The invention relates to a shot blasting room for metal plate machining. The shot blasting room comprises a blasting room body, a grid plate is arranged on the bottom in the blasting room body, a shotblasting mechanism is arranged above the grid plate, a separation and dust collection mechanism is arranged below the grid plate, the separation and dust collection mechanism comprises a separation assembly and a dust collection assembly, the separation assembly comprises a filter net, a vibrator and two guide plates, the dust collection assembly comprises a fan, an air supply pipe, a dust discharge pipe and a collection box, and the shot blasting mechanism comprises a loading assembly and an adjusting assembly. In the shot blasting room for metal plate machining, the height and the angle ofa nozzle can be adjusted, different workpieces are subjected to automatic comprehensive shot blasting treatment, work is safer and efficient, the shot blasting quality is better, dust is prone to being stacked, wind is adopted for conveying dust, cleaning is efficient and convenient, effective shots can be separated and recycled, the raw material waste is reduced, and production cost is reduced.