281 results about "Hexene" patented technology

The invention relates to the field of pouring sealants, and discloses a modified epoxy resin pouring sealant and a preparation method thereof, the pouring sealant comprises epoxy resin, a modified inorganic filler, a modified additive and an auxiliary agent; the modified inorganic filler is prepared by grafting a quaternized s-triazine derivative and an inorganic filler; the quaternized s-triazine derivative is prepared through the steps that 3, 5-diaminophenylboronic acid, cyanuric chloride, 3-chloropropyltrimethoxysilane and 1, 4-butanediamine are sequentially subjected to substitution to prepare a s-triazine derivative, then the s-triazine derivative reacts with N, N-dimethyl-1, 3-diaminopropane, and bromoethane is used for quaternization treatment. The modified additive is prepared from a modified bismaleimide monomer prepared from maleic anhydride and 5 (6)-amino-1-(4-aminophenyl)-1, 3, 3-trimethylindane and 1-methyl-4-isopropyl cyclohexene through a self-stabilization precipitation polymerization method, the prepared pouring sealant is high in tensile strength, good in impact resistance and good in mechanical property, and the prepared pouring sealant has the advantages of being good in mechanical property, good in mechanical property and good in mechanical property. Meanwhile, good heat resistance, flame retardance, dielectricity and antibacterial activity are achieved.

The invention provides a polyethylene composite film. The polyethylene composite film comprises a surface layer, a middle layer and a heat sealing layer which are sequentially stacked, wherein the surface layer is composed of 58%-76% of hexene copolymerized metallocene linear low density polyethylene, 18%-37% of low density polyethylene and a small amount of slipping agent and anti-blocking agent; the middle layer is composed of 79%-88% of octene copolymerized metallocene medium density polyethylene, 5%-21% of hexene copolymerized metallocene linear low density polyethylene and 6%-15% of high density polyethylene; and the heat sealing layer is composed of 47%-65% of hexene copolymerized metallocene linear low density polyethylene, 33%-45% of low density polyethylene and 2%-5% of a tackifier. According to the composite film disclosed by the invention, through gradient design of each layer of material, the whole composite film has rigidity and toughness, and the composite film is particularly suitable for manufacturing stand-up bag packages which stand stably and are compression-resistant and impact-resistant.

The invention provides a composition for luring bactrocera cucurbitae and application thereof, and relates to the technical field of green prevention and control of agricultural pests. The composition comprises the following active ingredients in percentage by weight: 10% of muscovone, 0.1% of heptanal and 0.1% of hexene. The main components of the composition all come from natural plant volatile matters, and the composition is easy to degrade in the natural environment, has no residual risk and is friendly to the ecological environment. Meanwhile, the composition has high safety to bees, pollination insects and other non-target organisms, and ecological side effects possibly brought by traditional chemical attractants are effectively avoided. According to the implementation of the method, an efficient and specific tool is provided for field monitoring of bactrocera cucurbitae populations, the occurrence dynamic of the bactrocera cucurbitae can be accurately mastered, the early warning capability is improved, a new technical path and an implementation basis are provided for promoting green comprehensive treatment of the bactrocera cucurbitae, and the method has good popularization and application prospects.

A method for separating and purifying 4MP1 from a mixture containing 4MTP2 and 1-Hexene comprises the following steps: continuously introducing a solution in which 4MTP2, 1-Hexene and 4MP1 with any concentration are dissolved into a simulated moving bed chromatography system as a raw material solution, collecting a high-purity 4MP1 solution from raffinate of the simulated moving bed chromatography system by adopting a metal organic framework material as a stationary phase, and separating the high-purity 4MP1 solution from the raffinate of the simulated moving bed chromatography system. The extraction liquid is a solution containing impurities 4MTP2 and 1-Hexene. The invention provides a brand new method for separating 4MP1 from 4MTP2 and 1-Hexene, and a complete separation scheme is provided for the prior art; in the separation of high-concentration 4MP1, the relative purity of the separated and purified 4MP1 can reach gt; the recovery rate is gt; and in the separation of low-concentration 4MP1, the rectification level is also exceeded, and the method is more suitable for 4MP1 thermosensitive substances.

The invention relates to the technical field of petroleum drilling fluid loss reduction, and discloses an anti-divalent salt fluid loss agent for drilling fluid, which is prepared by the following steps: step 1, beta-cyclohexylamine and 6-chloro-1-hexene are subjected to a reaction to obtain alkenyl beta-cyclohexylamine; step 2, initiating polymerization of alkenyl beta-cyclopentadiene, a hyperbranched monomer pentaerythritol triallyl ether and 2-acrylamide-2-methylpropanesulfonic acid under the action of azobis (isobutylamidine hydrochloride), so as to obtain an intermediate A; 3, 3-dimethylamino-1-propylamine and palmitic acid are subjected to a reaction, and an intermediate 2 is obtained; 4, the intermediate 2 and benzyl chloride are subjected to a reaction, and quaternary ammonium salt modified fatty acid is obtained; and 5, stirring and mixing the intermediate A, quaternary ammonium salt modified fatty acid and coupling agent modified walnut powder to obtain the divalent salt resistant filtrate reducer for the drilling fluid. The anti-divalent salt filtrate reducer for the drilling fluid has a relatively good anti-divalent salt effect.

This invention discloses a method for synthesizing a venetum intermediate, specifically as follows: Step 1: In an organic solvent, 2,4-difluorobenzoic acid and 5-hydroxy-7-azaindole undergo an etherification reaction under the action of an acid-binding agent. After the reaction, post-treatment yields 2-((1h-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fluorobenzoic acid; Step 2: 2-((1h-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fluorobenzoic acid reacts with 1-((2-(4-chlorophenyl)-4,4-dimethylcyclohexene-1-)methyl)piperazine in… An amination reaction occurs under the action of a base. After the reaction, post-treatment yields 2-(7-azaindole-5-oxy)-4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohexene-1-)methyl)piperazine-1-)benzoic acid, i.e., Venetantora intermediate III. The synthetic process provided by this invention avoids Grignard reactions and subsequent hydrolysis reactions, shortens the operation steps, simplifies the synthetic process, and provides a simple and easy-to-operate synthetic process. The raw materials are inexpensive and readily available, while avoiding the use of highly toxic raw materials. The production process is green and environmentally friendly, and suitable for industrial production.

This invention relates to the field of organic synthesis technology and discloses a method for preparing 3,4-epoxycyclohexylmethyl-3,4-epoxycyclohexylcarboxylic acid ester, comprising the steps of: S1, providing raw material: 3-cyclohexenecarboxylic acid-3′-cyclohexene methyl ester; S2, epoxidation reaction: mixing the raw material with hydrogen peroxide, a composite catalyst, and a buffer to obtain a reaction solution containing the target product; S3, separation and purification: allowing the reaction solution to stand and separate into layers, separating the organic phase, washing with water, drying, and vacuum distilling to obtain 3,4-epoxycyclohexylmethyl-3,4-epoxycyclohexylcarboxylic acid ester. This method for preparing 3,4-epoxycyclohexylmethyl-3,4-epoxycyclohexylcarboxylic acid ester uses hydrogen peroxide as the oxygen source, resulting in no heavy metal pollution, low wastewater volume, and conforming to the trend of green chemistry. The composite catalyst requires a small amount, has high activity and good selectivity, can be recycled ≥5 times, reducing costs, requiring less equipment, and is highly safe. The product is colorless and transparent, with a high epoxy value, purity ≥98.5%, low acid value, and good stability.

Systems and methods of producing 1-hexene are disclosed. The methods include oligomerizing ethylene to produce 1-hexene in a reactor unit, which involves flowing a first solvent system into the reactor unit, the first solvent system adapted to improve selectivity of 1-hexene in the oligomerizing of the ethylene. The methods can include flowing part of a second solvent system into the reactor unit under washing mode, the second solvent system adapted to dissolve by-products in the reactor unit being washed. The methods can include flowing part of a second solvent system into the catalyst preparation unit, the second solvent system adapted to dissolve catalysts in the catalyst preparation step. The systems can include a reactor, a wax / polymer removal unit, and at least two C6 distillation columns in series for producing 1-hexene.

The present invention uses a two-pack adhesive composition which is constituted from: a first agent containing at least one non-aromatic epoxy compound selected from among an aliphatic epoxy compound having a hydroxyl group and two or more epoxy groups and a cyclohexene oxide-based epoxy compound, an aromatic epoxy compound, rubber particles and an ionic liquid; and a second agent containing at least one curing agent selected from among an amine-based curing agent having two or more amino groups in the molecule, an acid anhydride-based curing agent, a phenol-based curing agent, a mercaptan-based curing agent and a polysulfide-based curing agent, and in which the ratio of the non-aromatic epoxy compound and the aromatic epoxy compound falls within a certain range.

The application discloses a preparation method of beta-carotene, which comprises the following steps: 3-methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienyl triphenyl phosphonium salt (C15 phosphonium salt) cis-trans isomer and 2,7-dimethyl-2,4,6-octatriene-1,8-dial (C10) are dissolved in a water and a water incompatible solvent system, and Wittig reaction is generated under the action of an alkali. The reaction system can avoid that by-product inorganic salt is wrapped in the product, and the content of inorganic salt impurities in the product is reduced. In addition, the proportion of C15 phosphonium salt cis-trans isomer is controlled, a C15 phosphonium salt hydrolysis side reaction is inhibited, and the reaction yield is improved.

[Problem] To provide a means capable of more efficiently exerting an antibacterial effect against bacteria. [Solution] An antibacterial agent containing at least two compounds selected from the group consisting of trans-2-methyl-2-pentenal, 2-methylbutanal, trans-2-hexenal, propionaldehyde, 3-methylpentanol, and 2,5-dimethylfuran.

The present invention relates to a multilayer film comprising: an inner layer system comprising a first surface and a second surface; a first skin layer adhered to the inner layer system at the first surface of the inner layer system; and a second skin layer adhered to the inner layer system at the second surface of the inner layer system; wherein the inner layer system consists of a polymer formulation (A), wherein the polymer formulation (A) comprises: > 60.0 and < 90.0 wt% of a first ethylene-based polymer which is a linear low density polyethylene A (LLDPE A); and > 10.0 and < 40.0 wt% of a high density polyethylene (HDPE) having a density > 940 and < 970 kg / m 3 , preferably > 955 and < 970 kg / m 3 ; measured according to ASTM D792 (2008); and the first and / or second skin layer is a sealing layer comprising a second ethylene-based polymer which is a linear low density polyethylene B (LLDPE B) comprising polymerized moieties derived from ethylene and 1-octene or 1-hexene having a density > 890 and < 915 kg / m 3 , preferably > 900 and < 915 kg / m 3 , measured according to ASTM D792 (2008); preferably, wherein the sealing layer comprises > 70.0 wt% of the second ethylene-based polymer, or wherein the sealing layer consists of the second ethylene-based polymer; wherein the multilayer film is a biaxially oriented film, wherein the biaxial orientation is introduced in solid state. This film allows the production of a sealed package having a sufficiently high seal strength at reduced sealing temperature (also referred to as seal initiation temperature) which at the same time has improved tensile properties, such as an improved tensile modulus in machine and transverse direction and an improved tensile strength in machine and transverse direction, which has proven.

A method of selectively producing oligomers can include contacting at least one antifouling agent with a first amount of at least one aluminum alkyl compound to form at least one antifouling compound comprising the following structure or dimer form thereof: (I); and adding the at least one antifouling compound, an additional amount of the at least one aluminum alkyl compound, the at least one titanate compound, and ethylene to a jet loop reactor to oligomerize the ethylene to produce one or more of 1-butene, 1-hexene, or 1-octene. (I)

The invention provides a polylactic acid composite material and a preparation method thereof. The polylactic acid composite material comprises the following components in parts by mass: 50-90 parts of polylactic acid, 5-50 parts of bio-based polycarbonate, 5-15 parts of an impact modifier and 0.1-3 parts of a chain extender, wherein the bio-based polycarbonate has the following structural unit: in the bio-based polycarbonate, R1 is selected from cyclohexenyl and-(CH2) n-, and n is equal to 0-6. The material provided by the invention also has good toughness and heat resistance on the basis of environmental friendliness.

The invention discloses a preparation method of beta-carotene. The preparation method comprises the following steps: dissolving an aqueous solution of 3-methyl-5-(2, 6, 6-trimethyl-1-cyclohexene-1-yl)-2, 4-pentadienyl triphenylphosphine salt (C15 phosphine salt) and 2, 7-dimethyl-2, 4, 6-octtriene-1, 8-dialdehyde (C10) cis-trans isomer in a solvent, carrying out wittig reaction under the action of alkali, and carrying out isomerization to obtain the product. By controlling the proportion of C10 cis-trans isomers of the reaction system, the content of the C25 aldehyde intermediate can be reduced, and the reaction yield and the product quality can be improved.

The invention provides a production method of 2, 3, 5-trimethylhydroquinone diester, which comprises the following steps: carrying out rearrangement reaction on 2, 6, 6-trimethyl-cyclohexyl-2-ene-1, 4-diketone and an acylating agent in a tubular reactor filled with a catalyst to obtain the 2, 3, 5-trimethylhydroquinone diester, all reaction parameters in the tubes of the tubular reactor meet the relationship shown in the formula 1. The production method has the advantages of high production efficiency, small corrosion to equipment and simple subsequent treatment process, and is suitable for wide popularization and application.

The application discloses special cement for wind power tower drum and a preparation method thereof, and relates to the technical field of low-carbon cement. The special cement for wind power tower drum comprises the following raw materials in parts by weight: low-carbon clinker 80-89 parts, desulfurization gypsum 3-5 parts, limestone 1-5 parts, blast furnace slag 6-15 parts, reinforcing modifier 8-12 parts, shrinkage reducing agent 0.8-1.2 parts and grinding aid 0.04 parts. The reinforcing modifier is prepared by the reaction of bis(4-isocyanate phenyl) methane and polyether amine to generate polyurethane prepolymer, the reaction of the polyurethane prepolymer and 6-chloro-1-hexene to generate tetraene polymer, and the reaction of the tetraene polymer and mercaptopropyl trimethoxysilane. The special cement for wind power tower drum prepared by the application has excellent flexural strength, compressive strength and low drying shrinkage.

This invention relates to the field of adipic acid synthesis technology and discloses a method for producing adipic acid with low N2O tail gas emissions. The method includes: Step S1. A first contact reaction is carried out between cyclohexene, hydrogen peroxide, and a first catalyst, wherein the first catalyst is a solid catalyst comprising a tungsten-doped titanium-containing molecular sieve; the liquid phase material from the contact reaction is subjected to oil-water separation to obtain an aqueous phase containing cyclohexane oxide and an oil phase containing cyclohexene; Step S2. A second contact reaction is carried out between the aqueous phase containing cyclohexane oxide and nitric acid and a second catalyst, wherein the second catalyst is a Cu-containing... 2+ V 5+ and Mo 6+ The method utilizes ionic liquid catalysts. It results in low N2O emissions, high exhaust gas absorption rate, low production cost, and is environmentally friendly, showing promising prospects for industrial application.

The invention discloses a trans-2-hexenal slow-release long-acting bacteriostatic packaging material and a preparation method and application thereof.According to the preparation method, halloysite nanotubes are modified, trans-2-hexenal is loaded into the modified halloysite nanotubes, and the trans-2-hexenal slow-release long-acting bacteriostatic packaging material is obtained; and carrying out encapsulation treatment on the modified halloysite nanotube loaded with the trans-2-hexenal by adopting chitosan or a derivative thereof, so as to obtain the trans-2-hexenal slow-release long-acting antibacterial packaging material. According to the invention, the halloysite nanotube is used as a carrier to load the trans-2-hexenal, and the chitosan or the derivative thereof is used for encapsulation, so that the slow-release long-acting antibacterial effect of the trans-2-hexenal is realized. The packaging material can be widely applied to the field of food preservation, and the shelf life of food is effectively prolonged.

The invention develops a cascade reaction strategy for realizing efficient synthesis of a caged ketal skeleton compound by taking Bronsted acid as a catalyst and taking a 3-hexene-2, 5-diketone derivative and a cinnamyl alcohol analogue as substrates, and synthesizes a natural product (+ / -)-catunaregin and a series of novel analogues of the natural product (+ / -)-catunaregin which are not reported in literatures. Important technical support and early-stage theoretical basis are provided for the creation of new drugs of the compounds. The cinnamyl alcohol analogue disclosed by the invention is simple and easy to prepare, wide in derivation range and low in price, and can better enrich the structural diversity of caged ketal skeleton compounds. The method disclosed by the invention can be prepared by a one-pot method, is efficient and rapid, simple to operate, short in reaction step, good in substrate tolerance, mild in reaction condition and wide in application range, and overcomes the defects of complex operation, harsh reaction conditions, substrate limitation, intolerant substrate functional groups, tedious steps and the like in the traditional reaction.

The invention discloses a tungsten filament wire binding force improving method and aims to solve the technical problems of insufficient binding force, high wire consumption and poor production stability in the existing tungsten filament thinning process. According to the method, electrolyte including quaternary ammonium base, absolute ethyl alcohol, 2-methyl-1-hexene, sodium sulfate and the balance deionized water in a specific proportion is adopted, a pit-shaped microcosmic rough structure is formed on the surface of the tungsten filament through the five steps of S1, electrolyte preparation, S2, equipment arrangement and inspection, S3, workpiece clamping, S4, core polishing and S5, aftertreatment and quality inspection, and meanwhile the diameter error is controlled. According to the method, the binding force of the tungsten filament and the diamond particles is remarkably improved, the wire consumption is remarkably reduced, the wire breakage rate is reduced to be lower than 5%, and the method is suitable for large-scale production of the diamond wire base material for photovoltaic silicon wafer cutting, high in stability and remarkable in economic value.

The invention relates to the technical field of building energy conservation, heat preservation and heat insulation materials, and discloses a flame-retardant phase-change heat preservation and heat insulation building material and a preparation method thereof.The preparation method of the flame-retardant phase-change heat preservation and heat insulation building material comprises the following steps that paraffin is loaded in ZnO / CuO hollow microspheres to obtain phase-change microspheres; modifying the phase change microspheres with polydopamine and acryloyl chloride to obtain functionalized phase change microspheres; the preparation method comprises the following steps: carrying out graft polymerization on a phosphorus-containing eugenol compound and 1-amino-5-hexene-2-alcohol on the functionalized phase change microspheres to obtain multifunctional phase change microspheres; polyether polyol, functionalized polyol, myricetin, multifunctional phase-change microspheres and the like are used as raw materials, foaming is performed, and the flame-retardant phase-change heat-preservation and heat-insulation building material is obtained. The flame-retardant phase-change heat-preservation and heat-insulation building material is excellent in heat-preservation and heat-insulation performance, flame-retardant performance and mechanical performance, has anti-ultraviolet performance and antibacterial and mildew-proof performance, can reduce erosion damage caused by external conditions, and prolongs the service life.

The invention discloses a method for constructing a highly conjugated aromatic ring system from bio-based (Z)-3-hexene-2, 5-diketone, and the method comprises the following steps: preparing a 1, 3-dinitroalkane aromatic compound with high yield from a bio-based aldehyde substance in nitromethane through a nickel-based catalyst, and then carrying out ring opening on the 1, 3-dinitroalkane aromatic compound and electro-catalytic 2, 5-dimethylfuran to prepare the highly conjugated aromatic ring system from the bio-based (Z)-3-hexene-2, 5-diketone and the bio-based (Z)-3-hexene-2, 5-diketone. The high-conjugation biaromatic ring system is constructed through the reaction of 1, 5-diketone; the preparation method has the advantages that the yield is high, the greenization degree is high, and the obtained highly conjugated biaromatic ring system has high bio-based content (gt; 86%), and has a high application value.

An electrocatalytic method includes passing current through a catalytic cathode in a reactor including an aqueous solution including the muconic acid, a supporting electrolyte, and an anode, so as to hydrogenate the muconic acid to yield a product including 3-hexene-1,6-dioic acid, 2-hexene-1,6-dioic acid, adipic acid, or a mixture thereof. An electrocatalytic method includes passing current through a catalytic cathode in a reactor including an aqueous solution including an organic substrate, a supporting electrolyte, and an anode, so as to electrocatalytically convert the organic substrate, wherein the aqueous solution includes a fermentation broth including the organic substrate and including one or more catalyst poisons that reduce catalytic activity of the catalytic cathode; removing one or more catalyst poisons from the catalytic cathode to form a rejuvenated catalytic cathode; and reusing the rejuvenated catalytic cathode in the method.

The present application relates to the production field of organic chemical raw material cyclohexene, and discloses a production method of cyclohexene.The method comprises the following steps: carrying out cracking reaction on cyclohexylbenzene and / or dicyclohexylbenzene raw material and a solid acid catalyst to obtain cyclohexene and benzene; and the solid acid catalyst is selected from at least one of amorphous silicon aluminum, molecular sieve and solid supported inorganic acid.The method has the advantages of high raw material conversion rate, high cyclohexene yield and no by-product cyclohexane, etc.

This invention discloses a method for enhancing the aroma of C6 aldehydes in cucumber fruits through artificial lighting, belonging to the field of plant cultivation technology. The method includes: when the intensity of natural light outside the facility reaches 60 μmol·m⁻¹… 2 ·s ‑1 Subsequently, cucumber seedlings in the facility were treated with red and blue light supplementation, with a red-to-blue light quality ratio of 3:1. The average photosynthetically active radiation after the LED artificial lighting tubes were accumulated was 424 μmol·m⁻¹. 2 ·s ‑1 The highest photosynthetically active radiation is 502 μmol·m⁻¹. 2 ·s ‑1 This invention discloses a method for enhancing the aroma of C6 aldehydes in cucumber fruits through artificial lighting, thereby increasing the net photosynthetic rate of cucumbers by 39.59% to 47.29% and the content of C6 aldehyde aromas by 31.1% to 37.52%, with the characteristic effect compound hexanal increasing by 38.14% to 46.17% and (E)-2-hexenal increasing by 26.76% to 41.06%.

This invention relates to the field of conductive gel technology, and particularly to an enhanced self-healing ionic conductive gel. The enhanced self-healing ionic conductive gel is obtained by copolymerizing a matrix and phosphate ester monomers, and further contains cations. The matrix is ​​one of the monomers selected from tributylhexadecenylphosphonium bromide, tributyl-n-octenephosphonium bromide, triphenylhexenephosphonium bromide, tributylhexadecenylphosphonium chloride, tributyl-n-octenephosphonium chloride, and triphenylhexenephosphonium chloride. The phosphate ester monomers are one of potassium dodecenyl phosphate, potassium hexadecenyl phosphate, potassium octadecenyl phosphate, and potassium octenyl phosphate. The total molar concentration of the matrix and phosphate ester monomers is 0.05~5 mol / L. This invention can effectively improve the stability and safety of flexible electronic devices; simultaneously, the gel electrolyte has good electrochemical performance, meeting the requirements of flexible electronic devices.

The application belongs to the technical field of high-frequency high-speed materials for electronic packaging, and particularly relates to a low-dielectric acenyl copolymer resin for M9 copper-clad plate and an ATRP preparation method thereof. A two-step method is used for full-process ATRP active controlled polymerization, and the two-step method comprises the following steps: S1, a single-end active bromine end group is prepared on a norbornene macromolecular initiator by ATRP polymerization with 3-bromocyclohexene as an ATRP initiator, and the length and structure of the norbornene segment are controlled; and S2, ATRP controlled copolymerization of acenylene monomers and divinylbenzene crosslinking monomers is carried out through the norbornene macromolecular initiator to obtain an acenyl copolymer resin.

The invention discloses a catalyst for preparing ethylene and propylene from n-hexene as well as a preparation method and application of the catalyst. The catalyst provided by the invention is a core-shell H-ZSM-5-coated SBA-15 molecular sieve, and the shell thickness of the SBA-15 molecular sieve is 10-200 nm. The core-shell H-ZSM-5-coated SBA-15 molecular sieve catalyst disclosed by the invention is applied to a reaction for preparing ethylene and propylene from n-hexene, and the conversion rate of the n-hexene and the selectivity of main products ethylene and propylene can be improved.

The invention provides a preparation method of a Vickaclara intermediate 2-(7-azaindole-5-oxy)-4-(4-((2-(4-chlorphenyl)-4, 4-dimethyl cyclohexene-1-) methyl) piperazine-1-) benzoic acid, which comprises the following steps: by taking a compound II, namely 1-((2-(4-chlorphenyl)-4, 4-dimethyl cyclohexene-1-) methyl) piperazine hydrochloride as an initial raw material, reacting at the temperature of 60-80 DEG C under the protection of nitrogen, thereby obtaining the Vickaclara intermediate 2-(7-azaindole-5-oxy)-4-(4-(2-(4-chlorphenyl)-4, 4-dimethyl cyclohexene-1-) methyl) piperazine-1-) benzoic acid. The key intermediate 2-(7-azaindole-5-oxyl)-4-(4-((2-(4-chlorphenyl)-4, 4-dimethylcyclohexene-1-) methyl) piperazine-1-) benzoic acid of the Venoclara bulk drug is prepared by taking 2-(7-azaindole-5-oxyl)-4-(4-(2-(4-chlorphenyl)-4, 4-dimethylcyclohexene-1-) methyl) piperazine-1-) benzoic acid as a raw material through hydrochloric acid removal, nucleophilic reaction, hydrochloride formation and deprotection reaction and adopting a proper purification method. The method does not need a noble metal catalyst, does not need column chromatography purification, is simple and convenient to operate and is suitable for industrial production.