49 results about "Intestinal Microbiome" patented technology

The present disclosure provides for characterization of normal flora and identifying biomarkers in the gut of healthy, neruotypical subjects. Aspect of the disclosure provide for the characterization of the gut microbiome in ADS subjects, characterized by reduced richness and significant loss of the ‘Prevotella-like enterotype’ compared to neurotypical subjects. The relative abundance of genera Prevotella, Coprococcus, Prevotellaceae and Veillonellaceae are significantly lower in autistic children than in neurotypical children. Further, Prevotella, is one of the three main classifiers for the human enterotypes, along with Bacteroides and Ruminococcus. These three core genera are among main contributors in the principle component analysis. ‘Prevotella-like enterotype’ was absent in the autistic group, while neurotypical samples showed an even distribution among the three enterotypes. The present disclosure provides for an understanding the association between gut microbiota, health, and disease states, and provides for potential diagnostic and therapeutic targets.

The present invention relates to the development of a targeted delivery system for the oral delivery of probiotics or therapeutic agent for various indications, including and not limited to active and prophylaxis treatment of Clostridium difficile infection, antibiotic associated diarrhea, irritable bowel syndrome, Crohn's disease, intestinal flora replacement, supplemental flora treatments for patients taking antibiotics, and for restoration of balance and signaling between the intestinal microbiome and the intestinal cells in patients under treatment of metabolic syndrome manifestations, specifically diabetes, insulin resistance, obesity, hyperlipidemia and hypertension.

The invention discloses a formula of probiotics for inhibiting pathogenic bacteria of colorectal cancer and a screening method thereof. The screening method of the probiotics comprises the following steps: finding the pathogenic bacteria of the colorectal cancer according to metagenome data and abundance of intestinal flora of normal people and colorectal cancer patients, then constructing an intestinal flora interaction network to screen the probiotics capable of inhibiting the pathogenic bacteria of the colorectal cancer, adjusting the proportion of the probiotics, and finally verifying. Theformula of the probiotics obtained by the method is shown in the specification, wherein the content of the clostridium butyricum is 1.3*10 <10> CFU/ml; the content of enterococcus faecalis is 1*10 <9> CFU/ml, the content of lactobacillus brevis is 1*10<9> CFU/ml, the content of lactobacillus plantarum is 1*10 <9> CFU/ml, the content of lactobacillus rhamnosus is 1*10 <9> CFU/ml, the content of lactobacillus sake is 1*10 <9> CFU/ml and the content of leuconostoc mesenteroides is 1*10 <9> CFU/ml. The method disclosed by the invention has the advantages that (1) an intestinal flora interaction network is constructed, so that the screened probiotic formula can be better colonized in intestinal tracts; (2) the obtained probiotic formula does not generate drug resistance, and is safe, effectiveand excellent in performance; and (3) an online warehouse database of human intestinal microbiome is constructed, so that the result is more universal and reliable.

A method to detect liver fibrosis or for the differential diagnosis of non-alchohlic fatty liver disease (NAFLD) in a subject is provided. The method comprises analyzing a biological sample from a subject to determine an intestinal microbiome signature for the subject, and inspecting the intestinal microbiome signature relative to a reference intestinal microbiome signature to detect presence or absence of liver fibrosis.

The invention relates to new application of schisandra chinensis total polysaccharide in preparation of medicines or health products for treating inflammatory bowel diseases, in particular to new application in preparation of medicines or health products for treating ulcerative colitis (UC), Crohn disease (CD) and acute and chronic intestinal diseases. Experiments show that the schisandra chinensis total polysaccharide can significantly improve inflammatory injury of colon, reduce spleen indexes, increase thymus indexes, effectively reduce the contents (activity) of MPO, NO, MDA and ROS in thecolons, and increase the contents of GSH and SOD at the same time. Meanwhile, the schisandra chinensis polysaccharide regulates the composition and diversity of intestinal microorganisms of colitis mice, obviously improves the relative abundance of Finnicutes, sugar bacteria, Enterorhabdus and the like, reduces the relative abundance of intestinal bacteria such as Firmicutes, Turicibacter and Akkermansia, remarkably increases the contents of propionic acid, butyric acid and isobutyric acid in the colon, and it is prompted that the schisandra chinensis total polysaccharide can be used for preparing medicines for treating or improving inflammatory bowel diseases.

The present invention aims to prevent and/or treat health-related conditions in infants born with a non-optimal intestinal microbiome, by providing specific probiotic lactic acid bacterial strains to the pregnant mother. This will enable early colonization of the infant gut, even before birth, and thus prevent and/or treat health-related conditions associated with non-optimal microbiome. Thus, the present invention provides a probiotic microorganism for use in the treatment of a fetus or neonate, wherein said probiotic microorganism is administered to the oral cavity of a pregnant female in a formulation suitable to colonize the oral cavity, wherein said probiotic microorganism is thereby administered to the fetus. The methods and uses of the invention can also provide for the colonization of a fetus or neonate or for shifting the microbiome of a fetus or neonate

A microfluidic device is directed to sustaining a complex microbial community in direct and indirect contact with living human intestinal cells in vitro. The device includes a first microchannel having cultured cells of a human intestinal epithelium and microbiota, the first microchannel further having a first level of oxygen. The device further includes a second microchannel having cultured cells of a vascular endothelium, the second microchannel further having a second level of oxygen. The device also includes a membrane located at an interface region between the first microchannel and the second microchannel, the membrane being composed of an oxygen-permeable material or further having pores via which oxygen flows between the first microchannel and the second microchannel to form a physiologically-relevant oxygen gradient.

The present invention provides a hard capsule comprising an outer and one inner capsule, wherein the outer capsule comprises a hydrophobic liquid and the inner capsule which comprises a composition comprising uncoated microorganisms and optionally at least one desiccant. The composition may comprise a filtrate composed of viable fecal bacteria useful forfecal microbiota transplantation (FMT) or a mixture of one or more different types of microorganisms isolated from intestinal microbiome, such as bacteria, archaea, virus, or fungi such as yeast. The composition may comprise a desiccant, preferably a food approved component which is degradable in the gastrointestinal tract. The hydrophobic liquid, if present, is preferably at least one edible oil. Also provided are methods of treating or preventing a dysbiosis in a human subject, comprising administering to the human subject at least one capsule of the invention.

The invention relates to a method of transplanting healthy fish intestinal feces and treating ill fishes. The method comprises the steps of S1, collecting healthy fish intestinal feces, adding the collected feces into stroke-physiological saline solution for dissolution, stirring the solution evenly, filtering the solution, placing the filtered healthy feces bacteria fluid into a vessel, S2, adding filter-feeding fishes in the vessel, wherein the mass of each fish is about 50 g, the adding quantity is 10-20 fishes per cubic meter of water body; supplementing oxygen into the water to keep the filter-feeding fishes alive, breeding the filter-feeding fishes in the vessel for 10-20 days continuously, S3, adding fishes inflicted with intestinal bacterial diseases into the vessel based on the quantity of 5-10 fishes per cubic meter of water body, and breeding for 10-20 days. According to the method of transplanting healthy fish intestinal feces and treating ill fishes, the transplantation of health fish intestinal bacteria can improve intestinal microbiome of the ill fishes, the survival rate of the ill fishes are obviously increased, and therefore the method is applicable for large scale application.

Compositions for affecting the intestinal microbiome of a mammalian subject can include a pharmaceutically-acceptable carrier and greater than or equal to 1*104 PFU/mL or PFU/mg of bacteriophage having a tropism that includes an obesogenic and/or inflammatory bacterium associated with an intestinal microbiome of a mammal. Processes for preparing the disclosed compositions can include isolating thebacteriophage from an environmental source, characterizing the bacteriophage, and combining the bacteriophage with the pharmaceutically acceptable carrier at greater than or equal to1*104 PFU/mL or PFU/mg. Methods can include administering the disclosed compositions to a mammalian subject with or without co-administration of the disclosed probiotics. Administering the disclosed compositions can reduce a concentration of obesogenic and/or inflammatory bacteria in the intestinal microbiome of the mammalian subject, promote or induce weight loss, reduce inflammation, support metabolic health, and/or support a healthy balance/diversity within the intestinal microbiome of the mammalian subject.

The invention discloses a feed additive for relieving heat stress in a beef cattle and a preparation device and method, and relates to the field of equipment. According to the technical solution, thefeed additive includes 40-50 parts of folium ginkgo, 40-50 parts of garlic skin, 1-5 parts of glycine betaine, 1-5 parts of sodium bicarbonate and 5-10 parts of potassium chloride. The feed additive has the beneficial effects that the folium ginkgo, the garlic skin, the glycine betaine, the sodium bicarbonate, the potassium chloride and other feed raw materials are compounded, for solving the problems of low appetite, large metabolic intensity, difficult heat dissipation, poor resistance and the like of the beef cattle under heat stress, heat stress reaction of the beef cattle is relieved fromstimulating appetite, improving the body antioxidant capacity and immunity, promoting gastrointestinal health, regulating the intestinal microbiome, improving peripheral blood circulation, regulatingosmosis pressure and other angles.

Embodiments of this invention include systems and methods for developing individualized dietary and health improvement plans based on an individual's intestinal microbiome and digestive activity. More particularly, the invention is related to a system providing a hydrogen and/or methane sensor device and a wireless platform in communication with the sensor device to periodically analyze the individual's metabolic activity in correlation with their gut microbiome and a personal database to provide personalized feedback to the individual of treatment plans and general techniques that can be used to improve the individual's general health and well being. The systems and methods further include a system for analyzing the hydrogen and/or methane levels in the individual's exhalations or flatulence in light of the individual's intestinal microbiome. This analysis uses bioinformatics to relate alterations in hydrogen and/or methane levels to the individual's intestinal microbiome and personal diet and tolerances/intolerances to identify and communicate real time dietary suggestions and general dietary and health treatment plans. The relationship of the bioinformatics and alterations in hydrogen and/or methane levels is also used to infer drug effectiveness. Such general dietary guidance, health treatment plans, and drug effectiveness contribute to an overall improvement in a person's general health and well being.

Disclosed is a composition comprising a microbe expressing ferritin. The composition also comprises elemental iron in an amount of at least 3% by weight on a dry matter basis of the microbe expressingferritin and the elemental iron. Also disclosed are ingestibles, dietary supplements, and pharmaceutical compositions comprising the composition. Also disclosed are methods for treating a subject comprising administering the composition to the subject. Also disclosed are methods of altering the composition of the gut bacterial microbiome in a subject, the method comprising administering the composition to the subject.

The invention relates to Bifidobacterium lactis. The Bifidobacterium lactis is Bifidobacterium lactis BL-11 of which the collection number is CGMCC No.20847. The Bifidobacterium lactis provided by the invention can eliminate intestinal tract metabolic disorders and can cause the composition of an intestinal tract microbiome to be normalized so as to effectively improve height, inhibit obesity and accelerate the growth and development as well as intellectual development of children and adolescents.

This invention relates generally to compositions and methods for increasing the efficacy of immunotherapies and vaccines. In particular, the present invention relates to elevating the richness and diversity of a subject's gut microbiome through administration of an agent (e.g., fiber containing prebiotic agent (e.g., epigallocatechin gallate (EGCG), fucoidan, potato starch, oligofructose and inulin)) (e.g., melatonin) with an immunotherapy or vaccine. Such compositions and methods are useful for treating cancer, infectious pathogens, autoimmune diseases, neurological disorders, and/or obesity.

The invention discloses an enteric microorganism combination and an application thereof as a systemic lupus erythematosus marker. Particularly, 16s rRNA sequencing is carried out on enteric microorganism samples from systemic lupus erythematosus individuals and healthy individuals to determine Sporobacter, Butyricimonas and Phascolarctobacterium which have level difference in SLE patients, and the relationship between the level difference and the SLE is defined. The enteric microorganisms with the level difference can be used as markers of the SLE.

The present invention provides a method, wherein the method treats a subject having a dysbiosis, the method comprising: determining a first metabolic profile of the gut microbiome of a subject having a dysbiosis; changing the first metabolic profile of the gut microbiome of the subject to a second metabolic profile of the gut microbiome of the subject, by administering to the subject a composition comprising at least one bacterial species selected from the group consisting of: Acidaminococcus intestinalis, Bacteriodes ovatus, Bifidobacterium adolescentis, Bifidobacterium longum, Blautia sp., Clostridium sp., Collinsella aerofaciens, Escherichia coli, Eubacterium desmolans, Eubacterium eligens, Eubacterium limosum, Faecallbacterum prausnitzii, Lachnospira pectinoshiza, Lactobacillus casei, Parabacteroides distasonis, Roseburia faecalis, Roseburia intestinalis, Ruminococcus sp., Ruminococcus species, and Ruminococcus torques, wherein the composition is administered at a therapeutically effective amount, sufficient to alter the first metabolic profile of the gut microbiome to the second metabolic profile of the gut microbiome.