The invention discloses a nano ZSM-5 molecular sieve based catalyst and preparation and use methods. The molecular sieve catalyst consists of molecular sieves and metal components, wherein the molecular sieves are nano ZSM-5 molecular sieves with a short b-axis, a medium high silica-alumina ratio, less strong acid, high Lewis acid content, and resistance to hydrothermal deactivation. The preparation method is as follows: mixing a silicon source, an aluminum source, a template agent, a structure promoter, an additive and alkali with water, and stirring to prepare a precursor solution, then crystallizing, separating solid from liquid, and calcinating to obtain molecular sieve raw powder; mixing the molecular sieve raw powder with an ammonium salt solution, stirring, filtering, mixing with the ammonium salt solution for several times, stirring, filtering, and calcinating to obtain hydrogen-type ZSM-5 molecular sieves; mixing with the metal precursor solution, drying and calcinating to obtain the aromatization catalyst. The use method is as follows: transforming oxy-compound raw materials to aromatic hydrocarbon through the catalyst under the reaction conditions. The nano ZSM-5 molecular sieve based catalyst has the characteristics of being high in aromatics yield (reaching up to 99%) and long in service life (the catalyst is alive after 300 hours, and the aromatics selectivity reaches up to 70% after the catalyst is subjected to hydrothermal aging at 760 DEG C for 4 hours).