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2 results about "Compound E" patented technology

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Compound E is a potent, blood-brain permeable γ-secretase inhibitor (GSI) commonly used in Alzheimer studies to rapidly block amyloid (Aβ) production. In cell culture, this non-transition state and non-competitive inhibitor of γ-secretase has an IC50 of 300nM (Duan, 2014).