Production process of water soluble ginkgo leaf extractive

A production process, ginkgo leaf technology, applied in the production process field of water-soluble ginkgo leaf extract, can solve the problems of preparation safety and applicability, loss of active ingredient ginkgolide, material pH, etc., to achieve high quality and safety of products , Optimizing the content of active ingredients and excellent product quality

Inactive Publication Date: 2008-09-03
ZHEJIANG CONBA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This kind of water-soluble ginkgo leaf extract was originally a fat-soluble ginkgo leaf extract. Due to the addition of organic or inorganic co-solvents, the water solubility has been improved, but the active ingredient gin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0029] Preparation of water-soluble Ginkgo biloba extract with Ginkgo biloba as raw material:

[0030] (1) Ginkgo biloba leaves with flavonoid content ≥ 0.6%, total lactone content ≥ 0.25%, and water content ≤ 10% are crushed to a size of about 1 cm 2 , with a concentration of 85% ethanol immersion extraction for 3 times, 3 hours for the first time, 2 hours each time for the second and third times; the amount of extraction solvent is: 5 times the amount of medicinal materials for the first time, 3 times the amount of medicinal materials for the second and third times. The extracts were combined, filtered and concentrated to obtain concentrated solution I.

[0031] (2) Dilute the above-mentioned concentrated solution I with purified water to form a drug solution with a crude drug ratio of 0.5 g / ml, let it stand for 24 hours, filter to obtain the drug solution II, and wash the filter residue repeatedly with purified water, stand still, and the supernatant The filtered medicinal...

example 2

[0037] Preparation of water-soluble Ginkgo biloba extract with common Ginkgo biloba extract as raw material:

[0038] (1) Common Ginkgo biloba extract with flavonoid content ≥ 22%, total lactone content ≥ 6.5%, bilobalide ≥ 2.8%, ginkgolide B ≥ 0.8%, and total ginkgolic acid content < 1ppm is 70% After the ethanol is fully dissolved, the ethanol is recovered to a thick paste, and an appropriate amount of 90% ethanol is added, and the extracts are combined after extraction for 4 times, and the extracts are left to stand at 0-10°C for 24 hours, and the filtrate is filtered and then concentrated to a thick paste VII;

[0039] (2) Heat and extract the thick paste VII with purified water 4 times, cool the extract to 0-10°C, let it stand for 72 hours, filter, and distill the filtrate in 12-13m 3 / h passes through the nanofiltration membrane, controls the temperature in the range of 25-35°C, controls the flow rate of the permeate to 500L / h, concentrates into a thick paste, and dries ...

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PUM

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Abstract

A production process of a water soluble ginkgo leaf extract comprises the following steps of pulverizing ginkgo leaf, and extracting with ethanol for 2-4 times to obtain concentrated solution I; diluting with purified water, filtering to obtain medicinal liquid II, washing the residue with purified water for several times, filtering the supernatant to obtain medicinal liquid III, mixing with the medicinal liquid II, diluting with water, and filtering to obtain clear medicinal liquid IV; adsorbing with macroporous adsorptive resin, pre-washing with purified water or ethanol, and eluting with ethanol to obtain medicinal liquid V; concentrating the medicinal liquid V to obtain alcohol-free concentrated extract VI; extracting the concentrated extract VI with ethanol for 2-4 times, filtering, and concentrating the filtrate to obtain concentrated extract VII; or alternatively completely dissolving conventional ginkgo leaf extract in ethanol, recovering ethanol to obtain concentrated extract, extracting with ethanol for 2-4 times, filtering, and concentrating the filtrate to obtain concentrated extract VII; and extracting the concentrated extract VII with purified water for 2-4 times, cooling the extractive solution, filtering, concentrating, and drying to obtain the water soluble ginkgo leaf extract. The inventive production process has the advantages of simple process, stable product quality, and good economic benefit.

Description

technical field [0001] The invention relates to a production process of water-soluble ginkgo leaf extract, which belongs to the technical field of traditional Chinese medicine preparations. Background technique [0002] Cardiovascular and cerebrovascular system diseases are one of the most common clinical diseases and a major class of diseases that affect people's health and longevity. Due to the remarkable effect of ginkgo biloba preparations in the field of treatment of such diseases, it has been more and more valued and favored by people all over the world, and has gradually become an evergreen tree in the preparation market in this field. With the interpenetration of new technology of preparation and the modernization of traditional Chinese medicine, ginkgo biloba preparations have developed from traditional dosage forms such as pills, tablets, granules and capsules to oral liquid preparations, injections and entered a new stage of sustained and controlled release and ta...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61P9/00
Inventor 胡季强鲍建伟姚德中张兰兴
Owner ZHEJIANG CONBA PHARMA
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