52 results about "Hard Capsule" patented technology

The invention discloses an oral hard capsule health-care product with an anti-aging function as well as a preparation method and application of the oral hard capsule health-care product. The health-care product is mainly prepared from eight active ingredients including EGT (Ergothioneine), Ca-AKG (alpha-ketoglutarate), PQQ (pyrroloquinoline quinone), fisetin, salidroside, urolithin A, spermidine and an apple stem cell extract. Through scientific compatibility of the various components, the composition disclosed by the invention can comprehensively intervene in a cell aging process through a synergistic effect of a plurality of pathways of enhancing the cell antioxidant capacity, improving the mitochondrial function, activating cell autophagy, promoting cell regeneration and repair and the like. The invention also provides a preferred content range of the health-care product, a preparation method of the health-care product and application of the health-care product in preparation of health-care foods for delaying senescence, improving cell viability or improving mitochondrial functions. The product provided by the invention has the characteristics of multiple targets and synergistic interaction, and provides a new effective scheme for anti-aging intervention.

The utility model discloses a hard capsule automatic subpackage and detection integrated equipment relates to capsule technical field, the utility model discloses: vibrating disk and side frame, side frame both ends close to the inside are provided with the ring, the outside of ring is provided with the conveyor belt, the surface of conveyor belt is provided with the mounting block, the mounting block is provided with the vibrating disk, the side frame is provided with the vibrating disk. A receiving box is arranged at the bottom of the side, away from the vibration disc, of the conveying belt, a detection device is arranged at the top of the center of the conveying belt, and a sorting device is arranged on the side, away from the vibration disc, of the detection device. According to the automatic capsule packaging machine, materials are automatically fed to the conveying belt through the vibration disc and detected through the detection device, unqualified capsules are pushed out through the sorting device and fall into the flow guide groove, the capsules which are detected to be qualified continue to be conveyed and finally fall into the material receiving box, the qualified products and the unqualified products are packaged on the basis of the detection function, and the packaging efficiency is improved. The functions of the device are more complete, and the production efficiency is improved.

The present application relates to the technical field of medicine, in particular to a kind of preparation and application of self-microemulsifying composition containing lamotrigine.The self-microemulsifying composition includes lamotrigine and self-microemulsifying drug delivery system (SMEDDS) carrier;The SMEDDS carrier includes: by lamotrigine, oil phase, emulsifier and co-emulsifier;The self-microemulsifying composition, by mass ratio, lamotrigine is 0.1% to 18.7%, oil phase is 20% to 33%, milk phase is 67% to 80%, the milk phase is by emulsifier and co-emulsifier, and the mass ratio of emulsifier and co-emulsifier is 25.7 to 32.9%:67.1% to 74.3%, and the mass concentration of lamotrigine reaches 18.7%.The particle size of microemulsion formed by the self-microemulsifying composition dispersed in aqueous medium is less than 50nm or even smaller.The self-microemulsifying composition is prepared into soft capsule, hard capsule, tablet, granule, temperature-sensitive gel and other dosage forms, and is applied in the preparation of antiepileptic drugs.

The invention relates to the technical field of hard capsule polishing, and discloses an automatic polishing system based on hard capsules and a device thereof. A data acquisition module of the system acquires surface characteristic data such as hard capsule surface roughness, stain distribution, capsule size and the like; the data analysis module receives the data and then obtains a polishing demand analysis result through random forest regression analysis; the optimization module adopts a genetic algorithm to optimize parameters and rules of the polishing controller according to the result; the control module carries out fuzzy logic calculation on the polishing amount through particle swarm optimization according to the optimized parameters and rules and converts the polishing amount into polishing control signals; after the execution module receives the signal, the polishing amount constraint condition is adjusted through a near-end gradient method, and integer programming is conducted on the polishing process in combination with a branch and bound method so as to automatically adjust the polishing amount; and the detection module detects surface characteristic data after polishing through Bayesian filtering and feeds back the processed data to the control, data analysis and optimization module so as to adjust a polishing strategy.

Provided is a hard capsule which does not use gelatin and contains the following components in proportions per dry weight of the capsule: (i) 98.0-99.49 wt% of a water-soluble cellulose ether; (ii) 0.4-1.0 wt% of gellan gum; (iii) 0.1-0.5 wt% of a potassium salt; and (iv) 0.01-0.5 wt% of sorbitan monolaurate. The hard capsule has excellent solubility and mechanical strength, is prevented from generating static electricity, and can be favorably used in the preparation of industrial capsule formulations.

The utility model relates to a hard capsule production line guide rail mould strip sliding damping device belongs to hollow capsule production equipment field, including support, damper mounting plate, moving assembly and damping generating subassembly, the damper mounting plate is installed in one end of support perpendicularly, the outer side of this damper mounting plate is installed with shock pad, the support on the inner side of this damper mounting plate is installed with limit block, connecting rod is along horizontal direction setting, one end of this connecting rod is installed with limit end plate, the other end is sequentially passed through shock pad and damper mounting plate and is connected together with moving assembly, the damping mechanism spring is sleeved on connecting rod. The utility model has the advantages of: on the high -speed production line, the mould strip is in the guide rail sliding speed fast, eliminates the impact force of mould strip, no longer has the noise of impact, solves the mould strip rebound caused by impact simultaneously, eliminates the trouble shutdown caused by the inaccuracy of mould strip rebound positioning, improves production efficiency.

The invention provides a vancomycin hydrochloride-containing pharmaceutical composition and a preparation method thereof, the pharmaceutical composition is prepared from vancomycin hydrochloride, PEG6000 and DL-alpha-tocopherol, nitrogen is continuously introduced in the preparation process of the pharmaceutical composition, the whole pharmaceutical composition has simple auxiliary materials and only two auxiliary materials, and the prepared pharmaceutical composition has low content of related substances and is suitable for clinical application. The vancomycin hydrochloride hard capsule is simple in preparation method, high in stability and low in cost, DL-alpha-tocopherol is adopted as an auxiliary material, the prepared vancomycin hydrochloride hard capsule reduces degradation and oxidation of vancomycin hydrochloride, the problem that vancomycin hydrochloride is poor in stability is solved, and the whole preparation method is simple, convenient to operate and suitable for industrial large-scale production.

The application relates to the technical field of capsule detection, and discloses a visual detection equipment and method based on capsule rejection production, which comprises two parallel rear mounting plates and two parallel front mounting plates, a detection conveying belt is fixedly installed between the two rear mounting plates, a feeding conveying belt is fixedly installed between the two front mounting plates, a detection assembly is arranged on the top of the detection conveying belt, and a feeding assembly is arranged on the top of the feeding conveying belt. Through the arrangement of the detection assembly, the side guide wheel drives the non-deformed hard capsule to rotate along with the conveying of the detection conveying belt, the clamping block on the inner side of the push gear ring further drives the deformed hard capsule to rotate, the stable rotation of the deformed hard capsule can be realized, the deformed area on the outer side of the hard capsule can be rotated to different angles for shooting and image collection, the situation that a single shooting angle cannot detect the defect position can be avoided, the detection software can quickly detect the unqualified hard capsule, and the detection and rejection precision of the hard capsule is improved.

The utility model relates to capsule medicine powder recycling technical field, concretely is a kind of hard capsule medicine powder recycling equipment, including sealing cover, the sealing cover one side abuts with medicine discharge box, the sealing cover side fixedly connected with lifting rod away from medicine discharge box, the sealing cover fixedly connected with suction pipe close to lifting rod side, the inside fixedly connected with locating rod of medicine discharge box close to sealing cover position, the locating rod is symmetrically arranged and there are two groups, retractable slot is set up in the locating rod, the utility model has the beneficial effect that sealing cover and medicine discharge box inside are extracted into vacuum by suction pipe, and the placing groove on the top of placing plate ensures that capsule is stably separated, the effect of quickly opening capsule is realized, after cutting and splitting, the problem that the production cost of capsule is increased is solved, the capsule shell is damaged, so it is necessary to clean medicine powder, and melt and reshape, which leads to the problem of high production cost of capsule, and production cost is reduced.

The invention provides a full-automatic hard capsule filling device and method, and belongs to the technical field of medical equipment.The full-automatic hard capsule filling device comprises a capsule feeding and separating system, a capsule transferring system, a medicament filling system, a waste removing system, a capsule closing system and a discharged material collecting system.The medicament filling system comprises a base and a driving device installed in the base; a metering panel fixedly connected with a rotating shaft of the driving device is arranged on the base, the metering panel is of a hollow structure with an opening in the top, the driving device is used for driving the metering panel to rotate, a scraping system is arranged in the metering panel, and the scraping system is coaxially and rotatably connected with the metering panel through a turning rotating device; according to the scheme, the scraping system capable of rotating reversely is integrated in the metering panel, so that the effects of continuously and uniformly supplementing the medicament to each metering hole and scraping the surface in the multi-stroke compaction process are achieved, and the variation of the filling dose caused by non-uniform medicament accumulation thickness or local collapse is effectively avoided.

The invention discloses double layered delayed-release hard capsules made by double dipping, that is by two consecutive dip molding steps on the same mold pin without removing the film, provided by the first dip molding step, from the mold pin between the two dip molding steps, but dipping the mold pin with this first film in the second dip molding step, each dip molding step is done with a different polymer melt, providing a double layered delayed-release capsule.

The invention discloses a double-bin liquid-filled hard capsule and a preparation method and application thereof in the field of pharmaceutical preparations, and the preparation method comprises the following steps: firstly, respectively preparing an inner capsule shell film forming solution and an outer capsule shell film forming solution containing specific functional compounds, and preparing a capsule shell through die dipping and multi-stage drying; the preparation method comprises the following steps: filling an inner capsule with active ingredients, sealing, suspending the inner capsule in an outer capsule filled with an oily medium, sealing the outer capsule by adopting a sealant containing a functional compound in combination with a laser technology, and carrying out vacuum leak detection and optional coating processes to obtain a finished product. The double-bin structure can effectively isolate incompatible components, precise space-time controlled release is achieved through collaborative design of inner and outer capsule materials, and the stability and bioavailability of sensitive components are remarkably improved. The capsule can be used for preparing oral sustained-release medicines or functional foods.

The utility model provides a glue dissolving device for hard capsule production, which comprises a glue dissolving box supported on the ground through a support frame, the top end of the glue dissolving box is connected with a top cover, the top end of the top cover is provided with a cutting table, the inner wall of the cutting table is provided with a cutting net plate, and the inner walls of the two sides of the cutting table are connected with a central shaft in a relatively rotating manner; one ends of the two center shafts are rotationally connected with each other, the center shafts are located below the dividing net plate, the side walls of the center shafts are connected with sealing plates, the sealing plates are in contact fit with the inner wall of the dividing table, the top end of the dividing table is connected with guide columns, and the outer walls of the multiple guide columns are slidably connected with the same connecting plate; the outer wall of the bottom end of the connecting plate is connected with a pressing plate. According to the gelatin dissolving device for hard capsule production, the central shaft and the closing plate are arranged, communication between the cutting table and the gelatin dissolving box is closed, and heat is prevented from being dissipated from the cutting table during heating.

The invention discloses a capsule stripping mechanism for a full-automatic hard capsule production line, which comprises a transmission case, a plurality of rotating shafts are connected to the transmission case, the plurality of rotating shafts are horizontally arranged at fixed intervals, the transmission case drives the plurality of rotating shafts to synchronously rotate according to a fixed rotating angle, and the tail ends of the rotating shafts are coaxially connected with stripping execution units. And the rotating shaft drives the stripping execution unit to rotate to tangentially extrude the mold needle of the mold coated with the molded capsule, so that the molded capsule is separated from the mold needle under the action of friction force. A plurality of independent mold needles of a single-row-needle mold or a double-row-needle mold can be tangentially and rotationally extruded at the same time in a limited space, the single mold needle is tangentially extruded from the two sides at the same time, stress is uniform, the single mold needle is not damaged, and the problem that in the full-automatic hard capsule production process, the production efficiency is high is solved. The problem that the capsule is not easy to separate from the mold due to the fact that the molded capsule wraps the mold needle too tightly is solved, and the requirement that demolding is easier under the standard free oil content is met.

This utility model discloses a fully automatic hard capsule filling machine for capsule preparation, including a frame. The frame is equipped with a material hopper for storing drug powder. A discharge pipe is located at the bottom of the material hopper, and a discharge turntable is located inside the discharge pipe. The discharge turntable has multiple metering grooves arranged along its axial direction. A receiving plate, which is in close contact with the surface of the discharge turntable, is fixed to the discharge pipe via a positioning frame. The receiving plate has receiving ports corresponding to the metering grooves, and a vertically arranged receiving pipe is located at the bottom of each receiving port. The frame is equipped with an injection pipe for injecting powdered drugs into hard capsules. This utility model ensures consistent drug delivery each time, guaranteeing accuracy and consistency, and can simultaneously fill multiple capsules, thus achieving high work efficiency.

The application discloses a transparent partially deacylated gellan gum and a preparation method thereof, and belongs to the technical field of post-processing of gellan gum fermentation liquor. The method comprises the following steps: diluting high-acyl gellan gum fermentation liquor to a polysaccharide content of 0.8-1.1%; adding sorbitol and buffer salt to adjust the pH to alkaline, adding lysozyme and protease to remove bacteria, proteins and to perform mild partial deacylation; adjusting the pH to terminate the deacylation, then reducing the viscosity at high temperature, and removing insoluble impurities through high-temperature and high-speed centrifugation; adding low-level alcohol to flocculate after the temperature is lowered and the pH is adjusted, and the finished product is obtained through solid-liquid separation, drying and crushing. The application solves the problem of clarification caused by high viscosity and high gel temperature, the prepared product has good transparency, a gel temperature of 50-60 DEG C, excellent gel elasticity, stable performance, and can be widely applied to food, daily chemical and pharmaceutical fields such as plant soft and hard capsules with high requirements on transparency, and fills the blank of commercial production of transparent partially deacylated gellan gum.

The present invention addresses the problem of providing a hard capsule that can be used in a health food and has higher acid resistance. The problem is solved by an acid-resistant hard capsule comprising a capsule shell, in which the capsule shell contains hydroxypropyl methylcellulose having a viscosity value of 15 mPa s or more and gellan gum.

The invention belongs to the technical field of medical equipment, and discloses a medicine filling mechanism of a full-automatic hard capsule filling machine, which comprises a rack, and the top of the rack is provided with a feed hopper for conveying medicines; the operation table is arranged on the rack; the filling mechanism is arranged at the bottom of the feeding hopper to fill medicine; and an adjusting mechanism. Through rotation of a mounting block, a first collecting groove and a filtering plate can be rotationally switched, medicine scattered during medicine filling can be conveniently filtered and collected, the medicine around the first collecting groove is scraped into the first collecting groove through the action of a scraping block, and the medicine is prevented from being scattered on the mounting block during filling; and then the metering hole is cleaned through the moving structure, and the situation that in the capsule medicine powder filling process, medicine powder is blocked at the filling opening, waste of the medicine powder is caused, and the medicine filling efficiency is affected is prevented.

The utility model provides a capsule forming machine for western medicine preparation. The capsule forming machine for western medicine preparation comprises a supporting frame; the forming table is fixedly connected to the top of the supporting frame, a driving assembly is installed at the bottom of the forming table, a rotating disc is installed at the output end of the driving assembly, and shaping molds are installed at the positions, close to the four directions, of the top of the rotating disc through fixing frames; and the mounting frame is fixedly connected to the top of the forming table, a second telescopic rod is mounted at the top of the mounting frame, a movable plate is fixedly connected to the telescopic end of the second telescopic rod, and two stabilizing rods are fixedly connected to the position, close to the back face, of the top of the movable plate. According to the capsule forming machine for western medicine preparation, through the structure, the hard capsule forming machine for western medicine preparation can prepare hard capsules in an assembly line mode, meanwhile, demolding is assisted through the demolding frame, and the preparation efficiency is improved.

An object of the present invention is to provide a hard capsule shell using calcium carbonate and having higher light-shielding ability. A hard capsule comprising a shell containing a cellulose compound and a light-shielding agent, wherein the light-shielding agent contains calcium carbonate having a median diameter by volume of 0.7 µm to 3.8 µm, and the content of the light-shielding agent in the shell is 3 to 20 mass% when the total of shell components of the hard capsule excluding moisture is set to 100 mass%.

The invention discloses a raw material crushing and recycling device for hard capsule production, comprising: a support structure comprising a support frame; the cutting structure comprises a cutting cylinder, and a feeding pipe communicating the inside and the outside is fixedly connected to the side wall of the cutting cylinder; the smashing structure comprises a rectangular shell fixedly connected to the supporting frame, a feeding opening corresponding to the guide hopper is formed in the side wall of the rectangular shell, and a second rotating shaft is rotationally connected into the rectangular shell; the driving mechanism comprises a driving motor fixedly connected to the supporting frame. Through organic combination of the L-shaped cutting blade, two-stage material guiding and filtering, the crushing cavity with the material guiding plate, the liftable vibrating screen plate and single-motor double-belt synchronous transmission, the problems of poor uniformity, discontinuous recovery, loose structure and the like in the background technology are creatively solved; the invention provides a hard capsule raw material treatment device which is efficient, energy-saving, high in recovery rate and continuous in operation.

The utility model relates to a hard capsule filling mechanism, in particular to a hard capsule filling mechanism suitable for pasty fluid, which comprises a hopper and a dosage control assembly, the hopper is provided with a material storage cavity, the material storage cavity is communicated with a feeding cavity, the dosage control assembly comprises a valve rod and a valve core, the valve rod is arranged in a fixed cavity in a front-back moving mode, and the valve core is arranged in the fixed cavity. The valve element rotates to be switched between a feeding state and a discharging state, a feeding port and a discharging port are formed in the valve element in the circumferential direction of the rotating axis, a movable cavity is communicated between the feeding port and the discharging port, when the valve element is in the feeding state, the feeding port is communicated with the feeding cavity, the discharging port is communicated with the fixed cavity, and when the valve element is in the discharging state, the movable cavity is communicated with the fixed cavity. The feeding port is communicated with the fixed cavity, the discharging port is communicated with the discharging cavity, the feeding cavity, the fixed cavity and the discharging cavity are arranged at intervals in the circumferential direction of the rotating axis of the valve element, the dosage cavity is divided into the movable cavity and the fixed cavity, the valve element rotates to drive the movable cavity to conduct feeding and discharging, the valve rod is movably matched in the fixed cavity, and the paste sucking and extruding device is suitable for sucking and extruding paste.

The application belongs to the technical field of capsule packaging, and particularly discloses a liquid-filled hard capsule filling and sealing method and system, which comprises the following steps: separating a capsule body from a capsule cap, filling a material into the capsule body, and filling inert gas into the capsule cap, wherein the material at least contains liquid; sleeving the capsule cap and the capsule body obtained in step S1 to obtain a liquid-filled capsule; injecting glue into a sleeving gap, applying pressure to the liquid-filled capsule, using negative pressure to fill the glue into the sleeving gap, and then heating the sleeving gap to realize sealing. The application can realize efficient cleaning and packaging of a large number of hard capsules and make the packaged capsules have better sealing performance.

The utility model belongs to the technical field of crushing devices, and particularly relates to a crushing device for producing hard capsules, which comprises a machine table, a cylinder is fixedly connected to the upper end of the machine table, and a round roller is rotatably connected to the inside of the cylinder; the through groove plays a role in slowly releasing the hard capsule particle raw materials in the hopper, the crushed hard capsule particle raw materials wriggle into the discharging channel along with rotation of the spiral cutter, and the hard capsule particle raw materials slowly enter the cylinder in the hopper through the slow release effect of the permeation groove on the hard capsule particle raw materials. Hard capsule particle raw materials entering the cylinder are rapidly crushed by the spiral cutter, the hard capsule particle raw materials conveyed by the hopper can be continuously crushed after the crushed hard capsule particle raw materials in the cylinder are emptied from the discharging channel, and the procedures of feeding, crushing, discharging and the like can be continuously executed in sequence. The problem that the working efficiency is reduced due to the fact that an existing crushing device is long in hard capsule particle crushing time is solved.

The invention relates to the technical field of oral sustained-release preparations, in particular to an oil-based protective hard capsule containing sustained-release pellets and a preparation method of the oil-based protective hard capsule. The preparation method comprises the following steps: firstly, preparing a capsule shell: dissolving hydroxypropyl methylcellulose, carrageenan, gellan gum and lauryl sodium sulfate in hot water in stages, aging to obtain a glue solution, dipping the glue solution, drying and cutting to obtain a primary capsule body; secondly, adding hydrophobic modified silica gel nanoparticles and a temperature response type copolymer into linseed oil to form a suspension; preparing an active drug and a sustained-release auxiliary material into a pellet core, and coating to obtain a sustained-release pellet; and finally, filling the sustained-release pellets into a capsule lower shell, filling the suspension, covering the capsule upper shell, sealing by adopting a hydroxypropyl methylcellulose solution, and heating and curing by hot air. The obtained capsule can be used for oral sustained-release medicines or functional foods after leakage detection and sterilization; liquid-solid split charging is achieved, the drug release behavior can be effectively controlled, the stability is improved, and good application prospects are achieved.

A multilayered enteric hard capsule consisting of a first layer having no enteric properties and a second layer of a hard capsule having enteric properties is provided. The multilayered enteric hard capsule comprising a cap portion and a body portion, the cap portion and the body portion each consisting of a capsule shell comprising at least a first layer and a second layer in whole or in part, wherein the first layer contains a water-soluble base, the second layer contains an enteric polymer, and the second layer coats an outside of the first layer in whole or in part.

The utility model provides an automatic filling mechanism for hard capsule medicines, which comprises a belt transmission mechanism, a support column is arranged at the top of the belt transmission mechanism, a feed hopper is fixedly connected onto the support column, and the bottom of the feed hopper is respectively communicated with a first discharge port and a second discharge port which are arranged opposite to the belt transmission mechanism through communication ports. The second discharging port and the first discharging port are each provided with an electric valve for controlling the second discharging port and the first discharging port to communicate with the communicating port, the belt transmission mechanism is provided with a position sensor in signal connection with the electric valves, the containing groove is detachably placed on the belt transmission mechanism, the containing groove is detachably connected with a containing disc, and the containing disc is detachably connected with the belt transmission mechanism. The first discharging opening and the second discharging opening are arranged right opposite to the containing disc, and the second discharging opening is fixedly connected with a scraping plate capable of being attached to the top of the containing disc. The automatic filling mechanism for the hard capsule medicine can play a role in ensuring that raw materials in a plurality of capsule shells on the placing disc are more uniform and sufficient.

The utility model belongs to the technical field of hard capsule production, and mainly relates to an automatic felt filling machine which comprises a rotary table mechanism, and a feeding assembly, a waste push-out assembly, a first filling assembly, a second filling assembly and a receiving assembly are sequentially arranged on the periphery of the rotary table mechanism. The feeding assembly is used for feeding an oiling pipe onto the rotating disc mechanism, the rotating disc mechanism is used for driving the oiling pipe to rotate in the circumferential direction, the waste pushing-out assembly is used for pushing out old felt in the oiling pipe, the first filling assembly and the second filling assembly are used for pushing new felt into the oiling pipe, and the receiving assembly is used for collecting the oiling pipe filled with the new felt. In the rotating process of the rotating disc mechanism, through operation of the feeding assembly, the waste pushing-out assembly, the first filling assembly, the second filling assembly and the receiving assembly in sequence, replacement and filling of two kinds of felts in the oiling pipe are completed, the problem that the replacement process of the felts in the oiling pipe is tedious is solved, and the production efficiency is improved.

A TiO2 free hard capsule shell including a water-soluble film forming compound selected from the group consisting of a water-soluble cellulose compound and gelatin. The shell optionally contains a gelling agent and / or a gelling aid. The capsule shell further includes ZnO, and CaCO3, wherein ZnO and CaCO3 are in a suitable amount to provide a white color to the film. A TiO2 free suspension for preparing the hard capsule and a capsule product comprising the TiO2 free hard capsule filled with a formulation comprising an active ingredient.

This invention discloses a method for preparing a pollen and carotenoid composition and its application. The composition is prepared using the following raw materials in parts by weight: 100-10000 parts bee pollen and 0.1-100 parts carotenoids. The carotenoid crystals are then processed into carotenoid microcapsule powder using food colloids or similar methods at 50-70°C. The bee pollen and carotenoid microcapsule powder can be directly mixed to prepare solid beverages, hard capsules, etc.; alternatively, bee pollen can be granulated by adding 5-10% povidone solution, then mixed with the microcapsule powder raw material and excipients, and prepared into tablets under 5-15 kN pressure. The product obtained by this invention exhibits significantly improved storage and delivery stability in the combined application of carotenoid and pollen raw materials, effectively improving and expanding the application scenarios and synergistic effects of the two functional raw materials. It is suitable for the industrial production and functional creation applications of these two related raw materials.