358 results about "Nitrobenzene" patented technology

The invention relates to the technical field of preparation of N-(2, 4-dinitrophenyl)-4-nitrobenzoyl aniline, in particular to a method for preparing a nitro amide compound by adopting a microreactor. The method for preparing the nitro amide compound comprises the following steps: introducing a sulfuric acid solution of 4-nitro-N-phenylbenzamide and a nitric acid aqueous solution into a microreactor, and reacting to obtain N-(2, 4-dinitrophenyl)-4-nitrobenzamide; the microreactor is provided with at least two reaction modules which are connected in series, and a sulfuric acid solution of 4-nitro-N-phenylbenzamide is divided into at least two strands which are respectively fed into a first reaction module of the microreactor and other reaction modules except the first reaction module; and the nitric acid aqueous solution enters the microreactor in a way of at least one stream. According to the method, the microreactor is used as a reaction carrier, the temperature in the reaction process is controllable, the raw material conversion rate is increased, and the residual amount of an intermediate N-4-nitro-(4-nitrophenyl) benzamide is reduced.

The invention relates to the technical field of synthesis of organic compounds, and discloses a synthesis method of an o-aminoanisole compound, which comprises the following steps: preparing a composite alkali slow-release system consisting of inorganic alkali and organic alkali; preparing a catalytic reduction reaction system containing a metal complex stabilizer, a transition metal catalyst and a hydrophilic ether cosolvent; a catalytic reduction reaction of o-nitroanisole is carried out, and the slow-release alkali-coated material gradually releases the composite alkali to maintain a stable pH environment; after the reaction is completed, adding a packing material rapid digesting agent to remove a packing material structure, and meanwhile, rapidly separating and protecting a product by using a product protective extracting agent and an antioxidant synergistic protective agent; and purifying and recovering the final product to obtain a high-purity o-aminoanisole product. The reaction efficiency, the product purity, the service life of the catalyst and the separation efficiency are comprehensively improved through the synergistic effect of the eight components, the product purity reaches 99.5% or above, the catalyst can be recycled for 5-8 batches, and the separation time is shortened to 0.5-1 hour.

The invention belongs to the technical field of catalysts, and particularly relates to a formaldehyde removal catalyst and a preparation method and application thereof. The formaldehyde removal catalyst is prepared by carrying out hydrothermal reaction and roasting treatment on a mixture of the following raw materials: metal salts including Mn salt, Co salt and Fe salt; an organic precursor, wherein the organic precursor comprises 2-nitroaniline and carboxymethyl cellulose; wherein the molar ratio of the Mn element to the Co element to the Fe element in the metal salt is (4.5 to 5.0): (2.0 to 2.5): (1.5 to 1.8); the ratio of the total mass of the Mn element, the Co element and the Fe element in the metal salt to the mass of the organic precursor is (80-85): (15-20). According to the formaldehyde removal catalyst, the metal elements are loaded on the hydrophobic carbon layer of the nitrogen-containing structure, so that the problem that the toluene adsorption capacity is weak due to the fact that a traditional catalyst does not have specific sites is solved, and the problem that the catalyst is inactivated due to the fact that multiple pollutants compete for active sites and a product overflows slowly can also be solved.

The application provides a method for continuously preparing nitrobenzene by using benzene and NO2 as raw materials. The method is characterized in that: a solid catalyst capable of catalyzing the nitration of benzene by NO2 is filled in a pipe reactor, benzene, NO2 and O2 are continuously fed into the pipe reactor at a certain flow rate, and the reaction is carried out at a certain temperature to obtain nitrobenzene. This route is safe, green, economical and efficient, and is a safe, green, economical and efficient nitrobenzene synthesis route.

The present invention proposes a method and use for stabilizing a simple agglomerate for pH and salt and with adjustable size. In phosphoric acid buffer solutions with different salt concentrations and pH values, the polyacrylic acid hydroxypropyl group condensation body has specific stability; hydrophobic thermal response blocks are introduced into a hydroxypropyl acrylate monomer through reversible addition-fragmentation chain transfer polymerization to regulate and control the size of a condensation body, and a phase separation behavior is shown at different temperatures; a hydrophobic block without thermal response is introduced to regulate and control the size of the aggregate, and no thermal response behavior is shown. Continuous regulation and control of the size of the aggregate from the micron level to the nano level are achieved, and the requirements of different application scenes are met. The hydroxypropyl polyacrylate condensation body can be used for packaging various dyes and drugs; high-efficiency enzyme protection is achieved, formed aggregates can protect glucose oxidase, and the retention rate of enzyme activity reaches 85% or above after treatment is conducted for 3 hours at 60 DEG C; as a micro-reactor for the reaction of generating p-nitrobenzaldehyde phenylhydrazone from p-nitrobenzaldehyde and phenylhydrazine, the reaction rate is greatly improved.

This invention discloses a method for preparing and analyzing trans-4-aminocyclohexylacetic acid. The preparation method is as follows: 4-nitrophenylacetic acid undergoes catalytic hydrogenation in a solvent, followed by filtration. The filtrate is then treated with acid to obtain a 4-aminophenylacetic acid salt solution. The collected catalyst is activated. The 4-aminophenylacetic acid salt solution is mixed with isopropanol, barium hydroxide, tetrabutylammonium bromide, 18-crown ether-6, and dibutyl phthalate. The activated catalyst is then added to initiate a catalytic hydrogenation reaction. After the reaction, the reaction solution is cooled and filtered. The resulting solid is mixed with a preheated dilute sulfuric acid solution and stirred to form a slurry. The mixture is then filtered, and the filtrate is neutralized and filtered again. The collected filtrate is concentrated and crystallized. The crystallized precipitate is washed and dried to obtain trans-4-aminocyclohexylacetic acid. The method provided by this invention has high reaction efficiency, mild conditions, and is suitable for industrial production. It yields high product purity and reliability. Furthermore, the analytical method provided by this invention is accurate and reliable.

The invention discloses a synthesis method of 5-(1H-pyrrole-1-yl)-2-mercaptobenzimidazole, which comprises the following steps: carrying out cyclization condensation reaction on o-phenylenediamine and thiourea in an acidic environment provided by hydrochloric acid to obtain 2-mercaptobenzimidazole; the preparation method comprises the following steps: carrying out nitration reaction on 2-mercaptobenzimidazole, sulfuric acid and nitric acid to obtain 2-mercapto-5-nitrobenzimidazole; the preparation method comprises the following steps: carrying out nitro reduction reaction on 2-sulfydryl-5-nitrobenzimidazole and hydrogen under the catalysis of nickel to obtain 5-amino-2-sulfydryl benzimidazole; the preparation method comprises the following steps: carrying out an N-alkylation reaction on 5-amino-2-mercapto benzimidazole and tetrahydro-2, 5-dimethoxyfuran under the catalysis of copper chloride to generate 5-(1H-pyrrole-1-yl)-2-mercapto benzimidazole, and carrying out a reaction on the 5-amino-2-mercapto benzimidazole and tetrahydro-2, 5-dimethoxyfuran to generate the 5-(1H-pyrrole-1-yl)-2-mercapto benzimidazole. The method disclosed by the invention has the outstanding advantages of mild and easily-controlled conditions, simple and convenient post-treatment, high yield, economy, environmental protection, suitability for large-scale production and the like, conforms to the green chemical development concept, and has important application value.

This invention discloses a continuous synthesis apparatus and process for nitrobenzene. The synthesis apparatus includes a mixed acid preparation system, a continuous benzene nitration system, an organic phase continuous stratification system, and a continuous water washing-alkali washing-water washing system. The process includes: concentrated sulfuric acid and concentrated nitric acid are pumped into the mixing module of the mixed acid preparation system to obtain a mixed acid solution; benzene and the mixed acid solution are pumped into the microchannel reactor of the continuous benzene nitration system; the nitrated material is cooled and then pumped into the continuous organic phase stratification system; the resulting intermediate organic phase nitrate enters the next processing unit; the organic phase nitrate and water enter the continuous water washing-alkali washing-water washing system for washing to obtain the final product, nitrobenzene. The synthesis apparatus and process of this invention achieve continuous production of nitrobenzene throughout the entire process, realizing continuous and automated operation from raw material benzene to the final product, nitrobenzene.

The application provides a preparation method of an indobufen key intermediate. The method uses 2-(4-nitrophenyl) butyric acid and phthalic anhydride as raw materials, and obtains the target compound (I) through a one-pot method. The method has the advantages of simple operation, mild conditions, high reaction yield, reduced cost through mother liquor recycling and reuse, significantly reduced "three wastes" and environmental protection, and is suitable for large-scale industrial production.

The present invention relates to the technical field of organic synthesis. Provided is a method for preparing 2,6-bis(4-azidobenzylidene)-4-methylcyclohexanone, comprising the following steps: S1, subjecting 4-nitrobenzaldehyde and trimethylsilyl azide to a nucleophilic aromatic substitution reaction to obtain 4-azidobenzaldehyde; S2, subjecting 4-azidobenzaldehyde and 4-methylcyclohexanone to an aldol condensation reaction, so as to obtain 2,6-bis(4-azidobenzylidene)-4-methylcyclohexanone. The described technical solution addresses the problems in the related art where the process for synthesizing 2,6-bis(4-azidobenzylidene)-4-methylcyclohexanone has low product yield, high costs and high energy consumption, and is not conducive to large-scale industrial production.

The invention relates to the technical field of metal surface treatment, in particular to a high-salt-spray-corrosion-resistance workpiece surface phosphating treatment method. The method comprises the following working procedures of ultrasonic oil removal, water washing, water washing, activation, dipping phosphorization, water washing, water washing, ultrasonic hot water washing and drying, and dipping phosphorization refers to that an activated workpiece is put into a phosphating solution to be subjected to phosphating treatment; the phosphating solution comprises the following components: 5-8 g / L of organic phosphonic acid, 30-40 g / L of zinc dihydrogen phosphate, 50-55 g / L of calcium nitrate, 2-4 g / L of sodium m-nitrobenzenesulfonate, 1-2 g / L of an accelerant, 0.5-0.8 g / L of a surfactant, 1-3 g / L of sodium molybdate, 2-4 g / L of citric acid and 0.2-0.44 g / L of rare earth salt. Through low-temperature high-efficiency process design and multi-component collaborative innovation, breakthrough is achieved in the aspects of compactness, corrosion resistance, adhesive force and other core performance of the phosphating film, the environment friendliness and economical efficiency are both achieved, and a new solution is provided for metal corrosion prevention in the fields of automobiles, ships, electronics and the like.

The present application relates to the technical field of biological materials, in particular to a light-responsive drug gel carrier and a preparation method thereof, in order to improve the controlled release function of the hydrogel material, the methyl methacrylate nitrobenzene compound containing nitrobenzene structure, hydantoin structure and propylene structure is prepared first, under the action of a photoinitiator, the double bond is crosslinked with methyl methacrylate and ethylene glycol methacrylate to form a hydrophilic gel network, so that the drug gel carrier is obtained; wherein the nitrobenzene structure has photosensitivity, and the crosslinking structure will be broken under ultraviolet irradiation, thereby reducing the stability of the gel material, destroying the rearrangement of the gel micelle structure, and realizing the release of the loaded drug; and the hydantoin structure introduced in the methyl methacrylate nitrobenzene compound also has good antibacterial performance, which can effectively avoid wound infection and improve wound recovery.

The application provides a regeneration method of halogenated nitrobenzene continuous hydrogenation catalyst, and relates to the technical field of fixed bed halogenated nitrobenzene hydrogenation. The regeneration method mainly comprises the following steps: using alcohol, alkali, petroleum ether and ethyl acetate to preliminarily clean the bed layer, removing azo compounds and other pollutants on the surface of the catalyst by using the special properties of ionic liquids, and then completing the regeneration of the catalyst through the steps of pickling, precious metal solution treatment and drying. The application overcomes the defects of the prior art, has the advantages of simple operation, mild conditions and low cost, realizes the in-situ removal of surface impurities such as reaction intermediates and azo compounds on the catalyst surface without damaging the structure of the catalyst and disassembling the catalyst, further supplements the lost metal active components, and can effectively restore the catalyst activity.

The application discloses a copper oxide nanowire loaded silver monatomic catalyst, a preparation method and application thereof, and comprises a substrate, CuO nanowires and metal Ag monatomic atoms loaded on a CuO nanowire electrode layer; the substrate is a commercial copper foam, and the substrate is used for providing a copper source and preparing an array material of the metal Ag monatomic atoms on the CuO nanowires. The application adopts the above-mentioned copper oxide nanowire loaded silver monatomic catalyst, the preparation method and the application thereof, through silver monatomic atom modification, copper-silver metal interaction jointly regulates an intermediate product in an adsorption electrocatalytic reduction process, excellent electrocatalytic nitrophenol reduction performance is obtained, and the application is suitable for environmental pollution treatment and pharmaceutical synthesis development fields.

The invention discloses a pseudomonas stutzeri strain, a microbial agent and application of the pseudomonas stutzeri strain in degradation of organic nitrogen pollutants in wastewater, and belongs to the technical field of microorganisms, the pseudomonas stutzeri strain is named as MDD 2025, and the preservation number of the strain is CGMCC NO. 33839. The pseudomonas stutzeri MDD 2025 can rapidly degrade nitrobenzene, 2, 4-dinitrotoluene, pyridine, aniline and other organic nitrogen pollutants in wastewater under the medium-temperature condition (the water temperature is 35 DEG C) by taking a target pollutant as a unique carbon and nitrogen source, and keeps certain degradation capacity under the low-temperature condition (the water temperature is 10 DEG C).

This invention discloses a method for preparing the DPP1 inhibitor bresocarte, belonging to the field of pharmaceutical synthesis. Specifically, the method includes the following steps: N-tert-butoxycarbonyl-L-4-bromophenylalanine reacts with methanesulfonyl chloride or 4-nitrobenzenesulfonyl chloride in the presence of a base, followed by amination substitution to obtain intermediate 1; then, it undergoes dehydration in the presence of trifluoroacetic anhydride to obtain intermediate 2; next, it undergoes a coupling reaction with pinacol diboronate to obtain intermediate 3; then, it undergoes a coupling reaction with bromide compound 4 to obtain intermediate 5; then, it undergoes cyclization with di-tert-butyl dicarbonate in the presence of sodium methoxide to obtain intermediate 6; then, it undergoes deprotection in the presence of hydrogen chloride to obtain intermediate 7; next, it undergoes condensation with compound 8 to obtain intermediate 9; finally, it undergoes deprotection in the presence of hydrogen chloride to obtain the inhibitor bresocarte. This method provides a new synthetic approach, with low overall cost, simple operation, high yield, and suitability for industrial production.

The application provides a preparation method and application of a near-infrared two-region fluorescent sensor, and chiral single-walled carbon nanotubes are separated by using a double water phase extraction method; materials in the separation process include deionized water, polyethylene glycol, dextran, sodium dodecyl sulfate, sodium deoxycholate and cholic acid sodium hydrate; the chiral single-walled carbon nanotubes are dispersed and mixed with 4-nitrobenzene tetrafluoroboric acid diazonium salt to obtain the fluorescent sensor; high-purity (6,5)-SWCNT is efficiently and simply separated by using the double water phase extraction technology, the prepared SWCNT-NBD nanomaterial has good optical performance, including bright light emission in the near-infrared two-region, has good penetration capacity on biological tissues, the fluorescent detector (SWCNT-NBD) has low detection line, wide linear range, good selectivity on DA, and is convenient to prepare and low in cost.

The invention relates to a preparation method of 4, 4 '-bis (3-aminophenoxy) biphenyl, and relates to the technical field of organic synthesis. The method comprises the following steps: adding m-fluoronitrobenzene, potassium carbonate, biphenol and a mixed solvent into a water separation device for reaction; after the reaction is finished, filtering, carrying out reduced pressure distillation, adding an ethanol solution of toluene, pulping and filtering; adding pure water into the filter cake for pulping, thermally filtering and drying to obtain an intermediate 1; adding the intermediate 1, a hydrogenation catalyst, a phase transfer catalyst and tetrahydrofuran into an autoclave for reaction, filtering, performing rotary evaporation on filtrate, adding methanol for pulping, filtering and drying to obtain 4, 4 '-bis (3-aminophenoxy) biphenyl; the phase transfer catalyst is prepared from allyl trimethyl ammonium chloride, 4-vinylbenzene-15-crown ether-5, isopropanol, azodiisobutyronitrile and an ethylene boron anhydride pyridine complex; the yield and the purity of the 4, 4 '-bis (3-aminophenoxy) biphenyl can be remarkably improved, and the method is suitable for industrial production.

The invention relates to the technical field of gas impurity removal, and discloses a metal modified molecular sieve as well as a preparation method and application thereof. The method comprises the following steps: (1) mixing a metal salt, a nitrogen-containing micromolecule complexing agent, a nitrogen-containing micromolecule dispersing aid and ethanol to obtain a mixed solution, and then adding a molecular sieve for mixing to obtain a mixture; (2) drying the mixture obtained in the step (1), and then roasting; wherein the metal in the metal salt is selected from at least one of Mg, Ca, Sr and Ba; the nitrogen-containing micromolecule complexing agent is selected from at least one of 2-nitrophenol, 3-nitrophenol and 4-nitrophenol. The metal modified molecular sieve prepared by the method has very high adsorption activity on nitrous oxide, oxygen-enriched liquid air containing nitrous oxide is treated, the content of nitrous oxide can be reduced to 5 ppm or below, and the whole process is low in energy consumption, does not generate new impurities, and is green and environment-friendly.

This invention discloses a complete process for preparing nitrobenzene using a microchannel reactor, belonging to the field of nitrobenzene synthesis. The complete process includes mixed acid, microchannel nitration reaction, intermediate product cooling and stratification followed by water and alkali washing, crude product distillation, waste acid recovery, and wastewater treatment. Compared with existing nitrobenzene synthesis technologies, this invention has high mass transfer efficiency, significantly shortens the nitration reaction time, greatly improves production efficiency, enhances reaction safety, and simultaneously achieves waste acid recovery and wastewater treatment, ensuring safe, environmentally friendly, and stable production.

The present invention aims to provide an additive for agricultural chemicals that exhibits excellent spreading properties. [Solution] The present invention provides an additive for pesticides and an additive for pesticides for paddy fields or hydroponics, which contains a lignin derivative having a weight-average molecular weight of 5,000 to 43,000, preferably 5,000 to 36,000, an organic sulfur content of 1.5 to 7.0% by mass, preferably 1.5 to 5.5% by mass, a water solubility of 10 to 100% by mass, an extractant content and a methoxy group content of 0.01 to 2.5% by mass and 3 to 17% by mass, respectively, with a mass ratio of extractant content to methoxy group content of 0.001 to 0.25, and having a functional group represented by formula (1):-SO3M. The lignin derivative preferably satisfies the following conditions: a total decomposition product yield by alkaline nitrobenzene oxidation of 14% or less, and a polydispersity of at least one selected from 1.5 to 4.7.

The application provides a kind of plane chiral boronic acid compound based on cycloaralkane skeleton and its synthesis method and application, the plane chiral compound has the structure shown in formula I;R 1 It is selected from one of C1-C8 alkyl, C1-C8 alkoxy, C1-C20 aryloxy.R 2 It is selected from one of hydrogen, fluorine, methyl, ethyl, methoxy, ester group, nitro group, phenyl, benzyl, tert-butyl, isopropyl.The application can effectively synthesize plane chiral boronic acid catalyst based on cycloaralkane skeleton, and the plane chiral boronic acid catalyst based on cycloaralkane skeleton can realize diol desymmetrization reaction.

The utility model relates to the technical field of aniline production through nitrobenzene hydrogenation, in particular to a safe feeding system of a solid-liquid two-phase reaction kettle in chemical production. The safe feeding system for the solid-liquid two-phase reaction kettle in chemical production comprises a reaction kettle and a membrane filter, the membrane filter is connected with a water removal tower through an activated carbon adsorption tower, the water removal tower is connected with the reaction kettle through a pre-heater, the reaction kettle is connected with a distillation tower through a gas-liquid separator, the distillation tower is connected with a storage tank through a rectifying tower, and the storage tank is connected with a gas-liquid separator. A temperature control sleeve is arranged on the outer side of the reaction kettle, a high-position cooling liquid storage tank is connected to the temperature control sleeve, and a liquid phase feeding tank is connected to the reaction kettle. According to the system, hydrogen is subjected to multi-stage filtration and impurity removal through the membrane filter, the activated carbon adsorption tower and the water removal tower, and impurities and water in the hydrogen are removed; and the hydrogen is preheated by the pre-heater to reach a proper reaction temperature, so that the production quality and efficiency are improved.

This invention relates to a method for the liquid-phase adsorption separation and purification of 2,3-dichloronitrobenzene and 3,4-dichloronitrobenzene, belonging to the field of chemical separation. This method for the simultaneous separation and purification of 2,3-dichloronitrobenzene and 3,4-dichloronitrobenzene involves preparing small spherical molecular sieve adsorbents from USY molecular sieves, silicon coupling agent-modified illite, and biomass polysaccharides, which are then loaded into a countercurrent simulated moving bed for separation and purification. This method can simultaneously obtain 2,3-dichloronitrobenzene and 3,4-dichloronitrobenzene with a purity ≥99%. The separation and purification method adopted in this invention is not only energy-efficient and highly effective, but also enables continuous production of two high-purity dichloronitrobenzenes, possessing significant industrial application value.

The invention relates to a preparation method and application of a bimetallic catalyst resistant to CO poisoning. The catalyst comprises the following components in percentage by weight: 0.5% of Pt, 0.5% of Ru and 99% of TiO2. The bimetallic PtRu / TiO2 catalyst resistant to CO poisoning is developed by using an isovolumetric-co-impregnation method through a lattice matching induced epitaxial growth strategy, the electronic structure of the catalyst can be adjusted, the CO poisoning resistance of the catalyst can be effectively enhanced, and the bimetallic PtRu / TiO2 catalyst still shows excellent nitrobenzene hydrogenation performance under the conditions that the temperature is 35 DEG C and the CO content is 5000 ppm. The catalyst has the advantages of simple and easy synthesis process, mild preparation conditions, easy industrial amplification production, and wide application prospects.

The application discloses a fluorescence analysis system for specific response to p-nitrophenol based on gold nanoclusters AuNCs@CFP, 200 muL of gold nanoclusters AuNCs@CFP, 500 muL of PB buffer solution with pH=10 and to-be-detected p-nitrophenol are diluted to 4 mL, the fluorescence intensity of the mixture is determined at an excitation wavelength of 334 nm after reaction at 45 DEG C for 50 min, the concentration of the to-be-detected p-nitrophenol is calculated according to the determined fluorescence intensity and a regression equation, the linear concentration range of the p-nitrophenol is 1.25-40 muM, the regression equation is F0 / F i =0.0258C+1.0003, F0 and F i are the fluorescence intensities of the mixture before and after the addition of the p-nitrophenol respectively, the correlation coefficient R 2 =0.9922, the detection limit LOD is 1.92 muM, the concentration of the p-nitrophenol is 25 muM, the relative standard deviation RSD is 1.13% in 11 repeated determinations. The preparation method of the gold nanoclusters AuNCs@CFP in the application is simple and easy to synthesize, and the fluorescence performance of the gold nanoclusters AuNCs@CFP is excellent.

The invention discloses a flavonol-based fluorescent probe for continuously detecting hydrogen sulfide and hypochlorous acid as well as a preparation method and application of the flavonol-based fluorescent probe. The flavonol-based fluorescent probe is 3-(2, 4-dinitrophenoxy)-7-(4-(diphenylamino) phenyl)-2-(4-(thiomorpholinophenyl) chromone, and the structural formula of the flavonol-based fluorescent probe is shown in the specification. According to the invention, 7-(4-(diphenylamino) phenyl)-3-hydroxy-2-(4-thiomorpholinophenyl) chromone is used as an initial raw material, and the 7-(4-(diphenylamino) phenyl)-3-hydroxy-2-(4-thiomorpholinophenyl) chromone and 2, 4-dinitrofluorobenzene are subjected to nucleophilic substitution reaction to obtain the compound 3-(2, 4-dinitrophenoxy)-7-(4-(diphenylamino) phenyl)-2-(4-(thiomorpholinophenyl) chromone. The compound is firstly subjected to selective thiolysis reaction under the action of hydrogen sulfide, the fluorescence color of a solution of the compound is changed from colorless to bright orange under the irradiation of ultraviolet light with the wavelength of 365 nm, then hypochlorous acid is continuously added into the solution, and the compound can be further subjected to specific oxidation reaction with the hypochlorous acid, so that the compound can be obtained. And the fluorescence color of the solution is changed from bright orange to bright cyan. Therefore, the compound can be used as a fluorescent probe for continuously detecting hydrogen sulfide and hypochlorous acid, has the advantages of low detection limit, high response speed, good light stability, wide pH application range and the like, and shows a good application prospect.

This invention discloses a novel method for preparing a clean fuel additive, relating to the field of clean fuel additive technology. Its components include: a main cleaning agent: Mannich base; a dispersant: polyetheramine; a surfactant: highly active polyisobutylene; an antioxidant: N,N-di-sec-butyl-p-phenylenediamine; an octane booster: dimethyl carbonate; a solvent: 120# solvent oil; a combustion improver: C9-C11 mixed olefins; a stabilizer: trimethylolpropane; an ignition promoter: nitrobenzene; and auxiliary additives: n-dodecane, sodium polystyrene sulfonate, and eugenol methyl ether. This invention achieves a significant synergistic effect among the core components such as Mannich base, polyetheramine, polyisobutylene, amine antioxidants, and dimethyl carbonate. This synergistic effect allows the additive to comprehensively optimize the cleanliness, anti-knock properties, stability, and combustion efficiency of fuel at a relatively low total addition amount.