83 results about "Hard Capsule" patented technology

The invention discloses an oral hard capsule health-care product with an anti-aging function as well as a preparation method and application of the oral hard capsule health-care product. The health-care product is mainly prepared from eight active ingredients including EGT (Ergothioneine), Ca-AKG (alpha-ketoglutarate), PQQ (pyrroloquinoline quinone), fisetin, salidroside, urolithin A, spermidine and an apple stem cell extract. Through scientific compatibility of the various components, the composition disclosed by the invention can comprehensively intervene in a cell aging process through a synergistic effect of a plurality of pathways of enhancing the cell antioxidant capacity, improving the mitochondrial function, activating cell autophagy, promoting cell regeneration and repair and the like. The invention also provides a preferred content range of the health-care product, a preparation method of the health-care product and application of the health-care product in preparation of health-care foods for delaying senescence, improving cell viability or improving mitochondrial functions. The product provided by the invention has the characteristics of multiple targets and synergistic interaction, and provides a new effective scheme for anti-aging intervention.

The utility model discloses a hard capsule automatic subpackage and detection integrated equipment relates to capsule technical field, the utility model discloses: vibrating disk and side frame, side frame both ends close to the inside are provided with the ring, the outside of ring is provided with the conveyor belt, the surface of conveyor belt is provided with the mounting block, the mounting block is provided with the vibrating disk, the side frame is provided with the vibrating disk. A receiving box is arranged at the bottom of the side, away from the vibration disc, of the conveying belt, a detection device is arranged at the top of the center of the conveying belt, and a sorting device is arranged on the side, away from the vibration disc, of the detection device. According to the automatic capsule packaging machine, materials are automatically fed to the conveying belt through the vibration disc and detected through the detection device, unqualified capsules are pushed out through the sorting device and fall into the flow guide groove, the capsules which are detected to be qualified continue to be conveyed and finally fall into the material receiving box, the qualified products and the unqualified products are packaged on the basis of the detection function, and the packaging efficiency is improved. The functions of the device are more complete, and the production efficiency is improved.

The present application relates to the technical field of medicine, in particular to a kind of preparation and application of self-microemulsifying composition containing lamotrigine.The self-microemulsifying composition includes lamotrigine and self-microemulsifying drug delivery system (SMEDDS) carrier;The SMEDDS carrier includes: by lamotrigine, oil phase, emulsifier and co-emulsifier;The self-microemulsifying composition, by mass ratio, lamotrigine is 0.1% to 18.7%, oil phase is 20% to 33%, milk phase is 67% to 80%, the milk phase is by emulsifier and co-emulsifier, and the mass ratio of emulsifier and co-emulsifier is 25.7 to 32.9%:67.1% to 74.3%, and the mass concentration of lamotrigine reaches 18.7%.The particle size of microemulsion formed by the self-microemulsifying composition dispersed in aqueous medium is less than 50nm or even smaller.The self-microemulsifying composition is prepared into soft capsule, hard capsule, tablet, granule, temperature-sensitive gel and other dosage forms, and is applied in the preparation of antiepileptic drugs.

The invention relates to the technical field of medical drugs, and particularly discloses a honeysuckle flower and mango capsule and a preparation method thereof. The honeysuckle flower and mango capsule comprises a medicine-containing core material and a plant capsule shell, the medicine-containing core material comprises the following raw materials: a medicine extraction composition, a filling agent and an adhesive. The medicine extraction composition is prepared by adopting a specific extraction method, effective components in all plants can be rapidly extracted through reflux extraction and decoction extraction, damage to the effective components is reduced, and the extraction efficiency is high; and effective components in the raw materials are extracted more thoroughly through a percolation method, so that the purity and quality of the extract are improved. The medicine-containing core material further comprises a filling agent and an adhesive besides the medicine extraction composition, the stability of effective components in the medicine extraction composition can be improved, continuous and stable release of the medicine effective components is guaranteed, and the treatment effect of the honeysuckle flower and mango capsule is improved. The plant capsule shell is selected as a hard capsule and is not easily polluted by microorganisms, so that the stability of the medicine is improved, and the medicine is convenient for patients to take.

The invention relates to the technical field of hard capsule polishing, and discloses an automatic polishing system based on hard capsules and a device thereof. A data acquisition module of the system acquires surface characteristic data such as hard capsule surface roughness, stain distribution, capsule size and the like; the data analysis module receives the data and then obtains a polishing demand analysis result through random forest regression analysis; the optimization module adopts a genetic algorithm to optimize parameters and rules of the polishing controller according to the result; the control module carries out fuzzy logic calculation on the polishing amount through particle swarm optimization according to the optimized parameters and rules and converts the polishing amount into polishing control signals; after the execution module receives the signal, the polishing amount constraint condition is adjusted through a near-end gradient method, and integer programming is conducted on the polishing process in combination with a branch and bound method so as to automatically adjust the polishing amount; and the detection module detects surface characteristic data after polishing through Bayesian filtering and feeds back the processed data to the control, data analysis and optimization module so as to adjust a polishing strategy.

The present invention discloses a Chinese medicine filling device and filling method for hard capsule production, comprising a base plate, a connecting shaft fixedly provided at the middle part of the upper end of the base plate, a rotating disk provided on the outer peripheral wall of the connecting shaft, a rotating structure provided at the bottom end of the rotating disk, and a rotating plate provided at the top end of the rotating disk. The present invention relates to the technical field of Chinese medicine hard capsule production. The Chinese medicine filling device and filling method for hard capsule production, through the setting of the upper mold groove, when the capsule falls into the interior of the upper mold groove, the capsule outer shell is stuck, and the capsule inner shell slides into the interior of the lower mold groove, and a negative pressure is formed by the air pressure regulating device, the capsule inner shell is sucked through the suction hole, and the lower mold seat is stretched downward to pull the capsule inner shell out from the capsule outer shell, thereby achieving the purpose of separating the capsule, and the lower mold seat moves downward, and the part of the capsule inner shell that is longer than the capsule outer shell will slide into the interior of the mounting groove, which can effectively avoid the problem of collision of the capsule inner shell and deformation.

Provided is a hard capsule which does not use gelatin and contains the following components in proportions per dry weight of the capsule: (i) 98.0-99.49 wt% of a water-soluble cellulose ether; (ii) 0.4-1.0 wt% of gellan gum; (iii) 0.1-0.5 wt% of a potassium salt; and (iv) 0.01-0.5 wt% of sorbitan monolaurate. The hard capsule has excellent solubility and mechanical strength, is prevented from generating static electricity, and can be favorably used in the preparation of industrial capsule formulations.

The utility model relates to a hard capsule production line guide rail mould strip sliding damping device belongs to hollow capsule production equipment field, including support, damper mounting plate, moving assembly and damping generating subassembly, the damper mounting plate is installed in one end of support perpendicularly, the outer side of this damper mounting plate is installed with shock pad, the support on the inner side of this damper mounting plate is installed with limit block, connecting rod is along horizontal direction setting, one end of this connecting rod is installed with limit end plate, the other end is sequentially passed through shock pad and damper mounting plate and is connected together with moving assembly, the damping mechanism spring is sleeved on connecting rod. The utility model has the advantages of: on the high -speed production line, the mould strip is in the guide rail sliding speed fast, eliminates the impact force of mould strip, no longer has the noise of impact, solves the mould strip rebound caused by impact simultaneously, eliminates the trouble shutdown caused by the inaccuracy of mould strip rebound positioning, improves production efficiency.

The utility model discloses a biological agent full-automatic hard capsule filling machine which comprises a capsule filling machine and a blast purging mechanism, the capsule filling machine comprises a machine body, a capsule sowing mechanism and a filling mechanism, and the capsule sowing mechanism and the filling mechanism are arranged in the machine body; the air guiding hose is connected with the air exhaust end of the air blower and penetrates into the machine body, the transverse pipe is connected with the end, located in the machine body, of the air guiding hose, and a plurality of air nozzles are installed on the surface of the side, away from the air guiding hose, of the transverse pipe. On the basis of the full-automatic hard capsule filling machine, the air blowing purging mechanism is arranged in the filling cabin area of the machine body, external air is filtered by the filter plate and the air filter element through the air blower and then is discharged into the air nozzle on the transverse pipe, and the air pressure produced by the air blower is matched with the air nozzle, so that the air blowing purging mechanism is used for purging hard capsules. The capsule filling machine can blow out waste materials or waste capsule shells in a cabin through high-speed flowing airflow during cleaning operation, and the problem that waste materials at the corners of equipment are difficult to clean is solved.

The invention discloses a preparation process of a hollow hard capsule of hypromellose, and relates to the technical field of the hollow hard capsule of hypromellose. The preparation process comprises the following steps: adding mixed hydroxypropyl starch, potassium citrate and modified chitosan into ultrapure water, heating and stirring to dissolve, and obtaining a glue solution; sequentially adding hydroxypropyl methylcellulose, carrageenan, succinic acid and a plasticizer into the glue solution, stirring evenly, adding gallic acid, stirring at room temperature for 10-15 minutes, adding alkyl dialdehyde, stirring at room temperature in the dark for 2 hours, removing bubbles, keeping warm for 2-4 hours, dipping in the glue to prepare capsules, and obtaining the hollow hard capsule of hypromellose.

The invention provides a vancomycin hydrochloride-containing pharmaceutical composition and a preparation method thereof, the pharmaceutical composition is prepared from vancomycin hydrochloride, PEG6000 and DL-alpha-tocopherol, nitrogen is continuously introduced in the preparation process of the pharmaceutical composition, the whole pharmaceutical composition has simple auxiliary materials and only two auxiliary materials, and the prepared pharmaceutical composition has low content of related substances and is suitable for clinical application. The vancomycin hydrochloride hard capsule is simple in preparation method, high in stability and low in cost, DL-alpha-tocopherol is adopted as an auxiliary material, the prepared vancomycin hydrochloride hard capsule reduces degradation and oxidation of vancomycin hydrochloride, the problem that vancomycin hydrochloride is poor in stability is solved, and the whole preparation method is simple, convenient to operate and suitable for industrial large-scale production.

The present invention relates to a method for preparing a polymer coated hard shell capsule filled with a filling comprising a bioactive ingredient wherein the hard shell capsule comprises a body and a cap wherein in a closed state the cap overlaps with the body in a pre-locked state or in a final locked state, wherein the material of the main body and the cap comprises cellulose ethyl ether, cellulose methyl ether or cellulose propyl ether, starch or pullulan, the hard shell capsule is coated with a coating layer, the coating layer covers the hard shell capsule in a pre-locked state, the coating layer comprises one or more (meth) acrylate copolymers, and the one or more (meth) acrylate copolymers comprise one or more (meth) acrylate copolymers. Wherein the coating layer is present in an amount of about 1 to 5.8 mg / cm2 wherein a dry film having a thickness of 250 [mu] m corresponding to the composition of the coating layer exhibits an elongation at break of about 15 to 500%, and wherein the polymer coated hard shell capsule is provided to a capsule filling machine in a pre-locked state, the capsule filling machine performs the steps of separating the body and the cap, filling the body with a filler, and reconnecting the body and the cap in a final locked state.

A method and a system for filling and sealing a liquid-filled hard capsule are provided. The method includes: separating a capsule body and a capsule cap, filling a material into the capsule body, and inflating an inert gas into the capsule cap, wherein the material at least includes a liquid; fitting the capsule cap and the capsule body obtained in step S1 to obtain a liquid-filled capsule; injecting a glue into a fitting gap, while applying pressure to the liquid-filled capsule, so that the glue fills the fitting gap using negative pressure, and then heating the fitting gap to implement sealing.

The application relates to the technical field of capsule detection, and discloses a visual detection equipment and method based on capsule rejection production, which comprises two parallel rear mounting plates and two parallel front mounting plates, a detection conveying belt is fixedly installed between the two rear mounting plates, a feeding conveying belt is fixedly installed between the two front mounting plates, a detection assembly is arranged on the top of the detection conveying belt, and a feeding assembly is arranged on the top of the feeding conveying belt. Through the arrangement of the detection assembly, the side guide wheel drives the non-deformed hard capsule to rotate along with the conveying of the detection conveying belt, the clamping block on the inner side of the push gear ring further drives the deformed hard capsule to rotate, the stable rotation of the deformed hard capsule can be realized, the deformed area on the outer side of the hard capsule can be rotated to different angles for shooting and image collection, the situation that a single shooting angle cannot detect the defect position can be avoided, the detection software can quickly detect the unqualified hard capsule, and the detection and rejection precision of the hard capsule is improved.

The utility model relates to capsule medicine powder recycling technical field, concretely is a kind of hard capsule medicine powder recycling equipment, including sealing cover, the sealing cover one side abuts with medicine discharge box, the sealing cover side fixedly connected with lifting rod away from medicine discharge box, the sealing cover fixedly connected with suction pipe close to lifting rod side, the inside fixedly connected with locating rod of medicine discharge box close to sealing cover position, the locating rod is symmetrically arranged and there are two groups, retractable slot is set up in the locating rod, the utility model has the beneficial effect that sealing cover and medicine discharge box inside are extracted into vacuum by suction pipe, and the placing groove on the top of placing plate ensures that capsule is stably separated, the effect of quickly opening capsule is realized, after cutting and splitting, the problem that the production cost of capsule is increased is solved, the capsule shell is damaged, so it is necessary to clean medicine powder, and melt and reshape, which leads to the problem of high production cost of capsule, and production cost is reduced.

The invention provides a full-automatic hard capsule filling device and method, and belongs to the technical field of medical equipment.The full-automatic hard capsule filling device comprises a capsule feeding and separating system, a capsule transferring system, a medicament filling system, a waste removing system, a capsule closing system and a discharged material collecting system.The medicament filling system comprises a base and a driving device installed in the base; a metering panel fixedly connected with a rotating shaft of the driving device is arranged on the base, the metering panel is of a hollow structure with an opening in the top, the driving device is used for driving the metering panel to rotate, a scraping system is arranged in the metering panel, and the scraping system is coaxially and rotatably connected with the metering panel through a turning rotating device; according to the scheme, the scraping system capable of rotating reversely is integrated in the metering panel, so that the effects of continuously and uniformly supplementing the medicament to each metering hole and scraping the surface in the multi-stroke compaction process are achieved, and the variation of the filling dose caused by non-uniform medicament accumulation thickness or local collapse is effectively avoided.

The invention discloses double layered delayed-release hard capsules made by double dipping, that is by two consecutive dip molding steps on the same mold pin without removing the film, provided by the first dip molding step, from the mold pin between the two dip molding steps, but dipping the mold pin with this first film in the second dip molding step, each dip molding step is done with a different polymer melt, providing a double layered delayed-release capsule.

A water-soluble film-forming compound selected from the group consisting of a water-soluble cellulose compound and gelatin; optionally a gelling agent, optionally a gelling aid; provided is a TiO2-free hard capsule shell containing ZnO and CaCO3, wherein ZnO and CaCO3 are in amounts suitable for imparting white color to the film. Also provided are a TiO2-free suspension for preparing hard capsules, and a capsule product containing TiO2-free hard capsules filled with a formulation containing an active ingredient.

The invention discloses a double-bin liquid-filled hard capsule and a preparation method and application thereof in the field of pharmaceutical preparations, and the preparation method comprises the following steps: firstly, respectively preparing an inner capsule shell film forming solution and an outer capsule shell film forming solution containing specific functional compounds, and preparing a capsule shell through die dipping and multi-stage drying; the preparation method comprises the following steps: filling an inner capsule with active ingredients, sealing, suspending the inner capsule in an outer capsule filled with an oily medium, sealing the outer capsule by adopting a sealant containing a functional compound in combination with a laser technology, and carrying out vacuum leak detection and optional coating processes to obtain a finished product. The double-bin structure can effectively isolate incompatible components, precise space-time controlled release is achieved through collaborative design of inner and outer capsule materials, and the stability and bioavailability of sensitive components are remarkably improved. The capsule can be used for preparing oral sustained-release medicines or functional foods.

The utility model provides a glue dissolving device for hard capsule production, which comprises a glue dissolving box supported on the ground through a support frame, the top end of the glue dissolving box is connected with a top cover, the top end of the top cover is provided with a cutting table, the inner wall of the cutting table is provided with a cutting net plate, and the inner walls of the two sides of the cutting table are connected with a central shaft in a relatively rotating manner; one ends of the two center shafts are rotationally connected with each other, the center shafts are located below the dividing net plate, the side walls of the center shafts are connected with sealing plates, the sealing plates are in contact fit with the inner wall of the dividing table, the top end of the dividing table is connected with guide columns, and the outer walls of the multiple guide columns are slidably connected with the same connecting plate; the outer wall of the bottom end of the connecting plate is connected with a pressing plate. According to the gelatin dissolving device for hard capsule production, the central shaft and the closing plate are arranged, communication between the cutting table and the gelatin dissolving box is closed, and heat is prevented from being dissipated from the cutting table during heating.

The invention discloses a capsule stripping mechanism for a full-automatic hard capsule production line, which comprises a transmission case, a plurality of rotating shafts are connected to the transmission case, the plurality of rotating shafts are horizontally arranged at fixed intervals, the transmission case drives the plurality of rotating shafts to synchronously rotate according to a fixed rotating angle, and the tail ends of the rotating shafts are coaxially connected with stripping execution units. And the rotating shaft drives the stripping execution unit to rotate to tangentially extrude the mold needle of the mold coated with the molded capsule, so that the molded capsule is separated from the mold needle under the action of friction force. A plurality of independent mold needles of a single-row-needle mold or a double-row-needle mold can be tangentially and rotationally extruded at the same time in a limited space, the single mold needle is tangentially extruded from the two sides at the same time, stress is uniform, the single mold needle is not damaged, and the problem that in the full-automatic hard capsule production process, the production efficiency is high is solved. The problem that the capsule is not easy to separate from the mold due to the fact that the molded capsule wraps the mold needle too tightly is solved, and the requirement that demolding is easier under the standard free oil content is met.

The utility model relates to the technical field of liquid hard capsule manufacturing, and mainly discloses a liquid hard capsule gluing box and a gluing device, the outer sides of two first side plates of the gluing box are respectively provided with a flow guide side plate, flow guide grooves are formed between the flow guide side plates and the first side plates, the two first side plates are provided with side opening holes, and the side opening holes are communicated with the flow guide grooves. A middle opening is formed in the middle partition plate, a glue solution is stored in the gluing box, the gluing box is arranged on the base, the lower portions of the first gluing wheel and the second gluing wheel are immersed in the glue solution of the gluing box, a chain plate running towards one side is horizontally arranged above the gluing box, and the chain plate is connected with the first gluing wheel and the second gluing wheel. The hard capsules are placed in the grooves of the chain plates, the upper portions of the first gluing wheel and the second gluing wheel make contact with the bottoms of the hard capsules for gluing, the glue solution loss can be reduced, the glue solution can be recycled to a certain degree, it is guaranteed that the glue solution is stably and continuously supplied in the gluing process, and the stability of products is guaranteed.

The present invention is in regard to multiple specification Hard Capsule, which is formed via the joint locking between the multiple Locks of the Cap (upper part) and Body (lower part) to allow production of single hard capsules capable of functioning as variable sizes.

This utility model discloses a fully automatic hard capsule filling machine for capsule preparation, including a frame. The frame is equipped with a material hopper for storing drug powder. A discharge pipe is located at the bottom of the material hopper, and a discharge turntable is located inside the discharge pipe. The discharge turntable has multiple metering grooves arranged along its axial direction. A receiving plate, which is in close contact with the surface of the discharge turntable, is fixed to the discharge pipe via a positioning frame. The receiving plate has receiving ports corresponding to the metering grooves, and a vertically arranged receiving pipe is located at the bottom of each receiving port. The frame is equipped with an injection pipe for injecting powdered drugs into hard capsules. This utility model ensures consistent drug delivery each time, guaranteeing accuracy and consistency, and can simultaneously fill multiple capsules, thus achieving high work efficiency.

The present invention provides a highly bioavailable water-soluble coenzyme Q10 composite carrier, a preparation method, and its application, belonging to the field of food technology. The present invention uses a porous material to adsorb a gel precursor, namely a molten mixture of a dispersed phase, a gelling agent, and coenzyme Q10, and controls the gelation process to obtain a highly loaded, highly bioavailable coenzyme Q10 composite carrier. By loading a high content of coenzyme Q10 on an oil gel system as a basis, porous adsorption is used to increase the specific surface area of ​​the gel and improve water permeability. The temperature change during the gelation process is also controlled to change the crystal form and gel structure of coenzyme Q10, increase its dissolution rate and concentration in the body, and further improve the bioavailability of coenzyme Q10. The present invention also provides an application of the coenzyme Q10 composite carrier in the preparation of coenzyme Q10 in the form of tablets, granules, and hard capsules for food supplements, thereby increasing the content of coenzyme Q10 in the human body through the form of food supplements.

The application discloses a transparent partially deacylated gellan gum and a preparation method thereof, and belongs to the technical field of post-processing of gellan gum fermentation liquor. The method comprises the following steps: diluting high-acyl gellan gum fermentation liquor to a polysaccharide content of 0.8-1.1%; adding sorbitol and buffer salt to adjust the pH to alkaline, adding lysozyme and protease to remove bacteria, proteins and to perform mild partial deacylation; adjusting the pH to terminate the deacylation, then reducing the viscosity at high temperature, and removing insoluble impurities through high-temperature and high-speed centrifugation; adding low-level alcohol to flocculate after the temperature is lowered and the pH is adjusted, and the finished product is obtained through solid-liquid separation, drying and crushing. The application solves the problem of clarification caused by high viscosity and high gel temperature, the prepared product has good transparency, a gel temperature of 50-60 DEG C, excellent gel elasticity, stable performance, and can be widely applied to food, daily chemical and pharmaceutical fields such as plant soft and hard capsules with high requirements on transparency, and fills the blank of commercial production of transparent partially deacylated gellan gum.

The present invention addresses the problem of providing a hard capsule that can be used in a health food and has higher acid resistance. The problem is solved by an acid-resistant hard capsule comprising a capsule shell, in which the capsule shell contains hydroxypropyl methylcellulose having a viscosity value of 15 mPa s or more and gellan gum.

The invention relates to an oxidized hydroxypropyl starch empty capsule, and belongs to the technical field of capsules. The adhesive comprises the following main components: oxidized hydroxypropyl starch, a plasticizer, a gelling agent, a gelling aid and water. The starch viscosity can be effectively reduced, the gelling characteristic and stability can be optimized, and the dispersing and dissolving capacity of starch molecules in water can be enhanced by accurately controlling key process parameters such as the moisture content of materials and the effective chlorine addition amount in the extrusion process. In the dry oxidation treatment, carboxyl and carbonyl and hydroxyl in amylose and amylopectin molecules form hydrogen bonds, so that the structural integrity of a polymer matrix is improved, and the tensile strength and flexibility of the film are further improved. After the starch and the colloid are compounded, the gel temperature is moderate, and the stability of the system can be maintained. The hard capsule product provided by the invention has excellent mechanical properties, low friability and efficient disintegration performance. The preparation process simplifies the production process, reduces the cost, is green and environment-friendly, and has remarkable market application potential and wide popularization value.

The invention belongs to the technical field of medical equipment, and discloses a medicine filling mechanism of a full-automatic hard capsule filling machine, which comprises a rack, and the top of the rack is provided with a feed hopper for conveying medicines; the operation table is arranged on the rack; the filling mechanism is arranged at the bottom of the feeding hopper to fill medicine; and an adjusting mechanism. Through rotation of a mounting block, a first collecting groove and a filtering plate can be rotationally switched, medicine scattered during medicine filling can be conveniently filtered and collected, the medicine around the first collecting groove is scraped into the first collecting groove through the action of a scraping block, and the medicine is prevented from being scattered on the mounting block during filling; and then the metering hole is cleaned through the moving structure, and the situation that in the capsule medicine powder filling process, medicine powder is blocked at the filling opening, waste of the medicine powder is caused, and the medicine filling efficiency is affected is prevented.

The utility model provides a capsule forming machine for western medicine preparation. The capsule forming machine for western medicine preparation comprises a supporting frame; the forming table is fixedly connected to the top of the supporting frame, a driving assembly is installed at the bottom of the forming table, a rotating disc is installed at the output end of the driving assembly, and shaping molds are installed at the positions, close to the four directions, of the top of the rotating disc through fixing frames; and the mounting frame is fixedly connected to the top of the forming table, a second telescopic rod is mounted at the top of the mounting frame, a movable plate is fixedly connected to the telescopic end of the second telescopic rod, and two stabilizing rods are fixedly connected to the position, close to the back face, of the top of the movable plate. According to the capsule forming machine for western medicine preparation, through the structure, the hard capsule forming machine for western medicine preparation can prepare hard capsules in an assembly line mode, meanwhile, demolding is assisted through the demolding frame, and the preparation efficiency is improved.