32 results about "Amyl ether" patented technology

The invention discloses a method for preparing high-quality mercaptoacetic acid from a tail solution from O-alkyl-N-alkyl thinocarbamate production. The method comprises the following steps: (1) performing acidizing treatment on the tail solution by using an inorganic acid, and controlling the pH value to be 0.5-1.5; (2) leaving to stand for 6-48 hours, separating suspended organic matters, extracting by using an organic solvent, and extracting by using an extraction agent, thereby obtaining an extraction liquid, wherein the volume ratio of the total amount of the organic solvent to an acidifying liquid is (2.5:0.01)-(2.5:0.1), the organic solvent consists of 40-60wt% of glutaric acid diethyl ester and 40-060wt% of ethyl malonic acid diethyl ester, the volume ratio of the total amount of the extracting agent to a new acidifying liquid is (2:0.1)-(2:2), and the extracting agent is prepared by mixing n-amyl ether, isoamyl ether and sec-butyl methyl ether in a mass ratio of (1-3):(1-3):(1-3); (3) removing the solvent and water from the extraction liquid, thereby obtaining crude acid; (4) performing flash evaporation on the crude acid. The method is high in recycling rate, high in product purity, good in quality and simple in process.

The invention discloses a synthesis method of oseltamivir. The synthesis method of oseltamivir comprises the following steps: starting from a compound 1,3-butadiene-3-amyl ether and compound 3-nitro-ethyl acrylate, carrying out Diels-Alder reaction, then reacting at room temperature in acetonitrile in the presence of a copper catalyst and PhI-NNs to prepare an aziridine compound in a one-pot method, wherein the mole ratio of the 1,3-butadiene-3-amyl ether to 3-nitro-ethyl acrylate to the copper catalyst is 1.1: 1: 0.025-0.1; and finally synthesizing the oseltamivir for preventing bird flu through the aziridine ring opening, nitryl and p-nitrobenzene sulfonyl removal, acetylation and hydrogenation. The method comprises short steps, the used reagent is cheap and easily available, the operation is simple, the total yield is up to 40%, and the method is a simple and efficient synthesis method of oseltamivir.

The invention discloses a cation exchange resin modification method and a methyl tert-amyl ether preparation method. According to the present invention, a sulfonic cation exchange resin is soaked sequentially with toluene and methyl isobutyl ketone, and soaking in stages is performed with distilled water, such that the specific surface and the pore size structure of the resin can be improved, andthe stability and the selectivity of the sulfonic cation exchange resin catalyst can be improved; and with the application of the modified resin as the catalyst in the preparation of methyl tert-amylether at a temperature of 75-250 DEG C under a pressure of 0.5-3.0 MPa by using C5 olefin and methanol as raw materials, the continuous production can be achieved, the advantages of high conversion rate, good stability and the like can be provided, and the method is the new environmentally friendly process.

The present invention provides a methyl tert-amyl ether preparation method. According to the present invention, a strong acid cation exchange resin catalyst suitable for catalyzing the etherificationbetween C5 olefin and methanol is placed into a low-carbon alcohol solution and is subjected to high-temperature high-pressure treatment, such that the specific surface and the pore size structure ofthe resin can be improved, and the stability and the selectivity of the sulfonic cation exchange resin catalyst can be improved; and the methyl tert-amyl ether is prepared at a temperature of 80-200 DEG C under a pressure of 0.1-4.0 MPa by using C5 olefin and methanol as raw materials, such that the continuous production can be achieved, the advantages of high conversion rate, good stability and the like can be provided, and the method is the new environmentally friendly process.