The application discloses a strain of
Rhodotorula mucilaginosa, a
fermentation product filtrate thereof and a
biological product thereof, and belongs to the technical field of microorganisms. The application obtains a strain of
Rhodotorula mucilaginosa BTN-HB-L28 from an
artemisia vulgaris in Lijiang, Yunnan, and the strain can be used in the field of
cosmetics, has the effects of resisting
skin oxidation, resisting aging, repairing
skin and soothing, and can be used as an active substance in
skin care products. The
fermentation product filtrate of the strain has excellent HAS inhibiting capacity, can significantly inhibit the expression of
matrix metalloproteinase 3, can significantly promote the proliferation of fibroblasts under various concentrations, can significantly down-regulate the proportion of SA-beta-Gal positive cells under various concentrations, has the effect of resisting aging, has significant
DPPH and
ABTS free radical
scavenging capacity, has good
antioxidant effect, and can significantly inhibit the
secretion amount of
cell inflammatory factors NO, IL-6 and TNF-alpha, and has good soothing effect.