166 results about "Adipose tissue" patented technology

The invention provides a method for constructing a CT-MRI (Computed Tomography-Magnetic Resonance Imaging) personalized three-dimensional heart model based on multi-modal imaging, which comprises the following steps of: firstly, carrying out myocardial and infarction region segmentation on a CMR-LGE image, and carrying out myocardial and intramyocardial adipose tissue segmentation on a CE-CT image to generate a corresponding Label image; then, a high-precision three-dimensional volume mesh model of the corresponding ventricle is constructed based on the segmentation results of the two types of images; and then, mapping the corresponding Label image with the tissue type to a corresponding finite element model according to the coordinates of the grid, and obtaining a corresponding personalized ventricular model with the tissue type. An interpolation method based on a general ventricular coordinate system is adopted, data of an MR ventricular model with infarct tissue attributes is transferred to a CT ventricular model, and therefore a mixed CT-MRI ventricular model is constructed. And finally, storing the constructed CT-MRI ventricular model data with the integrated tissue attributes as a standard geometric and topological file format.

Described are systems and methods to determine one or more regional body composition values for one or more regions of a body based on a processing of one or more two-dimensional images that include a representation of the body. Regional body composition values may include any of a fat tissue mass, a lean muscle mass, a bone mineral density, a skeletal muscle mass, etc., which may be determined for any one or more regions of the body, such as the right arm, left arm, right leg, left leg, trunk, android, gynoid, etc.

The invention discloses a culture medium for adipose-derived stem cells, and particularly relates to the technical field of stem cell culture. The culture medium comprises a basic culture medium and nerve-vascular niche components, wherein the basic culture medium comprises DMEM / F12, 10% of human-derived platelet lysate and 1% of antibiotic solution; the nerve-vascular niche comprises the following components: a Slit3 recombinant protein, a nerve growth factor-beta, a glial cell-derived neurotrophic factor, a lysyl oxidase inhibitor, dexamethasone, 3-isobutyl-1-methylxanthine and insulin. The traditional fetal calf serum is replaced by the human-derived platelet lysate, so that the risks of immunological rejection and pathogen pollution are avoided; through the synergistic effect of nerve-vessel niche factors, blood vessel maturation and innervation are promoted, programmed mechanical stretching culture is combined, the adipogenic differentiation efficiency of adipose-derived stem cells is remarkably improved, and engineered adipose tissue which is huge in lipid droplet, compact in structure and provided with a nerve-vessel network is formed.

The utility model provides a ruminant living body muscle adipose tissue minimally invasive sampling device, which relates to the technical field of animal tissue sampling, and comprises an outer sleeve and an inner cutting rod, one end of the outer sleeve is provided with a needle, the other end of the outer sleeve is provided with a handle, and the outer sleeve is provided with a sampling groove close to the needle; the inner cutting rod is movably arranged in the outer sleeve, and a sampling knife is correspondingly arranged at the sampling groove. The animal sampling device has the advantages of being high in sampling efficiency, capable of reducing animal injuries, convenient, easy and fast to operate and low in cost.

To provide a tissue product, more specifically, an extracellular tissue matrix made from adipose tissue.SOLUTION: A tissue product is provided, wherein the tissue product comprises a breast implant in the form of a porous acellular tissue matrix sponge, wherein the implant comprises an acellular adipose tissue matrix construct comprising a particulate acellular adipose tissue matrix, wherein the matrix is in a suspended, dried and stabilized form, and wherein the suspension comprises 2-10 wt.% solids.SELECTED DRAWING: None

The invention relates to the technical field of biological medicines, and discloses application of INHBC as a target spot in prevention and / or treatment of metabolic diseases. Specifically, the invention relates to application of substances for promoting INHBC gene expression or improving protein activity in preparation of products for preventing and / or treating metabolic diseases, and the metabolic diseases comprise diseases caused by energy metabolism disorder, such as obesity, diabetes, fatty liver disease, hyperlipidemia and the like. According to the application disclosed by the invention, liver specific overexpression or INHBC knock-in can improve mouse liver fatty degeneration and abnormal glucose metabolism induced by high fat diet, and in addition, the heat production activity of mouse adipose tissues can be enhanced, so that obesity induced by high fat diet is inhibited; the compound has an important application value in preventing and / or treating metabolic diseases such as obesity, type 2 diabetes and fatty liver diseases.

The invention discloses an adipose tissue obtaining needle capable of reducing bleeding and nerve injury, which comprises a guide rod, one end of the guide rod is fixedly communicated with a negative pressure suction bottle connecting assembly, the other end of the guide rod is fixedly communicated with a needle head, and the guide rod is provided with a plurality of water drop holes close to the needle head. A user cannot be stabbed when being accidentally touched, the sharp and solid round blunt needle penetrates through a collection part to reduce the resistance of a traditional blunt end, the phenomenon that the cortex of the collection part is damaged is avoided, and the strain of the collection part is reduced; the water drop holes are formed, stress is better dispersed, the tensile strength of the guide rod during fat collection is improved, the service life is prolonged, and compared with a traditional solid guide rod and a guide rod with the water drop holes, normal use is guaranteed, meanwhile, the weight of the guide rod is reduced, and positioning and transferring are convenient; and by arranging the guide groove, the problems that the needle deviates from the fat collecting direction, fat extraction is not uniform, and even the fat extraction position deviates are solved.

The invention provides application of loranthus parasiticus in preparation of a lipid-lowering medicine. The application has the advantages that the loranthus parasiticus extract can effectively improve HFD-induced obesity and glucose and lipid metabolism disorder; the loranthus parasiticus extract can relieve adipose tissue enlargement and liver fatty degeneration.

The present invention relates to an adipose tissue fluidification device, specifically an adipose tissue fluidification device for obtaining nanofat for reinjection into a patient as a facial or body filler, comprising a body, two ends aligned along the same geometric axis, and a plurality of channels internal to the body or three meshes internal to the body.

This invention provides tissue products manufactured from adipose tissue and methods for manufacturing the same. [Solution] A method for producing a tissue product is provided, comprising the steps of: selecting adipose tissue; processing the tissue to remove substantially all cellular material from the tissue; suspending the tissue in a liquid to form a suspension containing 2-4% by weight of solids; and freezing and drying the suspension to form a porous sponge.

The invention relates to the technical field of biomedical materials and tissue engineering, and discloses a preparation method and application of adjustable porous fat foam. Comprising the following steps: fat tissue pretreatment and freeze-thaw circulation, multi-step combined decellularization and impurity removal, graded washing and purification, freeze grinding and freeze drying, preparation of a decellularized fat matrix suspension, porous foam scaffold forming and foam scaffold gradient rehydration. By adopting a multi-step combined decellularization and impurity removal process, residual lipid droplets in adipose tissues can be actively extruded out by mechanical squeezing assisted by isopropanol degreasing, a lipid wrapping phenomenon is broken, meanwhile, residual nucleic acid and adipose components can be thoroughly removed by virtue of a synergistic degradation effect of nuclease and lipase, the immunogenicity risk is reduced, and the immunogenicity of the adipose tissues is improved. All the steps have a synergistic effect under strict control of temperature, concentration and time parameters, so that the structural integrity of the extracellular matrix is ensured, the decellularization efficiency and thoroughness are improved, and the biological safety and biocompatibility of a final product are ensured.

The present invention refers to a delivery system for molecules, preferably drugs, said system comprising fat tissue or derivatives thereof. Moreover, the present invention refers to a fat-based delivery system, preferably loaded with molecules having antitumor activities, for use in the treatment of cancers.

The invention belongs to the technical field of biology, and particularly relates to application of a herba artemisiae scopariae aqueous extract in enhancing liver chemotaxis of adipose-derived mesenchymal stem cells. In order to provide a way for enhancing the liver chemotaxis of the adipose-derived stem cells, the capillary artemisia aqueous extract is used for improving the expression level of chemotactic factors of the adipose-derived stem cells in vitro and intervening the proliferation, migration and chemotaxis capabilities of the adipose-derived stem cells to liver cells, the concentration of the capillary artemisia aqueous extract is 0.5 mg / mL to 1 mg / mL, the chemotaxis time is 24 h to 48 h, and the capillary artemisia aqueous extract is used for enhancing the liver chemotaxis of the adipose-derived stem cells. And the chemotactic factors are CCR1 and CXCR4.

Ultrasound emitting device for applying selective treatments to hypodermic tissue (adipose and connective tissue) in rejuvenation and / or body contouring processes, comprising an electrical pulse generator, an ultrasonic transducer (3), an electronic control unit (6) equipped with specific software that controls the frequency, voltage, and duty cycle of the pulse generator, and application means (4) for orienting and directing the acoustic field onto the area to be treated on the patient / user, wherein said transducer emits in each pulse an acoustic field with an energy density not exceeding 0.7W / cm2 and a minimum emission duration of 100ms. Preferably, the transducer emits either at a single frequency or in a frequency sweep, in a frequency range between 185 kHz and 333 kHz, and even more preferably at 244 kHz.

The present invention relates to the use of an s100a8 / a9 and complement 3 inhibitor in the preparation of a drug for treating or preventing cachexia. The treatment or prevention of cachexia comprises increasing the body weight, lean body mass and fat mass, and increasing food intake in a cachectic subject, or preventing fat mass consumption, slowing the rate of body weight loss, the rate of fat mass loss and the rate of lean body mass loss, counteracting anorexia, muscle strength loss, fatigue and body weight loss, or improving abnormal biochemical results. Provided is a new understanding for the mechanism of energy balance regulation in cancer cachexia, with an emphasis on the effects of S100a8 / a9 and C3 in cancer cachexia. The inhibition of S100a8 / a9 and complement 3 can promote fat recovery and increase food intake. Particularly, it is verified that an S100a8 / a9 inhibitor can prevent body weight loss, especially adipose tissue loss, in a cachectic subject, and significantly increases food intake in the subject.

A system for treating fat tissue, including: an ultrasound applicator, including: two or more ultrasound transducers configured to generate and direct ultrasonic waves to a selected tissue volume including fat tissue; a control unit, including: a control circuitry electrically connected to the two or more ultrasound transducers, wherein the control circuitry is configured to activate the two or more ultrasound transducers to heat the selected tissue volume.

The invention discloses an anti-drifting peritoneal dialysis pipeline convenient to fix, relates to the technical field of peritoneal dialysis pipelines, and aims to solve the technical problems that a polyester sleeve is insufficient in fixing and anti-traction capacity, and a catheter is prone to shifting and even falling off due to accidental pulling. Comprising a fixing bellyband surrounding the waist and belly, a first dialysis tube arranged at a subcutaneous tunnel section, a fixing mechanism and an auxiliary mechanism. According to the invention, the compressible elastic anchor wing is in a dry and compressed state in the implantation process, rapidly absorbs tissue fluid after implantation to generate hydration expansion and recover an outward expansion form, and is matched with micron-sized pyramid-shaped textures on the surface of the micro-texture biological anchoring area to provide an ideal scaffold for fibroblast attachment and collagen deposition; the catheter can be mechanically interlocked with surrounding abdominal wall fascia and subcutaneous fiber adipose tissue, the initial subcutaneous stability of the dialysis catheter is guaranteed, and the problems that a polyester sleeve is insufficient in fixing and anti-traction capacity, and the catheter is prone to displacement and even disengagement due to accidental pulling are solved.

The invention discloses application of knockout or inhibition of intestinal epithelium Ufbp1 gene expression in preparation of medicines for preventing and / or treating obesity, and belongs to the technical field of biological medicines. In order to solve the problems of limited effect, many side effects and the like of the existing obesity treatment means, the invention provides Ufbp1 specifically expressed by intestinal epithelial cells as a new anti-obesity intervention target for the first time. By knocking out or inhibiting intestinal epithelium Ufbp1, weight gain, adipose tissue accumulation, hyperlipidemia, liver fatty degeneration and insulin resistance induced by high fat diet can be effectively resisted. The action mechanism is related to influence on secretion of intestinal apolipoprotein ApoB48 / ApoA1 and further regulation and control of whole body lipid metabolism. The invention provides a clear target and theoretical basis for developing novel anti-obesity therapies such as small-molecule inhibitors and nucleic acid drugs of targeted intestinal epithelium Ufbp1, and has important clinical transformation prospects.

A kit for improving disorders related to adipocyte inflammation, venous lymphatic pathology and for muscle rehabilitation comprises a compression micro-vibration device having a body element (110) with a recess (111) suitable for storing at least one hand piece (150), a screen (112) adapted to provide a communication interface between a user and a computer terminal contained in said body element (110), an electrical connection cable (120) for connecting said hand piece (150) to said body element (110), an electrical stimulation device housed inside said body element (110) and connected via an electrical cable (260) to a common electrode (250) which can be positioned in the vicinity of a body part affected by treatment with said hand piece (150), and a digital thermography camera (300) connected via a common wireless connection system (310) or by an inlet plug (361) to a dedicated outlet (330) made in said body element (110).

The present application relates to a new use of Fuling Gancao Decoction, and specifically discloses application of Fuling Gancao Decoction in treatment of hyperlipidemia, wherein the Fuling Gancao Decoction is composed of the following components in parts by weight: Fuling 2 parts, Guizhi 2 parts, Zhigancao 1 part and Shengjiang 3 parts. It is found through animal experiment research that the Fuling Gancao Decoction can improve the symptoms of hyperlipidemia rats, reduce the content of TG, TC and LDL-C in serum, improve the liver lipid, blood sugar of hyperlipidemia model animals, reduce the liver coefficient, improve the liver cell fatty degeneration, reverse the pathological morphology of adipose tissue cells and the mitochondrial damage of hyperlipidemia model animals. A new indication of the Fuling Gancao Decoction is found, the development of traditional Chinese medicines is promoted, and a new drug composition with less side effects is provided for treatment of hyperlipidemia.

The present invention relates to the technical field of microorganisms, in particular to a Lactobacillus acidophilus GOLDGUT-LA100 having functions of lipid lowering, blood glucose lowering and weight loss and application thereof. The Lactobacillus acidophilus GOLDGUT-LA100 provided by the present invention is preserved in China General Microbiological Culture Collection Center, with the preservation number of CGMCC No. 28398. The strain has strong acid resistance, can adapt to the digestive tract environment, and has high bile salt hydrolase activity. At the same time, in animal experiments, the strain significantly reduces blood glucose and serum cholesterol levels, reduces liver fat deposition, reduces adipose tissue inflammation, effectively reduces the weight, and has broad application prospects in the development of products for improving obesity, lowering lipid and lowering blood glucose.

Mastopexy implants for breast lifts create new tissue planes in the breast that provide a more durable lift, and are particularly useful in breast lifts with a high content of fatty tissue; the implants can be implanted through small incisions using blunt dissection, reducing operating time, and providing a better aesthetic appearance with minimal scarring; the implants are designed to be temporary, and have sufficient retention strength to allow the new tissue planes to form and support the lifted breast without any significant loss of support during this regenerative period.

The utility model relates to a kind of adipose tissue preparation devices, belong to adipose tissue preparation technical field, including outer tube, outer tube upper end sealing connection upper end cover, outer tube lower end sealing connection lower end cover, upper end cover, lower end cover and outer tube are jointly surrounded to form cavity;Outer tube center is set through center shaft assembly;Turbine blade is rotationally set on center shaft assembly, and turbine blade is located in cavity;The utility model only processes adipose tissue by mechanical shearing, avoids the damage of chemical substance to adipose tissue biological activity, guarantees the biological safety of transplant tissue;Rely on manually pushing and pulling center shaft assembly, drive turbine blade to rotate under the resistance of component in cavity, without power or other power source, simple structure, small and exquisite, convenient to carry and operate;Shear stress generated by turbine blade rotation is even controllable, can stably and quickly break adipose tissue, and the broken efficiency is high, and particle size uniformity is good, meet the requirement of clinical transplantation injection.

A system for treating fat tissue, including: an ultrasound applicator, including: two or more ultrasound transducers configured to generate and direct ultrasonic waves to a selected tissue volume including fat tissue; a control unit, including: a control circuitry electrically connected to the two or more ultrasound transducers, wherein the control circuitry is configured to activate the two or more ultrasound transducers to heat the selected tissue volume.

The present disclosure is directed to the treatment of diseases or conditions characterized by the buildup of fatty tissue, or hyperphagia, such as Prader-Willi syndrome, obesity, metabolic syndrome, type II diabetes, etc. A composition containing a monoclonal antibody directed against gastric inhibitory polypeptide is administered. This results in a reduced rate of weight gain, weight loss, and / or reduction in fatty tissue, and a marked decrease in lipid synthesis and accumulation.

This invention discloses a culture medium, preparation method, and culture method for the industrial-scale preparation of mesenchymal stem cells, belonging to the field of cell therapy technology. The culture medium comprises a basal medium, cell growth factors, cell proliferation promoters, a vitamin mixture, a nucleoside mixture, and an amino acid mixture; wherein the cell growth factors are selected from one or more of TGF-β, bFGF, VEGF, PDGF, EGF, and IGF. Through the synergistic effect of the composite nutrient system, this invention significantly improves the proliferation rate and cell viability of mesenchymal stem cells, maintains stem cell stemness, trilineage differentiation ability, and secretion levels of key cytokines (VEGF, HGF, TGF-β, IL-10, etc.); it can be stably and continuously passaged up to the 15th generation without abnormal changes in genetic material. This culture medium contains no animal-derived components, has high batch-to-batch stability, and is cost-controllable, making it suitable for GMP-level large-scale industrial preparation of mesenchymal stem cells from various sources such as umbilical cord, bone marrow, adipose tissue, and placenta.

The invention relates to the technical field of high-yield collagen MSC (mesenchymal stem cell) engineering construction, and particularly discloses a fixed-point controllable high-yield collagen MSC engineering construction method, which comprises the following steps: 1, MSC separation and primary culture: separating from mammal bone marrow, umbilical cord or adipose tissue to obtain primary MSC, adopting a DMEM / F12 culture medium containing 13% of fetal calf serum, and carrying out primary culture on the primary MSC; carrying out primary culture and passage in a culture environment of 37 DEG C and 5% CO, and screening the fourth generation of MSC in the logarithmic phase as an engineered starting cell; and 2, constructing a collagen synthesis related gene fixed-point editing carrier: designing a fixed-point editing element aiming at a collagen synthesis key gene and an MSC differentiation regulation gene. According to the site-specific controllable high-yield collagen MSC engineering construction method, the collagen expression quantity of the engineered MSC can be greatly improved, the directional synthesis proportion of the type I collagen and the type III collagen is improved, and the requirement of industrialization for high-yield and high-purity collagen is effectively met.

Provided herein are conjugates for selective delivery of a therapeutic molecule, such as an oligonucleotide, to adipose tissue. In particular, the conjugate includes a NPR-C binding peptide, a therapeutic agent (e.g., an oligonucleotide), and optionally a linker conjugating the peptide to the therapeutic agent. The conjugates can also include one or more fatty acids. Also provided herein are methods and uses of treating diseases and conditions associated with adipose tissue (e.g., obesity or obesity-related comorbidity) by the conjugates described herein.

The invention discloses a high-concentration water-soluble salicylic acid supramolecular system and application thereof, and belongs to the technical field of supramolecules. The invention provides a water-soluble salicylic acid supramolecular system, and aims to solve the problem that in the prior art, the requirements of high drug loading capacity (gt; 30%), low irritation (soothing), continuous skin penetration and the like are difficult to synergistically meet. The invention aims to introduce a supramolecular technology to develop supramolecular salicylic acid which is high in drug loading capacity (more than or equal to 30wt%), is stable and uniform liquid at the low temperature of-5 DEG C, is low in irritation and has long-acting skin penetration and controlled release, so that the supramolecular salicylic acid has breakthrough significance in treatment of skin diseases and also has a good application prospect. The invention also finds that the supramolecular system can more effectively deliver salicylic acid to adipose tissues to enhance the metabolic regulation effect of salicylic acid, thereby providing an innovative solution for local weight loss.

The invention discloses a strain for regulating and controlling intestinal fatty acid absorption as well as a screening method and application thereof. The screening method of the bacterial strain comprises the following steps: (1) carrying out intragastric administration on an SPF-level mouse by 100 mu L of a wild boar excrement suspension with the concentration of 10g / 100mL to colonize a wild boar excrement flora; 2) performing 16S rRNA sequencing to detect differential intestinal flora, and detecting and analyzing the difference of relative abundance of each species through a Kruscal-Wallis rank sum to obtain a strain which is in negative correlation with fatty acid metabolism (including but not limited to a plurality of indexes such as weight, adipose tissue quality, serum total triglyceride level, serum total cholesterol level and the like). The bacterial strain Rombout ilealis is preserved in the China Center for Type Culture Collection, the preservation date is September 12, 2025, and the preservation number is CCTCC (China Center for Type Culture Collection) M 20252008. The invention relates to a feed probiotic additive for regulating and controlling intestinal fatty acid absorption. The functional effect of R.ilealis in lipid metabolism is provided for the first time, and a new probiotic screening method is provided for controlling absorption of fatty acid in the intestinal tract.