72results about How to "Improve loading performance" patented technology

The invention discloses an anti-tumor nano medicine based on cross-linking biodegradable polymer vesicae and a preparation method of the anti-tumor nano medicine. The anti-tumor nano medicine is prepared by loading a medicine on reversible cross-linking biodegradable polymer vesicae of asymmetric membrane structures; the medicine is a protein medicine, a polypeptide drug or a small molecule medicine; the reversible cross-linking biodegradable polymer vesicae of the asymmetric membrane structures are prepared from a polymer in a manner of self-assembling and cross-linking in sequence; the molecular chain of the polymer comprises a hydrophilic chain segment, a hydrophobic chain segment and PEI molecules which are connected in sequence; the hydrophobic chain segment comprises a polycarbonate chain segment and / or polyester chain segment; the medicine can be compounded and loaded under the electrostatic interaction of PEI; a membrane is reversible cross-linking biodegradable polyester / polycarbonate which is good in compatibility; dithiolane of a side chain is similar to a human body natural antioxidant lipoic acid; a shell takes PEG as a background and can target to cancer cells; the anti-tumor nano medicine has the potential to be a nano medicine system with advantages of simplicity, stability, multifunction and the like.

The invention relates to the field of glass sheet hot bending molding, in particular to a machining device and machining technology for glass sheet hot bending molding. The machining device and machining technology finish machining through a jig structure and the simple process. The machining device mainly comprises a whole rack and a supporting part. The whole rack is of a rack structure with the periphery sealed and a cavity inside. The supporting part is arranged under the whole rack to support the whole rack. The inner cavity of the whole rack is sequentially and transversely provided with a preheating area, a molding area and a cooling area from left to right. Isolation areas are installed at the left end and the right end of the outer side of the whole rack. Meanwhile, the whole rack is provided with a conveying rail which is communicated with the isolation areas at the two ends and connected with the preheating area, the molding area and the cooling area. Glass sheets are loaded and pressed through a jig so as to finish the whole process of glass sheet hot bending molding. Loading performance of the graphite jig is stable, pressing and heating of the jig are uniform, the structure of the whole machining device is simplified, and the machining technology is simple.

The invention discloses a reversible crosslinked biodegradable polymer vesicle having positive charges on an inner membrane, a preparation method thereof and application in preparation of antineoplastic drugs. The biodegradable polymer vesicle based on tumor targeting of a block polymer PEG-P (TMC-DTC)-SP or PEG-P (LA-DTC)-SP, having the positively charged membrane, reversibly crosslinked in reduction sensitivity and intracellularly solvable and crosslinked can effectively support and protect biological macromolecules such as proteins, DNA and siRNA and micromolecular drugs with negative charges in a physical environment and can be delivered to intravital tumor cells to induce apoptosis. The system has lots of unique advantages including simple and easy controllability of preparation, excellent biocompatibility, excellent controlled drug release property, super-strong in-vivo circulation stability, superior cancerous cell targeting and remarkable cancer cell apoptosis capability and the like. Therefore, the reversible crosslinked biodegradable polymer vesicle is expected to become a simple, stable, multifunctional nano system platform integrating multiple advantages and is used for efficient, active and targeted delivery from nucleic acids to in-situ tumors.

The invention discloses a DNA biosensor based on a three-dimensional ordered gold doped nano titanium dioxide electrode and a preparation method as well as a method for detecting breast cancer genes by using the sensor. The preparation method comprises the following steps: preparing a three-dimensional ordered gold doped nano titanium dioxide film electrode (3DOMGTD / ITO) on an ITO (indium tin oxide) electrode by adopting a template method; then dropping a DNA probe (5'-Fc-ssDNA) labeled with ferrocene at 5' end on the electrode, thereby preparing a modified electrode, namely the DNA biosensor; placing the modified electrode in a solution of a breast cancer gene segment, hybridizing, detecting the variation of hybridization signals by adopting a differential pulse volt-ampere method, and carrying out electrochemical detection on the breast cancer gene. According to the invention, the label-type DNA biosensor is prepared by utilizing the specificity recognition effect between the DNA probe and the breast cancer gene, and the DNA biosensor has favorable stability, reproducibility and electrode regeneration, and can be applied to the field of DNA hybridization and tumor electrochemical detection.

The invention discloses an electro-hydraulic loading device for a reducer test. The electro-hydraulic loading device comprises a base (14). A driving motor (1), a first coupler (2), a torque angle displacement sensor (3) of a reducer input end, a second coupler (4), the to-be-tested reducer (5), a third coupler (6), a torque angle displacement sensor (7) of a reducer output end and an electro-hydraulic loading mechanism (8) are kept horizontally coaxial and connected in sequence are arranged on the base (14). The electro-hydraulic loading mechanism (8) comprises a loading cylinder (15) which is provided with a spindle (16) with a brake disc (17). The loading cylinder (15) is sequentially connected with an energy accumulator (18), a switching valve (19), a check valve (20), a hydraulic pump (21), a filter (22) and an oil tank (23), and the check valve (20) is further connected with an overflow valve (24). The electro-hydraulic loading device for the reducer test is adaptable to the reducer test for a large torque efficient robot, also capable of testing a single reducer each time; and is stable in loading performance and convenient to use.

The invention discloses a method for loading data in parallel after splitting files, which is used for loading data by using an SQL (Structured Query Language) Loader. The method comprises the following steps of: reading control files and data files to generate log files, damaged files and waste files; configuring the parameters of the SQL Loader; judging whether the record number of files required to be loaded is larger than a record limit value of parameter configuration or not according to the configured parameters; sequentially splitting the files required to be loaded into n sub-files according to a sub-file record numerical value of the parameter configuration; and starting m sub-processes of the SQL Loader serving as a data loading tool to load the sub-files in parallel, wherein a plurality of sub-files are loaded in series in each sub-process. According to the method for loading data in parallel after splitting files disclosed by the invention, the loading performance of mass data is further optimized on the basis of the SQL Loader tool.

The invention relates to a novel flexural member sustained loading test device based on a secondary level effect. The device comprises an inclined strut (1), a built-in beam (2), a screw (3), a lever beam b (4), a lever beam a (5), a distribution beam (6), a weight hanging plate (7), a steel plate b (8), a dialgage bracket (9), an inclined strut b (10), a flexural test piece (11), a steel plate a (12), a counterforce beam (13) and a static data acquisition system. The weight hanging plate (7) is hung at one end of the lever beam b (4), the other end of which is fixed on the steel plate b (8). The lever beam a (5) is arranged between the steel plate b (8) and the steel plate a (12), and the flexural test piece (11) is disposed on the counterforce beam (13). Compared with the prior art, the device of the invention has the advantages of convenient assembling, strong applicability, stable loading performance, etc., and can be conveniently applied to flexural member long-term performance tests as well as flexural member durability tests under load-environment combined action.

The invention relates to a preparation method of an immobilized ionic liquid used for an ester exchange reaction. The preparation method comprises the steps of: regarding a pure silicon molecular sieve as a carrier and regarding epoxy chloropropane or epoxy bromopropane and 1-alkyl imidazole as raw materials to realize efficient immobilization of the ionic liquid on the surface of the pure silicon molecular sieve through two-step reaction. The preparation method is simple; and the obtained immobilized ionic liquid catalyst after the reaction can be recycled for the continuous cyclic utilization through a simple treatment, has a long service life and no pollution, and greatly reduces the reaction cost. Very good catalysis effects can be obtained when the catalyst prepared by the preparation method is used for the ester exchange reaction, such as the ester exchange reaction of dimethyl carbonate and diethyl carbonate and the ester exchange reaction of ethylene carbonate and methanol.

The invention discloses a bearing support structure for bearing multiple solar panels, which comprises a bottom plate, a framework, a junction box and a plurality of transmission lines. The bottom plate is used for bearing the multiple solar panels. The framework is arranged on the bottom plate, at least one accommodating space is formed in the framework, and the at least one accommodating space is used for accommodating the multiple solar panels so that the multiple solar panels are fixed on the bottom plate. The junction box is arranged on one side of the bottom plate and between the adjacent solar panels. Two ends of each transmission line are electrically connected with the corresponding solar panel and the junction box respectively, so that the electrical energy converted by the solar panel is transmitted to the junction box.

The invention discloses a triptolide derivative, a preparation method and a preparation thereof, wherein the chemical structure of the triptolide derivative is represented by a formula (I) defined in the specification, R represents straight chain alkyl acyl having a carbon atom number of 2n, and n is 2-9. The present invention discloses the preparation method of the compound, wherein triptolide and saturated fatty acid are subjected to an esterification reaction to obtain the compound. According t the present invention, the hydroxyl forms the ester by bonding the saturated fatty acid on the C14 site OH of TP so as to reduce the polarity while the fatty acid is introduced so as to effectively enhance the fat-solubility, the property is stable, the oxidation is not easily generated, and the drug forming property of the TP nanometer preparation can be significantly improved; liposomes, micelles, nanoparticles, fat emulsions and other nanometer preparations prepared from the compound of the present invention have good packing effect; and the prepared nanometer preparation has advantages of high drug loading, high entrapment efficiency, stable property, significant toxicity reducing, half-life prolonging, and the like.

The invention discloses a fatigue test method of a wind power blade. The fatigue test method comprises the following steps of installing the wind power blade, of which a rear edge faces upwards, a front edge faces downwards and chord length is in a direction perpendicular to ground, on a test platform; installing a plurality of exciters at different weight-balancing point positions on the wind power blade in a swinging direction and in a horizontal loading mode; and adjusting parameters of a plurality of exciters so that the plurality of exciters are synergically loaded, starting the pluralityof exciters, and maintaining stable vibration amplitude, and reaching stipulated target requirement. Traditional loading is changed to horizontal loading, multi-point synergic loading is performed bythe plurality of exciters, the loading efficiency of a single exciter can be improved, the insufficient loading force during fatigue test of a large-size wind power blade also can be prevented, and the fatigue test demand of the large-size wind power blade is satisfied. The test method more conforms to setting of a fatigue design load than a traditional test method and more approaches to time-space evolution working condition of fatigue accumulated damage during the running process of the wind power blade.

The invention discloses a fully-automatic screen printer for sheets. The fully-automatic screen printer for the sheets comprises a conveying unit arranged at the inner side of a rack, wherein the conveying unit is used for conveying a material to be processed and correcting a position to be printed, of the material; a printing unit is arranged above one end of the rack, and a discharge lifting unit is arranged at the other end of the rack; the discharge lifting unit is used for supplying the material to be processed and feeding back material lack information in time; a material taking mechanism is arranged at one end connected with the discharge lifting unit, of the rack; a vision unit is arranged above the material taking mechanism, and used for obtaining position image information of thematerial to be processed and on the conveying unit, and carrying out information feedback; and a material receiving mechanism is arranged on a part below the printing unit, of the rack. According tothe fully-automatic screen printer for the sheets, the accuracy of product alignment and printing is effectively increased, so that wider application range and higher universality are achieved, and electricity consumption and ink resource are saved; and moreover, the fully-automatic screen printer for the sheets is convenient to maintain and replace, so that the maintenance cost is greatly reduced.

The invention discloses a preparation method of a capsule-shaped chitosan gel bead capable of entrapping small-molecule dyes, belonging to the technical field of preparation processes of chitosan gel beads. The preparation method comprises the following steps: dissolving chitosan into an acetic acid solution, and slowly and drowise adding a beta-sodium glycerophosphate pentahydrate solution into an ice-water bath; regulating the pH value of the mixed solution to be neutral; drowise adding the prepared chitosan / beta-sodium glycerophosphate pentahydrate mixed solution (CS / beta-GP solution) into SDS receiving liquid, and carrying out curing, so as to form a chitosan drop packaging the CS / beta-GP solution; and heating in a water bath to generate internal gelatinization under the action of hydrogen bonds, so as to finally obtain the chitosan gel bead. The chitosan gel bead prepared by virtue of the preparation method has an excellent entrapment property to the small-molecule dyes with the molecular weights of 300-800, the leakage amount of the dyes is low, the entrapment stability is good, and the dyes are not obviously leaked after 12 hours.

The invention belongs to the technical field of biological medicine and discloses modified polyrotaxane, a medicine carrier micelle based on polyrotaxane and a preparation method and application of the micelle. The preparation method of the micelle includes the steps of (1) preparing hydrophilic modified polyrotaxane, wherein hydroxide radical of epoxy dextrin units in polyrotaxane is subjected toa reaction with a modifier, and the modifier is dicarboxylic anhydride; (2) making hydrophilic modified polyrotaxane subjected to amidation with a tumor-targeted ligand unit in water to obtain an amphipathic grafting product; (3) making hydrophobic antitumor medicine buried in the amphipathic grafting product to form and obtain the polyrotaxane medicine carrier micelle. Polyrotaxane is obtained after end capping is conducted by an end-capping reagent on quasi-polyrotaxane prepared by mixing active-ester-modified polyethylene glycol and cyclodextrin. The micelle is stable in structure, capableof carrying hydrophobic medicine, excellent in medicine encapsulating capability and high in encapsulation efficiency and has a targeting property. Meanwhile, the micelle has extremely low cytotoxicity and excellent blood compatibility.

The invention discloses an immobilized ionic liquid catalyst. The immobilized ionic liquid catalyst is formed by taking a mesoporous molecular sieve SBA-16 as a carrier, taking a 1-butyl-3-methylimidazole sulfonate ionic liquid as an active component and packaging the ionic liquid in the pore cage of the SBA-16 molecular sieve, wherein the mass ratio of the 1-butyl-3-methylimidazole sulfonate ionic liquid to the mesoporous molecular sieve SBA-16 is (1-5):10. When being used for catalyzing the synthesis of polyoxymethylene dimethyl ether through a reaction of methanol and trioxymethylene, the catalyst disclosed by the invention can solve the problems of difficult catalyst separation and poor stability, can be recycled for multiple times, and can improve the reaction activity of the synthesis reaction of the polyoxymethylene dimethyl ether and the selectivity of the target product.

The invention discloses a data desensitization device based on a distributed cluster. The device comprises a master server, a thread master scheduler and a plurality of slave servers, each slave server is provided with a thread scheduler for thread distribution of the slave servers, and the master server slices each source data table needing to be desensitized in a database and puts the table slices into a slice queue of a source data table; and the master server allocates a defined thread pipeline to each source data table through a thread total scheduler, and the thread total scheduler schedules a thread through a thread scheduler of slave servers to pull data from the fragmentation queue for desensitization and then loads the data to a target data table. According to the invention, thethread scheduler of the slave servers is coordinated through a thread total scheduler, so that dynamic thread allocation is realized and the loading performance is improved; due to distributed clustersetting of the master server and the slave servers, the extension performance is good; and high-speed data extraction is realized through table data fragmentation.

The invention relates to a preparation method of an immobilized ionic liquid used for an ester exchange reaction. The preparation method comprises the steps of: regarding a pure silicon molecular sieve as a carrier and regarding epoxy chloropropane or epoxy bromopropane and 1-alkyl imidazole as raw materials to realize efficient immobilization of the ionic liquid on the surface of the pure silicon molecular sieve through two-step reaction. The preparation method is simple; and the obtained immobilized ionic liquid catalyst after the reaction can be recycled for the continuous cyclic utilization through a simple treatment, has a long service life and no pollution, and greatly reduces the reaction cost. Very good catalysis effects can be obtained when the catalyst prepared by the preparation method is used for the ester exchange reaction, such as the ester exchange reaction of dimethyl carbonate and diethyl carbonate and the ester exchange reaction of ethylene carbonate and methanol.

The invention relates to the technical field of loading and unloading, and particularly relates to a quantitative loading device and a quantitative loading method. The invention provides a quantitative loading device. The quantitative loading device comprises a grabbing mechanism, a conveying mechanism, a loading platform, a leveling pipeline and a plurality of discharge openings. Materials are grabbed to the conveying mechanism by utilizing the grabbing mechanism, then the materials are conveyed to the leveling pipeline on the loading platform by utilizing the conveying mechanism, and finally, the materials are uniformly loaded on transportation equipment through the discharge openings. The quantitative loading device has the advantages of high degree of automation and good loading effect, and the influence of the floating of the materials on the work environment is reduced. The invention further provides a quantitative loading method. The quantitative loading method comprises the steps of grabbing, discharging, conveying, loading and leveling. The quantitative loading method has the advantages of good loading effect and high process controllability, and the clean work environmentcan be guaranteed.

The invention provides a preparation method of a palladium hydrogenation catalyst, the catalyst prepared through the method and a method for preparing piperidine through the catalyst. The preparation method comprises the following steps that firstly, active carbon is smashed and immersed in a pretreatment reagent and then filtered, washed and dried; secondly, a palladium, nickel and saccharose solution is prepared; thirdly, the hydrothermal reaction is conducted, then, filtering and washing are conducted, a catalyst precursor is obtained after vacuum drying, is roasted in the inert atmosphere and naturally cools, and after passivation, the supported catalyst is obtained. The prepared catalyst is mainly used for pyridine selectivity catalytic hydrogenation, and the conversion rate and selectivity of the catalyst can reach 98-100% and 99-99.99% respectively. The palladium hydrogenation catalyst further has the advantages that stability is good, and the preparation method is simple.

The invention provides a construction method of microbial carriers for wastewater treatment. The construction method comprises the following steps: taking wheat straws or other plant remains as microbial fixed carriers and taking sponge or porous plastic as supporting materials, uniformly mixing the microbial fixed carriers and the supporting materials, and filling in a swage treatment system. The affinity of the carriers in the biofilm process on the microbes in excellent, and the nutrition supply of the microbes is good; moreover, the sewage treatment system has the characteristics of high wastewater load impact resistance, can directly treat high-concentration and stable-quality polluted wastewater, and does not need diluting wastewater so as to solve the problem that polluted wastewater with three-high characteristics causes the high load impact.

The invention relates to a preparation method of an immobilized alkaline ionic liquid catalyst for ester exchange reaction. According to the method, by using pure silicon molecular sieves or silicon dioxide microbeads as a support and chloracetyl chloride, 1-alkyliminazole and tetramethylammonium hydroxide as raw materials, the ionic liquid can be effectively immobilized on the surface of the pure silicon molecular sieves or silicon dioxide microbeads by three reaction steps. The method is simple; and the obtained immobilized alkaline ionic liquid catalyst after reaction can be recycled for cyclic utilization after simple treatment, and thus, has the advantages of long service life and no pollution, thereby greatly lowering the reaction cost. The catalyst has favorable effect when being used in the ester exchange reaction of synthesizing methylethyl carbonate from dimethyl carbonate and diethyl carbonate.

The invention discloses a method for compression-based optimization of log storage of a cloud storage system, belonging to the technical field of server storage logs. The method for compression-based optimization of log storage of the cloud storage system comprises log storage and log playback, wherein the log storage is that a compression attribute is added into head information of each log and an disc drop operation is carried out after compression optimization; the log playback is that each log is read from a log storage medium, decompression optimization is carried out through the compression attribute and a log playback operation is carried out. The method for compression-based optimization of log storage of the cloud storage system has strong universality and cannot affect the existing cloud storage system framework, the performance of the cloud storage system can be improved, and the method has good popularization and application value.

The invention relates to a testing machine for testing a variable load reducer for washing machines. The testing machine comprises a servo motor. The servo motor is connected with a reducer under test, through a shaft sleeve. The reducer under test is clamped with an adjustable clamp which is positioned via a guide rail; a pneumatic cylinder is connected with the shaft sleeve through a connecting line and loads the reducer under test; the connecting line is supported by a pulley; an air pipe is mounted on the pneumatic cylinder; the guide rail and the pulley are directly mounted on a base; the servo motor and the pneumatic cylinder are fixed on the base through a rib plate. The pneumatic cylinder loads the reducer, low heat is generated, and loading performance is stable; different loads can be acquired by adjusting a pneumatic valve through an industrial personal computer according to the load of the reducer for washing machines.

The invention discloses an antitumor drug and a preparation method thereof. The antitumor drug is based on block polymer PEG-P (TMC-DTC)-SP or PEG-P (LA-DTC)-SP tumor targeting and has reduction-sensitive reversible crosslinking and intracellular-soluble crosslinking biodegradable polymeric vesicles with positively-charged internal membranes, and micromolecular drugs, which can be used for protecting biological macromolecules such as protein, DNA and siRNA and have negatively-charged physiological environments, can be efficiently loaded and can be conveyed into in-vivo tumor cells to induce the apoptosis of the tumor cells. The system has a variety of unique advantages, including simplicity and control in preparation, outstanding biocompatibility, excellent drug controlled release, superhigh in-vivo cycle stability, superior cancer cell targeted performance, remarkable cancer cell apoptosis capability and the like. Therefore, the antitumor drug advantageously becomes a nano-system platform integrating the advantages of simplicity, stability, multifunction and the like and is used for efficiently and actively conveying nucleic acid to in-situ tumors in a targeted manner.

The invention relates to a preparation method of a solid catalyst used in the process of synthesizing propylene carbonate. The method uses graphene oxide as a carrier, 1,2-dibromoethane and triethylamine as raw materials, and can be obtained by one-step reaction A solid catalyst for the synthesis of propylene carbonate by the cycloaddition reaction of carbon dioxide and propylene oxide. The method is simple to operate, and the obtained solid catalyst can be continuously recycled after simple treatment, has a long service life, is pollution-free, and greatly reduces production costs. When the catalyst is used in the synthesis of propylene carbonate, the catalytic activity is very high, the highest yield of cyclic carbonate can reach 84.2%, and the selectivity is 97.5%.

There is provided a technique which can realize stable loading performance irrespective of the state of a loaded object loaded on a tray. A loading information acquisition unit 106 acquires loading information relating to a sheet loading height on a loading tray 101 on which a sheet subjected to a specified processing is loaded, and a press force adjusting unit 107 moves, based on the loading information, at least one of the loading tray 101 and a pressing unit 104 to press from above the sheet loaded on the loading tray in a direction in which the loading tray and the pressing unit 104 are distanced from each other.

The invention provides a flexible base transmitting ejection loads. The flexible base comprises a bottom plate and a side wall. The bottom plate and the side wall form a barrel shape. The longitudinal section of the side wall is of an S shape. The flexible base transmitting the ejection loads has high self-deformation ability, and can meet the requirements for different ground unevenness, and control the ejection loads within the safety range.

There is provided a technique which can realize stable loading performance irrespective of the state of a loaded object loaded on a tray. A loading information acquisition unit 106 acquires loading information relating to a sheet loading height on a loading tray 101 on which a sheet subjected to a specified processing is loaded, and a press force adjusting unit 107 moves, based on the loading information, at least one of the loading tray 101 and a pressing unit 104 to press from above the sheet loaded on the loading tray in a direction in which the loading tray and the pressing unit 104 are distanced from each other.

The invention discloses an upper support frame of an automobile dashboard crossbeam. The upper support frame comprises a support frame body and a mounting plate which are integrally formed by punching. The support frame body is of a flat plate structure, small sections of lower turnups are arranged at two side edges of the support frame body respectively to serve as reinforcing ribs, and thus, the cross section of the support frame body is C-shaped. Two wing-shaped plates and a pair of welding plates are arranged on two sides of the front portion of the support frame body, the wing-shaped plates extend downwardly along the reinforcing ribs, and the welding plates are connected to the front lower ends of the wing-shaped plates respectively. The mounting plate is smoothly connected to the rear end of the support frame body, and an included angle larger than 90 degrees is formed between the mounting plate and the support frame body. Small sections of front turnups are arranged at two side edges of the mounting plate respectively to serve as reinforcing ribs, and thus, the cross section of the mounting plate is C-shaped. The upper support frame of the automobile dashboard crossbeam is improved greatly in terms of cost, technique and strength and has good mounting effect and high stability.

The invention relates to a large-load hydraulic bidirectional loading apparatus. According to the invention, servo cylinders respectively positioned in a loading cylinder and symmetrically and axially distributed along a thrust plate are adopted. A plurality of oil duct pipes are arranged between the servo cylinders and the loading cylinder. An oil channel A and an oil channel B are respectively arranged at a box body and a box cover. The oil channel A penetrates the surface of the thrust plate through the loading cylinder, the oil duct pipes, and the servo cylinders. The oil channel B penetrates a bonding interface of the loading cylinder and the servo cylinders through the loading cylinder. One end of a thrust shaft is connected to a driving apparatus through a coupler, and inputs power. The other end of the thrust shaft outputs power through a flange plate. With existing large-load thrust loading apparatuses, mechanical loading or electric loading is adopted, such that an interface of rotation parts can easily get abraded, and service life and efficiency are influenced. Further more, independent function requirements of heavy load and high-speed rotation can not be satisfied simultaneously by mechanical loading and electric loading, and a structure is complex. With the apparatus provided by the invention, the defects are overcome. The apparatus is suitable to be used as a matched loading apparatus in industries such as mining, electricity, coal, metallurgy, transportation, chemical industry, water conservancy, machine tools, and the like.