1174results about How to "No side effects" patented technology

The invention discloses a modified Trim 21 (delta Trim 21)-based target protein degradation control system, which takes a modified protein delta Trim 21 degradation system as a basis, takes blue light, abscisic acid, Danoprevir and / or MK-5172 as inductors, controls the combination of target protein and delta Trim 21 by introducing and modifying a controllable protein dimerization system on the basis of the modified protein delta Trim 21 degradation system, and improves the target protein degradation control system. The protein targeted degradation capable of being modularly regulated and controlled is carried out. Two regulation and control modules, namely a target protein recognition module and a degradation module based on E3 ubiquitinase, are constructed by splitting and recombining a controllable protein dimerization system and a delta Trim 21 structural domain. The invention also discloses a degradation device comprising the system. The invention also discloses a method for accurately regulating endogenous proteins (degradation of proteins related to tumorigenesis) by using the programmable regulation type modular protein degradation device, so as to achieve the effect of specifically killing tumors. The invention also provides a eukaryotic expression vector and a regulation method of the programmable regulation type protein targeted degradation device.

The invention relates to lactobacillus crispatus LC30 for preventing and treating female genital tract infection and application of the lactobacillus crispatus LC30. The lactobacillus crispatus LC30 is preserved in the China General Microbiological Culture Collection Center with the preservation number of CGMCC NO.31923. The lactobacillus crispatus LC30 has good hydrogen peroxide production capacity and adhesion capacity, has a strong inhibition effect on main vaginitis pathogenic bacteria, and can be used for preventing and treating female genital tract infection. The composition is effective to nutritional pathogenic bacteria, and can also reduce form transformation and biological membrane formation of the pathogenic bacteria and prevent and treat drug resistance; besides, the fermentation product can reduce the content of pathogenic bacteria metabolites, regulate the secretion of cytokines and achieve the effect of relieving inflammation, so that the fermentation product can be used for preparing products for preventing and treating genital tract pathogenic bacteria infection, preventing and treating vaginitis and / or removing pudendum peculiar smell.

The invention relates to the technical field of biology, in particular to application of cycloastragenol in delaying cell senescence and increasing passage times of the cell senescence, and the cycloastragenol can delay the cell senescence and increase the passage times of the cell senescence by improving the relative telomerase activity of the cell. Cell experiments prove that the natural telomerase activator cycloastragenol used in the invention has no toxic or side effect on cells under the conditions of low-concentration (25-100 [mu] M) and short-time (12-24 h) incubation. Finally, a culture scheme of cycloastragenol is determined through drug toxicity and anti-aging tests: P3 and P6 generation cells are cultured for 24 hours by using 100 [mu] M cycloastragenol, P9 generation cells are cultured for 12 hours by using 100 [mu] M cycloastragenol, and under the culture condition, the relative telomerase activity of the cells can be remarkably improved, the aging level of the cells can be delayed, and the passage frequency of the cells can be remarkably prolonged.

The invention discloses a multi-effect biological fermentation essence milk containing a skin external preparation and a preparation method and application thereof, and the preparation method specifically comprises the following steps: inoculating saccharomycetes into a fermentation substrate composed of coix seeds, sorghum seeds, vegetable oil and water, and carrying out fermentation culture and sterilization to obtain the fermentation essence milk, wherein the saccharomycetes are composed of yellow wine saccharomycetes and saccharomyces cerevisiae, and the viable count ratio of the yellow wine saccharomycetes to the saccharomyces cerevisiae is 1: (0.5-5). According to the present invention, the active components of coix seed and vegetable oil are effectively utilized by using the yellow wine yeast and the saccharomyces cerevisiae in the fermentation manner so as to obtain the fermented essence milk containing the active components of natural plants, such that the loss of the active components is reduced while the fermented essence milk has good repairing, tightening and anti-aging effects, and does not have any side effect; under the condition that no additive is added, the cold-resistant and heat-resistant oil has ideal cold-resistant and heat-resistant stability, and can be widely applied to the field of cosmetics.

The invention discloses carboxymethyl chitosan-hyaluronic acid-stem cell exosome eye drops as well as a preparation method and application thereof, and relates to the technical field of eye drops and medical biogel. The carboxymethyl chitosan-hyaluronic acid-stem cell exosome eye drops are prepared from tannic acid modified carboxymethyl chitosan and adipose tissue-derived stromal cell exosome freeze-dried powder, the carboxymethyl chitosan-hyaluronic acid-stem cell exosome eye drops provided by the invention can effectively treat xerophthalmia, and are stable in components, safe and reliable. The three components including the tannic acid modified carboxymethyl chitosan, the hyaluronic acid and the adipose tissue-derived stromal cell exosome coexist, so that the functions of all the components can be fully played, a synergistic effect is achieved, and a better treatment effect on xerophthalmia is achieved.

The invention provides an animal bifidobacterium subsp. Lactis HNU329 with uric acid reducing ability and application thereof, the animal bifidobacterium subsp. Lactis HNU329 is preserved in Guangdong Microbiological Culture Collection Center GDMCC, the preservation address is Institute of Microbiology, Guangdong Academy of Sciences, on 5th floor, No. 59, No. 100 Courtyard, Xianlie Middle Road, Guangzhou, the preservation date is April 22, 2024, the preservation number is GDMCC No: 64546, and the preservation number is CGMCC No: 64546. The preparation method comprises the following steps of: classifying and naming Bifidobacteria animata subsp.lactis, and carrying out classification and naming on the Bifidobacteria animata subsp.lactis. The strain has good capacity of degrading nucleoside and purine in vitro, also shows good uric acid reducing capacity and anti-inflammatory capacity in animal model evaluation, and can regulate intestinal flora of mice with hyperuricemia and improve symptoms of hyperuricemia. The traditional Chinese medicine composition has no toxic or side effect, high safety and wide application prospect.

The invention discloses a pyridyl anti-aging agent as well as a synthesis method and application thereof, the anti-aging agent is obtained by taking 5-nitro-N-phenylpyridine-2-amine synthesized by 2-chloro-5-nitropyridine and aniline and iodide synthesized by alcohol and iodine as raw materials, and reacting in the presence of a hydrogen source and a catalyst. The anti-aging agent provided by the invention can effectively slow down the emigration speed of the anti-aging agent in rubber and greatly improve the phenomenon that the appearance of a tire becomes red, has one more N heteroatom than other anti-aging agents in the structure, has good oxidation resistance and flex cracking resistance, and is high in anti-ozone activity, environment-friendly and small in pollution.

The invention provides a preparation method of an electron-ion mixed conductor sulfide electrolyte material, which is characterized by comprising the following steps: taking a sulfide solid electrolyte as an inner core, taking a two-dimensional transition metal layered material MXene as a surface coating layer, and coating the surface of the inner core with the two-dimensional transition metal layered material MXene, and carrying out ball milling and calcining to obtain the electron-ion mixed conductor sulfide electrolyte material. The two-dimensional transition metal layered material MXene is used as a surface coating layer, the air stability of the sulfide solid electrolyte is improved, calcination treatment is carried out, S in the sulfide solid electrolyte is combined with metal ions in MXene, the sulfide solid electrolyte has high electronic conductivity, the appearance of a space charge layer can be inhibited, and the performance of the sulfide solid electrolyte is improved. The electronic conductivity of the positive electrode is improved, the multiplying power of a battery cell is improved, the content of conductive carbon is reduced, and the intrinsic ion conductivity of sulfide electrolyte can be kept to the maximum extent.

The invention discloses a photocatalyst antibacterial hydrogel-based fresh-keeping material as well as a preparation method and application thereof, and belongs to the technical field of fresh-keeping materials. The photocatalyst antibacterial hydrogel-based fresh-keeping material is prepared from the following raw materials in parts by mass: 180 to 220 parts of water, 1 to 6 parts of graphite-phase carbon nitride, 10 to 20 parts of polyvinyl alcohol, 1 to 3 parts of carboxymethyl chitosan and 8 to 12 parts of tannic acid. The invention further discloses a preparation method of the photocatalyst antibacterial hydrogel-based fresh-keeping material and application of the photocatalyst antibacterial hydrogel-based fresh-keeping material in fruit fresh keeping. The photocatalyst antibacterial hydrogel-based fresh-keeping material disclosed by the invention solves the problems of potential toxicity, easiness in inactivation, poor fresh-keeping effect and poorer mechanical property of an existing fresh-keeping material, realizes long-time effective fresh keeping of high-moisture fruits, does not involve chemical reaction in the preparation process, is non-toxic, easily available and degradable in raw materials, and has excellent environmental friendliness.

The invention relates to a microbial preparation containing arbuscular mycorrhizal fungi and application thereof, and belongs to the technical field of plant cultivation. According to the application disclosed by the invention, it is found that all of the glomus amarae, the rhizopus intro-rhizosporium, the glomus mosseae and the cyst macrosporium in the arbuscular mycorrhizal fungi can promote the growth of plants under the condition of double pollution of molybdenum and micro-plastics, and the plant height and the grain yield of the plants are effectively improved. Further experiments find that under the same condition, the effect is better than that of applying a single arbuscular mycorrhizal fungus inoculant when the near-phoma globosum, the rhizosporium intraradices and the glomus mosseae or the mixed inoculant of the near-phoma globosum, the glomus mosseae and the cyst macrosporium is applied. Furthermore, after beneficial bacteria and auxiliary materials are added into the mixed bacterial agent, the mixed bacterial agent has a better promoting effect on plant growth under the condition of double pollution of molybdenum and micro-plastics. The microbial preparation provided by the invention can reduce poison of microplastics and molybdenum to plants, so that the plants can normally grow under dual pollution.

The invention relates to a skin care composition containing white truffle and plant exosome and application thereof. The skin care composition containing white truffle and plant exosome comprises white truffle extract, chlorella exosome, DNA sodium, superoxide dismutase and fermentation product filtrate, the fermentation product filtrate comprises any one or a combination of at least two of lactobacillus / soybean milk fermentation product filtrate, lactobacillus / mung bean seed extract / sodium glutamate fermentation product filtrate, bifidobacterium fermentation product filtrate or saccharomycetes / rice fermentation product filtrate. According to the invention, the white truffle extract, the chlorella exosome, the DNA sodium, the superoxide dismutase and the fermentation product filtrate are creatively combined, and the composition has unexpected synergistic interaction in the aspects of inhibiting melanin synthesis, accelerating melanin metabolism and resisting oxidation and aging. The composition is mild in performance and free of irritation and toxic and side effects, and can be applied to cosmetic products more safely.

The invention discloses a composite degradable modified atmosphere preservative film, preparation and application thereof and a cherry preservation method. The preparation method comprises the following steps: mixing copolyester PBTF, poly (butylene adipate-succinate)-terephthalate and a solvent to obtain a film casting solution, pouring the film, and drying to obtain the composite degradable modified atmosphere preservative film. The preservative film has the characteristics of high CO2 permeability and low O2 permeability, and can inhibit respiration of fruits and vegetables and slow down metabolism of the fruits and vegetables, so that the storage time is prolonged, the composite degradable controlled atmosphere preservative film is heat-sealed into a bag and is used for preserving Dalian cherries, and an excellent preservation effect can be achieved.

The invention belongs to the technical field of medicines and health-care products, and particularly relates to compound prebiotics with an intestinal tract improving function as well as a preparation method and application of the compound prebiotics. The compound prebiotics with the function of improving the intestinal tract, disclosed by the invention, are prepared from the following components in parts by mass: 2 to 5 parts of polydextrose, 1 to 2 parts of erythritol, 8 to 10 parts of oat beta-glucan, 4 to 6 parts of stachyose, 12 to 15 parts of beta-galactomannan oligosaccharide, 20 to 30 parts of isomaltooligosacharide and 2 to 4 parts of a multifunctional additive. The multifunctional additive comprises fructo-oligosaccharide, red wine polyphenol and fatty acid. The compound prebiotics provided by the invention not only can promote the growth and reproduction of probiotics, improve the micro-ecological balance in intestinal tracts, improve the immunity of the intestinal tracts and improve the functions of the intestinal tracts, but also can prevent diarrhea.

The invention relates to the field of food and health care products, and discloses a composition for dispelling effects of alcohol and protecting liver, which comprises 20-100 parts of ampelopsis grossedentata leaf extract; 50 to 200 parts of a radix puerariae extract; 10-50 parts of a semen hoveniae extract; 10-50 parts of a turmeric extract; 10 to 100 parts of a yeast extract; 5-50 parts of a licorice extract; and 5 to 20 parts of pyrroloquinoline quinone disodium salt. The ampelopsis grossedentata leaf extract, the kudzuvine root extract and the hovenia dulcis thunb extract are utilized, alcohol decomposition is promoted, the blood ethanol concentration is reduced, and drunkenness symptoms are relieved. Puerarin improves activity of liver metabolic enzymes, accelerates discharge of ethanol and acetaldehyde, and reduces liver damage. The anti-oxidation effects of dihydromyricetin and PQQ can eliminate alcohol metabolism free radicals and protect liver cells. The components such as puerarin, hovenia dulcis thunb, curcumin and glycyrrhizic acid jointly promote liver cell regeneration, inflammation and oxidative damage are reduced, the levels of ALT and AST in serum are reduced, and liver health is maintained.

The invention discloses a composition as well as a preparation method and application thereof, and relates to the technical field of compound bacterium extract compositions. The compound bacteria comprise schizochytrium limacinum, acremonium terricola and gordonia alcalivorans; the mass ratio of the compound bacterium extract to the antioxidant is 100: (0.5-5). The preparation method of the composition comprises the following steps: adding the antioxidant into the compound bacterium extract, mixing, and drying to obtain the compound bacterium extract. The compound bacterium extract disclosed by the invention is rich in lipid and other components, and when the compound bacterium extract is applied to a laying hen feed, the cholesterol content in eggs can be effectively reduced on the premise of safety, no toxicity, no side effect and no influence on the production performance of laying hens, so that the low-cholesterol eggs are produced.

The invention provides primary amino modified solution polymerized styrene-butadiene rubber and a preparation method thereof. The preparation method comprises the following steps: in a polymerization system, initiating polymerization of a butadiene monomer and a styrene monomer by taking n-butyllithium as an initiator and tetrahydrofuran as a polymerization activator to obtain a styrene butadiene rubber active chain; adding a diisocyanate compound into the polymerization system to terminate polymerization, and introducing an isocyanate group to the end part of a styrene butadiene rubber active chain to obtain a styrene butadiene rubber solution; and adding a terminator into the styrene-butadiene rubber solution, stirring, separating out precipitate, and drying to obtain the primary amino modified solution polymerized styrene-butadiene rubber. The primary amino modified solution polymerized styrene-butadiene rubber is prepared by the preparation method, has high polarity and strong binding force with silicon dioxide filler, promotes generation of a more stable filler-polymer network with a more perfect structure, and remarkably improves the dynamic performance of a rubber material.

The embodiment of the invention relates to a phycobiliprotein active peptide with a hypoglycemic function and a preparation method and application thereof, and belongs to the technical field of biological active peptides. According to the phycobiliprotein active peptide with the blood sugar reducing function, the amino acid sequence of the phycobiliprotein active peptide is Ser-Tyr-Phe-Asp-Arg-Ala, Ile-Ala-Ser-Tyr-Phe-Asp-Arg, Gly-Tyr-Tyr-Leu-Arg or Val-Ala-Phe-Gly-Arg-Phe, and the amino acid sequence of the phycobiliprotein active peptide with the blood sugar reducing function is shown in the description. The phycobiliprotein active peptide in the embodiment of the invention is separated from spirulina phycobiliprotein, and the spirulina phycobiliprotein is an important protein resource in spirulina and a high-quality source of bioactive peptide, and has wider application; the phycobiliprotein active peptide is low in molecular weight, and compared with a chemically synthesized hypoglycemic preparation, food-borne peptides are safer and more efficient, free of toxic and side effects and easy to digest and absorb; the phycobiliprotein active peptide has high binding affinity with the alpha-glucosidase and the DPP-IV, can form a very stable ligand receptor compound, and has a good inhibition effect on the alpha-glucosidase and the DPP-IV; the compound has excellent inhibition performance on alpha-glucosidase, alpha-amylase and DPP-IV (dipeptidyl peptidase-IV).

The invention relates to an antibacterial catheter which is made of antibacterial plastic, and the antibacterial plastic comprises at least one first plastic matrix, a second plastic matrix or a thermoplastic elastomer material and at least one antibacterial agent. The antibacterial agent comprises metal of molybdenum and / or tungsten, or metal oxide thereof, or molybdenum and / or tungstate, or molybdenum and / or zincate, or polyoxometallate (POM) containing molybdenum and / or tungsten. The antibacterial function of the antibacterial catheter is achieved through a non-contact antibacterial mechanism, toxic and side effects are avoided, and common pathogenic microorganisms and super bacteria can be effectively resisted; the composition is safe and harmless, does not change hereditary characteristics of cells, does not cause carcinogenesis, does not generate drug resistance, and is efficient and lasting in antibiosis.

The invention discloses a multifunctional anti-tumor nano-drug delivery system based on copper death as well as a preparation method and application of the multifunctional anti-tumor nano-drug delivery system. The nano-drug delivery system comprises chemotherapy drug-loaded aminated diselenide bond doped mesoporous silica, a copper-based shell covering the surface of the chemotherapy drug-loaded aminated diselenide bond doped mesoporous silica, and a liposome membrane covering the surface of the copper-based shell and loaded with a small-molecule inhibitor, the copper-based shell is formed by self-assembly of copper ions and a ligand 3, 3 '-dithiobis (propionyl hydrazide). In the nano-drug delivery system, diselenide bond doped mesoporous silica has GSH responsive matrix degradation behavior, shows good biological safety, and can realize on-demand release of chemotherapeutic drugs; the nano-drug delivery system can realize acid and GSH dual-response degradation and gradually release a small-molecule inhibitor, Cu < 2 + > and a chemotherapeutic drug, has good Fenton reaction activity, can effectively block tumor cell energy supply and massive GSH consumption, and provides conditions for ferroptosis and copper hyperplasia. In-vivo and in-vitro experiments show that the combination of ferroptosis and copper death and synergistic chemotherapy can show a remarkable anti-tumor curative effect. The preparation method of the nano-drug delivery system is simple and easy to operate.

The invention provides a feline animal bifidobacterium, a metagen, a pharmaceutical composition and application, the feline animal bifidobacterium is named as animal bifidobacterium GYJC-001, the strain is preserved in the China Center for Type Culture Collection on July 22, 2024, and the preservation number is CCTCC NO: M 20241621. The invention further provides a preparation method of the feline animal bifidobacterium, the metagen, the pharmaceutical composition and the application of the feline animal bifidobacterium, the metagen, the pharmaceutical composition and the application of the feline animal bifidobacterium, the metagen, the pharmaceutical composition and the application of the feline animal bifidobacterium. The bifidobacterium animalis GYJC-001 disclosed by the invention has the advantages that the acid resistance and cholate resistance are high, the intestinal colonization ability is strong, the probiotic effect is better, the toxic and side effects are avoided, and a certain theoretical basis is provided for the development of the bifidobacterium animalis GYJC-001.

The invention provides a ZIF-8-based composite antibacterial material and a preparation method and application thereof.Ce6 is efficiently packaged into ZIF-8 through a simple one-pot method, Ce6 at-ZIF-8 is synthesized, Ce6 at-ZIF-8 is endowed with excellent photodynamic bacterium killing efficiency, then MnO2 is doped into Ce6 at-ZIF-8, the antibacterial efficiency is greatly improved under photodynamic and chemical kinetics synergistic antibacterial effects, and meanwhile, the composite antibacterial material can be used for preparing a composite antibacterial material. Due to the addition of berberine, the antibacterial effect is improved, the healing rate of a wound is increased, the berberine has good dispersity, can be uniformly dispersed in water, has large specific surface area, can well inhibit growth and adhesion of bacteria, can be used as a dressing for promoting wound healing or resisting bacteria, not only can effectively kill bacteria except the wound, but also can be used as a dressing for promoting wound healing or resisting bacteria. In particular, wound healing of diabetic patients can be promoted, and the antibacterial material can be used as a novel antibacterial material for antibiosis and wound healing.

The invention relates to a skin care composition containing perigord truffle and plant exosome and application of the skin care composition. The skin care composition containing perigord truffle and plant exosome comprises perigord truffle extract, chlorella exosome, malachite extract, fermentation product filtrate and soluble collagen. The fermentation product filtrate comprises any one or a combination of at least two of a Thermus thermophilus fermentation product, a lactobacillus / soybean milk fermentation product filtrate or a lactobacillus / mung bean seed extract / sodium glutamate fermentation product filtrate. The perigord truffle extract, the chlorella exosome, the malachite extract, the fermentation product filtrate and the soluble collagen are creatively combined to form the composition with the whitening, anti-allergy and anti-oxidation effects, and the composition has the effects of inhibiting melanin synthesis, relieving skin inflammation response, whitening skin, resisting allergy and resisting oxidation. And an unexpected synergistic effect is achieved in the aspects of oxidation resistance and aging resistance. The composition is mild in performance and free of irritation and toxic and side effects, and can be applied to cosmetic products more safely.

The invention provides a multi-tower series connection method and device for boron isotope separation, and relates to the technical field of isotope separation. According to the multi-tower series connection method for boron isotope separation, four stages of low-temperature rectifying towers which are sequentially connected in series are adopted to achieve low-temperature rectifying separation of boron isotopes at the specific temperature and pressure, tower bottom materials of the previous stage of rectifying tower serve as feeding raw materials of the next stage of rectifying tower, and materials of all stages of rectifying towers are conveyed through pumps; after rectification of the four-stage rectifying tower, a 10BF3 product with abundance greater than 99% can be extracted from the tower bottom of the ultimate rectifying tower; and condensing the gas-phase material at the top of each stage of rectifying tower into liquid through a condenser, extracting the 11BF3 light component, and mixing and collecting the 11BF3 light component through a collecting tank. The method and the device are operated under the normal pressure condition, the boron isotope product can be continuously produced, the energy consumption is low, the production speed is high, the technological operation is simple, no side reaction exists, the product impurity is few, the purity of the boron isotope separated product can be ensured, the cost is low, and the method and the device have good industry prospects.

The invention relates to siRNA for treating androgenetic alopecia, a nano preparation and a preparation method of the siRNA. The siRNA comprises a positive-sense strand and an antisense strand, the positive-sense strand is as shown in SEQ ID NO. 1, and the antisense strand is as shown in SEQ ID NO. 2. The siRNA disclosed by the invention can be used for efficiently and quickly inhibiting the expression of an androgen receptor in vivo and in vitro. When the medicine containing the siRNA is applied to the surface of the alopecia skin, the treatment effect can be quickly achieved, the hair growth speed is increased, and the hair regeneration time of the alopecia part is shorter.

The invention discloses a composition for treating diabetes mellitus and a preparation method and application thereof. The composition is prepared from, by weight, 3-7 parts of rice bran, 3-7 parts of bitter gourd, 1-5 parts of cinnamon, 3-7 parts of fermented soybean, 6-10 parts of fig, 1-5 parts of ginseng, 3-7 parts of fructus lycii, 1-5 parts of folium mori, 3-7 parts of radix puerariae, 1-5 parts of dendrobium officinale and 1-5 parts of wheat oligopeptide. 6-10 parts of fructo-oligosaccharide and 1-3 parts of dry yeast. The composition is unique and reasonable in compatibility, simple in preparation method and free of toxic and side effects, the medicine synergistic effect generated among the combined medicines is higher, the curative effect is better, the treatment effect is obvious, and the adverse reaction is low.

The invention provides a traditional Chinese medicine compound for treating sicca syndrome and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compounds. The traditional Chinese medicine compound provided by the invention has the effects of eliminating dampness and heat, removing blood stasis and promoting salivation, can safely and effectively treat sicca syndrome by improving functions of exocrine glands and regulating immunity, belongs to a pure traditional Chinese medicine preparation, and has no toxic or side effect. The traditional Chinese medicine compound is proved to be capable of remarkably relieving the sicca syndrome, relieving dry mouth and eye symptoms of a patient, relieving fatigue, regulating and controlling a plurality of signals taking RAGE / TLR4 as a core, inhibiting excessive activation of an HMGB1-RAGE / TLR4-NF-kappa B pro-inflammatory pathway from gene and protein levels, inhibiting generation of pro-inflammatory cytokines, reducing inflammatory response and improving the immunity of the patient. The effect of treating the sicca syndrome is achieved. By acting on STAT3 phosphorylation, Tfh proliferation is inhibited, IL-21 secretion is reduced, humoral immune disorder is relieved, and the sicca syndrome is treated, so that the condition of the sicca syndrome is relieved, and the prognosis of the sicca syndrome is improved.

The invention discloses a long-acting anti-aging composition capable of quickly removing dark circles and application of the composition. The composition is prepared from the following components: beta-nicotinamide mononucleotide, glutathione, acetyl hexapeptide-8, acetyl tetrapeptide-5, snake venom-like peptide, arginine / lysine polypeptide, tocopheryl acetate and ergothioneine. According to the present invention, multiple functions are adopted, such that the effects of dark circle removing, repair, elasticity recovery, aging resistance and the like are provided so as to block the generation of dark circle, and the normal function of skin is ensured. The composition disclosed by the invention has the effect of quickly removing dark circles, and when the eye cream contains the composition, the eye cream can effectively remove the dark circles and has an obvious and quick effect within 15 minutes; after being used for a long time, the eye mask can remove dark circles and play a good control role.

The invention relates to a citric acid-based particle injection material as well as a preparation method and application thereof. The preparation method comprises the following steps: melting and heating citric acid and 1, 8-octylene glycol to form a POC prepolymer, dissolving the POC prepolymer with an organic solvent to obtain a dissolved solution, and slowly pouring the dissolved solution into ultrapure water for multiple times for purification to obtain a purified POC degradable prepolymer; and dissolving the POC degradable prepolymer with a solvent, adding inorganic salt particles, and carrying out a cross-linking reaction to obtain the POC injectable particle material. Medicines, active molecules, various metal ions and the like are loaded on POC in a physical compounding or chemical crosslinking mode, and the citric acid-based particle injection material is obtained. The citric acid-based biological material provided by the invention, as a novel medical beauty raw material and a related particle injection filler thereof, can effectively promote regeneration, proliferation, migration and chemotaxis of skin cells, promote the production of collagen and achieve a medical beauty effect. Meanwhile, the immune response of the organism can be activated, inflammation is reduced, the product after degradation is citric acid which can be metabolized randomly, and obvious immunogenicity and toxic and side effects are avoided.

The invention discloses eye drops containing L-ergothioneine and a preparation method of the eye drops. The eye drops are prepared from the following components in parts by weight: 0.0015 to 15 parts of L-ergothioneine, 0.001 to 0.01 part of a bacteriostatic agent, 0.05 to 15 parts of a buffering agent and the balance of normal saline, and the pH value of the eye drops is 5.0 to 7.0. Experiments show that L-ergothioneine can prevent and reverse denaturation of crystalline lens protein, the prepared eye drops containing L-ergothioneine can prevent and reduce opacity of crystalline lens protein, and the prevention and treatment effects on cataract are better than those of existing eye drops.

The invention discloses a composition for resisting porcine viral diarrhea and application of the composition. The composition for resisting porcine viral diarrhea is prepared from the following components in parts by mass: 2 parts of phloretin, 1 part of N-acetyl-D-galactosamine and 100 parts of proline. The composition can further comprise one or more auxiliary materials of absolute ethyl alcohol, propylene glycol, dimethyl sulfoxide, edible oil, water, tween-80, lactose, defatted rice bran, corncob powder, soluble starch, bran, silicon dioxide, montmorillonite, vermiculite, medical stone, zeolite powder, white carbon black and the like. The composition can significantly inhibit the proliferation of PEDV, TGEV and PoRV, and inhibit the infection of PEDV, TGEV and PoRV on cells, and further, the composition can be used for preparing drugs or feed additives for resisting porcine diarrhea diseases caused by viruses such as PEDV, TGEV and PoRV.