57 results about "Phototoxicity" patented technology

The invention specifically discloses a beta-diketone iridium complex as well as a preparation method and application thereof, and relates to the technical field of biological medicines. The beta-diketone iridium complex provided by the invention has high phototoxicity and low dark toxicity, can be applied to tumor cells as effective PSs of PDT, and is specifically delivered to the tumor cells by taking a traditional Chinese medicine monomer tripterine as a supplement in combination with a nano-targeting delivery technology for photodynamic / immune synergistic treatment of hypoxic tumors.

The application discloses a kind of polypeptide modified long afterglow nano-complex and its preparation method and application, nano-complex, for core-shell structure, core-shell structure is composed of the core body in inside and the shell that surrounds core body, core body is long afterglow nanomaterial, shell is by polypeptide modification and modified molecule modification, and drug loaded dendritic polymer;The nano-complex of the application can realize multiscale imaging to osteoclast, through in vivo afterglow imaging and in vivo two-photon microscopic imaging, the morphology, migration and distribution of osteoclast can be more accurately analyzed, avoid photo toxicity and background interference, improve imaging sensitivity;The nano-complex of the application is loaded with osteoporosis treatment drug alendronate ALN, and treatment drug can be replaced according to actual demand, and treatment scheme is adjusted, so that the drug loading system has universality.

A system (10) and method (70) for quantifying light exposure of a patient's retina (25) during an ophthalmic procedure. A light source (32) illuminates the patient's retina (25) with directional light (LL) during the procedure to generate an illuminated retinal surface. A camera (36) collects image data (38) of the illuminated retinal surface (25I). An electronic control unit (ECU) (50) in communication with the camera (36) and a pointing device (40) receives the image data (38), calculates a cumulative energy spectral density of the directional light (LL) incident on the retina (25), and performs a control action indicative of possible phototoxicity, including activating the pointing device (40) in response to the cumulative energy spectral density exceeding a phototoxicity threshold. The illuminated retinal surface (25I) may be divided into virtual zones (Z1, Z2) by the ECU (50) mapping the cumulative energy spectral density to the illuminated retinal surface (25I). Each of the optional zones (Z1, Z2) has a corresponding cumulative energy spectral density.

The application discloses a compound morinda officinalis color-increasing liniment for treating vitiligo and a preparation method thereof, and particularly relates to the technical field of traditional Chinese medicine preparations, wherein the liniment is prepared from morinda officinalis, spilanthes acmella, giant knotweed, caesalpinia sappan, psoralea corylifolia, radix angelicae dahuricae and rhizoma smilacis glabrae as raw medicinal materials. The preparation method comprises the following steps: dynamic reflux extraction, percolation extraction, macroporous adsorption resin purification and preparation molding. Through the classification extraction and purification process, the photosensitive active ingredients are retained, and the photo-toxic impurities are effectively removed, so that the photo-toxicity is completely negative. The pharmacodynamic test shows that the liniment has a significant curative effect on vitiligo. The safety test shows that the liniment has no skin irritation and no allergenicity, and has excellent light safety. The quality research shows that the quality of the liniment is stable and controllable. The liniment has definite curative effect, high safety and stable quality, and has a good clinical application prospect.

The application belongs to the technical field of fluorescent probe, and particularly relates to a non-oxygen-dependent multi-mode selenium rhodamine-based photodynamic photosensitizer as well as preparation and application. In order to develop a non-oxygen-dependent and efficient photosensitizer, based on the selenium rhodamine spiro ring 'on-off' mechanism, a N-nitroso functionalized selenium rhodamine photosensitizer SeR-NO is developed, which exists in the form of lactone with closed ring in PBS, has very small cell dark toxicity and excellent cell permeability; under light, the photosensitizer can not only produce a large amount of ROS through type I and type II mechanism, but also can catalyze NADPH oxidation and Cyt c reduction in an oxygen-independent manner, therefore, SeR-NO has large phototoxicity, and can induce cell death through ferroptosis in normoxia (21% O2) and hypoxia (2% O2).

The application belongs to the technical field of molecular biology, and relates to a polypeptide with a light protection function and application of the polypeptide. An amino acid sequence of the polypeptide comprises a sequence shown in SEQ ID No. 1 or SEQ ID No. 2. The polypeptide disclosed by the application is derived from heat-soluble protein, has a significant light protection effect, can effectively prevent and repair skin damage caused by light, has strong stability, has no sensitization, has no phototoxicity, and has a good application prospect.

The application belongs to the technical field of fluorescent probe, and relates to a self-reporting photosensitizer as well as a preparation method and application thereof, and comprises the following steps: 1) under nitrogen protection, IrCl3*3H2O is added into a 2-ethoxyethanol-water solution and mixed; 2-(2,4-difluorophenyl)pyridine is further added, stirred and heated, and then the obtained mixture is subjected to condensation reflux, cooling and vacuum filtration to obtain precipitate; the precipitate is washed and dried to obtain a chloro-bridged dimer; 2) the chloro-bridged dimer is further added into DMSO, and the obtained mixture is subjected to ultrasonic treatment, freeze-drying and separation and purification to obtain the self-reporting photosensitizer. The self-reporting photosensitizer prepared by the application has simple synthesis steps and is easy to operate; the molar absorption coefficient is 6.84*10 4 M ‑1 cm ‑1 , the singlet oxygen yield is 0.45, and the cell phototoxicity index is 15.4; in the application of light-induced cancer cell apoptosis, the fluorescence intensity and fluorescence distribution are observed, and the cell apoptosis is monitored in real time in a double mode, and the living cells and dead cells are obviously distinguished.

The present application provides a kind of fluorine boron compound, the fluorine boron compound contains anthraquinone group, can generate strong oxidizing anion radical after photoexcitation efficiently, thus has lower half inhibitory concentration, stronger inhibitory effect, has stronger phototoxicity, can kill cancer cells in shorter time;Meanwhile, the superoxide anion radical generated can specifically oxidize FADH2 coenzyme in mitochondrial electron transport chain, by oxidizing its isoalloxazine ring structure to cause coenzyme inactivation, then mitochondrial electron transport process, and inhibit cancer cell energy metabolism, so as to effectively inhibit the proliferation activity of cancer cells.

The invention discloses a self-assembled fluorescent probe as well as a preparation method and application thereof. The preparation method comprises the following steps: adding 1-ethyl-2-methylbenzo [cd] indole-1-onium into a mixed solution of 10-[4-(dimethylamino) phenyl]-7-phenyl-3, 11-dithia-7-aza-tricyclo [6.3. 0.02, 6] undec-1 (8), 2 (6), 4, 9-tetraene-4-formaldehyde, acetic acid, acetic anhydride and triethylamine, and then mixing with methyl tert-butyl ether, so as to obtain the small molecule DMA-IN3, and carrying out ultrasonic self-assembly to obtain the nano-particle DINP. The self-assembled fluorescent probe DINP obtained by the invention has fluorescence property and phototoxicity, can be enriched to tumor tissues in a targeted manner, generates a large amount of heat under an illumination condition, realizes visual diagnosis and treatment of tumors, is good in biological safety, and provides a new scheme for clinical tumor treatment.

The invention relates to a preparation method and application of a novel RNA-targeted selenium-containing photosensitizer, and belongs to the technical field of medical chemistry and biological medicine. The invention designs and synthesizes a photosensitizer RNA-S for targeting RNA (Ribonucleic Acid), and the RNA-S is a novel multifunctional near-infrared photosensitizer constructed on the basis of a 2, 1, 3-benzoselenadiazole skeleton. The molecule shows high phototoxicity, low dark toxicity and good biocompatibility in tumor cells, and can effectively inhibit tumor cell growth and realize synchronous imaging. The invention provides a theoretical basis and a practical basis for developing a novel efficient selenium-containing photosensitizer, and has a very good clinical application prospect.

The invention discloses a polypeptide nanoring material and a preparation method thereof, and belongs to the technical field of high polymer materials. The preparation method comprises the following steps: co-assembling poly (gamma-benzyl ester-L-glutamic acid) (PBLG) and achiral triphenylamine derivatives {N, N-bis (2-methylphenyl) aniline (MTPA), 4-(5-aldehyde-2, 2 ': 5', 2 ''-terthienyl)-N, N-bis (2-methylphenyl) aniline (MTTH) or 4-[5-(2, 2-dicyanovinyl) thiophene-2-yl]-N, N-bis (2-methylphenyl) aniline (MTTV)} to obtain the poly (gamma-benzyl ester-L-glutamic acid)-N, N-bis (2-methylphenyl) aniline derivative. According to the present invention, the emission of multi-color circularly polarized light (CPL) (near ultraviolet to deep red light, 370-660 nm) is achieved, and the maximum luminescence asymmetry factor (glum) is up to 1.1 * 10 <-2 >, and is improved by more than 30% compared with the prior art. Meanwhile, the generation inhibition rate of reactive oxygen species (ROS) is increased to 98% or above through a compact nanostructure of the material, the problem of phototoxicity of traditional triphenylamine derivatives is solved, and the material is suitable for high-resolution biological imaging and targeted diagnosis and treatment.

The present invention belongs to the field of pharmaceutical chemistry technology, and specifically relates to a near-infrared light-releasing binuclear ruthenium complex, its preparation, and its application in combating drug resistance in non-small cell lung cancer. The binuclear ruthenium complex disclosed in the present invention has the structural formula shown below. The complex has a strong photochemotherapy effect on cisplatin-resistant human non-small cell lung cancer cell lines. Under light conditions, it has a strong growth and proliferation inhibition ability (IC 50 The phototoxicity of the metallo-photosensitive material was 0.22 μM, while in the dark, its cytotoxicity was only 75.6 μM, and the phototherapy index (PI) was as high as 343, which is of great significance for the study of metallo-medicines for anti-drug-resistant tumors. It is expected to be used to prepare anti-tumor photoactivated drugs or drugs for anti-proliferation of cisplatin-resistant strains of human non-small cell lung cancer, and even anti-tumor metal photosensitizers.

The application discloses a curcuminoid xanthene compound shown in formula I, a preparation method of the curcuminoid xanthene compound and application of the curcuminoid xanthene compound as a photodiagnosis and treatment agent. The compound has the characteristics of long absorption and emission wavelength, good stability, high phototoxicity, large Stokes shift, good biocompatibility and good cell membrane permeability. Compared with curcumin, the photosensitizer has a longer absorption wavelength, lower dark toxicity and can generate ROS under type-I and type-II synergistic action, and is expected to be applied to PDT in an anaerobic tumor microenvironment.

The invention belongs to the technical field of preparation of antitumor drugs, and particularly relates to an activatable BODIPY photosensitizer and a preparation method and biological application thereof, and a water-soluble photosensitive probe BDP-1 is obtained by modifying a BODIPY structure with a GSH response unit and piperazine salt. The BDP-1 can be activated by GSH (glutathione) overexpressed by tumor cells, and has good biocompatibility and tumor targeting property. By modifying different functional groups, the imaging effect is better, the water solubility is better, the phototoxicity is stronger, and an excellent PDT effect on a tumor-bearing Balb / c mouse model is shown. This is due to the specific enrichment of BDP-1 on tumor sites, and the concentration of the photosensitizer in tumor tissues is improved, so that the photodynamic therapy efficiency is improved.

The invention relates to the technical field of biomedical materials, in particular to a nano assembly for releasing NO through red light triggering and a preparation method and application of the nano assembly. The nano assembly is prepared from an amphiphilic block polymer with a polyethylene glycol hydrophilic end and a hydrophobic segment containing NO donor molecules and photocatalyst molecules through a hydrophilic and hydrophobic self-assembly forming method. Photocatalyst molecules in the amphiphilic block polymer are excited under irradiation of red light, decomposition of NO donor molecules can be triggered through an electron transfer process, and space-time controllable adjustment of NO release is achieved. The nano assembly has the red light response characteristic, excellent biological safety and antibacterial property, and has a wide application prospect in the aspects of antibiosis, anti-inflammation and the like. In addition, the red light has the characteristics of large tissue penetration depth and low phototoxicity, so that the problem that the penetration depth of the traditional ultraviolet light or blue light response NO donor molecular monomer is limited is effectively solved.

The invention provides a TB derivative with photodynamic antibacterial and anti-tumor activity and a synthesis method thereof, the derivative comprises a carbazole-TB-thiophene-pyridinium derivative, the structural formula of the derivative is shown in the specification, and the four derivatives have good viscosity response and aggregation-induced emission property and can efficiently and synchronously generate I-type and II-type active oxygen. The TB-CB-1, the TB-TPA-1 and the TB-TPA-2 have good photodynamic antibacterial activity on tested gram positive bacteria (G + bacteria), and the antibacterial rates of the TB-CB-1, the TB-TPA-1 and the TB-TPA-2 on the three kinds of G + bacteria are all larger than 90% when the concentration of the TB-CB-1, the TB-TPA-1 and the TB-TPA-2 is 2 mol. L <-1 >. The four compounds have strong photodynamic anti-tumor activity and large light and dark toxicity difference, the IC50 values of the TB-CB-1 to MCF-7, A549 and HepG2 cells are all greater than 100 [mu] g.mL <-1 > in the absence of illumination, and the IC50 values are respectively reduced to 1.53 [mu] g.mL <-1 > and 0.28 [mu] g.mL <-1 > under illumination; the IC50 of the TB-TPA-2 to A549 cells under a dark condition is greater than 200 [mu] g.mL <-1 >, and the illumination is reduced to 2.01 [mu] g.mL <-1 >. The invention provides a new thought for design and synthesis of a novel photodynamic antibacterial / antitumor photosensitizer.

This invention discloses a method for preparing tree tomato leaf extract, its products, and applications, belonging to the field of natural product extraction and application. The method involves taking tree tomato leaf powder, using a 60% ethanol aqueous solution as the extraction solvent, extracting at a material-to-liquid ratio of 1:30 g / mL and a temperature of 60°C for 45 min, repeating the extraction twice, combining the two filtrates, concentrating, and drying to obtain the tree tomato leaf extract. This extract is highly enriched with polyphenols, flavonoids, and other active ingredients, exhibiting multiple effects such as antioxidant, anti-inflammatory, tyrosinase inhibition, and promotion of hyaluronic acid synthesis. It has also been confirmed that it has no significant cytotoxicity, phototoxicity, or skin sensitization. Cosmetic compositions containing this extract can effectively improve skin hydration, barrier function, redness, and dullness, and are suitable for preparing multifunctional pharmaceuticals or cosmetics with anti-inflammatory, whitening, moisturizing, and anti-aging properties, providing strong support for the high-value utilization and development of tree tomato leaf resources.

This invention belongs to the field of pharmaceutical chemistry technology, specifically relating to a near-infrared II luminescent iridium(III) complex photosensitizer, its preparation method, and its application. The near-infrared II luminescent iridium(III) complex photosensitizer disclosed in this invention generates singlet oxygen (…) under 550 nm illumination. 1 O2), hydroxyl radicals (•OH), superoxide anions (O2) •‑ We evaluated the antitumor activity of near-infrared luminescent iridium complexes using mouse breast cancer cells (4T1). Under unilluminated conditions, the near-infrared II luminescent iridium(III) complex photosensitizers showed no significant cytotoxicity to 4T1 cells, while under illumination, they exhibited good phototoxicity to 4T1 cells, with an IC50 value of [missing value]. 50 The concentration is 15.92 μM. We have invented a near-infrared II luminescent iridium(III) complex photosensitizer, which has excellent photoimmunodynamic therapeutic effects and will have important application prospects in the treatment of hypoxic tumors.

Intraluminal photodynamic therapy (PDT) of a target tumor tissue that is carried out from within a blood vessel is disclosed. The PDT method may be a vascular-targeted photodynamic therapy (VTP) or any other form of PDT where photosensitizer concentration in the blood vessel endothelium is not phototoxic. The PDT of this disclosure is carried out from within a blood vessel in the vicinity of the target tissue or organ with a light-diffusing section of an irradiating optical fiber being positioned within the confines of an inflatable balloon section of a balloon catheter, which is inflated during irradiation to occlude blood flow.

This invention belongs to the fields of biomedicine and fluorescent probe technology, and relates to a biheaded functional molecule and its application in the preparation of products for imaging cell tailpods or migration bodies. The biheaded functional molecule has the chemical structure shown in Formula I; wherein R is a hydrophilic positive ionic fluorescent group, X is methylene or O, Y is methylene or carbonyl, and n is 1~3. The biheaded functional molecule provided by this invention can achieve long-term cell membrane anchoring and can dynamically track the migration body formation process with low phototoxicity, low background fluorescence, high photostability, and high brightness.

This paper describes a class of dyes containing 1,4-diazabicyclo[2.2.2]octane, their preparation methods, and applications, belonging to the fields of optical diagnostics and biomedicine. The dye comprises the dye molecule and 1,4-diazabicyclo[2.2.2]octane covalently coupled to the dye. 1,4-diazabicyclo[2.2.2]octane directly quenches singlet oxygen generated by the dye, affecting the triplet state of the dye, thereby improving its anti-bleaching ability and photostability, and reducing phototoxicity during fluorescence imaging. Furthermore, the introduction of 1,4-diazabicyclo[2.2.2]octane significantly improves the brightness of the dye, inhibits photoscintillation, and enhances its water solubility. Its protonation characteristic enhances the dye's mitochondrial targeting ability. These compounds, by reducing singlet oxygen and enhancing the local photothermal and reactive oxygen species production in mitochondria, induce potent cell necrosis, apoptosis, and immunogenic cell death, comprehensively improving anticancer efficacy. These compounds exhibit excellent photostability and low skin toxicity, showing broad application prospects.

The invention discloses a small organic molecule photosensitizer for photodynamic sterilization and a preparation method and application thereof, pyridine cations and malononitrile structures are used as electron withdrawing groups, furan-triphenylamine structures are used as electron donating groups, and the photosensitizer with an electron acceptor-donor structure in molecules is constructed. The reaction conditions required by the synthesis method are mild and simple. The ultraviolet absorption peak of the prepared photosensitizer in water is 580 nm, the emission spectrum peak is 710 nm, and the photosensitizer has large Stokes shift and can efficiently sensitize oxygen in the environment into active oxygen under illumination. According to the photosensitizer prepared by the invention, the electropositivity of pyridine cations is utilized, the photosensitizer is rapidly combined with staphylococcus aureus through electrostatic interaction, and relatively high dark toxicity and phototoxicity are generated to kill bacteria; by utilizing the lipophilicity of a triphenylamine structure, the triphenylamine structure is combined with escherichia coli and pseudomonas aeruginosa through a hydrophobic effect, and two bacteria are killed by utilizing the dark toxicity of the triphenylamine structure and active oxygen generated by illumination, so that the photodynamic sterilization application is successfully realized.

The invention discloses a preparation method of a phallus impudicus extract as well as a product and application of the phallus impudicus extract, and belongs to the technical field of biology. The phallus impudicus extract is prepared by taking phallus impudicus buds as a raw material and adopting a water extraction process, and the mass percentage of polysaccharide in the extract is not less than 70%. The obtained extract has the biological activity effects of resisting oxidation, resisting inflammation, resisting saccharification, inhibiting elastinase, relieving repair activity or promoting skin repair, and experiments prove that the extract is free of cytotoxicity, sensitization and phototoxicity. The phallus impudicus extract is very suitable for sensitive skin and used as a daily skin care product. Development of traditional fungus phallus impudicus is led to the field of high-tech cosmetic raw materials, a complete technical scheme and solid data support are provided for high value-added utilization of phallus impudicus, and the phallus impudicus is wide in application prospect.

This invention provides a reagent for labeling phytosterols, its application, and a method for labeling phytosterols, belonging to the field of phytosterol detection technology. The cholesterol alkyne analog in this reagent specifically binds to phytosterols without affecting the plant's natural biochemical reactions. The azide fluorescent compound used has strong resistance to laser quenching, mitigating phototoxicity to some extent and enabling long-term observation in living plants. Therefore, the reagent of this invention provides rapid, efficient, stable, and highly specific fluorescent labeling of phytosterols in living plant cells, allowing for direct observation of phytosterol distribution in plants. The method for labeling phytosterols described in this invention uses a bioorthogonal reaction, which is simple to operate and highly reproducible.

The invention belongs to the field of application of lignin, and particularly relates to application of nano lignin dispersion liquid, base paper, coating liquid, anti-ultraviolet paper and a preparation method. The nano lignin dispersion liquid is applied to coating liquid and / or base paper. The nano lignin dispersion liquid is prepared by the following steps: dispersing alkali lignin or enzymatic hydrolysis lignin, and then adding a cationic polymer; and performing high-pressure homogenization. According to the technical scheme, lignin is adopted as a bio-based ultraviolet shielding material to replace a traditional chemical ultraviolet absorbent, and the environmental accumulation and phototoxicity risk can be effectively reduced. And the lignin is added, so that better protection and absorption effects can be achieved in an ultraviolet region, and human eye injury is reduced.

This invention discloses a method for preparing anthocyanin extract from tree tomato, along with its products and applications, belonging to the field of natural plant extraction and application. The method uses tree tomato peel as raw material, employing an acidic ethanol aqueous solution containing 0.5% (w / v) trifluoroacetic acid as the extraction solvent, at a material-to-liquid ratio of 1:30 (g / mL), at a temperature of 50℃, and for 60 minutes to obtain a high-content anthocyanin extract. This tree tomato anthocyanin extract possesses excellent anti-inflammatory, antioxidant, anti-glycation, elastase-inhibiting, and whitening activities, and exhibits low cytotoxicity, no phototoxicity, and no skin sensitization. The efficient and stable anthocyanin extraction process provided by this invention has high extraction efficiency and good enrichment effect of active ingredients, meeting the requirements for subsequent industrial production. The obtained extract has whitening, anti-aging, and anti-inflammatory effects, providing a high-quality raw material and formulation solution for developing multifunctional and highly safe natural plant-based skincare products.

The application discloses a multi-cyan structure near-infrared fluorescent dye, by changing the structure of end group and intermediate condensing agent, the accurate control of dye electron donating type, charge separation degree and electron mobility is realized. The multi-cyan structure near-infrared fluorescent dye compound prepared by the application has significant advantages in spectral characteristics, the molar extinction coefficient is higher than that of traditional multi-cyan dye, the light energy absorption capacity is strong, which is helpful to improve the light energy utilization rate and reduce the dye amount; the absolute fluorescence quantum yield reaches a high level, the imaging signal intensity and sensitivity are significantly enhanced, a more sensitive and reliable tool is provided for biological imaging and molecular detection; the fluorescent dye compound has excellent biocompatibility and phototoxicity, the safety of the dye in the application in the biological and medical fields is ensured, and strong support is provided for the application of the dye in the field of cancer treatment.

The invention provides a coumarin-TB-pyridinium derivative as well as a synthesis method and application thereof, 4-bromoaniline, 4-bromo-3-methoxyaniline, paraformaldehyde, pyridine-4-boric acid, 4-(diethylamino) salicylaldehyde and the like are selected as raw materials, and compounds TB-CM-1 and TB-CM-2 are synthesized through a multi-step reaction, so that the coumarin-TB-pyridinium derivative is obtained. The structure is as follows: the compounds TB-CM-1 and TB-CM-2 both have excellent photophysical properties, viscosity response, aggregation-induced emission characteristics and good biocompatibility, can efficiently generate type I active oxygen, and have good application prospects in an anoxic environment. The TB-CM-2 also has photodynamic antibacterial activity on a staphylococcus aureus biological membrane. The two compounds have strong photodynamic anti-tumor activity and large difference of light toxicity and dark toxicity, wherein the IC50 of the TB-CM-2 on three tested tumor cells is greater than 100 [mu] g.mL <-1 > in the absence of illumination, and the IC50 of the TB-CM-2 on MCF-7, A549 and HepG2 cells is respectively reduced to 0.40 [mu] g.mL <-1 >, 0.13 [mu] g.mL <-1 > and 1.58 ng.mL <-1 > under illumination. The invention provides a new thought for design and synthesis of a novel efficient photodynamic antibacterial / antitumor photosensitizer.

According to the present invention, the R-lycosin-I / porphyrin coupling phototherapy nanometer aggregate (R-LTNPs) is designed; the multifunctional material consists of polypeptide R-lycosin-I for inhibiting tumor growth and migration and inducing apoptosis, and a porphyrin part capable of realizing fluorescence imaging, photodynamic therapy (PDT) and photothermal therapy (PTT). Through covalent coupling, the nanospheres are uniformly distributed, and excellent phototherapy performance, colloidal stability and tumor targeting specificity are shown. In-vitro experiments use B16-F10 melanoma cells show that R-LTNPs retains the intrinsic cytotoxicity and cellular uptake efficiency of peptides, and can induce strong light to activate phototoxicity under light irradiation. In in-vivo experiments, the combination of R-LTNPs and light irradiation realizes remarkable tumor growth inhibition and ablation effects which exceed the effect of single-drug treatment. According to the invention, a nano assembly material is reasonably designed, and the nano assembly material shows excellent potential in the aspect of promoting combined oncology, provides a general framework for integrating molecular targeting, imaging and multi-modal treatment, and is used for a next-generation anti-cancer strategy.

The present invention relates to: a sonosensitizer composition that does not exhibit phototoxicity, the sonosensitizer composition comprising a phthalocyanine compound with paramagnetic ions bonded thereto, or a pharmaceutically acceptable salt thereof; and a use thereof. According to an aspect, a sonosensitizer composition comprising a phthalocyanine compound with paramagnetic ions of copper (II) or nickel (II) bonded thereto or a pharmaceutically acceptable salt thereof can effectively kill cancer cells, by exhibiting excellent ROS generation activity when exposed to ultrasound, without exhibiting phototoxicity, which is one of the side effects of conventional photosensitizers. In addition, the sonosensitizer composition has sonodynamic properties, improved tumor specificity, and excellent biocompatibility, and thus can be effectively used as an anticancer agent. Meanwhile, the present invention was achieved with the support of the following in-hospital research project under the supervision of Seoul National University Bundang Hospital. [In-Hospital Research Project Supporting Present Invention] [MSRI Project Number] 13-2021-0003 [Specialized Research Management Agency] Seoul National University Bundang Hospital [Project Name] Development of tumor-targeting high-sensitivity ultrasound-responsive agent using focused ultrasound equipment and research on immunomodulatory mechanism [Contribution Rate] 50% [Main Organization] Seoul National University Bundang Hospital [Research Period] 01 March 2021 - 31 August 2024