289 results about "Trimethylsilyl" patented technology

The invention relates to a method for continuously synthesizing a dapagliflozin intermediate, and belongs to the technical field of drug intermediate synthesis. The method comprises the following steps: mixing 5-bromo-2-chloro-4 '-ethoxydiphenylmethane, a photocatalyst and THF (tetrahydrofuran), introducing the mixture into an ultraviolet light catalytic micro-channel for pre-activation to generate an aryl free radical intermediate, namely a pre-activation solution, carrying out contact reaction on the pre-activation solution and a THF solution of 2, 3, 4, 6-tetra-O-trimethylsilyl-D-glucolactone in a low-temperature coupling area of a micro-reactor, and carrying out purification, purification and purification to obtain the aryl free radical intermediate. The reaction liquid is introduced into a dynamic quenching zone and is mixed with supercritical CO2 on line, an intermediate I is obtained through supercritical fluid extraction and separation, and the photocatalyst is recycled; the method has the advantages of high reaction efficiency, convenience in catalyst recovery and simplicity in product separation.

Described herein are lithium-metal rechargeable electrochemical cells comprising a lithium-metal negative electrode, a positive electrode, and a liquid electrolyte. The liquid electrolyte comprises a core mixture and a diluent. The diluent comprises a fluorinated ether. The core mixture comprises a set of salts and a set of solvents. The set of solvents comprises a pyrrolidinium-containing ionic liquid and a molecular solvent. The molecular solvent is a non-fluorinated ether, for example including but not limited to 1,2-dimethoxyethane. In some examples, the electrolyte further comprises an electrolyte additive, for example including but not limited to tris(trimethylsilyl)phosphate. In some examples, the set of salts comprises one or more imide-containing lithium salts. In some examples, the set of salts comprises lithium bis(fluorosulfonyl)imide and an additional salt and the mole fraction of lithium bis(fluorosulfonyl)imide in the set of salts is 0.5 or greater.

The invention provides a sodium ion battery as well as a preparation method and application thereof, and belongs to the technical field of battery materials. The sodium ion battery comprises a positive electrode, a negative electrode and an electrolyte, the positive electrode is a sodium-supplemented positive plate treated by a biphenyl sodium complex solution; the electrolyte comprises a NaPF6 basic electrolyte and an additive; and the additive is selected from at least one of 3-trimethylsilyl-2-oxazolidinone and N, N-dimethyl formamide. The resistance and capacity of the positive electrode are improved by supplementing sodium to the positive electrode, and the charge-discharge cycle life of the battery is prolonged by adding a polar reagent into the electrolyte to capture PF5 and remove trace water and harmful gas HF generated in charge and discharge.

The invention provides a low-temperature sodium-ion battery containing a modified negative electrode as well as a preparation method and application of the low-temperature sodium-ion battery. The low-temperature sodium-ion battery comprises a positive electrode, a negative electrode and an electrolyte, the negative electrode comprises negative electrode slurry, and the negative electrode slurry comprises an active substance, conductive carbon, sodium carboxymethyl cellulose and butadiene styrene rubber; the active substance comprises modified hard carbon; the modified hard carbon is prepared by oscillating and mixing hard carbon with a single-walled carbon nanotube, graphite carbon and soft carbon to obtain physical coating, further oscillating and mixing with the doped modified precursor powder, and calcining at high temperature to complete element doping and chemical coating; and the electrolyte comprises an additive selected from trimethylsilyl nicotinate, methyl 4-hydroxy-3-methoxycinnamate and the like. On one hand, the adhesive force of the negative electrode slurry on the current collector is improved, on the other hand, the solvent formula is optimized, the desolvation ability of sodium ions in the electrolyte is improved, the viscosity is reduced, and the additive is added to modify an electrode surface interface film, so that the charge-discharge performance of the battery at low temperature is improved.

The present invention provides a preparation method of lithium difluorooxalate borate, belonging to the technical field of lithium battery electrolyte additives. The present invention obtains a bis(methylsilyl) oxalate compound by a substitution reaction between a methylchlorosilane compound and oxalic acid, and mixes the bis(methylsilyl) oxalate compound with lithium oxalate, a boron trifluoride complex and an organic solvent to obtain lithium difluorooxalate borate; wherein the bis(methylsilyl) oxalate compound is used as a raw material, has strong reaction activity, generates a stable methylfluorosilane gas byproduct while introducing oxalate into the system, and does not cause chloride ions and free acid residues; in addition, when the raw material is bis(trimethylsilyl) oxalate, even if there is a small amount of raw material residue, it can be used as a new multifunctional electrolyte additive, play a certain synergistic role, and can improve the compatibility between electrolytes. The whole process is simple, the product yield obtained by the reaction is high, the product purity is high, and the separation is easy, which is suitable for industrial production.

The invention relates to a battery monomer, a battery device and a power utilization device, the battery monomer comprises an electrode assembly and an electrolyte, the electrode assembly comprises a positive pole piece, an isolating membrane and a negative pole piece, the positive pole piece comprises a positive current collector and a positive active material layer arranged on at least one side of the positive current collector, the positive electrode active material layer comprises lithium-containing phosphate with an olivine structure, and the single-side coating weight of the positive electrode active material layer is 250 mg / 1540.25 mm < 2 > to 320 mg / 1540.25 mm < 2 >; the electrolyte comprises a carboxylic ester solvent and a silane-based additive, the mass content of the carboxylic ester solvent in the electrolyte is 8%-30%, the silane-based additive comprises one or more of tris (trimethylsilyl) phosphate and trimethylfluorosilane, and the mass content of the silane-based additive in the electrolyte is 0.05%-1%.

The invention specifically discloses an electrolyte containing a silane additive and a lithium ion battery. The electrolyte containing the silane additives comprises a first additive and a second additive, the first additive comprises organic fluoride, and the organic fluoride comprises N, O-bis (trimethylsilyl) trifluoroacetamide, N-methyl-N-(trimethyl-d9-silyl) trifluoroacetamide, 2, 2, 2-trifluoro-N, N-bis (trimethylsilyl) trifluoroacetamide, N, N-bis (trimethylsilyl) trifluoroacetamide, N, N-bis (trimethylsilyl) trifluoroacetamide, N, N-bis (trimethylsilyl) trifluoroacetamide, N, N-bis (trimethylsilyl) trifluoroacetamide, N, N-bis ( the solvent is at least one of N, N-di (trimethylsilyl) acetamide and N-tert-butyl dimethyl silyl-N-methyl trifluoroacetamide; the chemical structure of the second additive is shown as a formula I: # imgabs0 #, at least one of R1, R2, R3 and R4 is a silicon-oxygen-containing group, and a Si-O-Si bond is formed by a center Si connected with R1, R2, R3 and R4 and at least one of R1, R2, R3 and R4. The method has the advantage of improving the cycle performance and the rate capability of the lithium battery.

The invention provides a preparation method of dipeptide-2, which comprises the following specific steps: carrying out amino protection on L-valine by using 2-(trimethylsilyl) ethoxycarbonyl, carrying out condensation reaction on the product and L-tryptophan benzyl ester, carrying out deprotection to remove the 2-(trimethylsilyl) ethoxycarbonyl, removing benzyl under a palladium-carbon hydrogenation condition, and purifying to obtain the dipeptide-2. Belongs to the technical field of organic synthesis. According to the method, 2-(trimethylsilyl) ethoxycarbonyl is adopted as an amino acid protecting group, amino groups can be accurately and specifically protected, the operation steps of protecting the amino acids are simplified, conditions are simple to control and easy to implement, meanwhile, a dipeptide intermediate is generated through a condensation reaction, and a good product foundation is laid for subsequent preparation steps of dipeptide-2; in addition, the process reaction is rapid, the operation steps are simple and clear, the used reagents are easy to purchase and low in price, the method is very suitable for industrial large-scale production, and a new synthesis way is provided for preparation of the dipeptide-2.

The preparation method comprises the following steps: by taking cephalosporin carboxylic acid containing the side chain of the 2-aminothiazole-4-oxime as a raw material, carrying out carboxyl protection reaction on the cephalosporin carboxylic acid containing the side chain of the 2-aminothiazole-4-oxime and a trimethylsilylation reagent; cooling the reaction liquid, directly carrying out amidation reaction on the reaction liquid and AE-active ester under the action of organic alkali, directly adding water into the reaction liquid to carry out hydrolysis deprotection, and growing crystals to obtain a crude product of cephalosporin dioxime; and purifying and drying to obtain the cephalosporin dioxime compound. According to the method, carboxyl is protected firstly, then the organic base is added to serve as the catalyst, amino is activated, the reaction can be effectively carried out, the purity of the cephalosporin dioxime obtained through aftertreatment and preparative chromatography purification is high, and the method can be used for impurity research of the cephalosporin antibiotics containing the aminothiazoly loxime side chain.

The invention discloses a sodium ion battery electrolyte as well as a preparation method and application thereof, and belongs to the technical field of sodium ions. The sodium ion battery electrolyte provided by the invention comprises a sodium salt, an organic solvent, a main additive and an auxiliary additive, the main additive is one or more of sodium difluorophosphate NaDFP, sodium tetrafluoroborate NaBF4, sodium trifluoroacetate NaTFA or sodium nitrate NaNO3, and the auxiliary additive is one or more of sodium difluorophosphate NaDFP, sodium tetrafluoroborate NaBF4, sodium trifluoroacetate NaTFA or sodium nitrate NaNO3. According to the present invention, one or more of tris (trimethylsilane) borate TMSB, tris (trimethylsilane) phosphate TMSP, (pentafluorophenyl) silane TPFS or tris (trimethylsilane) phosphite TMSPi are adopted, the circulation capacity retention rate in a wide temperature range is significantly improved through the synergistic mechanism in a certain proportion range, the capacity retention rate is high at a high rate of 10 C and above, the rapid charging performance is provided, and the application prospect is broad. The cost is reduced; and commercialization is promoted.

The invention discloses a low-damping PVC-U electrical conduit and a processing technology thereof, and belongs to the technical field of conduit preparation. The low-damping PVC-U electrical conduit is prepared from the following components in parts by weight: 70 to 80 parts of PVC resin, 30 to 42 parts of light calcium carbonate, 8 to 15 parts of ethylene-vinyl acetate copolymer, 0.5 to 1 part of ethylene bis stearamide, 3 to 6 parts of epoxy compound and 4 to 7 parts of compound stabilizer, the preparation method comprises the following steps: preparing an epoxy compound from ethyl benzoylacetate, 2-(trimethylsilyl) phenyl trifluoromethane sulfonate, p-toluenesulfonyl azide, p-aminophenol, p-toluenesulfonyl chloride, iodobenzene diacetic acid and rhodium diacetate as raw materials, and preparing the compound stabilizer from 2-(2-aminoethoxy) ethanol, 4-fluorophenol and xylene alkane diisocyanate as raw materials. The PVC-U electrical conduit prepared from the substances has the advantages of low damping, excellent stability, excellent mechanical property and excellent aging resistance.

The invention belongs to the field of organic synthesis, and particularly relates to a synthesis method of isoindolone. An N-methylbenzylamine compound as shown in a formula 1 and a 2-fluorobenzoic acid methyl ester compound as shown in a formula 2 are mixed with methyl tert-butyl ether in the presence of bis (trimethylsilyl) lithium amide and cesium fluoride, and the isoindolone as shown in a formula 3 is synthesized through reaction. The isoindolone derivative is synthesized through a one-pot method, and the method has the prominent advantages that raw materials are simple and easy to obtain, operation is easy and convenient, economy and environment friendliness are achieved, and the substrate applicability is wide.

The invention discloses a preparation method of an SGLT2 inhibitor key intermediate, and belongs to the technical field of medicinal chemistry. The preparation method comprises the following steps: 1) reacting a compound B with trimethylchlorosilane under an alkaline condition to generate a compound C; 2) reacting the compound C with an aldehyde group reagent on an aromatic ring to generate a compound D; 3) reacting the compound E with a bromination reagent to generate a compound F; 4) preparing the compound F into a Grignard reagent to generate a compound G; 5) carrying out addition reaction on the compound D and a compound G to generate a compound H; and 6) carrying out dehydroxylation and trimethylsilyl protection on the compound H to generate a compound A. According to the preparation method, the risk caused by amplification of the Sandmeyer reaction in the original route is avoided, and meanwhile, the preparation cost of the key intermediate is greatly reduced.

The invention discloses a 3-imido-4, 5-diaryl boron oxygen heterocyclic ring onium salt derivative as well as a preparation method and application of the 3-imido-4, 5-diaryl boron oxygen heterocyclic ring onium salt derivative. The 3-imido-4, 5-diaryl boron oxygen heterocycle onium salt derivative is prepared by taking acetylenic ketone potassium fluoborate, organic amine and 2-(trimethylsilyl) phenyl trifluoromethanesulfonate as raw materials, inorganic alkali and a weak acid buffer as accelerators and water and acetonitrile as solvents through a one-pot two-step reaction, and the compound can be used for preparing organic fluorescent materials, such as organic fluorescent materials, organic fluorescent materials, organic fluorescent materials, organic fluorescent materials, organic fluorescent materials and organic fluorescent materials. The compound has obvious aggregation-induced emission (AIE) property, high quantum yield and wider fluorescence range. The target product is prepared with high atom economy reaction and high yield, and the method has the advantages of cheap and easily available raw materials, mild reaction conditions, short synthetic route, wide universal range of substrates and the like.

The present invention relates to the technical field of compound preparation, specifically discloses a method for producing three (trimethylsilyl) phosphate using fluorosilane tail gas, comprising the following steps: at 60 ℃ 110 ℃ temperature, 0.1MPa 2.0MPa pressure, the production tail gas containing trimethylsilyl fluorosilane is passed into polyphosphoric acid and reacted, after the completion of the reaction, three (trimethylsilyl) phosphate and phosphorus oxyfluoride are obtained. The present invention effectively processes the production tail gas containing trimethylsilyl fluorosilane, converts the trimethylsilyl fluorosilane in the tail gas into three (trimethylsilyl) phosphate with high added value, not only solves the tail gas treatment problem, but also increases economic benefit, while saving tail gas treatment cost. In addition, the present invention realizes the efficient recovery of fluorine resources, and the byproduct phosphorus oxyfluoride produced in the preparation process can be directly put into production again as the raw material for synthesizing lithium difluorophosphate, forming a closed-loop recycling of fluorine resources, further reducing production costs, and improving resource utilization.

A hydrosilylation-curable composition contains the following components: (a) hydroxyl-functional polyorganosiloxane gum; (b) alkenyl-functional polyorganosiloxane gum; (c) optionally, tetraalkoxysilane; (d) trimethylsilyl-capped MQ resin; (e) hydrosilylation inhibitor; (f) silylhydride-functionals crosslinker at a concentration sufficient to achieve a molar SiH / alkene ratio in the hydrosilylation-curable composition that is in a range of 10-200; (g) platinum hydrosilylation catalyst at a concentration sufficient to provide 0.1 to 200 mass parts platinum per million mass parts of hydrosilylation-curable composition; (h) optionally, non-functional trimethylsilyl-capped polydimethylsiloxane gum; and (i) solvent; wherein the combined concentration of components (a) and (c) is in a range of 7 to 20 mass-percent relative to the combined concentration of components (a) through (h).

The application discloses a kind of flame-retardant mildew-proof prepolymer, transparent flame-retardant mildew-proof silicone sealant and preparation method thereof.The flame-retardant mildew-proof prepolymer is prepared from raw materials including the following components by weight: mildew-proof agent 0.5-10 parts, flame retardant 20-50 parts, tackifier composition 0.2-2 parts;The tackifier composition is composed of alkyl acetoacetate, trimethylsilyl ethyl acetate, 3-isocyanate propyl trimethoxysilane and polyether silicone oil.The transparent flame-retardant mildew-proof silicone sealant is prepared from raw materials including the following components: alkyl alkoxy-terminated polydimethylsiloxane, white carbon black, the flame-retardant mildew-proof prepolymer, crosslinking agent, catalyst, coupling agent.The transparent flame-retardant mildew-proof silicone sealant prepared by the application not only has very high transparency, but also has excellent flame-retardant effect, long-lasting mildew-resistant and antibacterial properties, and good bonding stability and mechanical strength.

The invention discloses a (2-phenoxyphenyl) phenyl sulfide compound and a synthesis method thereof, comprising the following steps: placing a 3-(phenylsulfinyl) tert-butyl propionate compound and a 2-(trimethylsilyl) phenyl trifluoromethanesulfonate compound in a 10 mL Shrek tube under an argon atmosphere, adding cesium fluoride and then adding a solvent, acetonitrile, and reacting at room temperature for 6 hours; after the reaction is completed, extraction, chromatographic separation, and drying are performed to obtain the target product. The present invention only uses cheap and readily available cesium fluoride as a fluorine source, and can efficiently obtain aryl sulfide compounds under mild conditions without the participation of a transition metal catalyst. The method provides a new approach for preparing various functionalized aryl sulfide compounds.

The invention relates to a method for detecting primary metabolites and / or secondary metabolites in flavors and fragrances, which comprises the following steps: (1) mixing flavors and fragrances, an internal standard substance and a solvent, extracting, taking clear liquid, and removing the solvent to obtain a dry product; (2) mixing the dry product, an oximation reagent and a solvent for an oximation reaction, and then mixing a reaction system and a silanization reagent for a silanization reaction to obtain a solution to be detected; the silanization reagent comprises a combination of N-methyl-N-(trimethylsilyl) trifluoroacetamide and N, O-bis (trimethylsilyl) trifluoroacetamide, and the silanization reagent comprises N-methyl-N-(trimethylsilyl) trifluoroacetamide and N, O-bis (trimethylsilyl) trifluoroacetamide; and (3) detecting the solution to be detected by adopting a gas chromatography-mass spectrometry method, and obtaining the content of primary metabolites and / or secondary metabolites in the flavors and fragrances by utilizing an internal standard method. According to the method provided by the invention, the flavors and fragrances are subjected to oximation and silanization treatment, and then the flavors and fragrances are detected by using the gas chromatography-mass spectrometry, so that the metabolites contained in the flavors and fragrances can be precisely and accurately detected.

The embodiment of the invention discloses a production method of N, O-bis (trimethylsilyl) acetamide, and belongs to the technical field of chemical production. The method comprises the following steps: trimethylchlorosilane and acetamide are taken as raw materials, acylation reaction is carried out in the presence of triethylamine and under the protection of inert gas, N, O-bis (trimethylsilyl) acetamide is obtained, and the mass ratio of acetamide to triethylamine is 1: (9-12). According to the method, the problem of pipeline blockage is solved, the raw material conversion rate is high, the once-through yield is larger than 95%, the product purity is larger than 99.7%, and the method has good application value. According to the invention, trimethylchlorosilane and acetamide are directly reacted, and triethylamine is used as an acid-binding agent and a reaction solvent at the same time, so that the flowability of reactants in a pipeline can be improved, the viscosity of a reaction system can be reduced, and the problem of pipeline blockage can be effectively solved; the raw material conversion rate is high, the once-through yield is greater than 95%, the product purity is greater than 99.7%, and the method has a good industrial application prospect.

The application belongs to the field of organic synthesis, and discloses a method for preparing chiral 2-(1,3-diarylallyl)malonate by using a Pd / phosphine oxygen bidentate phosphine phenol ligand catalysis, which comprises the following steps: under a protective atmosphere, mixing P, O-bidentate phosphine phenol ligand, a palladium catalyst, N, O-bis(trimethylsilyl)acetamide, a malonate nucleophilic reagent and an allyl acetate electrophilic reagent in dichloromethane, and reacting to obtain chiral 2-(1,3-diarylallyl)malonate product. The system has the advantages of high enantioselectivity, high catalytic efficiency, wide substrate application range and mild conditions.

The invention discloses a preparation method and application of a silicon-based functionalized fluorenyl polysubstituted acetylene copolymer and a gas separation membrane thereof. Belongs to the technical field of polymer material and gas separation. The invention provides a new thought for preparation of a high-permeability gas separation membrane material. The preparation method comprises the following steps: carrying out copolymerization on 1-phenyl-2-(7-trimethylsilyl-9, 9-bis (trimethylsilyl-fluorene-2-yl) acetylene and 1-phenyl-2-(7-trimethylsilyl-9, 9-dimethyl-fluorene-2-yl) acetylene under the catalysis of TaCl5-n-Bu4Sn, so as to prepare a copolymer with high molecular weight; the preparation method comprises the following steps of: carrying out film casting on a solution of the nano-silver oxide, and then carrying out desiliconization treatment by using normal hexane / trifluoroacetic acid to obtain a gas separation membrane with the thickness of 100-220 microns, the specific surface area of 298-492 m / g and the total pore volume of 0.134-0.299 cm / g. The prepared separation membrane has the advantages that the COpermeability is up to 36,900 Barrer, the Opermeability is 19,800 Barrer, the thermal decomposition temperature exceeds 420 DEG C, the separation membrane can be used for separating gases such as COO, ON and the like, the preparation process is simple and convenient, and the industrial potential is realized.

Certain aspects of the present disclosure may include a battery including a cathode including a fluorinated carbon material and manganese oxide, an anode including one or more of a lithium metal or a lithium alloy, and a non-aqueous electrolyte including: an organic solvent, one or more lithium salts including lithium perchlorate, and an additive material having lithium nitrate and tris-trimethyl silyl phosphite.

The invention belongs to the technical field of organic synthesis, and particularly provides a preparation method of (trimethylsilyl) methylamine hydrochloride. The preparation method provided by the embodiment of the invention comprises the following steps: carrying out reduction reaction on N-[(trimethylsilyl) methyl] benzylamine, and salifying with hydrochloric acid to generate (trimethylsilyl) methylamine hydrochloride. According to the preparation method disclosed by the embodiment of the invention, milder reduction hydrogenation operation is selected, severe conditions such as high temperature and high pressure are avoided, and the reaction yield and the product purity are improved.

The invention discloses a new lithium battery material and a preparation method thereof, and relates to the technical field of lithium ion batteries, the new lithium battery material comprises an electrolyte, and the electrolyte comprises a solvent, a composite lithium salt and a functional additive; the solvent comprises fluoro-carbonate, ionic liquid and fluoro-ether; the composite lithium salt comprises lithium bis (fluorosulfonyl) imide (LiFSI), lithium bis (trifluoromethyl) sulfonyl imide (LiTFSI) and lithium bis (oxalato) borate (LiBOB); the functional additive comprises silane modified vinylene carbonate and tris (trimethylsilyl) phosphate. The composite lithium salt is matched with the functional additive and the solvent, so that the battery has relatively good discharge performance and cycle performance in a temperature range of-30 DEG C to 70 DEG C, and has good wide-temperature applicability.

This work investigates the beneficial roles of lithium bis(trimethylsilyl) phosphate (LiTMSP) which may act as a novel bifunctional additive for lithium ion batteries, in particular, LiNi0.5Mn1.5O4 (LNMO) / graphite cells. The cycle performance of LNMO / graphite cells is significantly improved with incorporation of LiTMSP. Trimethylsilyl functional group therein can react with HF generated through hydrolysis of LiPF6 by residual water in electrolyte solution, followed by a decrease in the concentration of metal ions dissolution from the electrode. The generation of superior passivating surface film derived by LiTMSP on graphite electrode, suppressing further electrolyte reductive decomposition and deterioration / reformation caused by migrated metal ions, is confirmed. Furthermore, LiTMSP derived surface film is likely to have better lithium ions conductivity with a decrease in resistance of the graphite electrode, improving rate performance of cells. The HF scavenging and film-forming effects of LTMPS are responsible for the less polarization of cells enabling to improve cycle performance.

The invention belongs to the field of organic synthesis, and particularly relates to a synthesis method of a 3-phenoxy substituted benzofuran compound. In an inert gas environment, a 2-fluorobenzyl phenyl ether compound as shown in a formula 1 and a methyl benzoate compound as shown in a formula 2 are mixed with an organic solvent tetrahydrofuran to react in the presence of bis (trimethylsilyl) caesium amino, and the 3-phenoxy substituted benzofuran compound as shown in a formula 3 is synthesized under a heating condition. According to the method, the raw materials which are easy to obtain are used, benzofuran is synthesized through a transition-metal-free method, and the method has potential application value in synthesis of active pharmaceutical ingredients.

The invention discloses an immersion plating method for a nano-palladium layer on the surface of a bonded oxygen-free copper wire and a palladium-plated bonded oxygen-free copper wire. Relates to the technical field of palladium-plated copper wires. According to the dip plating method for the nano-palladium layer on the surface of the bonded oxygen-free copper wire, the bonded oxygen-free copper wire is soaked in ethyl alcohol to be cleaned and dried for standby application; the preparation method comprises the following steps: dissolving a surfactant, benzotriazole and rosin in an organic solution; adding nano palladium powder to obtain a dip plating solution; carrying out dip plating treatment on the bonded oxygen-free copper wire in the dip plating solution, drying after dip plating, and carrying out vacuum annealing; the surfactant is prepared from methyl amyl alcohol, trimethylsilyl glucoside, sodium dodecyl diphenyl ether disulfonate, a carbon nano tube and deionized water. The surface active agent is added, so that nano palladium particles can be uniformly dispersed in the plating solution, the palladium particles are prevented from being agglomerated, a more uniform and compact palladium plating layer can be obtained, the quality of the plating layer is improved, and the corrosion resistance is better.

The invention relates to the technical field of medicines, and discloses an anti-breast cancer toosendanin derivative as well as a preparation method and application thereof. The toosendanin derivative is C-12 deacetylated toosendanin, and the toosendanin derivative is prepared by one step through an enolation / molecular lactone exchange / hydrolysis cascade reaction under the condition of lithium bis (trimethylsilyl) amide. The toosendanin derivative obtained by the invention has a better anti-breast cancer curative effect, particularly has an obvious inhibitory effect on HER2 positive breast cancer, has lower in-vivo hepatotoxicity, and has a better anti-breast cancer drug application value.

The invention discloses a synthesis method of (1-oxo-1, 2, 3, 4-tetrahydronaphthalene-2-yl) phosphonate, which comprises the following steps: mixing a raw material compound with bis (trimethylsilyl) potassium amide and dimethyl chlorophosphate, and reacting in a solvent to obtain a target compound. According to the method, the bis (trimethylsilyl) potassium amide is adopted to replace traditional lithium diisopropylamide to serve as a deprotonation reagent, the synthesis process of the target phosphinate is successfully optimized, the system does not need an extremely low temperature condition, the rearrangement side reaction participated by LDA is avoided, meanwhile, the requirement for multi-equivalent strong base is reduced, and the method is suitable for industrial production. Therefore, the synthetic method is more efficient and controllable and has industrial application potential.