61results about How to "Lower synthesis cost" patented technology

The invention relates to a method for electrochemically preparing monatomic alloy, which comprises the following steps: preparing ionic liquid containing a main metal precursor, the main metal is Fe, Co, Ni, Cu, Au and / or Ag, and the ionic liquid is choline chloride-based ionic liquid; preparing the main metal through a three-electrode system by taking the ionic liquid containing the main metal precursor as electrolyte; pure ionic liquid serves as electrolyte to prepare monatomic alloy through a three-electrode system, a working electrode adopts main metal, a counter electrode adopts precious metal, the precious metal is Ru, Rh, Pt, Ir and / or Pd, and the precious metal is deposited on the surface of the main metal in a replacement mode. The invention further relates to the monatomic alloy and application of the monatomic alloy as a catalyst in water electrolysis hydrogen production. According to the method, the method is simple, rapid and low in cost, the problems that main metal is easy to sinter and the catalyst is inactivated due to noble metal single atom agglomeration are solved, and the monatomic alloy electrocatalyst with high catalytic activity is obtained.

This invention relates to the field of biopharmaceutical technology, providing a self-assembled peptide-rhein conjugate, its formulation, preparation method, and applications. The MMP-9-responsive self-assembled peptide-rhein conjugate of this invention, with the sequence Rhein-GFFPLGLAGACE, can respond to abnormally activated MMP-9 in atherosclerotic plaques, self-assembling in situ into a stable nanofiber structure at the lesion site. The rhein in this conjugate exhibits significant anti-inflammatory and antioxidant functions, but its water solubility and oral bioavailability are low. These are significantly improved after conjugation with the peptide, achieving targeted delivery and prolonging retention time. The introduction of the tripeptide ACE, which mimics the function of glutathione, further enhances the conjugate's ability to resist oxidative stress. Furthermore, this conjugate exhibits excellent anti-inflammatory and antioxidant effects, scavenging ROS, inhibiting inflammatory pathways, regulating macrophage phenotype, and inhibiting apoptosis, providing a new strategy for the treatment of atherosclerosis.

The invention discloses a method for preparing phenyl acetate with high selectivity. A phosphoric acid solution is added into a magnesium chloride solution, stirring and heating are performed to obtain a suspension, the suspension is dried to constant weight to obtain a white solid, the white solid is ground to obtain powder, and the powder is calcined to obtain the catalyst. Then mixing phenol and a catalyst, placing the mixture in an oil bath for reflux reaction, dropwise adding acetic anhydride, distilling after the reaction is finished, and collecting a fraction at 190-195 DEG C, namely phenyl acetate. According to the magnesium chloride loaded phosphoric acid type catalyst (MgCl2-H3PO4) prepared by the method disclosed by the invention, phenol and acetic anhydride react without a solvent, MgCl2-H3PO4 is a solid catalyst, can be recycled only by filtering and can be repeatedly used after being washed, and MgCl2-H3PO4 also improves the selectivity of phenyl acetate and reduces the production cost.

The invention discloses a xanthene nitroreductase-responsive fluorescent dye compound as well as a preparation method and application thereof, and belongs to the technical field of xanthene derivatives. The fluorescent dye compound can be used for quickly and specifically recognizing overexpressed nitroreductase in tumor cells; after the fluorescent probe acts with nitroreductase, the fluorescence intensity of the fluorescent probe at 718 nm is obviously enhanced, and the fluorescent probe has excellent targeting capability on mitochondria; meanwhile, under the excitation of illumination with the specific wavelength of 660 nm, an acting product of the fluorescent dye compound and nitroreductase can efficiently generate reactive oxygen species (ROS), and then the effect of specifically killing tumor cells is achieved. The xanthene nitroreductase response type fluorescent dye compound provided by the invention can achieve the goal of integration of diagnosis and treatment of solid tumors, and has important clinical application value.

The invention belongs to a DNA storage method, and provides a DNA encoding method, a DNA decoding method and a related device for solving the technical problems that a compression ratio does not reach an optimal state and the storage efficiency and the information density are low in a compression technology in the technical field of DNA information storage at present. Besides, when decoding is carried out after the super-resolution model is recovered and stored by adopting the storage object, the storage quality of the storage object can also be ensured, and an effective lossy compression algorithm based on DNA information storage is formed. Moreover, in practical application, the method can be combined with any DNA coding and decoding algorithm, so that other functions can be expanded on the basis of lossy compression, such as single base repetition or GC content of a control sequence. Therefore, on the premise of ensuring the decoding effect of the storage object, the storage density of the DNA information of the storage object is effectively improved, and the synthesis cost is reduced.

The application discloses a kind of carolic acid and preparation method thereof, and specifically relates to the field of medical technology.The method comprises the following steps: stirring catalyst H2WO4 / C with hydrogen peroxide, then adding dichloro chrysanthemic acid ethyl ester; oil bath heating is carried out, reaction temperature is controlled, repeated reflux is carried out, and oxidation reaction is carried out; after the reaction, homogeneous transparent solution is filtered, extracted, and subjected to reduced pressure distillation to obtain carolic acid product.In the application, when catalyzing and oxidizing dichloro chrysanthemic acid ethyl ester, a high-activity H2WO4 / C heteropoly acid is used as a catalyst, the reaction scheme is optimized, the selectivity of the reaction is greatly improved, the number of cycles of the catalyst is increased, and after 20 cycles of the new catalyst, the catalyst activity does not decrease obviously.Furthermore, due to the great improvement of selectivity, the loss of product is reduced, and the yield is improved.

This invention belongs to the field of molecular biology and medical detection technology, and discloses a bladder cancer-specific nucleic acid aptamer, nucleic acid aptamer derivatives, and their applications. The nucleotide sequences of the nucleic acid aptamer are shown in SEQ ID NO: 1, 2, and 3. This invention screened three monoclonal nucleic acid aptamer DNA chains from bladder cancer tissue samples using the exponential enrichment systematic evolution (SELEX) technique and identified two target proteins that bind to these three nucleic acid aptamers. The nucleic acid aptamers specifically target the target proteins CAPRIN1 and FXR1 on the surface of bladder tumor cells. The nucleic acid aptamers obtained by this invention have advantages such as high affinity and specificity, no immunogenicity, simple chemical synthesis, stability, and ease of storage and labeling, providing a new molecular tool for the early diagnosis and targeted therapy of bladder cancer.

The invention provides a method for preparing chiral amine by catalyzing asymmetric hydrogenation of aromatic imine through a manganese / chiral ferrocene P, N, N ligand. The manganese precursor and ligand adopted by the method are easy to obtain, the reaction condition is mild, the operation is simple, the target chiral amine compound can be obtained with high yield and high stereoselectivity, and continuous large-scale preparation can be realized. The catalyst system is high in activity, the molar ratio of imine to the catalyst can reach 100000: 1, and the catalyst has a very good industrial application prospect.

The invention discloses high-entropy carbide ceramic as well as a preparation method and application thereof. The preparation method of the high-entropy carbide ceramic comprises the following steps: 1) mixing metal oxide powder and carbon powder, carrying out wet ball milling, and drying to obtain mixed powder; 2) pressing the mixed powder into a green body, performing flash sintering, taking out the obtained clinker, crushing and screening to obtain clinker powder with a core-shell structure; and 3) pressing the core-shell structure clinker powder into a green body, and performing spark plasma sintering to obtain the high-entropy carbide ceramic. The high-entropy carbide ceramic has high fracture toughness, and the preparation method of the high-entropy carbide ceramic has the advantages of simple operation and process flow, short reaction time, low synthesis cost and the like, is suitable for microstructure regulation and large-scale industrial production, and has a very wide application prospect in the fields of high-temperature thermal structure components, nuclear fuel cladding, high-speed cutting tools and the like.

The invention discloses an organic fluorescent probe EDA-ATPM for detecting quizalofop-p-ethyl as well as a preparation method and application of the organic fluorescent probe EDA-ATPM, and belongs to the technical field of organic synthesis and analytical chemistry. The organic fluorescent probe EDA-ATPM is a compound of ethylenediamine bridged tetraphenylimidazole derivatives, the chemical name of the organic fluorescent probe EDA-ATPM is 1, 2-(pyridine-4-(1, 4, 5-triphenyl-1H-imidazolyl-2-yl)) acetamido ethane, and the molecular formula of the organic fluorescent probe EDA-ATPM is C58H48I2N8O2. KI is used as a catalyst in a nitrogen atmosphere, and 4-(1, 4, 5-triphenyl-1H-imidazolyl-2-yl)-4-(2-pyridine-4-(1, 4, 5-triphenyl-1H-imidazolyl-2-yl)-4-pyridine-4-(1, 4, 5-triphenyl-1H-imidazolyl-2-yl)-4-pyridine-4-( The preparation method comprises the following steps: adding 1, 2, 5-triphenyl-1H-imidazolyl-2-yl) pyridine and 1, 2-chloroacetamido ethane into dry acetonitrile, stirring, refluxing and reacting, filtering a reactant after the reaction is finished, concentrating filtrate under reduced pressure, and separating a light green solid product, namely the organic fluorescent probe EDA-ATPM, by virtue of rapid column chromatography; the organic fluorescent probe EDA-ATPM can form a complex with quizalofop-p-ethyl in a dimethyl sulfoxide-water mixed solution, so that the fluorescence intensity is enhanced, and the organic fluorescent probe EDA-ATPM can be used as an ideal rapid quizalofop-p-ethyl detection fluorescent probe.

The invention discloses a novel benzyl acrylate neutron / gamma discrimination plastic scintillator and a preparation method and application thereof. The plastic scintillator is composed of a polymer matrix, a main fluorescent dye and a secondary fluorescent dye, the polymer matrix is benzyl acrylate (BA), the main fluorescent dye is 2, 5-diphenyl oxazole (PPO), and the secondary fluorescent dye is 7-diethylamino-4-methylcoumarin (MDAC) or 9, 10-diphenyl anthracene (DPA). The prepared plastic scintillator uses a new organic polymer matrix, and compared with a plastic scintillator of the same type, the preparation cost is lower, the forming time is shorter, and the plastic scintillator has good stability, optical transparency and mechanical strength and has neutron-gamma discrimination capability.

The invention discloses a stable, efficient and environment-friendly silver nanoparticle lactic acid bacteria biosynthesis method and application, firstly, a nitrate reduction test is carried out to determine the ability of strains to reduce nitrate into nitrite, and optimized strains are screened from six lactic acid bacteria; then, a response surface method is used for optimizing culture medium components for nitrate reductase production, and synthesis conditions are optimized; and synthesizing the silver nanoparticles by using the screened optimized strains. Compared with physical and chemical methods, the lactobacillus synthesis of AgNPs has the advantages of cost effectiveness, environmental friendliness, low toxicity to human cells, easiness in large-scale production, no need of dangerous chemicals, high temperature and high pressure and the like. The invention provides an efficient, stable and environment-friendly method for biologically synthesizing silver nanoparticles by using lactic acid bacteria, the improvement of antibacterial packaging materials is a key strategy and method for controlling microorganisms of chilled meat putrefaction in China, and powerful technical support is provided for scientifically, systematically, efficiently and practically guaranteeing meat safety.

The application discloses a method for constructing a multi-enzyme complex engineering strain, and has the characteristics that the method comprises the following steps: S1, constructing a light decarboxylase FAP and an oil-producing yeast fatty acid synthase fusion expression vector; S2, electrically shocking and transforming the constructed target vector into an agrobacterium competent AGL1, and introducing the target vector into a starting strain through an agrobacterium-mediated transformation method to obtain an engineering strain that is back-supplemented with a fatty acid defect; the engineering strain that is back-supplemented with the fatty acid defect is obtained, the FAP-FAS2 fusion expression is realized at the same time as the self-assembly of the intracellular FAS1, and a FAP-FAS synthase complex is obtained. The complex not only back-supplements the fatty acid defect function, so that the strain grows normally, but also can synthesize alkanes in the process of blue light irradiation fermentation culture, and realizes the intracellular assembly of protein macromolecules.

The invention discloses a novel oligopeptide PSP for angiogenesis and vascularized bone regeneration. The tripeptide innovatively screened by the invention is short in amino acid sequence, small in molecular weight, high in bioavailability, low in synthesis cost and easy to transport, modify and recombine. The tripeptide provided by the invention can significantly promote vascularized bone regeneration and improve skull defect repair. Good application prospects are realized.

The invention provides a synthesis method of n-butyl isocyanate. The synthesis method comprises the following steps: S1, introducing raw materials including an n-butylamine solution and phosgene into a tubular reactor for substitution reaction to obtain a reaction solution; s2, raw materials including the reaction liquid and protective gas are introduced into the reaction kettle for a cracking reaction, and the n-butyl isocyanate is obtained. Reaction liquid and protective gas in the step S2 enter a high-pressure reaction kettle to be subjected to cracking reaction, and hydrogen chloride can be discharged in time by introducing the protective gas, so that the content of by-products of n-chlorobutane and 1, 3-dibutyl urea can be reduced, and the purity can be improved. Meanwhile, phosgene is in a liquid state under high pressure and can continuously react with n-butylamine which does not participate in the reaction, so that the phosgene does not need to be additionally introduced, and the synthesis cost of the n-butyl isocyanate is reduced.

The invention discloses a method for preparing a polyfluoroalkyl coumarin derivative, and belongs to the field of organic synthesis. According to the method, cheap and easily available polyfluorocarboxylic acid anhydride is used as a polyfluoroalkylating reagent, and in-situ activation of NHPI is combined to prepare the C3-site polyfluoroalkyl substituted coumarin derivative. Under the condition of visible light catalysis, polyfluoroalkyl carboxylic acid anhydride is used as a polyfluoroalkylating reagent, polyfluoroalkyl free radicals are generated through in-situ activation of NHPI, the free radicals and aromatic propiolate are subjected to a free radical cyclization rearrangement reaction, and finally preparation of the C3-site polyfluoroalkyl substituted coumarin derivative is achieved. The polyfluoroalkyl carboxylic acid anhydride used in the method is stable in property, low in price and easy to obtain, and the synthesis cost is reduced. The method is wide in applicable substrate range and applicable to various polyfluoroalkyl carboxylic acid anhydrides, and the tolerance of reaction functional groups is good.

This invention belongs to the field of organic light-emitting materials and semiconductor technology, and provides a multi-aryl aromatic heterocyclic compound, its preparation method, and an electroluminescent device. The structural formula of the multi-aryl aromatic heterocyclic compound is: [structure omitted]. Using this multi-aryl aromatic heterocyclic compound as the guest light-emitting material, the luminous efficiency of the electroluminescent device is effectively improved, its lifespan is extended, and the purity of the emitted color is significantly improved. The light emitted by the electroluminescent device is in the green to red light range.

The invention discloses a preparation method of a Sn-MWW molecular sieve, the molecular sieve prepared by the preparation method and application of the Sn-MWW molecular sieve. Comprising the following steps: mixing raw materials containing a silicon source, a tin source, a template agent, an additive and water, crystallizing in a stainless steel reaction kettle, and pickling a solid product to obtain the Sn-MWW molecular sieve. According to the method, the Sn-MWW molecular sieve can be prepared by reasonably matching the addition amounts of the tin source, the additive and the template agent, and the method has the characteristics of short crystallization time and adjustable framework tin content of the Sn-MWW molecular sieve product. The method is low in synthesis cost, environment-friendly, easy for large-scale production and wide in product application range.

The invention discloses an organic fluorescent probe Tri-ATPM for detecting bromoxynil octanoate as well as a preparation method and application of the organic fluorescent probe Tri-ATPM, and belongs to the technical field of organic synthesis and analytical chemistry. The organic fluorescent probe Tri-ATPM is a compound of a crown ether bridged tetraphenylimidazole derivative, and the chemical name of the organic fluorescent probe Tri-ATPM is 1, 2-(pyridine-4-(1, 4, 5-triphenyl-1H-imidazolyl-2-yl)) acetyl triethylene glycol ester; the preparation method comprises the following steps: uniformly mixing 4-(1, 4, 5-triphenyl-1H-imidazolyl-2-yl) pyridine and triethylene glycol dichloro acetate in dry acetonitrile by taking KI as a catalyst in a nitrogen atmosphere, stirring, refluxing and reacting, filtering reactants, decompressing and concentrating to obtain a crude product, washing with ethanol, performing secondary decompressing and concentrating, washing and concentrating with a mixture of methylbenzene and dichloromethane, and drying to obtain the 4-(1, 4, 5-triphenyl-1H-imidazolyl-2-yl) pyridine. The dried yellow green solid is collected, and the yellow green solid is the organic fluorescent probe Tri-ATPM. The organic fluorescent probe Tri-ATPM can be used as an ideal fluorescent probe for rapidly detecting bromoxynil octanoate.

The present application belongs to the technical field of zeolite molecular sieve, and particularly relates to an AFX type zeolite molecular sieve, a preparation method and application thereof. An initial gel obtained by mixing an aluminum source, a silicon source, an inorganic base (sodium carbonate and / or sodium hydroxide), seeds and water is subjected to a hydrothermal crystallization reaction, and a crystallization product obtained is subjected to solid-liquid separation, washing and solid drying in sequence to obtain the AFX type zeolite molecular sieve. The AFX type zeolite molecular sieve with no organic template agent and low silicon-aluminum ratio is synthesized by using a traditional hydrothermal synthesis method, using seeds and an inorganic cation double-oriented design, and has great potential application value in the future catalysis field of diesel vehicles and non-road mobile machinery and the industrial adsorption separation industry due to the properties of no organic template agent and low silicon-aluminum ratio, and the synthesis does not use an organic template agent, reduces industrial production cost, and also reduces environmental pollution, and has great economic advantages in industrial production.

The invention relates to the technical field of polymer materials, and is a high-adhesive comb-shaped branched polymer and a synthesis method and application thereof. The high-adhesive comb-shaped branched polymer is obtained according to the following method: firstly, an anionic polymerization technology is used to synthesize a polymer active chain, which is sequentially reacted with an alkylene oxide and a halogen-containing styrene compound to prepare a macromolecular monomer containing a styrene structure, and an anionic reaction monomer is continuously added, and polymerization is initiated again with n-butyl lithium. The high-adhesive comb-shaped branched polymer synthesized by the invention has excellent adhesion performance, and the synthesis method thereof is simple to operate, has low synthesis cost, is convenient for industrial production, and can be used in plastic or rubber blending, which is beneficial to improving the adhesion performance of the polymer.

This invention provides a method for preparing a high-breakdown-voltage plant-based synthetic ester insulating oil, belonging to the field of insulating oil preparation technology. The resulting plant-based synthetic ester insulating oil exhibits good insulation performance, low dielectric loss, suitable viscosity, and low synthesis cost. Under standard testing conditions, it has an acid value above 0.014 mgKOH / g and also possesses good viscosity, dielectric properties, and breakdown voltage, among other physicochemical characteristics. Furthermore, the materials are sourced from environmentally friendly and low-cost materials, making this method significant for the application of plant-based synthetic ester insulating oil in high-voltage, high-capacity transformers.

The invention relates to the field of chemical engineering, and particularly discloses a preparation method of a bifunctional catalyst, which sequentially comprises the following steps: mixing alkali metal salt and activated aluminum oxide, and roasting to obtain a solid super alkali carrier; the preparation method comprises the following steps: adding a solid super alkali carrier, a Pd precursor and a Cu precursor into deionized water, carrying out ultrasonic mixing, carrying out vacuum drying, roasting in an inert gas atmosphere, carrying out a thermal insulation reduction reaction in an H2 atmosphere, washing, and carrying out vacuum drying to obtain the bifunctional catalyst. The invention further provides application of the bifunctional catalyst, the bifunctional catalyst is used for preparing the thiophene compound through a one-pot method, the one-pot method is simpler and more convenient to operate, meanwhile, environmental pollution is reduced, and the production cost is further reduced.

The present invention discloses a method for synthesizing TS-1 using tetramethoxysilane as a raw material. Using tetramethoxysilane as a silicon source, tetrabutyl titanate as a titanium source, tetrapropylammonium hydroxide as a template, and isopropanol as a solvent, a hydrothermal method is used to synthesize titanium silicon molecular sieve TS-1 by two dealcoholizations. The present invention uses tetramethoxysilane to replace the ethyl orthosilicate in the traditional hydrothermal method, and the catalytic performance of the titanium silicon molecular sieve synthesized using ethyl orthosilicate as a raw material can still be achieved. However, since the market price of tetramethoxysilane is much lower than that of ethyl orthosilicate, this significantly reduces the production cost of the titanium silicon molecular sieve, so the synthesis of titanium silicon molecular sieve using tetramethoxysilane as a raw material has industrial significance for large-scale production.

The application provides a denitration catalyst, a preparation method and application thereof, and the denitration catalyst comprises a layered MCM molecular sieve carrier and a composite oxide active component loaded on the surface of the layered MCM molecular sieve carrier, and the chemical formula of the composite oxide active component is CeCuO x The denitration catalyst has high surface acidity and redox capacity, the CeCuO x The alkali metal poisoning resistance of the catalyst is improved, so that the catalyst has high catalytic activity and nitrogen selectivity in the use temperature range of 250-400 DEG C after being poisoned by alkali metal.

The invention discloses a novel phase separation peptide for intracellular protein delivery and a synthesis method and application thereof. The structural formula of the novel phase separation peptide is shown in the specification. According to the novel phase separation peptide, coacervate microdroplets are formed through liquid-liquid separation (LLPS) self-assembly, meanwhile, protein can be rapidly collected, and after a coacervate enters cells by bypassing a classical endocytosis way, glutathione (GSH) in the cells triggers dissociation to release the protein.

The invention provides a halide electrolyte, a preparation method thereof and an electrochemical device, and particularly relates to the technical field of solid-state batteries. The chemical formula of the halide electrolyte is Li < 2 + n > Zr < 1-n > MnCl < 6-x-y > Br < x > I < y >, wherein n is more than 0 and less than or equal to 0.6; 0 < = x < = 6, 0 < = y < = 6, and x + y < = 6; m is a doping element and is selected from one or more of V, Cr, Mn, Fe, Co and Ni, and the preparation method of the halide electrolyte comprises the following steps: uniformly mixing raw materials according to the stoichiometric ratio of the chemical formula of the halide electrolyte, dispersing the raw materials in a solvent, and carrying out wet grinding treatment to obtain wet grinding slurry; carrying out drying treatment on the wet grinding slurry to obtain a halide precursor; and carrying out microwave sintering on the halide precursor to obtain the halide electrolyte. The preparation method can effectively improve the performance and production efficiency of the electrolyte, and can greatly reduce the synthesis cost of the halide electrolyte.

The application discloses a CO-SCR catalyst, a preparation method and application thereof, and the CO-SCR catalyst comprises a cerium-based composite oxide carrier and a noble metal active component, and the noble metal active component is dispersed on the surface of the cerium-based composite oxide carrier by means of a surfactant. The CO-SCR catalyst utilizes the dispersion and loading of the noble metal assisted by the surfactant, so that the CO-SCR catalyst has higher metal dispersion and redox capacity. Meanwhile, the suitable pH value of the carrier surface is also beneficial to the adsorption of CO and NO, and the low-temperature catalytic activity and high-temperature stability of the catalyst are improved, and the CO-SCR catalyst has higher catalytic activity and nitrogen selectivity in the use temperature range of 250 DEG C to 400 DEG C.

The application discloses a diflunisal derivative, a preparation method and application thereof, and belongs to the technical field of agricultural fungicides. The preparation method comprises the following steps: mixing 2', 4'-difluoro-4-hydroxy-[1, 1'-biphenyl]-3-carboxylic acid, a condensing agent and an organic base in an ice bath and an inert organic solvent, and activating for 10-30 minutes; then adding an amine compound with a general formula of R-NH2, and stirring and reacting at room temperature for 20-28 hours; after the reaction is completed, extraction, washing, drying, concentration and column chromatography purification are performed, so that the target diflunisal derivative is obtained. The compound disclosed by the application has a novel structure, shows excellent inhibitory activity on cucumber botrytis cinerea, rice pellicularia sasakii, brassica rapa sclerotium, wheat fusarium graminearum and other plant pathogenic fungi, can be used as an active ingredient for preparing an agricultural fungicide or a fungicide composition, and provides a new lead structure for developing a new succinate dehydrogenase inhibitor fungicide.

The present invention relates to an alkoxypropylamine compound and its application in organic sulfur absorption and removal. The compound has the following structural formula: #imgabs0# wherein R1 is a C1-6 alkyl substituent, and R2 is H or a C1-3 alkyl substituent. Compared with the prior art, the alkoxypropylamine compound of the present invention has a good deep removal effect on various types of sulfides, and the compound has stable chemical properties, is not easy to decompose, has a small bubble point vapor pressure, has little volatilization loss, is weak in alkalinity, and has light corrosion to equipment, and thus has a good industrial application prospect.