49 results about "Isobutanol" patented technology

The invention provides a preparation method of hexafluoroisobutene, which comprises the following steps: firstly, reacting hexafluoroisopropanol with p-toluenesulfonyl chloride to generate an organic phase, then reacting with a cyano source to obtain 3, 3, 3-trifluoro-2-(trifluoromethyl) propionitrile, then reacting with an acid solution and a reducing agent in sequence to obtain hexafluoroisobutanol, and finally reacting with an acid solution and a reducing agent to obtain the hexafluoroisobutanol. And finally, carrying out alkali dehydration to generate hexafluoroisobutene. The preparation method provided by the invention is simple in process route and mild in reaction condition, the solvent used in the preparation process can be recycled, the pollution in the preparation process is reduced, and the preparation method is less in three wastes, environment-friendly and suitable for large-scale production.

The invention provides a method for preparing isobutanol by directional conversion of methanol and ethanol, which comprises the following steps: by taking methanol and ethanol as raw materials, converting methanol and ethanol into isobutanol under the action of a Cu-doped composite metal oxide catalyst, a precursor of the catalyst is hydrotalcite-like, Cu in the catalyst is dispersed in a carrier in an atomic scale, and the loading capacity of Cu is 0.1-1.5 wt%. The Cu-doped composite metal oxide solid acid-base catalyst designed and prepared by the invention is easy to synthesize, the Cu species are highly dispersed on the oxide carrier, the catalyst has the characteristics of high activity, high selectivity and high stability in the reaction for preparing isobutanol by directional conversion of methanol and ethanol, and under the conditions of 300 DEG C and normal pressure, the conversion rate of ethanol is 99.5%, the selectivity of isobutanol is higher than 60%, and the catalyst is suitable for industrial production. In a 600h stability test, the ethanol conversion rate is greater than 80%, and the C-C coupling product selectivity is greater than 80%; meanwhile, the product is easy to separate, the whole process has economical efficiency and practicability, the sustainable development concept is met, and the method has good industrial application prospects in the field of biomass conversion.

The invention discloses lactobacillus casei capable of improving the flavor of a tea beverage through fermentation and application of the lactobacillus casei. The lactobacillus casei is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number of the lactobacillus casei is CGMCC No.32672, and the preservation date of the lactobacillus casei is November 18, 2024. The lactobacillus casei can be used for producing extracellular beta-glucosidase, polyphenol oxidase and peroxidase; when being used for fermentation, the fermentation broth can improve the flavor and color of a tea beverage, increase the content of organic acid, reduce the bitter taste of the tea beverage, generate new volatile aroma substances such as nerolidol, isobutanol, ethyl hexanoate, ethyl 3-hexenoate, ethyl caprylate, ethyl 2-hexenoate and the like, and enrich the aroma substance composition of the tea beverage. The invention provides a novel tea beverage production process which has the advantages of simplicity and convenience in operation, low cost, remarkable effect and the like, and is suitable for industrial production.

The invention relates to a method for preparing an aryl compound by taking ethanol as a green reducing agent and a solvent. According to the method, under the condition of a palladium catalyst, fluoro-aromatic hydrocarbon is mixed with alkali and alcohol to be subjected to a defluorination hydrogenation reaction, and the alcohol comprises ethanol and / or isobutanol. In the reaction, ethanol and / or isobutanol serve as a solvent and a reducing agent at the same time, no extra reducing agent needs to be added, and use of dangerous reducing agents such as hydrogen and lithium aluminum hydride is avoided. The catalyst system is excellent in substrate applicability and can be well compatible with common electron donating groups, electron withdrawing groups and heterocyclic rings, and the highest yield can reach 99%. In addition, the reaction system can be carried out in analytically pure ethanol and air, complicated anaerobic operation is not needed, and large-scale industrial application is facilitated.

The present disclosure relates to processes for producing isobutylene and isobutylene- based polymers. In some embodiments, a process includes dehydrating a bio-based isobutanol in an isobutanol dehydration unit to form a butenes composition. The process includes providing the butenes composition to one or more of an acid extraction unit or a butyl ether formation unit.

There is provided a method for producing isobutylene, in which isobutylene is produced from isobutanol with a high selectivity while suppressing a decrease in the isobutanol conversion rate under pressure. In the method for producing isobutylene according to the present invention, a raw material gas containing isobutanol is brought into contact with a catalyst to produce isobutylene from isobutanol, the method including bringing the raw material gas containing isobutanol into contact with a catalyst at a linear velocity of 1.20 cm / s or more under a pressure of 120 kPa or more in terms of absolute pressure to produce isobutylene from isobutanol.

The invention discloses a catalyst for acetylene method synthesis of vinyl acetate, a preparation method and application thereof, and relates to the technical field of acetylene gas phase method synthesis of vinyl acetate, in the preparation process of the catalyst, a mixed solvent is used for dissolving an active component, then a carrier is impregnated, the volume of water in the mixed solvent is 20-95%, and the volume of water in the carrier is 20-95%; the residual volume is one or a mixture of two of methanol, ethanol, n-propanol, isopropanol, n-butanol and isobutanol, or a mixture of three or more than three solvents. The solvent can significantly reduce the polarity of the solution, and experiments and characterization show that the agglomeration of the active components is significantly reduced, the dispersion of the active components is enhanced, and the performance of the catalyst is improved.

The application provides a preparation method of dibutyl adipate, belongs to the technical field of organic compound preparation, and can solve the problems of low catalytic efficiency, low raw material conversion rate, and the problems of the obtained product after treatment, such as the presence of catalyst residues, flocculent turbid substances in the obtained product, and the significant influence on product quality. The technical scheme comprises the following steps: taking adipic acid and monohydric alcohol as raw materials, fully reacting in a reactor filled with an organotin salt supported catalyst to obtain crude dibutyl adipate, and then performing vacuum distillation, adsorption impurity removal and rectification stripping on the crude dibutyl adipate to obtain dibutyl adipate product, wherein the monohydric alcohol is n-butanol or isobutanol. The preparation method has the advantages of high raw material conversion rate, fast reaction rate, high product yield, product purity ≥ 99.5% after refining treatment, low impurity content, and compliance with the cosmetic product standard, and can be applied to cosmetics.

This invention belongs to the field of bioengineering technology, specifically relating to a BmoR protein mutant capable of sensitively detecting n-butanol or isobutanol, and its application in n-butanol or isobutanol detection or biosensors. The BmoR protein mutant is obtained by mutating the wild-type BmoR protein shown in SEQ ID NO.1 to the E54G mutation. The E54G mutant, possessing the amino acid sequence shown in SEQ ID NO.3, is more sensitive to n-butanol (2.64 × 10⁻⁶). ‑6 mM) and isobutanol (2.16×10 ‑6 The method uses mM) detection to solve the problem of low sensitivity of wild-type BmoR protein, which cannot screen for extremely low concentrations of n-butanol or isobutanol. It can be used for screening and application of strains that produce low levels of higher alcohols.

Multi-carbon compounds such as ethanol, n-butanol, sec-butanol, isobutanol, tert-butanol, fatty (or aliphatic long chain) alcohols, fatty acid methyl esters, 2,3-butanediol and the like, are important industrial commodity chemicals with a variety of applications. The present invention provides metabolically engineered host microorganisms which metabolize methane (CH4) as their sole carbon source to produce multi-carbon compounds for use in fuels (e.g., bio-fuel, bio-diesel) and bio-based chemicals. Furthermore, use of the metabolically engineered host microorganisms of the invention (which utilize methane as the sole carbon source) mitigate current industry practices and methods of producing multi-carbon compounds from petroleum or petroleum-derived feedstocks, and ameliorate much of the ongoing depletion of arable food source “farmland” currently being diverted to grow bio-fuel feedstocks, and as such, improve the environmental footprint of future bio-fuel, bio-diesel and bio-based chemical compositions.

The invention relates to the field of green chemistry and renewable carbon sources, more in particular to the synthesis of (R)-3-hydroxybutyric acid using renewable carbon feedstock as starting materials. Provided is a method for the manufacture of a (R)-hydroxybutyric acid salt, comprising: (i) subjecting a starting material comprising polyhydroxyalkanoates (PHA) to an extraction / transesterification reaction using isobutanol in the presence of an acid to obtain the isobutyl ester of (R)-hydroxybutyric acid; and (ii) converting the isobutyl ester of (R)-hydroxybutyric acid to the corresponding salt.

The application relates to the technical field of catalysts for fine chemical products, and provides a zinc-chromium-based catalyst and a preparation method and application thereof.The method comprises the following steps: mixing a zinc salt, a chromium salt, an alkali metal salt and activated carbon, and carrying out a combustion reaction to obtain a zinc-chromium-based catalyst.Compared with a traditional preparation method, the application has the advantages of simple operation, cheap and easily-obtained raw materials, low requirement on equipment, easy batch production, no generation of a large amount of waste water in the reaction process, and wide industrialization prospect; the catalyst provided by the application does not need further reduction treatment when used, operation steps are reduced, and operation cost is reduced; the catalyst obtained by the application is applied to the synthesis of isobutanol, CO conversion rate reaches 31%, and the isobutanol selectivity in total alcohol reaches 41.4%.

This invention provides an apparatus and method for producing isobutyl methacrylate using a novel membrane reactor. The apparatus integrates a tubular fixed-bed reactor with a pervaporation membrane system. A compartmentalized structure maintains the pressure difference across the membrane, and a dual-tube module optimizes the channel spacing to suppress polymerization side reactions. During the reaction, the pervaporation membrane selectively removes the byproduct water, breaking the equilibrium limitation of the esterification reaction and significantly improving the feed conversion rate. Simultaneously, it disrupts the water-isobutanol azeotropic system, reducing subsequent separation energy consumption and achieving integrated reaction and separation processes. This invention solves the problems of equilibrium limitation on conversion rate, high separation energy consumption, and easy polymerization in traditional processes. It features high conversion rate, low energy consumption, and stable operation, making it suitable for the continuous and green production of isobutyl methacrylate.

An injectable pharmaceutical composition comprising a solution of 3-acyl-buprenorphine or a pharmaceutical salt thereof in a biocompatible organic solvent, wherein the injectable pharmaceutical composition exhibits a sustained release profile lasting for more than one week when injected into a patient. The acyl group is an alkylcarbonyl group and an alkyl portion of the alkylcarbonyl group is straight chain, branched chain, having 1-20 carbon atoms. The biocompatible organic solvent is N-methyl-2-pyrrolidone, ethyl acetate, ethanol, butanol, 2-butanol, isobutanol, isopropanol, glycerin, benzyl benzoate, dimethyl sulfoxide, N,N-dimethylacetamide, propylene glycol, dimethyl glycol, benzyl alcohol, or a combination of two or more thereof.

The present invention relates to a genetically engineered bacterium comprising a deletion of the ndh gene; deletion of one or more nuo genes; the one or more nuo genes are selected from the group consisting of: nuoA, nuoB, nuoC, nuoD, nuoE, nuoF, nuoG, nuoH, nuoI, nuoJ, nuoK, nuoL, nuoM, and nuoN; the one or more nuo genes are selected from the group consisting of: nuoA, nuoB, nuoC, nuoD, nuoE, nuoF, nuoG, nuoH, nuoI, nuoJ, nuoK, nuoL, nuoM, and nuoN; wherein the genetically engineered bacterium is capable of oxygen uptake, i.e. The genetically engineered bacterium is capable of using oxygen as an electron acceptor, and wherein the bacterium is genetically engineered to produce a fermentation product in the presence of oxygen. In particular, the present invention provides bacteria genetically engineered to produce lactic acid from glycerol or from glucose in the presence of oxygen. The invention also provides bacteria genetically engineered to produce isobutanol and / or ethanol from glycerol in the presence of oxygen. Methods of producing fermentation products using the genetically engineered bacteria of the present disclosure are also described.

A process for preparing 2,2,4,4-tetramethylcyclobutane-1,3-diol by reacting 2,2,4,4-tetramethylcyclobutanedione with isobutanol in the presence of a tandem transfer hydrogenation and Tischenko reaction catalyst.

The present invention relates to methods to produce isobutyric acid and / or isobutanol by converting a carbohydrate such as e.g. glucose and / or lactic acid using a microorganism. More in particular, the present invention discloses the usage of the bacterium Clostridium luticellarii in order to convert a carbohydrate and / or lactic acid into isobutyric acid and / or isobutanol and presents the process sequence. The latter compounds can be applied in animal feed and food, as flavor ingredient, as pharmaceutical compound, as plastic precursor etc...

The present invention relates to recombinant microorganisms comprising at least one nucleic acid molecule encoding a ketol-acid reductoisomerase (KARI) or modified NADH-dependent variant thereof, wherein said KARI is at least about 60% identical to SEQ ID NO: 2. In various aspects of the invention, the recombinant microorganisms may comprise an isobutanol producing metabolic pathway and can be used in methods of making isobutanol.

The present invention relates to a degradable ceramic green mud and a manufacturing method thereof, belonging to the technical field of ceramics. The method comprises the following steps: grinding and crushing calcined talc, wollastonite, phlogopite and yttria-stabilized zirconia, screening, adding stearic acid and carboxymethyl chitosan solution and ball milling, adding polyhydroxycitronellal and anhydrous ethanol under a nitrogen atmosphere and stirring at a constant temperature, filtering out the solvent and drying, adding isobutanol and an aluminum zirconium coupling agent and continuing to stir, filtering, washing, vacuum drying, adding a binder and deionized water and stirring, standing, pressing and molding, vacuum drying and calcining. Polyvinyl alcohol is selected as a green binder. Its excellent bonding properties enhance the molding efficiency of the mud and are harmless to the environment. Polyhydroxycitronellal and carboxymethyl chitosan enhance the modification of the stone surface and its uniform distribution, thereby improving the microstructure of the material. The addition of an environmentally friendly dispersant and a binder reduces environmental pollution and achieves a dual improvement in performance and green ecology.

The utility model discloses a device for optimizing the structure of a butyl octanol product. The device is characterized in that a side line feed port of a butyraldehyde isomer tower is connected with a feed pipeline, and a tower top discharge port is respectively connected to an isobutyraldehyde hydrogenation unit and an isobutyraldehyde storage tank; a tower bottom discharge hole is connected to an n-butyraldehyde condensation unit; a gas phase extraction opening in the side wall of the tower kettle is connected to a feeding opening of an n-butyraldehyde buffer tank through a gas phase extraction pipeline, an n-butyraldehyde condenser and a first n-butyraldehyde cooler are arranged on the gas phase extraction pipeline, and a discharging opening of the n-butyraldehyde buffer tank is connected to a feeding opening of the n-butyraldehyde tank; and a discharge port of the n-butyraldehyde tank is respectively connected to the n-butyraldehyde hydrogenation unit and the n-butyraldehyde condensation unit through a first branch extraction pipeline and a second branch extraction pipeline. According to the utility model, the structure of the butanol and octanol product can be conveniently and quickly optimized, and any several of high-purity n-butyraldehyde, isobutyraldehyde, n-butyl alcohol, isobutyl alcohol and octanol can be selectively produced according to requirements.

The invention relates to a high-solid-content amino silicon oil microemulsion and a preparation method thereof. The microemulsion comprises an amino silicon oil compound, a modified emulsification mixture, an anti-yellowing agent, ammonium acetate and deionized water, the amino silicon oil compound comprises linear amino silicon oil, branched chain amino silicon oil and star amino silicon oil, the modified emulsion mixture comprises polyether modified polysiloxane, fatty alcohol-polyoxyethylene ether and isobutanol, and the anti-yellowing agent is bicyclic phosphate; the preparation method comprises the following steps: premixing the amino silicon oil compound and polyether modified polysiloxane at 50 DEG C, dropwise adding isobutanol to form an oil phase, adding an acid buffer aqueous solution and deionized water, performing high-pressure homogenization, adding an anti-yellowing agent, and performing curing, so as to obtain a finished product. The obtained high-solid-content amino silicone oil microemulsion has excellent shear resistance and yellowing resistance, can resist the high temperature of 80 DEG C, has low foaming property and strong stability, and is suitable for high-speed textile processing.

The present invention relates to recombinant microorganisms comprising at least one nucleic acid molecule encoding a ketol-acid reductoisomerase (KARI) or modified NADH-dependent variant thereof, wherein said KARI is at least about 60% identical to SEQ ID NO: 2. In various aspects of the invention, the recombinant microorganisms may comprise an isobutanol producing metabolic pathway and can be used in methods of making isobutanol.

There is provided a method for improving glucose, xylose and arabinose utilization in Saccharomyces cerevisiae, the method comprising the steps of: using Saccharomyces cerevisiae having the ability to convert xylose and / or arabinose to ethanol, lactic acid, succinic acid, farnesene or isobutanol as a chassis cell, the saccharomyces cerevisiae gene is modified in the following mode in a genome: A, mutation in a TRK1 gene of a potassium ion intracellular transporter causes increase of a potassium ion / sodium ion ratio in a saccharomyces cerevisiae cell, and / or B, mutation in a PUF2 gene of mRNA binding protein or knockout of the PUF2 gene causes deactivation, deletion, function reduction or mRNA translation intensity reduction of the PUF2. The constructed recombinant saccharomyces cerevisiae can produce ethanol, lactic acid, succinic acid, farnesene or isobutanol through fermentation by utilizing cellulase hydrolysate containing glucose, xylose and / or arabinose, and has a wide application prospect.

The invention provides a method for measuring the content of isobutanol in baijiu, and belongs to the technical field of baijiu quality evaluation. The method for determining the content of isobutanol in Baijiu comprises the following steps: (1) preparing isobutanol standard solutions with different mass concentrations and carrying out gas chromatographic analysis to obtain a peak area corresponding to each isobutanol standard solution, drawing a standard curve by taking the mass concentrations of the plurality of isobutanol standard solutions as abscissas and taking the peak areas corresponding to the plurality of isobutanol standard solutions as ordinates; and (2) performing gas chromatographic analysis on the white spirit by adopting an external standard method to obtain a peak area corresponding to the isobutanol in the white spirit, and then obtaining the content of the isobutanol in the white spirit according to the peak area and the standard curve. According to the determination method, the capillary chromatographic column is utilized to effectively separate the isobutanol in the white spirit, and the isobutanol in the white spirit is quantified by an external standard method, so that the determination method has the advantages of high efficiency and high precision.

Disclosed is a process for preparing 2,2,4,4-tetramethylcyclobutane-1,3-diol by reacting 2,2,4,4-tetramethylcyclobutane dione with isobutanol in the presence of a tandem transfer hydrogenation and Tischenko reaction catalyst.

The invention discloses a complex microbial inoculant for increasing the content of phenethyl alcohol and isobutanol in a liquor fermentation process, and belongs to the technical field of liquor fermentation. According to the invention, pichia kudriavzevii CCTCC NO: M 20252385 is compounded with a plurality of strains of Witzia ciliaris, so that the complex microbial inoculant capable of simultaneously increasing the content of isobutanol and phenethyl alcohol in the fermentation process of Baijiu is obtained. The obtained mixed microbial inoculum can increase the content of isobutanol and phenethyl alcohol, and compared with only using the same amount of pichia kudriavzevii CCTCC NO: M 20252385, the content of isobutanol and the content of phenethyl alcohol are increased by 62.5% and 45.5% respectively.

A process for the manufacture of polyisobutene comprising the steps of:-condensing methanol and a second alcohol in the gas phase, thereby producing an isobutanol-containing reaction mixture,-dehydrating isobutanol to isobutene,-subsequently polymerizing the isobutene thus obtained to polyisobutene.

Processes for making isobutanol are described. The processes involve a first reaction between methanol and ethanol in the presence of a first catalyst to produce an alcohol mixture containing propanol, isobutanol and n-butanol, and a second reaction between the produced propanol and synthesis gas in the presence of a second catalyst to produce isobutanol. The methanol and ethanol produced in the second reaction are recycled and used in the first reaction, and the unreacted propanol is recycled and used in the second reaction.

This invention includes an extractive distillation method for separating isobutanol-isobutyl formate azeotrope using ionic liquids. The process flow is as follows: The mixture of isobutanol and isobutyl formate to be separated is preheated and then enters an extractive distillation column. The ionic liquid 1-butyl-3-methylimidazolium acetate ([BMIM][OAC]) enters from the top of the column. High-purity isobutyl formate product is collected from the top of the column, and the mixture of isobutanol and ionic liquid is collected from the bottom of the column. The mixture is subjected to a two-stage flash distillation process to recover the ionic liquid. The vapor streams from the two flash distillations are condensed to obtain the isobutanol product. The ionic liquid regenerated liquid obtained from the bottom of the second flash distillation is introduced from the top of the extractive distillation column as a circulating stream. This process features high product purity, low energy consumption, high thermal efficiency, and environmental friendliness. Furthermore, it requires less equipment, is simple to operate, and is easily applicable to industrial production.

The invention discloses a method for preparing crystalline L-carnitine, which comprises the step of crystallizing L-carnitine in a mixed solvent consisting of cyclohexane and alcohol, and the alcohol is selected from one or more of n-propanol, isobutanol and n-butanol.