Production process of water soluble ginkgo leaf extractive

Abstract

A production process of a water soluble ginkgo leaf extract comprises the following steps of pulverizing ginkgo leaf, and extracting with ethanol for 2-4 times to obtain concentrated solution I; diluting with purified water, filtering to obtain medicinal liquid II, washing the residue with purified water for several times, filtering the supernatant to obtain medicinal liquid III, mixing with the medicinal liquid II, diluting with water, and filtering to obtain clear medicinal liquid IV; adsorbing with macroporous adsorptive resin, pre-washing with purified water or ethanol, and eluting with ethanol to obtain medicinal liquid V; concentrating the medicinal liquid V to obtain alcohol-free concentrated extract VI; extracting the concentrated extract VI with ethanol for 2-4 times, filtering, and concentrating the filtrate to obtain concentrated extract VII; or alternatively completely dissolving conventional ginkgo leaf extract in ethanol, recovering ethanol to obtain concentrated extract, extracting with ethanol for 2-4 times, filtering, and concentrating the filtrate to obtain concentrated extract VII; and extracting the concentrated extract VII with purified water for 2-4 times, cooling the extractive solution, filtering, concentrating, and drying to obtain the water soluble ginkgo leaf extract. The inventive production process has the advantages of simple process, stable product quality, and good economic benefit.

Description

technical field [0001] The invention relates to a production process of water-soluble ginkgo leaf extract, which belongs to the technical field of traditional Chinese medicine preparations. Background technique [0002] Cardiovascular and cerebrovascular system diseases are one of the most common clinical diseases and a major class of diseases that affect people's health and longevity. Due to the remarkable effect of ginkgo biloba preparations in the field of treatment of such diseases, it has been more and more valued and favored by people all over the world, and has gradually become an evergreen tree in the preparation market in this field. With the interpenetration of new technology of preparation and the modernization of traditional Chinese medicine, ginkgo biloba preparations have developed from traditional dosage forms such as pills, tablets, granules and capsules to oral liquid preparations, injections and entered a new stage of sustained and controlled release and ta...

AI Technical Summary

Problems solved by technology

This kind of water-soluble ginkgo leaf extract was originally a fat-soluble ginkgo leaf extract. Due to the addition of organic or inorganic co-solvents, the water solubility has been improved, but the active ingredient ginkgolide has serious loss and damage, which affects the pH of the material. impact, and the added co-solvent has a certain impact on the safety and applicability of the preparation, and there are serious restrictions on use