The invention relates to the field of refinement methods of compounds, and particularly relates to a refinement technique of fluorometholone. The refinement method is characterized by comprising the following particular technical steps of (1), dissolving 100g of fluorometholone crude product in 400mL to 500mL of one or several of
amide organic solvents, agitating and heating an obtained first mixture to 80 to 90 DEG C, and maintaining the temperature for 0.5h; (2), slowly adding 1L to 2L of
alcohol solvent, maintaining a temperature in an interval of 60 to 75 DEG C in an entire addition process, after the addition is completed, maintaining temperature for 0.5h, then decreasing the temperature to 0 to 5 DEG C, maintaining the second mixture at 0 to 5 DEG C to crystallize the second mixture for 12h; (3), filtering and
drying an obtained third mixture to obtain 25g to 33g of similarly white
crystal fluorometholone refined product. The
mass concentration of the fluorometholone crude product in the step (1) is 97 to 98 percent. By using the refinement method, the
impurity problem in the refinement of the fluorometholone is solved; not only is a related substance of the fluorometholone enabled to completely meet requirements in the British
Pharmacopoeia BP2008 and the United States
Pharmacopoeia USP36, that is, the purity is more than 99 percent, and a single
impurity is less than 0.5 percent, but also a known single
impurity can be guaranteed to be less than 0.15 percent, the total impurity can be guaranteed to be less than 0.1 percent; the great improvement is achieved compared with the requirements in the Pharmacopoeias.