4615 results about "Oil phase" patented technology

The invention relates to the field of oil exploitation, and discloses a polymer with a heavy oil cold recovery function as well as a preparation method and application thereof. After the polymer disclosed by the invention enters a stratum, hydrophobic groups on a polymer chain can be adsorbed on an oil-water interface, the aggregation state of micelles is destroyed, the size of the micelles is greatly reduced, and released energy can provide energy required by emulsification. And meanwhile, after the amphiphilic groups are adsorbed to an oil-water interface, the tension of the oil-water interface is reduced, a low-surface-tension oil phase is automatically diffused to a high-surface-tension water phase, and spontaneous permeation emulsification viscosity reduction of the thick oil is realized without external force or under the low-power condition by virtue of the Malangori effect.

The invention relates to the technical field of functional materials, in particular to a hollow multi-shell material as well as a low-temperature preparation method and application thereof, which comprises the following steps: 1) mixing a water or alcohol solution of a precursor A with an oil phase to prepare a water-in-oil emulsion, or dispersing the water solution of the precursor A into liquid drops by a spraying method; 2) freezing the emulsion or liquid drops obtained in the step 1) at low temperature to obtain ice template particles containing a precursor A; (3) adding the ice template particles obtained in the step (2) into a precursor B solution, controlling the temperature by a program, melting the ice template, and carrying out precipitation or polymerization reaction on A and B to obtain metal fluoride, carbonate or other hollow multi-shell materials; and 4) using the hollow multi-shell layer obtained in the step 3) as an electrolyte additive. The electrolyte additive can improve the viscosity of an electrolyte, improve the ionic conductivity, stabilize a solid electrolyte interface film, effectively inhibit the growth of lithium dendrites, improve the coulombic efficiency of a battery and prolong the cycle life of the battery.

The invention discloses a self-crosslinking temperature-resistant salt-resistant emulsion type fracturing fluid thickening agent and a preparation method thereof, and belongs to the technical field of oilfield chemistry. The raw materials adopted by the invention comprise 30 to 50 parts of an oily solvent, 15 to 25 parts of deionized water, 10 to 20 parts of acrylamide, 5 to 10 parts of acrylic acid, 2 to 4 parts of 2-acrylamido-2-methylpropanesulfonic acid, 0.05 to 0.2 part of a crosslinking monomer, 0.5 to 1 part of a quaternary ammonium salt type hydrophobic association monomer, 4 to 8 parts of an emulsifier and 1 to 2 parts of a phase inversion agent. The self-crosslinking emulsion is formed through water phase-oil phase mixing, high-speed emulsification, low-temperature initiation polymerization and phase inversion treatment. Based on physical-chemical double-crosslinking temperature control cooperation, a salt-resistant-hydrophobic double-shielding mechanism and an integrated design without an exogenous crosslinking agent, the contradiction between the temperature-resistant and salt-resistant performance of a traditional thickening agent and the process complexity is broken through, and a technical support is provided for efficient development of high-temperature and high-salt oil and gas reservoirs.

The invention discloses roe polypeptide essence water, which is prepared from a water phase component, an active component, an oil phase component, a stabilizer and a thickening agent, the water phase component is prepared from the following components in parts by mass: 60 to 150 parts of purified water, 3 to 7 parts of glycerol, 2 to 5 parts of propylene glycol, 1 to 2 parts of panthenol and 0.1 to 0.3 part of sodium hyaluronate; the oil phase component is prepared from the following components in parts by mass: 2 to 4 parts of squalane, 1 to 3 parts of jojoba oil and 0.5 to 2 parts of shea butter; the active components comprise the following components in parts by mass: 2 to 5 parts of roe extract, 0.5 to 2 parts of argireline, 0.1 to 0.5 part of oligopeptide-1, 1 to 3 parts of collagen, 0.5 to 2 parts of elastin and 2 to 5 parts of nicotinamide; 0.1 to 0.3 part of hydroxyethyl cellulose is adopted as the stabilizer; 0.2 to 0.5 part of carbomer is adopted as the thickening agent. The roe extract is rich in proteins, amino acids, fatty acids, vitamins and trace elements, and is helpful for nourishing the skin so as to provide the effects of nourishing, resisting aging, moisturizing, brightening the skin color and repairing the skin.

The present invention relates to the technical field of nanofiltration membranes, and particularly relates to a preparation method for a positively charged nanofiltration membrane for improving a "trade-off" effect. The preparation method comprises the following process: sequentially adding a water phase and an oil phase to the surface of a support layer to perform a reaction, so as to prepare a polyamide layer; pouring in a functionalized graphene dispersion; and sequentially placing same into an N,N-dimethyl propane diamine solution, a sodium borohydride solution and an iodomethane solution to perform a reaction, so as to obtain a nanofiltration membrane, wherein the functionalized graphene is pyrrolidone-based graphene. According to the present invention, a mixture of piperazine and polyethyleneimine is used as a water phase and is subjected to interfacial polymerization with an oil phase 1,3,5-trimesoyl chloride on the surface of the support membrane; and by means of the compounding of micromolecular piperazine and macromolecular polyethyleneimine, the rapid formation of a polyamide layer is promoted, the distance of a system cross-linked network is increased, a positively charged polyamide layer having a large pore diameter and good hydrophilicity is formed, and a good water flux and a good rejection rate are achieved, thereby improving the "trade-off" effect.

The invention discloses a Pickering emulsion with cinnamyl aldehyde as an oil phase and a preparation method of the Pickering emulsion. The Pickering emulsion is prepared by the following steps: carrying out a cross-linking reaction on anions released by sodium tripolyphosphate and protonated cations of chitosan to prepare chitosan nanoparticles as a water phase, and then taking cinnamyl aldehyde as an oil phase. The Pickering emulsion delivery system disclosed by the invention can effectively release cinnamyl aldehyde, shows the remarkable antibacterial property of cinnamyl aldehyde on a wound surface, promotes wound surface healing, and shows good treatment potential.

The invention discloses a shearing emulsifying machine for medicine production, and relates to the technical field of pharmacy, the shearing emulsifying machine comprises a base, a tank body is fixedly mounted on the inner wall of the base, a feeding device is arranged above the tank body, and a stirring device and an auxiliary device are arranged in the tank body; a baffle is driven to rotate through a rotating motor, a first belt, a rotating disc, a second belt, a rotating rod, a first reciprocating spiral groove, a connecting button and a circular groove button, liquid is intermittently blocked through reciprocating rotation of the baffle, the emulsification process can be controlled through intermittent quantity control input, it is ensured that a water phase and an oil phase are mixed in a proper proportion, and therefore stable emulsion is obtained; the oil-phase material is added into the oil-phase barrel, the oil-phase material is fully mixed through rotation of the stirring rod, bubbles generated in the mixing process after the oil-phase material is input into the tank body can be reduced through pretreatment stirring of the oil-phase material, and therefore the stability and quality after the oil-phase material is mixed with a water phase are improved.

The invention provides water-in-oil type emulsion gel loaded with probiotics and a preparation method of the water-in-oil type emulsion gel, and belongs to the technical field of probiotic products, the water-in-oil type emulsion gel loaded with the probiotics comprises a water phase and an oil phase, and the internal water phase is composed of gel and probiotic suspension; and the external oil phase consists of edible oil, a lipophilic emulsifier and at least one oil gelator. According to the water-in-oil emulsion gel, the stability of entrapped probiotics can be remarkably improved, meanwhile, the activity of the entrapped probiotics in the processing, storage and digestion processes is improved, particularly, the normal-temperature storage time is prolonged by 3 months, and a scientific basis is provided for normal-temperature food development.

The application belongs to the technical field of daily chemical industry, and particularly relates to an emulsion and a preparation method thereof. The emulsion provided in the application comprises an emulsifier, glycerol, oil-phase active substance, pentaerythritol tetra(ethylhexanoate) and water; the emulsifier is a lipopeptide; the weight percentage of the lipopeptide and the glycerol is not less than 3%; the weight ratio of the oil-phase active substance and the pentaerythritol tetra(ethylhexanoate) is 1:3-10; the ratio of the sum of the weights of the lipopeptide and the glycerol to the sum of the weights of the oil-phase active substance and the pentaerythritol tetra(ethylhexanoate) is 1:3-10; and the ratio of the sum of the weights of the lipopeptide, the glycerol, the oil-phase active substance and the pentaerythritol tetra(ethylhexanoate) to the weight of the water is 1:1-4. The emulsion is prepared by using sodium bacillomycin, glycerol and pentaerythritol tetra(ethylhexanoate), can effectively inhibit the diffusion of the oil-phase active substance at the interface of the emulsion, reduce the oxidative degradation of the oil-phase active substance, and greatly prolong the effective action time of the oil-phase active substance in the emulsion.

The invention relates to an oral mucosa repairing medicine and a preparation method thereof, and belongs to the technical field of medicines, the medicine comprises barnacle peptide, salivary lactobacillus, resveratrol, a biphasic adhesion matrix, hydroxyapatite, vitamin B family and other components. The preparation method comprises the following steps: sequentially carrying out enzymolysis on barnacle gooseneck by pepsin and lumbrukinase to obtain barnacle peptide. The double-phase adhesion matrix comprises a water-phase matrix, an oil-phase matrix and lecithin; the water-phase matrix contains a chondroitin sulfate-chitosan quaternary ammonium salt compound, sodium alginate and other components; the oil-phase matrix comprises sesame oil, beeswax, a polylactic acid-glycolic acid copolymer and the like. According to the invention, barnacle peptide and salivary lactobacillus are prepared by adopting a special method and are matched with resveratrol for use, so that multi-target and multi-path promotion of oral mucosa repair can be realized; the chondroitin sulfate-chitosan quaternary ammonium salt compound is prepared through electrostatic and physical embedding, the chondroitin sulfate-chitosan quaternary ammonium salt compound is matched with other components to prepare the biphasic adhesion matrix, the biocompatibility is good, the adhesion is high, and the action time of a sustained-release drug is well prolonged.

The invention provides a W1 / OG / W2 type multiple emulsion based on a micro-fluidic chip and a preparation method, and belongs to the technical field of multiple emulsions. The intermediate phase of the multi-emulsion is separated by the oil gel phase OG, so that the exchange of internal and external two-phase substances is thoroughly prevented, the reaction of the internal and external two-phase substances is avoided, the substance compatibility is enhanced, and meanwhile, the aqueous phase thickener is added into the hydrogel phase W2, so that the viscosity of the hydrogel phase W2 is increased, the aggregation of liquid drops is delayed, and the stability of the emulsion is improved. According to the method, the active encapsulant can be encapsulated in the microdroplet to form a protective layer, so that the contact with air and the external environment is reduced, the encapsulant in the water-in-oil phase W1 / O is effectively prevented from being oxidized, the stability and the slow-release effect of the encapsulant are improved, and the storage life is prolonged. The multi-emulsion has wide applicability and can be widely applied to the fields of food, medicines, health care products and the like.

The invention provides an embolism microsphere capable of slowly releasing drugs and controlling degradation speed and a preparation method thereof, the method comprises the following steps: dissolving a dispersant in an oil phase liquid, and stirring at a first preset temperature to obtain a dispersion liquid; dissolving gelatin in water at a second preset temperature to obtain a gelatin solution; the preparation method comprises the following steps: dissolving a compound with negative electricity groups in water, and adding alkali liquor and an initiator in an ice bath to obtain a modified solution; adding the modified solution into a gelatin solution, stirring to obtain a water-phase pre-polymerized solution, dropwise adding the water-phase pre-polymerized solution into the dispersion solution, premixing, adding a cross-linking agent and a catalyst, and directly grafting negative electricity groups onto gelatin molecules in a low-temperature free radical polymerization manner to obtain an intermediate product; and performing post-treatment to obtain the embolism microspheres. According to the preparation method disclosed by the invention, a non-degradable material is not needed, negative electricity groups can be directly grafted on the surface of gelatin, so that the embolism microspheres have efficient drug loading performance and good long-period drug sustained release, and the degradation speed of the embolism microspheres is controlled.

The invention discloses a method for preparing recombinant collagen antioxidant microspheres without a cross-linking agent. The method comprises the following steps: 1, dissolving recombinant collagen and chitosan in deionized water containing glacial acetic acid to serve as a water phase; petroleum ether containing a surfactant is used as an oil phase; 2, injecting the oil phase into the water phase, emulsifying and stirring through a homogenizer, and reducing the temperature of the system to obtain an emulsion; 3, a fixing agent, water and absolute ethyl alcohol are blended and precooled, and fixing liquid is obtained; 4, adding the stationary liquid into the emulsified liquid for curing, and washing the cured microspheres; and 5, transferring into a tannic acid aqueous solution to soak, then washing with deionized water, and freeze-drying to obtain the recombinant collagen microspheres with uniform size. The recombinant collagen microspheres prepared by the method have good dispersity and uniform and controllable size, avoid the toxicity problem of a cross-linking agent, can be applied to the fields of medical instruments, tissue engineering, drug delivery and the like as a filling agent, and have wide commercial application prospects.

The invention discloses an ultra-low-density high-strength resin proppant capable of being carried by clear water or low-viscosity slickwater. The proppant is prepared by dispersing, polymerizing and curing a mixture comprising 15 to 50 weight percent of vinyl monomer, 5 to 10 weight percent of acrylate monomer and 50 to 70 weight percent of unsaturated resin. The preparation method comprises the following steps: controlling the resin composition in a water phase by virtue of a dispersing agent and a rotating speed to form spherical liquid drops with the particle size of 12-140 meshes and the sphericity of nearly 100%; then, the temperature ranges from 30 DEG C to 80 DEG C; the propping agent provided by the invention has ultra-low density, can be carried by clear water or low-viscosity slickwater, is suitable for low-viscosity fracturing fluid, low-displacement construction and small-scale fracturing, can realize ultra-far-end seam net support, and greatly increases the oil and gas drainage area. The breaking rate under the closing pressure of 20-90 MPa is lower than 2%, the surface is weakly lipophilic, and the oil-phase flow conductivity is higher than the water-phase flow conductivity.

The invention relates to the field of electrode materials, in particular to an antimony-based composite material and a preparation method and application thereof.The preparation method comprises the steps that graphene quantum dots are dispersed in deionized water to obtain a water phase A, antimony trichloride is added into the deionized water and mixed to be uniform to obtain a water phase B, and the water phase B is prepared; the preparation method comprises the following steps: uniformly mixing a surfactant, n-butyl alcohol, an organic solvent and 1-aminopropyl-3-methylimidazole phosphate to obtain an oil phase, dividing the oil phase into two parts, namely an oil phase A and an oil phase B, respectively adding the water phase A and the water phase B into the oil phase A and the oil phase B, stirring to obtain a microemulsion A and a microemulsion B, mixing the microemulsion A and the microemulsion B, quickly stirring to obtain a mixed reaction solution, and drying to obtain a finished product. Transferring the mixed reaction solution into a hydrothermal reaction kettle, sealing, heating to 100-120 DEG C, reacting for 1-10 hours, recovering to room temperature after the reaction is finished, centrifuging, collecting a product, washing and drying, thereby obtaining the antimony-based composite material which is used as a sodium-ion battery negative electrode material and has excellent electrochemical performance.

The invention provides a cinnamyl aldehyde drug-loaded self-microemulsion as well as a preparation method and application thereof, and belongs to the technical field of biological pharmacy. The cinnamyl aldehyde drug-loaded self-microemulsion disclosed by the invention is prepared from the following raw materials in parts by weight: 0.5 to 5.5 parts of cinnamyl aldehyde, 0 to 5.5 parts of oil phase, 0.5 to 5.5 parts of emulsifier and 0.01 to 0.045 part of insoluble drug. By adopting the self-microemulsion drug delivery system, the drug effect of the cinnamyl aldehyde and the combination of the cinnamyl aldehyde and other traditional Chinese medicine components is improved, the drug loading capacity is high, dispersion is easy, the stability is high, the drug effect is remarkable after the cinnamyl aldehyde and other traditional Chinese medicine components are combined, and the curative effect is good. The traditional Chinese medicine composition has an improvement effect on hepatic fibrosis, has a remarkable treatment effect on non-alcoholic steatohepatitis, and has certain application and development values.

The invention belongs to the field of pharmaceutical preparations, and relates to a brexpiprazole long-acting microsphere and a preparation method thereof, and the preparation method comprises the following steps: (1) dissolving brexpiprazole and a degradable polymer in an organic solvent to obtain a drug-containing polymer solution as an oil phase; (2) mixing the drug-containing polymer solution with a polyvinyl alcohol solution through a microfluidic technology to obtain an oil-in-water emulsion; and (3) under a stirring condition, carrying out curing, washing and freeze drying on the oil-in-water type emulsion to obtain the brexpiprazole long-acting microspheres. By adjusting the volatilization stirring time when the O / W primary emulsion is formed, the final in-vitro release rate of the microspheres is adjusted, and the microspheres which are free of burst release and hysteresis period and are slowly released can be screened out. The brexpiprazole long-acting microsphere provided by the invention is simple in preparation process, easy to industrially amplify, high in encapsulation efficiency, large in drug loading capacity, uniform in microsphere particle size distribution, round in shape, good in flowability and good in needle passing property, is easier to inject, has an obvious slow release effect, and can be used for reducing the fluctuation of blood concentration and effectively improving the compliance of psychiatric patients.

The invention relates to the field of hydrogel materials, in particular to a preparation process of intragastric volume hydrogel, a product and application. The preparation process comprises the following steps: S1, preparing a KGM filtrate: adding konjaku flour into an acid solution for swelling, performing high-temperature treatment after swelling, and then adding an alkali solution to terminate the reaction to obtain the KGM filtrate; s2, preparing an oil phase mixture; s3, preparing KGM particles: mixing the oil phase mixture and the KGM filtrate, stirring and emulsifying, and then adding a cross-linking agent for cross-linking reaction to obtain the KGM particles; s4, hydrogel preparation: washing the KGM particles, and freeze-drying to obtain KGM microspheres, namely a hydrogel product. According to the invention, the konjac flour is selected as a main raw material to prepare the intragastric volume hydrogel particles, and the obtained product has good hydrophilicity, different swelling characteristics and an adjustable degradation period, can prolong the emptying time of the hydrogel in the stomach, and has a wide application prospect.

The invention discloses a pH response type pesticide microcapsule and a preparation method thereof, and the preparation method comprises the following steps: mixing a pesticide raw material, an organic cosolvent and a diisocyanate monomer to obtain an oil phase; mixing a surfactant with water to obtain a water phase; adding the oil phase into the water phase, and carrying out shear emulsification to obtain O / W type emulsion; and mixing the O / W type emulsion with an aqueous solution of polyamine containing the vanillyl Schiff base structure, and carrying out an interfacial polymerization reaction to obtain the pH response type polyurethane pesticide microcapsule with the vanillyl Schiff base structure. According to the invention, the organic cosolvent and diisocyanate are used as oil phase components, can dissolve the raw pesticide and do not react with the raw pesticide, has good pH responsiveness, can realize stimulation response to an acid environment caused by pathogenic bacteria infected crops, improves the utilization rate of the pesticide, and reduces the usage amount of the pesticide.

The invention relates to the technical field of medicine, and discloses an artificial exosome and application thereof in drug delivery, the artificial exosome is prepared into an oil phase based on PLGA and DOTAP, and a water phase based on OCT4 protein and siTrim28; mixing the two phases to obtain a primary emulsion, and adding a PVA aqueous solution to obtain a double emulsion; stirring the double emulsion and volatilizing the solvent to form an emulsified solution, and centrifuging to obtain PLGA nanoparticles; the lipid mixture is prepared from lipid, DPPE-PEG2000, alpha-tocopherol and alpha-lactalbumin, and a lipid film is formed after a solvent is evaporated; the preparation method comprises the following steps: mixing PLGA nanoparticles, a lipid film and membrane protein, uniformly mixing and heating to obtain a film-coated solution, and finally extruding through a cellulose acetate film to obtain the artificial exosome. The artificial exosome disclosed by the invention combines the stability of the PLGA nanoparticles and the biocompatibility of the lipid membrane, and provides new possibility for a drug delivery system.

The utility model discloses reaction equipment with high crude methyl ester yield, which comprises a stirring kettle and a material circulating system, the material circulating system comprises a circulating pump, a spray pipe arranged in the stirring kettle and a mixing nozzle arranged on the spray pipe, and a bottom outlet of the stirring kettle is connected with a feed port of the circulating pump through a first pipeline. An outlet of the circulating pump is connected with the spray pipe through a second pipeline; the mixing nozzle comprises a first sprayer and a second sprayer, and an outer flaring in the lower portion of the second sprayer is in clearance fit with the conical head through a connecting piece. The material circulating system can realize bottom-out and top-in of materials, so that the mixing of an oil phase and an enzyme water phase is promoted through the reciprocating circulation. In addition, the material circulating system is provided with a plurality of mixing nozzles, the flow speed of spraying of the first spray head is large, so that a negative pressure suction gap is formed at the joint of the second spray head and the first spray head, materials in the stirring kettle can enter the mixing nozzles under the action of negative pressure, an oil phase and an enzyme water phase are intensively mixed, and the yield of fatty acid methyl ester is improved.

The invention belongs to the technical field of cosmetics, and particularly relates to an emulsifier-free face cream and a preparation method thereof. The face cream provided by the invention is mainly prepared from the following components in parts by weight: 50 to 67 parts of water, 10 to 40 parts of grease, 5 to 25 parts of a humectant, 0.2 to 0.7 part of a thickening agent, 0.5 part of a preservative and 0.1 to 0.4 part of a pH (Potential of Hydrogen) regulator. According to the face cream provided by the invention, the system stability can be kept without adding an emulsifier, the requirement on the compatibility of the used grease is low, the high stability of the system can be kept only by adjusting the melting point of the oil phase, and the grease proportion of the system can reach 40%. The system is extremely low in irritation, more friendly to sensitive skin, capable of rapidly dissolving water in use, free of sticky feeling after being smeared and capable of providing strong moistening feeling after being absorbed. Compared with a traditional emulsification system, the preparation process has a relatively wide requirement on a homogenizing temperature range, and the temperature is kept above the melting point of an oil phase during homogenizing dispersion.

The invention discloses an integrated oil phase emulsion explosive and a preparation method thereof. The emulsion explosive is prepared from the following raw materials: a water-phase component, an oil-phase component and an emulsifier for emulsifying the water-phase component and the oil-phase component, wherein the water-phase component contains a modified oxidant formed by loading a nitrate oxidant component on p-aminophenyl POSS (Polyhedral Oligomeric Silsesquioxane); the preparation process of the modified oxidizing agent comprises the following steps: A, fully dispersing a nitrate oxidizing agent component and p-aminophenyl POSS in an aqueous solution, so that the nitrate oxidizing agent component is fully attached to the p-aminophenyl POSS; and B, separating a solid-phase component, namely the modified oxidant, from the solution system obtained in the step B. According to the integrated oil phase emulsion explosive and the preparation method thereof provided by the invention, the sensitivity and the power can be well considered.

The utility model discloses a static emulsification integrated device for M-type emulsion explosives. The static emulsification integrated device is formed by connecting and combining a water phase tank (12), an oil phase tank (13), a water phase delivery pump (14), an oil phase delivery pump (15), two mass flowmeters (16), a venturi tube (17) and a multi-stage jet flow static emulsifier (G), the multi-stage jet flow static emulsifier (G) is formed by combining an SK type static mixing pipe (1), an SK type static mixing unit (2), a first jet flow perforated plate (3), a jet flow emulsifying pipe (4), a forward spiral blade (5), a second jet flow perforated plate (6), a diaphragm type pressure gauge (7), a reverse spiral blade (8), an SV type uniform emulsion mixing pipe (9), an SV type uniform emulsion mixing unit (10) and a pressure relief pipe (11). The device disclosed by the utility model integrates SK type static mixing, multi-stage jet emulsification and SV type uniform emulsion mixing, and has the characteristics of good emulsification effect, high productivity, stable product quality, constant working pressure, high production line safety and excellent product performance index.

The invention relates to the technical field of petroleum drilling fluids, in particular to a preparation method of an anti-calcium tackifier, a brine-based drilling fluid and a preparation method. The preparation method of the anti-calcium tackifier comprises the following steps: A, uniformly mixing the white oil and the emulsifier to form an oil phase for later use; b, dissolving 2-acrylamido-2-methyl-1-propanesulfonic acid, acrylonitrile, a cationic monomer and a vinyl monomer with carboxyl in pure water, adjusting the pH value to 7.0, and uniformly stirring to form a water phase; c, dropwise adding the water phase in the step B into the oil phase in the step A, and uniformly mixing to obtain a stable inverse emulsion; and D, in a nitrogen atmosphere, adding an initiator into the stable inverse emulsion in the step C, and reacting to obtain the anti-calcium tackifier. The brine-based drilling fluid disclosed by the invention can keep good rheological property and stability in a high-temperature environment of 180 DEG C.

The invention belongs to the field of nano preparations, and discloses a preparation method of nano microspheres coated with a nicotinamide mononucleotide shell membrane structure, which comprises the following steps: coating NMN in a pregel formed by chitosan and sodium tripolyphosphate, heating and stirring, adjusting the pH value to separate out chitosan-coated nano microspheres, drying to remove moisture on the surfaces of the nano microspheres, and drying to obtain the nano microspheres coated with the nicotinamide mononucleotide shell membrane structure. Then selecting a water phase and an oil phase in a proper proportion, preparing a chitosan / sodium alginate composite nano-microsphere with sodium alginate as an outer membrane by adopting an emulsion cross-linking method, and washing and drying to obtain the NMN nano-microsphere with a core-shell structure. According to the invention, NMN is coated in the nano-microsphere which is composed of two materials and has a nuclear membrane structure, so that the stability of NMN in a natural environment can be improved, hydrolysis of NMN by gastric acid and gastrointestinal tract enzyme in a drug delivery process can be prevented, the bioavailability of NMN is improved, and a drug sustained release effect is achieved.

The invention discloses a method for constructing food-grade Janus liquid drops with adjustable particle sizes based on multiphase spatial recombination, and belongs to the technical field of liquid drop preparation. According to the preparation method, space phase behaviors of a zein solution and a sodium alginate solution are controlled, the zein solution and the sodium alginate solution which are incompatible with each other are taken as a dispersion phase, and an emulsifier is dissolved in an oil phase to serve as a continuous phase. The laminar behavior of the zein solution and the sodium alginate solution is controlled, and the food-grade Janus liquid drops are prepared under the shearing action of a continuous phase. A series of food-grade Janus liquid drops with controllable particle sizes are constructed by controlling the molecular weight of sodium alginate, the concentration of a dispersed phase, the concentration of an emulsifier, three-phase interface equilibrium and three-phase flow velocity. According to the method for constructing the food-grade Janus liquid drops, the Janus liquid drops which are uniform in particle size and stable in structure can be constructed, and meanwhile, the material for constructing the Janus liquid drops has good biocompatibility and safety.

The invention belongs to the field of separation membranes, and particularly relates to a preparation method of a reverse osmosis membrane. Comprising the following steps: a) coating a water phase solution containing multifunctional amine on the surface of a supporting layer of a base membrane, then coating an oil phase solution containing multifunctional acyl halide, and drying to form a polyamide separation layer on the surface of the supporting layer to obtain a nascent state membrane; b) soaking the nascent state membrane in an alkaline solution with the pH value of 9-12, and then rinsing to obtain a semi-finished membrane; c) coating a post-treatment solution containing polyvinyl alcohol, polydimethylsiloxane and an amino silane coupling agent on the surface of the polyamide separation layer of the semi-finished product membrane, and drying; d, the membrane treated in the step c is soaked in a 3-chloro-2-hydroxypropyl trimethyl ammonium chloride aqueous solution for quaternization reaction and dried, and the reverse osmosis membrane is obtained.The reverse osmosis membrane prepared through the method has good permeability, hydrophilicity, pollution resistance, antibacterial property and washing resistance.

The utility model belongs to the technical field of recovery of coking chemical products in the metallurgical coking industry, and particularly relates to a crude benzene oil-water separation integrated device which is characterized by comprising an oil-water separation area, an oil phase collection area and a water phase collection area, and a partition plate is annular and defines the oil-water separation area in the middle and the oil phase collection area surrounding the oil-water separation area; a crude benzene diversion weir is arranged between the periphery of the top of the partition plate and the oil phase collecting region; a flow guide expansion head and a flow guide baffle are arranged at the bottom of the inlet liquid guide pipe, and a dispersion flow channel in the transverse circumferential direction is formed between the flow guide expansion head and the flow guide baffle; a drainage pipe at the bottom of the oil-water separation area is provided with a diversion collector for transversely draining and collecting separated water from the periphery. The crude benzene oil-water separation device has the beneficial effects that the existing crude benzene oil-water separation process is improved, oil-water separation and reflux are integrated, and the equipment integration device saves the occupied area, simplifies the process flow and is convenient to operate and maintain.

The invention relates to the technical field of membrane separation, in particular to a high-flux high-salt rejection rate reverse osmosis membrane as well as a preparation method and application thereof. The preparation method comprises the following steps: sequentially contacting a porous base membrane with a water phase solution and an oil phase solution to generate an interfacial polymerization reaction to form a primary reverse osmosis membrane, and sequentially contacting the primary reverse osmosis membrane with a nitrous acid or salt solution thereof and a hydrosulfite solution to obtain the reverse osmosis membrane with high flux and high salt rejection rate, the water-phase solution contains a water-phase cosolvent, and the oil-phase solution contains an oil-phase cosolvent. According to the preparation method, cosolvents are creatively added into a water-phase solution and an oil-phase solution in an interfacial polymerization reaction process to regulate and control the microstructure of a polyamide layer, and a diazo reaction promotes further crosslinking of residual aniline groups, so that in-situ densification regulation and control of a polyamide network structure are realized; the trade-off effect of the water flux and the salt rejection rate of the traditional reverse osmosis membrane is successfully broken through.