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71results about How to "Improve loading performance" patented technology

Anti-tumor nano medicine based on cross-linking biodegradable polymer vesica and preparation method of anti-tumor nano medicine

The invention discloses an anti-tumor nano medicine based on cross-linking biodegradable polymer vesicae and a preparation method of the anti-tumor nano medicine. The anti-tumor nano medicine is prepared by loading a medicine on reversible cross-linking biodegradable polymer vesicae of asymmetric membrane structures; the medicine is a protein medicine, a polypeptide drug or a small molecule medicine; the reversible cross-linking biodegradable polymer vesicae of the asymmetric membrane structures are prepared from a polymer in a manner of self-assembling and cross-linking in sequence; the molecular chain of the polymer comprises a hydrophilic chain segment, a hydrophobic chain segment and PEI molecules which are connected in sequence; the hydrophobic chain segment comprises a polycarbonate chain segment and / or polyester chain segment; the medicine can be compounded and loaded under the electrostatic interaction of PEI; a membrane is reversible cross-linking biodegradable polyester / polycarbonate which is good in compatibility; dithiolane of a side chain is similar to a human body natural antioxidant lipoic acid; a shell takes PEG as a background and can target to cancer cells; the anti-tumor nano medicine has the potential to be a nano medicine system with advantages of simplicity, stability, multifunction and the like.
Owner:SUZHOU UNIV

Machining device and machining technology for glass sheet hot bending molding

The invention relates to the field of glass sheet hot bending molding, in particular to a machining device and machining technology for glass sheet hot bending molding. The machining device and machining technology finish machining through a jig structure and the simple process. The machining device mainly comprises a whole rack and a supporting part. The whole rack is of a rack structure with the periphery sealed and a cavity inside. The supporting part is arranged under the whole rack to support the whole rack. The inner cavity of the whole rack is sequentially and transversely provided with a preheating area, a molding area and a cooling area from left to right. Isolation areas are installed at the left end and the right end of the outer side of the whole rack. Meanwhile, the whole rack is provided with a conveying rail which is communicated with the isolation areas at the two ends and connected with the preheating area, the molding area and the cooling area. Glass sheets are loaded and pressed through a jig so as to finish the whole process of glass sheet hot bending molding. Loading performance of the graphite jig is stable, pressing and heating of the jig are uniform, the structure of the whole machining device is simplified, and the machining technology is simple.
Owner:东莞市华星镀膜科技有限公司

Reversible crosslinked biodegradable polymer vesicle having positive charges on inner membrane, preparation method thereof and application in preparation of antineoplastic drugs

The invention discloses a reversible crosslinked biodegradable polymer vesicle having positive charges on an inner membrane, a preparation method thereof and application in preparation of antineoplastic drugs. The biodegradable polymer vesicle based on tumor targeting of a block polymer PEG-P (TMC-DTC)-SP or PEG-P (LA-DTC)-SP, having the positively charged membrane, reversibly crosslinked in reduction sensitivity and intracellularly solvable and crosslinked can effectively support and protect biological macromolecules such as proteins, DNA and siRNA and micromolecular drugs with negative charges in a physical environment and can be delivered to intravital tumor cells to induce apoptosis. The system has lots of unique advantages including simple and easy controllability of preparation, excellent biocompatibility, excellent controlled drug release property, super-strong in-vivo circulation stability, superior cancerous cell targeting and remarkable cancer cell apoptosis capability and the like. Therefore, the reversible crosslinked biodegradable polymer vesicle is expected to become a simple, stable, multifunctional nano system platform integrating multiple advantages and is used for efficient, active and targeted delivery from nucleic acids to in-situ tumors.
Owner:SUZHOU UNIV

DNA biosensor based on three-dimensional ordered gold doped nano titanium dioxide electrode as well as preparation method and application of DNA biosensor

The invention discloses a DNA biosensor based on a three-dimensional ordered gold doped nano titanium dioxide electrode and a preparation method as well as a method for detecting breast cancer genes by using the sensor. The preparation method comprises the following steps: preparing a three-dimensional ordered gold doped nano titanium dioxide film electrode (3DOMGTD/ITO) on an ITO (indium tin oxide) electrode by adopting a template method; then dropping a DNA probe (5'-Fc-ssDNA) labeled with ferrocene at 5' end on the electrode, thereby preparing a modified electrode, namely the DNA biosensor; placing the modified electrode in a solution of a breast cancer gene segment, hybridizing, detecting the variation of hybridization signals by adopting a differential pulse volt-ampere method, and carrying out electrochemical detection on the breast cancer gene. According to the invention, the label-type DNA biosensor is prepared by utilizing the specificity recognition effect between the DNA probe and the breast cancer gene, and the DNA biosensor has favorable stability, reproducibility and electrode regeneration, and can be applied to the field of DNA hybridization and tumor electrochemical detection.
Owner:NANJING NORMAL UNIVERSITY

Fatigue test method of wind power blade

The invention discloses a fatigue test method of a wind power blade. The fatigue test method comprises the following steps of installing the wind power blade, of which a rear edge faces upwards, a front edge faces downwards and chord length is in a direction perpendicular to ground, on a test platform; installing a plurality of exciters at different weight-balancing point positions on the wind power blade in a swinging direction and in a horizontal loading mode; and adjusting parameters of a plurality of exciters so that the plurality of exciters are synergically loaded, starting the pluralityof exciters, and maintaining stable vibration amplitude, and reaching stipulated target requirement. Traditional loading is changed to horizontal loading, multi-point synergic loading is performed bythe plurality of exciters, the loading efficiency of a single exciter can be improved, the insufficient loading force during fatigue test of a large-size wind power blade also can be prevented, and the fatigue test demand of the large-size wind power blade is satisfied. The test method more conforms to setting of a fatigue design load than a traditional test method and more approaches to time-space evolution working condition of fatigue accumulated damage during the running process of the wind power blade.
Owner:SHANGHAI ELECTRIC WIND POWER GRP CO LTD

Fully-automatic screen printer for sheets

PendingCN110834465AGood depolarization performanceReduce eccentric disturbanceConveyorsScreen printersManufacturing engineeringPrinting press
The invention discloses a fully-automatic screen printer for sheets. The fully-automatic screen printer for the sheets comprises a conveying unit arranged at the inner side of a rack, wherein the conveying unit is used for conveying a material to be processed and correcting a position to be printed, of the material; a printing unit is arranged above one end of the rack, and a discharge lifting unit is arranged at the other end of the rack; the discharge lifting unit is used for supplying the material to be processed and feeding back material lack information in time; a material taking mechanism is arranged at one end connected with the discharge lifting unit, of the rack; a vision unit is arranged above the material taking mechanism, and used for obtaining position image information of thematerial to be processed and on the conveying unit, and carrying out information feedback; and a material receiving mechanism is arranged on a part below the printing unit, of the rack. According tothe fully-automatic screen printer for the sheets, the accuracy of product alignment and printing is effectively increased, so that wider application range and higher universality are achieved, and electricity consumption and ink resource are saved; and moreover, the fully-automatic screen printer for the sheets is convenient to maintain and replace, so that the maintenance cost is greatly reduced.
Owner:深圳市亿宝莱印刷设备有限公司

Modified polyrotaxane, medicine carrier micelle based on polyrotaxane and preparation method and application of micelle

The invention belongs to the technical field of biological medicine and discloses modified polyrotaxane, a medicine carrier micelle based on polyrotaxane and a preparation method and application of the micelle. The preparation method of the micelle includes the steps of (1) preparing hydrophilic modified polyrotaxane, wherein hydroxide radical of epoxy dextrin units in polyrotaxane is subjected toa reaction with a modifier, and the modifier is dicarboxylic anhydride; (2) making hydrophilic modified polyrotaxane subjected to amidation with a tumor-targeted ligand unit in water to obtain an amphipathic grafting product; (3) making hydrophobic antitumor medicine buried in the amphipathic grafting product to form and obtain the polyrotaxane medicine carrier micelle. Polyrotaxane is obtained after end capping is conducted by an end-capping reagent on quasi-polyrotaxane prepared by mixing active-ester-modified polyethylene glycol and cyclodextrin. The micelle is stable in structure, capableof carrying hydrophobic medicine, excellent in medicine encapsulating capability and high in encapsulation efficiency and has a targeting property. Meanwhile, the micelle has extremely low cytotoxicity and excellent blood compatibility.
Owner:SOUTH CHINA UNIV OF TECH

Upper support frame of automobile dashboard crossbeam

InactiveCN104723885AStamping deformation is reducedSimple molding processDashboardsDashboardMechanical engineering
The invention discloses an upper support frame of an automobile dashboard crossbeam. The upper support frame comprises a support frame body and a mounting plate which are integrally formed by punching. The support frame body is of a flat plate structure, small sections of lower turnups are arranged at two side edges of the support frame body respectively to serve as reinforcing ribs, and thus, the cross section of the support frame body is C-shaped. Two wing-shaped plates and a pair of welding plates are arranged on two sides of the front portion of the support frame body, the wing-shaped plates extend downwardly along the reinforcing ribs, and the welding plates are connected to the front lower ends of the wing-shaped plates respectively. The mounting plate is smoothly connected to the rear end of the support frame body, and an included angle larger than 90 degrees is formed between the mounting plate and the support frame body. Small sections of front turnups are arranged at two side edges of the mounting plate respectively to serve as reinforcing ribs, and thus, the cross section of the mounting plate is C-shaped. The upper support frame of the automobile dashboard crossbeam is improved greatly in terms of cost, technique and strength and has good mounting effect and high stability.
Owner:SHANGHAI HEDA AUTOMOBILE FITTINGS

Large-load hydraulic bidirectional loading apparatus

ActiveCN102817914ASolve the complex structureAdd application functionsBearingsChemical industryCoal
The invention relates to a large-load hydraulic bidirectional loading apparatus. According to the invention, servo cylinders respectively positioned in a loading cylinder and symmetrically and axially distributed along a thrust plate are adopted. A plurality of oil duct pipes are arranged between the servo cylinders and the loading cylinder. An oil channel A and an oil channel B are respectively arranged at a box body and a box cover. The oil channel A penetrates the surface of the thrust plate through the loading cylinder, the oil duct pipes, and the servo cylinders. The oil channel B penetrates a bonding interface of the loading cylinder and the servo cylinders through the loading cylinder. One end of a thrust shaft is connected to a driving apparatus through a coupler, and inputs power. The other end of the thrust shaft outputs power through a flange plate. With existing large-load thrust loading apparatuses, mechanical loading or electric loading is adopted, such that an interface of rotation parts can easily get abraded, and service life and efficiency are influenced. Further more, independent function requirements of heavy load and high-speed rotation can not be satisfied simultaneously by mechanical loading and electric loading, and a structure is complex. With the apparatus provided by the invention, the defects are overcome. The apparatus is suitable to be used as a matched loading apparatus in industries such as mining, electricity, coal, metallurgy, transportation, chemical industry, water conservancy, machine tools, and the like.
Owner:HUNAN CHONGDE IND TECH
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