701 results about "Pentene" patented technology

The invention discloses a perovskite solar cell based on buried interface modification and a preparation method and application thereof. The invention relates to an application of 2-(acrylamide) benzoic acid and / or 2-(4-pentenoylamido) benzoic acid in a trans-perovskite solar cell buried interface modifier. According to the invention, 2-(acrylamide) benzoic acid and / or 2-(4-pentenylamido) benzoic acid are / is used as a buried interface modifier, such molecules take benzoic acid as an anchoring group, and through the synergistic effect among carboxyl, amido and carbon-carbon double bonds, the defects at the thin film grain boundary of the hole transport layer and the perovskite layer are reduced; according to the invention, the NiOX thin film is introduced into the small molecules, and the alkyl chain is further introduced into the small molecules and can effectively fill small recesses and holes in the NiOX thin film, so that the flatness of the NiOX thin film is improved, a compact and compact modification layer is formed, the morphology of the perovskite layer thin film is further regulated and controlled, and the photoelectric conversion efficiency of the perovskite solar cell is improved.

A technology for preparing glutaraldehyde through cyclopentene oxidation belongs to the technical field of organic synthesis, glutaraldehyde is prepared through cyclopentene oxidation by adopting a photocatalysis-electrocatalysis synergistic catalyst g-C3N4 / TiO2 (at) Au-Co / N-G. The catalyst is of a unique core-shell structure, is stable in property, promotes an oxygen reduction reaction in a catalysis technology, and has good catalytic activity. The conversion rate of cyclopentene and the selectivity of glutaraldehyde are remarkably improved, and the effect is remarkable.

The invention belongs to the technical field of organic synthesis, and relates to a preparation method of 5, 5-dimethyl-4, 5-dihydroisoxazole. The method comprises the following steps: (1) reacting isopentenal with an oximation agent to obtain a reaction solution containing isopentenal oxime; (2) dropwise adding the reaction liquid into a mixture containing isopentenal and an acid catalyst for reaction to obtain a product; or when the reaction liquid contains water, performing phase splitting on the reaction liquid to obtain an organic phase, and dropwise adding the organic phase into a mixture containing the isopentenal and the acid catalyst for reaction to obtain a product. The method does not produce ketone by-products, and is good in atom economy, high in reaction yield, good in technological process continuity, low in cost, few in materials, simple to operate, mild in reaction condition, low in requirements on production equipment and suitable for large-scale industrial production.

The invention relates to a polycarboxylic acid water reducer and a preparation method thereof, and the water reducer is prepared from the following raw materials: 45 to 55 percent of isopentenyl polyoxyethylene ether, 28 to 35 percent of acrylic acid, 1.5 to 2.5 percent of modifier, 0.3 to 0.5 percent of ammonium persulfate, 0.03 to 0.06 percent of ascorbic acid, 5 to 8 percent of hydroxyethyl methylacrylate, 0.15 to 0.25 percent of 2, 4-diphenyl-4-methyl-1-pentene and the balance of water. The modifier is prepared from the following raw materials: 1, 5-dichloronaphthalene, p-nitrostyrene, dimethyl sulfate, ceric ammonium nitrate and tetramethylpiperidine oxide. The polycarboxylate superplasticizer has excellent neat paste fluidity and fluidity retention capability, has low 1h time-dependent variable slump which is below 18mm and optimally 10mm when applied to concrete, has a water-reducing rate of more than 40% and a gas content of less than 3.8%, and also has more advantages in compressive strength ratio.

Methods for treating patients with wAIHA comprising administering at least one compound chosen from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (rilzabrutinib) and pharmaceutically acceptable salts thereof are disclosed.

The application discloses a preparation method of a hollow fiber exchange membrane and the hollow fiber exchange membrane, and the preparation method comprises the following steps: stirring and melting poly(4-methyl-1-pentene), a diluent, an antioxidant and an anti-volatilization agent at 220 DEG C to 280 DEG C to obtain a casting solution; extruding and spinning the casting solution through a spinneret to form a hollow fiber, then passing through an air gap to enter a cooling liquid to solidify to obtain a semi-finished product membrane; placing the semi-finished product membrane into an extracting agent to remove the diluent in the semi-finished product membrane through extraction; and drying the semi-finished product membrane after the diluent is removed to obtain the hollow fiber exchange membrane. The preparation method of the hollow fiber exchange membrane adds the antioxidant and the anti-volatilization agent into the diluent, solves the problems of discoloration and decomposition of the diluent caused by high temperature during high-temperature mixing and extrusion molding of the casting solution, the size, gas flux and mechanical properties of the prepared membrane are more stable, and the prepared hollow fiber exchange membrane has a better membrane structure and better performance.

The invention provides a preparation method of 2-pentyl-2-cyclopentenone, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: carrying out a first-stage isomerization reaction on 2-pentylidene cyclopentanone and a first composite catalyst in a first atmosphere to obtain an intermediate, carrying out a second-stage isomerization reaction on the intermediate and a second composite catalyst in a second atmosphere, and controlling the volume ratio of nitrogen to hydrogen in the first atmosphere and the second atmosphere to obtain the 2-pentylidene cyclopentanone. In the first-stage isomerization reaction, the conversion rate of converting 2-pentylidene cyclopentanone into 2-pentyl-2-cyclopentenone is increased, and in the second-stage isomerization reaction, the use amount of hydrogen in the second atmosphere is reduced, the temperature of the second-stage isomerization reaction is increased, generation of by-products is inhibited, and the yield of 2-pentylidene cyclopentanone is increased. Further, the yield and the purity of the 2-pentyl-2-cyclopentenone can be improved. According to the preparation method, the first-stage isomerization reaction and the second-stage isomerization reaction are continuous reactions, intermittent reactions are not needed, and the preparation method is more suitable for industrial application.

The invention discloses a high-temperature-resistant poly (4-methyl-1-pentene) dielectric film with synergistically improved insulating strength and dielectric property and a preparation method and application thereof, and belongs to the field of preparation processes of polymer energy storage dielectric materials. The invention aims to solve the problems that the existing polymer energy storage material is low in energy storage density at high temperature, and the dielectric property and the insulating strength cannot be improved at the same time. The invention provides a method for preparing a norbornene dianhydride grafted poly (4-methyl-1-pentene) film by a two-step method by using poly (4-methyl-1-pentene) particles, norbornene dianhydride and dicumyl peroxide and combining a solution suspension technology with a melt casting extrusion technology and a one-way stretching traction technology. The high-temperature-resistant poly (4-methyl-1-pentene)-based dielectric film prepared by the invention has excellent breakdown strength and dielectric property, and the discharge energy density is as high as 5.92 J / cm < 3 > when the charge-discharge efficiency is greater than or equal to 90% at 150 DEG C.

The invention belongs to the technical field of building materials, and particularly relates to a silane modified starch-based polycarboxylate superplasticizer and a preparation method thereof. The water reducing agent is prepared by taking renewable sulfonated starch as a raw material, performing graft modification through vinyltriethoxysilane (A151), introducing active double bonds into starch molecules, and then copolymerizing with monomers such as isopentenol polyoxyethylene ether (TPEG) and acrylic acid. Compared with the prior art, the mixing amount of the vinyltriethoxysilane (A151) is only 1%-5% of the mass fraction of the acrylic acid, the mixing amount is low, and the cost is saved; the water reducing and dispersing performance of the starch-based polycarboxylic acid water reducing agent is improved, and a certain viscosity reducing effect is achieved.

The invention belongs to the technical field of novel material catalysis, and particularly relates to a hollow mesoporous silica supported phosphotungstic acid catalyst and a preparation method and application thereof. According to the invention, the advantages of high specific surface area and regional effect performance of hollow mesoporous silica and the characteristic of adjustable acidity of vacancy heteropolyacid quaternary ammonium salt are innovatively combined, and the cationic surfactant is loaded on the surface of the hollow mesoporous silica, so that the contact surface of raw materials is effectively increased, efficient conversion of reactants is assisted, and the reaction efficiency is improved. The supported catalyst with efficient catalysis and stable performance is obtained. The catalyst can be used for a reaction for preparing glutaraldehyde through heterogeneous catalysis of cyclopentene oxidation, and the reaction condition is mild. Experiments show that under the catalytic system, the cyclopentene conversion rate can reach 90% or above, the glutaraldehyde selectivity is improved to 75% or above, double improvement of the cyclopentene conversion rate and the glutaraldehyde selectivity is successfully achieved, meanwhile, the advantage that the catalyst is easy to separate is achieved, and an efficient solution is provided for industrial application of synthesis of glutaraldehyde through cyclopentene oxidation.

A method for separating and purifying 4MP1 from a mixture containing 4MTP2 and 1-Hexene comprises the following steps: continuously introducing a solution in which 4MTP2, 1-Hexene and 4MP1 with any concentration are dissolved into a simulated moving bed chromatography system as a raw material solution, collecting a high-purity 4MP1 solution from raffinate of the simulated moving bed chromatography system by adopting a metal organic framework material as a stationary phase, and separating the high-purity 4MP1 solution from the raffinate of the simulated moving bed chromatography system. The extraction liquid is a solution containing impurities 4MTP2 and 1-Hexene. The invention provides a brand new method for separating 4MP1 from 4MTP2 and 1-Hexene, and a complete separation scheme is provided for the prior art; in the separation of high-concentration 4MP1, the relative purity of the separated and purified 4MP1 can reach gt; the recovery rate is gt; and in the separation of low-concentration 4MP1, the rectification level is also exceeded, and the method is more suitable for 4MP1 thermosensitive substances.

The invention belongs to the technical field of biomedical materials, and particularly relates to a poly-4-methyl-1-pentene (PMP) gas-blood exchange membrane for an extracorporeal membrane oxygenation (ECMO) system, which realizes a long-acting antithrombotic function through a bionic interface construction technology. The invention aims to provide a bionic antithrombotic PMP gas-blood exchange membrane based on zwitter-ion gradient grafting, and through material and process innovation, the following problems existing in a traditional ECMO gas-blood exchange membrane: an antithrombotic coating is easy to fall off, and the long-term effect is insufficient; the risk of blood injury caused by dependence on heparin or anticoagulants; and the surface modification process destroys the membrane pore structure and air permeability.

The invention discloses a preparation method and application of a catalyst with a high-valence tungsten coordination structure, and the preparation method of the catalyst comprises the following steps: enabling tungstic acid and hydrogen peroxide with specific concentration and proportion to react at a certain temperature to prepare a peroxy tungstic acid solution; dissolving a polydentate organic ligand capable of forming a stable chelation structure with a tungsten center in an organic solvent, mixing the obtained ligand solution with a peroxytungstic acid solution according to a specific ratio, and carrying out a coordination reaction at a certain temperature until the ligand is completely reacted; and finally, carrying out solid-liquid separation, washing and drying to obtain the high-valence tungsten coordination structure catalyst. The catalyst can be used for a reaction for synthesizing glutaraldehyde through cyclopentene oxidation, under the mild condition, hydrogen peroxide serves as a green oxidizing agent, the conversion rate of cyclopentene reaches 90% or above, the selectivity of glutaraldehyde exceeds 60%, the catalyst is stable in structure and can be recycled for 10 times or above, and the problems that in the prior art, a catalyst is difficult to separate, low in activity, poor in stability and the like are solved; the method has a remarkable industrial application value.

The invention belongs to the technical field of organic matter preparation, and particularly relates to a preparation method of 2-pentylcyclopentyl-2-ketene. According to the method, methanol is used as a solvent, sulfonic acid type resin doped with lewis acid is used as a catalyst to catalyze the isomerization reaction of 2-pentylidene cyclopentanone, the catalyst and the methanol solvent can jointly promote the isomerization reaction of 2-pentylidene cyclopentanone, and the catalytic efficiency is high, so that the reaction yield is remarkably increased, and the catalyst cost is reduced; in addition, a fixed bed reactor continuous production mode is adopted, waste salt is prevented from being generated when the acid catalyst is quenched by processes such as HCl / HBr / p-toluenesulfonic acid, and methanol is used as a solvent, so that the byproduct dimethyl ether is simply separated from water and the solvent methanol. In addition, when the sulfonic acid type resin doped with the lewis acid is used for catalyzing the isomerization reaction of 2-pentylidene cyclopentanone, the stability is high, and the service life is long.

The invention discloses a preparation method of 3-chloro-5, 5-dimethyl-4, 5-dihydroisoxazole, which comprises the following steps: taking a hydroxylamine oxygen sulfonic acid aqueous solution and isopentenal as raw materials, carrying out oximation reaction in an organic solvent under an alkaline condition, then directly adding an acid or an organic base catalyst into the reaction system, and reacting for 2-4 hours to obtain 3-chloro-5, 5-dimethyl-4, 5-dihydroisoxazole, thereby obtaining the 3-chloro-5, 5-dimethyl-4, 5-dihydroisoxazole. Under the catalytic action of the catalyst, a cyclization reaction is carried out, after the reaction is finished, an intermediate solution containing 5, 5-dimethyl-4, 5-dihydroisoxazole is obtained, and the next step is directly carried out; and carrying out a chlorination reaction by taking the intermediate solution as a raw material and sodium hypochloride or chlorine as a chlorination reagent, and after the reaction is finished, carrying out post-treatment to obtain the 3-chloro-5, 5-dimethyl-4, 5-dihydroisoxazole. The hydroxylamine oxygen sulfonic acid is used for enabling the isopentenal to be subjected to oximation reaction under the alkaline condition, then cyclization is carried out under the catalytic action of acid or alkali, the 5, 5-dimethyl-4, 5-dihydroisoxazole is generated, and the process has the advantages that the yield is high, the production steps are simplified, and the production cost is reduced.

The invention relates to the technical field of biological medicines, in particular to a polycyclic polyisopentenyl cyclopentanone compound as well as a preparation method and application thereof. The polycyclic polyisopentenyl cyclopentanone compound provided by the invention has a structural formula as shown in a formula 1; the preparation method comprises the following steps: by taking dry fruits of hypericum berry as raw materials, carrying out percolation extraction and concentration to obtain an extract, suspending the extract in water to obtain a suspension, and extracting and concentrating the suspension with petroleum ether to obtain a crude extract; the crude extract is taken and subjected to positive and negative phase silica gel column separation, MCI medium-pressure column chromatography, Sephadex LH-20 gel column chromatographic separation, high performance liquid chromatography preparation and CHIRALPAK IG chiral column resolution, and the polycyclic polyisopentenyl cyclopentanone compound is obtained. The protection activity of the compound on AC16 myocardial cell injury induced by cold ischemia is evaluated, and the compound can be used for preparing the polycyclic polyisopentenyl cyclopentanone compound. The compounds can be used as lead compounds for developing medicines for preventing and treating myocardial cold ischemia injury.

Methods for treating Sickle Cell Disease (SCD) comprising administering a BTKi, such as at least one compound chosen from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (rilzabrutinib) and pharmaceutically acceptable salts thereof, are disclosed.

Disclosed herein are novel formulations of 2-[(3R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4[4-(oxetan-3-yl)piperazin-1-yl]-pent-2-enenitrile, including formulations including various solid forms thereof. Also disclosed are processes for preparing formulations of 2-[(3R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4[4-(oxetan-3-yl)piperazin-1-yl]-pent-2-enenitrile.

The invention provides an application of two polycyclic polyisopentenyl acyl phloroglucinol compounds (PPAP) with different skeleton types in preparation of drugs for relieving / treating neurodegenerative diseases. Belongs to the technical field of medicines. Hypheronone A provided by the invention is a 1, 9-split-ring polycyclic polyisopentenyl phloroglucinol compound, and hypheronone L is a polycyclic polyisopentenyl phloroglucinol compound which is formed by carrying out intramolecular [4 + 2] cyclization on a monocyclic polyisopentenyl phloroglucinol compound and has a complex ring system. The compound hypherone A and the compound hypherone L both have the activity of enhancing the current of a voltage-gated T-type calcium channel, can be used for preparing medicines for treating neurodegenerative diseases, particularly can be used for preparing medicines for relieving and / or treating diseases such as spinal cerebellar ataxia, Alzheimer's disease and intellectual syndrome, and have clinical application value.

The invention provides an anodic oxidation solution. The anodic oxidation solution comprises the following components of 5 g / L to 20 g / L of citric acid, 20 g / L to 50 g / L of oxalic acid, 4 g / L to 7 g / L of inorganic cerium salt, 5 g / L to 9 g / L of triethanolamine, 1 g / L to 3 g / L of aluminum isopropoxide and 5 g / L to 7 g / L of 3-methyl-2-pentene-4-alkyne-1-alcohol. The invention further provides an anodic oxidation method suitable for the aluminum material, according to the anodic oxidation method, the anodic oxidation liquid is adopted for oxidation, the oxidation temperature is 8-12 DEG C, the oxidation current density is 1-5 A / dm < 2 >, the oxidation voltage is 30-50 V, and the oxidation time is 20-30 min. The anodic oxidation liquid is matched with oxidation parameters, so that the film forming speed of an oxidation film is increased, and the voltage resistance of a product is improved.

The invention provides a 7-acylhydrazone-cyclopentene pyridine compound, a preparation method and application thereof, a pharmaceutical composition and application thereof, and relates to the technical field of medicines. According to the invention, an acylhydrazone group with pesticide activity is connected to the 7th site of cyclopentene pyridine to obtain the cyclopentene pyridine compound containing an acylhydrazone active fragment. The 7-acylhydrazone-cyclopentene pyridine compound provided by the invention contains a special Schiff base structure of a-CONHN = C-substructure, and an acylhydrazone group contains oxygen atoms and nitrogen atoms at the same time, can participate in formation of hydrogen bonds in organisms, has certain flexibility, is firmer in combination with receptors, has wide biological activity, and can be used for preparing a novel compound for preparing the 7-acylhydrazone-cyclopentene pyridine compound. And the compound has good application prospects in preparation of insecticides, bactericides, herbicides, anti-HIV drugs, anti-virus drugs or anti-cancer drugs, especially in plant protection, for example, the compound has good application prospects in preparation of insecticides, bactericides, herbicides, anti-virus drugs, anti-HIV drugs or anti-cancer drugs.

Mixtures configured to etch a thin film of an integrated circuit material are disclosed. The mixtures may include a first compound comprising one or more of: A, B, and C; and a second compound comprising one or more of: oxygen, argon, helium, nitrogen, octafluorocyclobutane (C4F8), hexafluorobutadiene (C4F6), carbonyl fluoride (COF2), difluoromethane (CH2F2), trifluoromethane (CHF3), carbon tetrafluoride (CF4), methyl fluoride (CH3F), octafluorocyclopentene (C5F8), 2,3,3,3-tetrafluoropro-l-ene (C3H2F4), 2,3,3,3-tetrafluoropro-l-ene (C3H2F4), hexafluoropropene (C3F6), hexafluorocyclopropane (C3F6), or 1,1,3,3,3-pentafhioropropene (C3HF5).

The invention discloses an icaritin derivative, a composition and application, the structural formula of the icaritin derivative is as follows: in the structural formula, R1 is independently selected from hydrogen, hydroxyl and C1-C3 alkoxy; r2 is independently selected from hydrogen, an isopentenyl group, an isoamyl group and a Mannich base; r3 is independently selected from hydrogen, hydroxyl or OR3 ', R3 'is selected from rhamnosyl, rhamnose-(2-> 1)-glucosyl, rhamnose-(3-> 1)-glucosyl, propynyl and triazole groups substituted by alcoholic hydroxyl, benzyl and glycosyl; r4 is independently selected from a hydroxyl group or OR4 ', and R4' is selected from a propynyl group, a glucosyl group, and an alcoholic hydroxyl group, a benzyl group and a glycosyl substituted triazole group; r5 is independently selected from hydrogen, isopentenyl and Mannich base; mannich base is selected from N (CH3) 2 and N (CH2CH3) 2, R6 is independently selected from hydroxyl and OR6 ', and R6' is selected from hydrogen, rhamnosyl, rhamnose-(2-> 1)-xylosyl and rhamnose-(2-> 1)-rhamnosyl.The icaritin derivative provides a new direction for treatment of sarcopenia.

This invention relates to the field of insulating materials, and more particularly to a thermoplastic polyolefin insulating material, its preparation method, and its applications. The raw materials for preparing the thermoplastic polyolefin insulating material mainly include functional modified monomers and polyolefins. The polyolefins include poly4-methylpentene, and the functional modified monomers are unsaturated acid anhydrides and their analogues, including at least one of citrate anhydride, maleimide, and maleic anhydride. The thermoplastic polyolefin insulating material prepared by this invention exhibits excellent high-temperature resistance and high-temperature DC volume resistivity, making it suitable for long-term use under high temperature and high electric field strength conditions. It can be used in the field of cable insulation materials and has thermoplastic recyclability.

[Problem] To provide a means capable of more efficiently exerting an antibacterial effect against bacteria. [Solution] An antibacterial agent containing at least two compounds selected from the group consisting of trans-2-methyl-2-pentenal, 2-methylbutanal, trans-2-hexenal, propionaldehyde, 3-methylpentanol, and 2,5-dimethylfuran.

This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain examples, modulators are derivatives of hexahydropental ene. In certain examples, this disclosure relates to methods of treating or preventing cancer, diabetes, or cardiovascular disease by administering an effective amount of a hexahydropentalene derivative disclosed herein.

The application relates to the technical field of concrete, and discloses high-permeability-resistant recycled micro-powder concrete and a preparation method thereof. The steps are as follows: 3-(isobutenoyloxy)propyl trimethoxysilane is taken, ethanol aqueous solution is added, the temperature is increased to 40-60 DEG C, and stirring is carried out for 1-2 hours; nano glass beads are added, and the temperature is continuously kept and stirred for 2-4 hours; filtration, washing and drying are carried out, and double-bonded glass beads are obtained; iso-pentenyl polyoxyethylene ether is taken, water is added, and stirring is carried out until the water is uniformly mixed; an initiator is added, and stirring and dissolution are carried out, so that a mixed solution A is obtained; acrylic acid, sodium methallyl sulfonate and double-bonded glass beads are taken, water is added, and stirring is carried out until the water is uniformly mixed; the temperature is increased to 60-70 DEG C, the mixed solution A is added dropwise, the dropwise addition is completed in 2-3 hours, the temperature is increased to 75-80 DEG C, and the temperature is kept for 3-4 hours; the pH value is adjusted to be neutral; filtration and drying are carried out, and modified micro-beads are obtained; coarse aggregate, fine aggregate, recycled micro-powder, fly ash, cement, modified micro-beads, an additive and water are mixed, and high-permeability-resistant recycled micro-powder concrete is obtained.

The invention relates to an isopentenol polyoxyethylene ether defoaming agent and a preparation method thereof, the defoaming agent is mainly prepared from a cross-linked acrylic copolymer emulsion, an alkali swelling thickener, a modified organic silicon defoaming active matter, a pH regulator (NaOH / KOH), an isothiazolinone bactericide, deionized water and the like in proportion, and the defoaming agent has excellent defoaming performance and stability. A specific auxiliary agent is added. The foam problem of an isopentenol polyoxyethylene ether product in downstream application is solved, and the defoaming agent is mainly applied to defoaming of isopentenol polyoxyethylene ether.

The invention relates to the technical field of concrete, and discloses high-impermeability regenerated micro-powder concrete and a preparation method thereof. The preparation method comprises the following steps: adding 3-(methacryloyloxy) propyltrimethoxysilane into an ethanol water solution, heating to 40-60 DEG C, stirring for 1-2 hours, adding nano glass beads, continuously carrying out heat preservation and stirring for 2-4 hours, filtering, washing and drying to obtain double-bond glass beads; the preparation method comprises the following steps: taking isopentenyl polyoxyethylene ether, adding the isopentenyl polyoxyethylene ether into water, uniformly stirring, adding an initiator, and stirring and dissolving to obtain a mixed solution A; adding acrylic acid, sodium methallyl sulfonate and double-bond glass beads into water, uniformly stirring, heating to 60-70 DEG C, dropwise adding the mixed solution A for 2-3 hours, heating to 75-80 DEG C, keeping the temperature for 3-4 hours, adjusting the pH value to be neutral, filtering, and drying to obtain modified microspheres; and mixing the coarse aggregate, the fine aggregate, the regenerated micro powder, fly ash, cement, the modified microbeads, an additive and water to obtain the high-impermeability regenerated micro powder concrete.

This invention provides a novel phosphine oxide compound that inhibits SHP2, a composition thereof, a method for preparing the compound, and a method for treating SHP2-related diseases (such as cancer).