429 results about "Pentene" patented technology

Methods for treating patients with wAIHA comprising administering at least one compound chosen from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (rilzabrutinib) and pharmaceutically acceptable salts thereof are disclosed.

The invention belongs to the technical field of novel material catalysis, and particularly relates to a hollow mesoporous silica supported phosphotungstic acid catalyst and a preparation method and application thereof. According to the invention, the advantages of high specific surface area and regional effect performance of hollow mesoporous silica and the characteristic of adjustable acidity of vacancy heteropolyacid quaternary ammonium salt are innovatively combined, and the cationic surfactant is loaded on the surface of the hollow mesoporous silica, so that the contact surface of raw materials is effectively increased, efficient conversion of reactants is assisted, and the reaction efficiency is improved. The supported catalyst with efficient catalysis and stable performance is obtained. The catalyst can be used for a reaction for preparing glutaraldehyde through heterogeneous catalysis of cyclopentene oxidation, and the reaction condition is mild. Experiments show that under the catalytic system, the cyclopentene conversion rate can reach 90% or above, the glutaraldehyde selectivity is improved to 75% or above, double improvement of the cyclopentene conversion rate and the glutaraldehyde selectivity is successfully achieved, meanwhile, the advantage that the catalyst is easy to separate is achieved, and an efficient solution is provided for industrial application of synthesis of glutaraldehyde through cyclopentene oxidation.

A method for separating and purifying 4MP1 from a mixture containing 4MTP2 and 1-Hexene comprises the following steps: continuously introducing a solution in which 4MTP2, 1-Hexene and 4MP1 with any concentration are dissolved into a simulated moving bed chromatography system as a raw material solution, collecting a high-purity 4MP1 solution from raffinate of the simulated moving bed chromatography system by adopting a metal organic framework material as a stationary phase, and separating the high-purity 4MP1 solution from the raffinate of the simulated moving bed chromatography system. The extraction liquid is a solution containing impurities 4MTP2 and 1-Hexene. The invention provides a brand new method for separating 4MP1 from 4MTP2 and 1-Hexene, and a complete separation scheme is provided for the prior art; in the separation of high-concentration 4MP1, the relative purity of the separated and purified 4MP1 can reach gt; the recovery rate is gt; and in the separation of low-concentration 4MP1, the rectification level is also exceeded, and the method is more suitable for 4MP1 thermosensitive substances.

The invention discloses a preparation method and application of a catalyst with a high-valence tungsten coordination structure, and the preparation method of the catalyst comprises the following steps: enabling tungstic acid and hydrogen peroxide with specific concentration and proportion to react at a certain temperature to prepare a peroxy tungstic acid solution; dissolving a polydentate organic ligand capable of forming a stable chelation structure with a tungsten center in an organic solvent, mixing the obtained ligand solution with a peroxytungstic acid solution according to a specific ratio, and carrying out a coordination reaction at a certain temperature until the ligand is completely reacted; and finally, carrying out solid-liquid separation, washing and drying to obtain the high-valence tungsten coordination structure catalyst. The catalyst can be used for a reaction for synthesizing glutaraldehyde through cyclopentene oxidation, under the mild condition, hydrogen peroxide serves as a green oxidizing agent, the conversion rate of cyclopentene reaches 90% or above, the selectivity of glutaraldehyde exceeds 60%, the catalyst is stable in structure and can be recycled for 10 times or above, and the problems that in the prior art, a catalyst is difficult to separate, low in activity, poor in stability and the like are solved; the method has a remarkable industrial application value.

The invention discloses a preparation method of 3-chloro-5, 5-dimethyl-4, 5-dihydroisoxazole, which comprises the following steps: taking a hydroxylamine oxygen sulfonic acid aqueous solution and isopentenal as raw materials, carrying out oximation reaction in an organic solvent under an alkaline condition, then directly adding an acid or an organic base catalyst into the reaction system, and reacting for 2-4 hours to obtain 3-chloro-5, 5-dimethyl-4, 5-dihydroisoxazole, thereby obtaining the 3-chloro-5, 5-dimethyl-4, 5-dihydroisoxazole. Under the catalytic action of the catalyst, a cyclization reaction is carried out, after the reaction is finished, an intermediate solution containing 5, 5-dimethyl-4, 5-dihydroisoxazole is obtained, and the next step is directly carried out; and carrying out a chlorination reaction by taking the intermediate solution as a raw material and sodium hypochloride or chlorine as a chlorination reagent, and after the reaction is finished, carrying out post-treatment to obtain the 3-chloro-5, 5-dimethyl-4, 5-dihydroisoxazole. The hydroxylamine oxygen sulfonic acid is used for enabling the isopentenal to be subjected to oximation reaction under the alkaline condition, then cyclization is carried out under the catalytic action of acid or alkali, the 5, 5-dimethyl-4, 5-dihydroisoxazole is generated, and the process has the advantages that the yield is high, the production steps are simplified, and the production cost is reduced.

Methods for treating Sickle Cell Disease (SCD) comprising administering a BTKi, such as at least one compound chosen from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (rilzabrutinib) and pharmaceutically acceptable salts thereof, are disclosed.

This invention relates to the field of insulating materials, and more particularly to a thermoplastic polyolefin insulating material, its preparation method, and its applications. The raw materials for preparing the thermoplastic polyolefin insulating material mainly include functional modified monomers and polyolefins. The polyolefins include poly4-methylpentene, and the functional modified monomers are unsaturated acid anhydrides and their analogues, including at least one of citrate anhydride, maleimide, and maleic anhydride. The thermoplastic polyolefin insulating material prepared by this invention exhibits excellent high-temperature resistance and high-temperature DC volume resistivity, making it suitable for long-term use under high temperature and high electric field strength conditions. It can be used in the field of cable insulation materials and has thermoplastic recyclability.

[Problem] To provide a means capable of more efficiently exerting an antibacterial effect against bacteria. [Solution] An antibacterial agent containing at least two compounds selected from the group consisting of trans-2-methyl-2-pentenal, 2-methylbutanal, trans-2-hexenal, propionaldehyde, 3-methylpentanol, and 2,5-dimethylfuran.

This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain examples, modulators are derivatives of hexahydropental ene. In certain examples, this disclosure relates to methods of treating or preventing cancer, diabetes, or cardiovascular disease by administering an effective amount of a hexahydropentalene derivative disclosed herein.

The invention relates to an isopentenol polyoxyethylene ether defoaming agent and a preparation method thereof, the defoaming agent is mainly prepared from a cross-linked acrylic copolymer emulsion, an alkali swelling thickener, a modified organic silicon defoaming active matter, a pH regulator (NaOH / KOH), an isothiazolinone bactericide, deionized water and the like in proportion, and the defoaming agent has excellent defoaming performance and stability. A specific auxiliary agent is added. The foam problem of an isopentenol polyoxyethylene ether product in downstream application is solved, and the defoaming agent is mainly applied to defoaming of isopentenol polyoxyethylene ether.

This invention provides a novel phosphine oxide compound that inhibits SHP2, a composition thereof, a method for preparing the compound, and a method for treating SHP2-related diseases (such as cancer).

The application provides a preparation method of citral. By controlling the content of isopentenoic acid in a citral intermediate composition in the range of 10-2000 ppm, and then performing a thermal rearrangement reaction, citral product is prepared. The method can effectively reduce the selectivity of isomerization side reactions, and the yield of the final product citral is increased to more than 95%.

The invention relates to the technical field of catalysts, and discloses a catalyst and a preparation method thereof, and a method for preparing 4-methyl-1-pentene through propylene dimerization, the catalyst comprises a carrier, and an active metal component and an auxiliary metal component loaded on the carrier; wherein the carrier comprises potassium carbonate and a binder, the active metal component is selected from sodium and / or potassium, and the auxiliary metal component is selected from at least one of precious metals; wherein on the basis of the mass of the carrier, the content of the active metal component is 1-20wt% and the content of the auxiliary metal component is 0.1-10wt% in terms of metal elements. The catalyst has high catalytic activity and stability in propylene dimerization reaction.

The invention relates to an immersion cooling unit (1) comprising an immersion cell defining an internal cavity (3), a bath (5) comprising a dielectric working fluid partially filling the internal cavity and a gaseous phase so as to form a two-phase system; the unit (1) further comprising a condensation device which is positioned in the internal cavity above the electronic component such as not to be immersed in the dielectric working fluid and at least one electronic component (7) which is totally or at least partially immersed in said bath (5); the unit (1) is notable in that the dielectric working fluid comprises perfluoro-4-methyl-2-pentene and in that the gaseous phase comprises a moisture content of at least 20%. Figure for the abstract: Figure 1

The application discloses a catalyst for preparing n-pentene by hydrogenation of piperylene, which comprises a carrier alpha-Al2O3 modified by a metal M, an active noble metal and a Lewis acid supported on the carrier alpha-Al2O3, wherein the active noble metal is Pd; the mass percentage of the metal M in the catalyst is 0.8-2% according to 100%, the metal M is at least one metal selected from W, V or Ga, the mass percentage of the active noble metal Pd is 0.05-0.08%, the mass percentage of the Lewis acid is 0.06-0.3%, and the rest is the carrier. In addition, the application also discloses a preparation method of the catalyst and application of the catalyst in production of n-pentene; and the catalyst can keep high catalytic activity and n-pentene selectivity in a long-time reaction process.

The invention discloses a fuel detergent, a preparation method thereof and a mixed fuel. The fuel clearing agent comprises a clearing agent main agent and an optional auxiliary agent, and the clearing agent main agent comprises a pentene amine compound, polyether amine and a phenylacetone compound. The pentene amine compound, the polyether amine and the phenylacetone compound are combined, the pentene amine compound, the polyether amine and the phenylacetone compound are mixed for use to generate a synergistic effect, the cleaning effect of the fuel detergent can be remarkably improved, the polyether amine provides good dispersity and solubility, the phenylacetone compound can be fully dispersed in fuel, and the cleaning effect of the fuel detergent is improved. The ketone group of the phenylacetone compound can further enhance the removal capability of polyether amine to specific pollutants and improve the cleanliness of the fuel, and the pentene amine compound is combined, so that the combustion efficiency can be further improved and the emission of harmful gas can be further reduced.

This invention relates to the field of polyethylene insulation materials and discloses a polyethylene cable insulation material and its preparation method. The method includes: (1) blending an antioxidant, an anti-scorching agent, and low-density polyethylene by gravity metering, extruding, and then water-cooling and pelletizing to obtain granules; (2) preheating the granules by gravity metering and then sequentially mixing and impregnating them with a peroxide; the anti-scorching agent is 1,1-diphenylethylene and / or 2,4-diphenyl-4-methyl-1-pentene. The method provided by this invention can prepare a polyethylene cable insulation material with anti-scorching properties and high cleanliness. Furthermore, the performance of ultra-high voltage polyethylene cables above 110KV produced using the polyethylene cable insulation material provided by this invention is stable, and the scorching time is longer. Therefore, the polyethylene cable insulation material provided by this invention is suitable for the production of long-cycle cables.

The application belongs to the technical field of fine chemical industry, and discloses a method for synthesizing cyclopentanol, which comprises the following steps: (1) taking cyclopentene and water as raw materials, adding a solubilizer, and mixing to obtain a reaction liquid; (2) continuously hydrating the reaction liquid in a fixed bed reactor filled with a cation exchange resin to obtain a reaction product; and (3) distilling and separating the reaction product to obtain cyclopentanol. The synthesis method has the advantages of simple process flow, environmental protection, low energy consumption, excellent product indexes, and long operation cycle of the catalyst. Polyethylene glycol-400 or polypropylene glycol-400 is used as a single solubilizer, and a specific macroporous strong acid cation exchange resin catalyst is used to realize the efficient and high-selectivity hydration reaction of cyclopentene.

The invention provides a production method of high-purity cyclopentene, and belongs to the technical field of olefin production. According to the method, a crude cyclopentene raw material rich in cyclopentene, cyclopentane and 1, 2-pentadiene is mixed with hydrogen, the mixture is introduced into an adiabatic bubbling bed reactor for a selective hydrogenation reaction, and a catalyst is modified Pd / Al2O3. After hydrogenation reaction liquid is subjected to light component removal and refining, a high-purity cyclopentene product with the content of 99.9% or above and the content of 1, 2-pentadiene being 10 ppm or below is obtained, and the monomer requirement for producing cyclopentene rubber is met.

The invention provides 4-methyl-1-pentene and a preparation method of the 4-methyl-1-pentene. The preparation method comprises the following steps: carrying out dimerization reaction on propylene in a reactor of a fixed bed to obtain a dimerization product system; carrying out gas-liquid separation on the dimerization product system to obtain a liquid phase system containing 4-methyl-1-pentene; 4-methyl-1-pentene is obtained through separation from the liquid phase system; the fixed bed reactor is filled with a catalyst, and the catalyst comprises a carrier and alkali metal loaded on the carrier; the carrier is obtained by mixing and molding alkali metal salt, cyclodextrin and derivatives thereof, graphite, a reinforcing agent and water and then roasting; the reinforcing agent is selected from borate and / or silicate. The preparation method can improve the selectivity of 4-methyl-1-pentene and the conversion rate of propylene.

This invention discloses a photosensitive supramolecular fluorescent polymer, its preparation method, and its anti-counterfeiting application in water, using trifluoroethyl methacrylate, hexafluorobutyl acrylate, 4-(acryloyloxy)butyl4-(2-methyl-3-(2-(2-methylbenzo[b]thiophen-3-yl)-4-oxo-5,6-2H-4H-thiaran[2,3-)b]thiaran-3-yl)benzo[b]thiophen-6-yl)-4-oxobutyrate, 4 This polymer was prepared by a simple one-step free radical copolymerization method using 1,1-(acryloyloxy)butyl3-(3,3,4,4,5,5-hexafluoro-2-(2-methyl-1,1-dioxide benzo[b]thiophene-3-yl)cyclopent-1-en-1-yl)-2-methylbenzo[b]thiophene-6-carboxylate 1,1-dioxide and phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide (photoinitiator-819) as raw materials. The polymer exhibits excellent multicolor light-switching performance, high stretch ratio, high self-healing efficiency, strong substrate adhesion, and antifouling properties, especially demonstrating excellent stability under strong acid, strong alkali, and high salt environments. The synthetic route is simple, and it has great application potential in underwater anti-counterfeiting and encryption technologies.

The invention discloses a composition for repelling aphids and preventing potato Y virus infection and a virus and insect inhibitor, and belongs to the technical field of plant disease prevention and control. The pharmaceutical composition provided by the invention is prepared from at least two of 1-pentene-3-ketone, 2-ethyl furan and cis-4-heptenal, and the pharmaceutical composition is prepared from at least two of 1-pentene-3-ketone, 2-ethyl furan and cis-4-heptenal. The pharmaceutical composition not only can avoid aphids and reduce the probability that crops are infected by potato Y viruses, but also can realize the synergistic interaction among the drugs and avoid or reduce the drug resistance of the aphids to the drugs, so that the pharmaceutical composition has important practical value and application prospect in the technical field of plant disease control.

The invention relates to the technical field of propylene dimerization catalysts, and discloses a propylene dimerization catalyst, a preparation method thereof and a method for preparing 4-methyl-1-pentene through propylene dimerization, the preparation method comprises the following steps: (1) mixing alkali carbonate, graphite fluoride, methylcellulose and potassium stearate, and carrying out molding and molding roasting to obtain a carrier; wherein the mass ratio of the alkali carbonate to the graphite fluoride to the methyl cellulose to the potassium stearate is 100: (0.5-5): (0.1-20): (0.1-30); (2) loading an active metal on the carrier; wherein the active metal is selected from sodium and / or potassium. The catalyst prepared by the preparation method has high propylene conversion per pass and high 4M1P selectivity.

The application provides a kind of main catalyst for preparing poly (4-methyl-1-pentene) and its application.The main catalyst for preparing poly (4-methyl-1-pentene) of the application has the structure shown in formula I, in formula I, R1 is selected from hydrogen or phenyl, when R1 is selected from phenyl, R1 is fused with the benzene ring in formula I to form anthracene ring;R2 is selected from methyl or isopropyl.The main catalyst of the application is applied in catalytic system for catalyzing the homopolymerization reaction of 4-methyl-1-pentene, the catalyst shows high catalytic activity, and the poly (4-methyl-1-pentene) prepared has high molecular weight, narrow molecular weight distribution and high stereoregularity, and has broad market application prospect.

The application belongs to the technical field of food processing, and particularly relates to a processing method for improving aroma components of sweet potato stem and leaf powder. In the application, a traditional preparation process of sweet potato stem and leaf powder is improved, that is, a combination of ultra-low temperature crushing and superheated steam treatment is adopted to prepare a kind of sweet potato stem and leaf powder. In the obtained sweet potato stem and leaf powder, the total amount of volatile aroma substances is increased by 21.95% compared with that of the sweet potato stem and leaf powder prepared by the traditional method, wherein the relative content of 2-methyl butyric acid ethyl ester is increased from 0.35% to 2.17%, the relative content of terpinolene is increased from 0.12% to 2.15%, and the relative content of 1-pentene-3-ketone is increased from 0.21% to 1.52%. These aroma components endow the sweet potato stem and leaf powder with unique and strong original aroma of sweet potato, and significantly improve the quality of the sweet potato stem and leaf powder.

The invention discloses a preparation method of a propylene dimerization catalyst, which comprises the following steps: placing a nickel source, an organic ligand and a cobalt molybdenum compound in an anion solution, heating and stirring uniformly, and then drying, roasting and crushing to obtain catalyst active component powder; dissolving non-water-soluble resin, a surfactant and a porous material in ethanol to obtain a resin mixed solution; dissolving a dispersing agent in deionized water to obtain a microsphere forming solution, performing ultrasonic treatment on the resin mixed solution, dropwise adding the resin mixed solution into the microsphere forming solution, stirring, filtering out the formed microspheres, and drying at room temperature to obtain porous material microspheres; and placing the porous material pellets in a coating machine, enabling the active component to be attached to the pellet carrier under centrifugal force, and drying and roasting to obtain the catalyst pellets. The catalyst provided by the invention has higher activity, and improves the conversion rate of the dimerization reaction and the selectivity of the reaction target product 4-methyl-1-pentene under the synergistic cooperation of the catalyst and the cocatalyst.

The application discloses a prenylated polyketide compound, a preparation method and application thereof, and the prenylated polyketide compound is separated from rice fermented with Xylaria nigriplicata. The neuroprotective effect of the prenylated polyketide compound on glutamate-induced excitotoxicity of PC12 cells is clarified through comprehensive evaluation of cell viability, apoptosis and key oxidative stress markers.

The application discloses a synthesis method of 3,3-difluorocyclopentylamine hydrochloride, and particularly relates to the technical field of chemical synthesis. The synthesis method comprises the following steps: taking 2-cyclopentenone and phthalimide as raw materials, and sequentially performing a Michael addition reaction, deoxygenation fluorination, removal of a phthaloyl protecting group, Boc protection and deprotection and salt formation reaction to obtain 3,3-difluorocyclopentylamine hydrochloride. The synthesis route and process design of the application are reasonable, the starting raw material is 2-cyclopentenone, the required reaction condition is mild, the post-treatment method is simple, the operability is strong, the raw material and reagent are cheap and easy to obtain, and the total yield can reach 43.6%, so the synthesis method has large-scale preparation value.

This invention proposes a poly(4-methyl-1-pentene) resin based on a supported metallocene catalyst and its preparation method. Based on a stepwise loading process using a silanized porous support, by optimizing the type of support (such as SiO2, Al2O3, MCM-41), the amount of support added (3 to 15 times), and the stepwise loading sequence (co-catalyst first, then main catalyst), the catalyst activity, stability, and product performance are synergistically improved, providing an innovative solution for the conversion of supported catalysts into industrial-scale high-efficiency systems.

The present invention relates to the technical field of preparing 4-methyl-1-pentene, and specifically relates to a method and apparatus for preparing 4-methyl-1-pentene. The method comprises: causing a raw material containing propylene, a coke formation inhibitor and an optional diluent to undergo a dimerization reaction in the presence of a catalyst; performing gas-liquid separation on a resulting reaction mixture, to obtain a gas and / or supercritical phase flow and a liquid phase flow; splitting the gas and / or supercritical phase flow into two portions, a portion of the gas and / or supercritical phase flow undergoing heat recovery treatment and being returned as a recycled stream to the dimerization reaction; and performing distillation of the remaining portion of the gas and / or supercritical phase flow and the liquid phase flow, to obtain 4-methyl-1-pentene. The method and the corresponding apparatus enable efficient temperature control, high 4M1P selectivity, and long-cycle operation with relatively low energy consumption.