Method for extracting campherol from ginkgo by subcritical water technology

Abstract

The invention provides a method for extracting campherol from ginkgo by a subcritical water technology. The method comprises the following steps of crushing the ginkgo; performing extraction for 2 to4 times by butyl cellosolve to obtain concentration solution I; adding purified water into the concentration solution I for dilution; performing filtering to obtain medicine liquid II; then, repeatedly washing filter slag by the purified water for many times; filtering liquid supernatant to obtain medicine liquid III to be merged with the medicine liquid II; adding water for dilution; performing filtering to obtain clarified medicine liquid IV; adsorbing the medicine liquid IV by macroporous resin; preforming pre-washing by purified water or butyl cellosolve; then, performing elution by the butyl cellosolve to obtain medicine liquid V; concentrating the medicine liquid V to obtain alcohol-free thick paste VI; taking the thick paste VI; adding the butyl cellosolve for extraction for 2 to 4times; after the filtering, concentrating filter liquid into thick paste VII; sufficiently dissolving ordinary ginkgo campherol by butyl cellosolve; then recovering the butyl cellosolve to thick paste; then, adding a proper amount of butyl cellosolve; performing filtering after the extraction for 2 to 4 times; concentrating the filter liquid to the thick paste VII; extracting the thick paste VII by pure water for 2 to 4 times; cooling and filtering extraction liquid; performing concentration and drying to obtain grease dissolution ginkgo campherol. The production process is simple and convenient; the product quality is stable; the economic benefits are good.

Description

technical field [0001] The invention relates to a method for extracting kaempferen from ginkgo by applying subcritical water technology, and belongs to the technical field of traditional Chinese medicine preparations. Background technique [0002] Cardiovascular and cerebrovascular system diseases are one of the most common clinical diseases and a major class of diseases that affect people's health and longevity. Due to the remarkable effect of ginkgo preparation in the field of treatment of such diseases, it has been more and more valued and favored by people all over the world, and has gradually become an evergreen tree in the preparation market in this field. With the interpenetration of new technology of preparations and the modernization of traditional Chinese medicine, ginkgo preparations have developed from traditional dosage forms such as pills, tablets, granules and capsules to oral liquid preparations, injections and entered a new stage of sustained and controlled ...

AI Technical Summary

Problems solved by technology

This kind of fat-soluble ginkgo naiflavin was originally fat-soluble ginkgo naiflavin. Due to the addition of organic or inorganic co-solvents, the fat solubility has been improved. However, there is serious loss and damage of the active ingredient bilobalide, which affects the pH of the material. impact, and the added co-solvent has a certain impact on the safety and applicability of the preparation, and there are serious restrictions on use