A production process of a water soluble ginkgo leaf extract comprises the following steps of pulverizing ginkgo leaf, and extracting with ethanol for 2-4 times to obtain concentrated solution I; diluting with purified water, filtering to obtain medicinal liquid II, washing the residue with purified water for several times, filtering the supernatant to obtain medicinal liquid III, mixing with the medicinal liquid II, diluting with water, and filtering to obtain clear medicinal liquid IV; adsorbing with macroporous adsorptive resin, pre-washing with purified water or ethanol, and eluting with ethanol to obtain medicinal liquid V; concentrating the medicinal liquid V to obtain alcohol-free concentrated extract VI; extracting the concentrated extract VI with ethanol for 2-4 times, filtering, and concentrating the filtrate to obtain concentrated extract VII; or alternatively completely dissolving conventional ginkgo leaf extract in ethanol, recovering ethanol to obtain concentrated extract, extracting with ethanol for 2-4 times, filtering, and concentrating the filtrate to obtain concentrated extract VII; and extracting the concentrated extract VII with purified water for 2-4 times, cooling the extractive solution, filtering, concentrating, and drying to obtain the water soluble ginkgo leaf extract. The inventive production process has the advantages of simple process, stable product quality, and good economic benefit.