionprevent invasionOrganic active ingredientsTripeptide ingredientsPullulanEfficacy
The application provides an exosome composition for reducing side effects of chemotherapy treatment and a preparation method thereof, and belongs to the technical field of medicines. Methotrexate, vinblastine and daunorubicin are prepared into a co-crystal, loaded on UiO-66-NH2 connected with RGD, loaded on exosomes, and embedded in an acrylic acid, traditional Chinese medicine polysaccharide and pullulan compound to obtain a sustained-release high half-life exosome system, which is uniformly mixed with D-ribose, yeast-beta glucan and glutathione to obtain the exosome composition for reducing side effects of chemotherapy treatment. The traditional Chinese medicine polysaccharide is traditional Chinese medicine polysaccharide obtained by boiling water extraction and ethanol precipitation of radix codonopsis, angelica, polygonatum sibiricum and dendrobium officinale. The exosome composition for reducing side effects of chemotherapy treatment is prepared, drug resistance of tumor cells is reduced, drug efficacy is improved, side reactions after chemotherapy are reduced, the effect of targeted slow release of drugs is achieved, and the exosome composition has a wide application prospect.
Owner:GUANGZHOU AISODA BIOMEDICAL TECH CO LTD