18 results about "Dithiolane" patented technology

The invention relates to a preparation method of 1-(5-[1, 2] dithiolane-3-yl valeryl) pyrrolidine-2, 5-diketone, a reaction equation is as follows: the preparation method comprises the following steps: S1, adding pyrrolidine-2, 5-diketone, alpha-lipoic acid and a solvent into a microwave reaction bottle, and stirring to form a solution I; s2, adding a coupling agent and a catalyst into the solution I, and stirring to form a solution II; and S3, placing the microwave reaction bottle filled with the solution II in a microwave reactor for reaction, and performing post-treatment to obtain the 1-(5-[1, 2] dithiolane-3-yl valeryl) pyrrolidine-2, 5-diketone. According to the microwave method preparation process adopted by the invention, the reaction efficiency of the preparation process of the 1-(5-[1, 2] dithiolane-3-yl valeryl) pyrrolidine-2, 5-diketone is greatly improved, and the yield and the purity of the product are greatly improved.

The application belongs to the field of nucleic acid drug delivery, and mainly relates to a glycerophosphoryl ethanolamine skeleton compound and a lipid nano drug carrier comprising the same. The glycerophosphoryl ethanolamine skeleton compound has a structure as shown in formula (I): The application modifies a dithiolane structure at the phosphate hydrophilic end of a glycerophosphoryl ethanolamine lipid, so that the dithiolane structure is more fully exposed on the surface of LNP, so that more dithiolane is exposed on the surface of the prepared LNP, and the endocytosis of mucosal cells to LNP can be further promoted. The glycerophosphoryl ethanolamine skeleton compound has a wide adjustment range in the LNP prescription, and can increase the content of dithiolane in LNP. The nucleic acid lipid nanoparticle composition and the pharmaceutical preparation provided by the application can be used for ocular delivery, pulmonary inhalation delivery and nasal spray of nucleic acid drugs, and provide a new choice for extrahepatic delivery of nucleic acid drugs.

The invention provides a phosphatidyl glycerol skeleton compound containing a dithiolane structure and application of lipid nanoparticles of the phosphatidyl glycerol skeleton compound in biological medicine, and belongs to the technical field of nucleic acid drug delivery. The structural formula of the compound provided by the invention is as shown in formula I in the specification. The phosphatidylglycerol skeleton compound containing the dithiolane structure provided by the invention takes phosphatidylglycerol as a skeleton, the molecular structure is mainly formed by connecting glycerol, phosphoric acid, fatty acid and fatty acid containing the dithiolane structure through ester bonds, the degradability is stronger, the number of dithiolane in the molecule is large, and the dithiolane skeleton compound containing the dithiolane structure has a good application prospect. The dithiolane derivative has higher efficiency and safety in nucleic acid delivery, and can be used as a functional lipid material for preparing lipid nanoparticles, so that the surfaces of the prepared lipid nanoparticles have dithiolane structures, and the dithiolane derivative can chemically react with sulfydryl on the surfaces of cells, thereby facilitating the uptake of LNP by NK cells and improving the capacity of nucleic acid drugs entering the cells.

The invention discloses an adhesive hydrogel microneedle as well as a preparation method and application thereof, belongs to the technical field of biological materials, and solves the problem that the curative effect of a drug delivery system applied to gout treatment in the prior art is not ideal enough. The hydrogel microneedle based on the dithiolane carboxylic acid derivative, provided by the invention, is prepared by mixing the dithiolane carboxylic acid derivative with tea polyphenol nanoparticles and passing through a silica gel microneedle mold through an ultraviolet irradiation crosslinking effect. The hydrogel microneedle based on the dithiolane carboxylic acid derivative, provided by the invention, can be used for treating gouty arthritis by cooperating with the effects of the tea extract and the indometacin medicine.

The invention discloses an efficient polymerization method based on 1, 2-dithiolane and derivative monomers thereof, and belongs to the technical field of polymer synthesis. The method comprises the following steps: dissolving an organic monomer containing 1, 2-dithiolane in an organic solvent to obtain an organic solution of the monomer; the preparation method comprises the following steps: adding an initiator with oxidation activity into an organic solution of a monomer, and stirring under the conditions of normal temperature, normal pressure and air to realize rapid ring-opening polymerization to prepare the polymer. The reaction conditions are mild, compared with a traditional method, the reaction temperature is low, severe conditions such as heating, water removal and inert gas protection are not needed, energy consumption and equipment requirements are reduced, and the conversion rate of the monomer is increased to 70-80% or above. The oxidative polymerization method used in the invention is suitable for a variety of organic solvents and a variety of 1, 2-dithiolane monomers, is easy for large-scale popularization, and has considerable universality.

The present invention relates to the technical field of new uses of compounds, and more specifically, to a novel application of N-(2-(5-(1,2-dithiolane-3-yl)pentanamido)ethyl)nicotinamide. This drug has a favorable therapeutic effect on Alzheimer's disease, not only expanding the drug options for treating Alzheimer's disease but also further broadening the application range of N-(2-(5-(1,2-dithiolane-3-yl)pentanamido)ethyl)nicotinamide.

The present application relates to a kind of polyether ether ketone aerogel fiber and its preparation method, belong to aerogel fiber technical field.The preparation method of polyether ether ketone aerogel fiber of the present application, first by crystalline polyether ether ketone material preparation obtainable soluble polyether ether ketone-1, 3-dithiolane, then soluble polyether ether ketone-1, 3-dithiolane and polyvinylpyrrolidone are dissolved in polar solvent stirring to obtain spinning solution, after vacuum defoaming, extruding to coagulation bath, finally by solvent replacement, vacuum freeze drying, obtain polyether ether ketone aerogel fiber.The preparation method process is simple, subsequent process is continuous, and it is expected to realize large-scale production;Preparation obtained aerogel fiber has typical three-dimensional network structure, lower linear density, higher strength and good toughness, and has good spinnability, its porous structure provides the possibility for subsequent filling or adsorbing phase change material and then applied in textile, special clothing and other thermal insulation field.

The invention discloses a lipoic acid eutectic adhesive which is prepared by the following steps: preparing small molecules of a lipoic acid hydroxyl derivative; the invention further discloses a preparation method of the lipoic acid eutectic adhesive. The preparation method is used for preparing the lipoic acid eutectic adhesive. According to the eutectic adhesive disclosed by the invention, the derivative small molecules and the lipoic acid are mixed according to a certain proportion, and a eutectic system is constructed under a solvent-free condition, so that the eutectic adhesive is in a molten state at room temperature, and meanwhile, the use of an organic solvent is also avoided, and the safety of a product is greatly improved; the eutecticevaporate adhesive provided by the invention has very remarkable responsiveness to ultraviolet light; the dithiolane ring-opening polymerization reaction can be effectively triggered through short irradiation of ultraviolet light so as to cure the adhesive, high and reliable adhesive strength and eutectic adhesive are achieved, the production process is simple, timely and effective, the service life is long, and the dithiolane ring-opening polymerization adhesive has a good application prospect in the fields of biological adhesives and industrial adhesives.

The application provides a 1,2-dithiolane-based dynamic covalent hemostatic hydrogel and a preparation method and application thereof, the dynamic covalent hemostatic hydrogel is composed of a cross-linked dynamic polymer network, the cross-linked dynamic polymer network is prepared through ring-opening polymerization of a mixture containing the following components: a polyethylene glycol modified thioctic acid derivative TA-PEG, a tris(hydroxymethyl)aminomethane modified thioctic acid derivative TA-Tris, and a thioctic acid derivative TOS modified with a sulfonic acid group and a quaternary ammonium cation. The application provides a multifunctional dressing capable of considering the ultra-high swelling liquid absorption capacity, the strong wet surface interfacial adhesion, the structural mechanical stability and the persistent broad-spectrum antibacterial performance in a complex, dynamic and large amount of exudate accompanied wound surface environment.

This invention provides a highly thermally and electrically conductive polyetheretherketone (PEEK)-based composite material based on reversible conversion and its preparation method. The invention provides a reversible chemical conversion method based on polyetheretherketone (PEEK) and soluble polyetheretherketone-1,3-dithiolane (PEEK-dithiolane). This method converts the semi-crystalline polymer PEEK, which is insoluble in most solvents, into a soluble dithiolane derivative. Through reversible modification, the semi-crystalline PEEK is transformed into an amorphous material with greater solubility and processability. Further, catalytic ketalization converts the soluble PEEK-dithiolane back into PEEK. This invention utilizes the reversible chemical conversion reaction between the poorly soluble semi-crystalline PEEK and the soluble PEEK-1,3-dithiolane, enabling solution processing of the PEEK composite material. This results in better dispersibility of the filler in the matrix, overcoming the technical barriers of traditional melt processing of PEEK-based composite materials and achieving superior electrical and thermal conductivity.

The invention provides a self-adaptive antibacterial biological adhesive based on 1, 2-dithiolane as well as a preparation method and application of the self-adaptive antibacterial biological adhesive based on 1, 2-dithiolane, and the molecular structure of the self-adaptive antibacterial biological adhesive based on 1, 2-dithiolane contains 1, 2-dithiolane. The self-adaptive antibacterial biological adhesive containing the molecular structure of 1, 2-dithiolane solves the problems that an existing adhesive for wound protection is insufficient in antibacterial performance, poor in adhesion, unmatched in mechanical performance, poor in biocompatibility, non-degradable, non-recyclable and the like in a complex wound environment.

The application discloses a kind of high-strength concrete materials and preparation method thereof, it is related to concrete technical field.The high-strength concrete material prepared by the application, include Portland cement, coarse aggregate, fine aggregate, pure water, water reducing agent, modified polyacrylate emulsion, modified floating bead;The modified polyacrylate emulsion is obtained by the reaction of polyacrylate and 4-(dithiolane-3-yl) but-2-ketone;The modified floating bead is obtained by the reaction of floating bead containing octanoic acid after aminization by silane coupling agent and cage monomer;The cage monomer is obtained by the reaction of 2,4,6-tris(benzimidazole) trimethylbenzene and 2,4,6-tribromomethyl trimethylbenzene, and then by bromination reaction.The high-strength concrete material prepared by the application has high strength, anti-aging performance and antibacterial performance.

The application discloses an epoxy polymer containing dynamic reversible polysulfide bond and a preparation method and application thereof, and relates to the technical field of polymer materials. The preparation method comprises the following steps: mixing 1,2-dithiolane glycol and elemental sulfur, and heating to react to obtain a linear polysulfide prepolymer; adding an alkaline catalyst and an epoxy monomer into the linear polysulfide prepolymer, and continuing to heat to react to obtain the epoxy polymer containing dynamic reversible polysulfide bond. The epoxy polymer containing dynamic reversible polysulfide bond prepared by the application contains both hydroxyl groups and ether bonds, two kinds of polar groups, can form hydrogen bonds with polar groups on the surface of a plate, and can provide strong bonding force; and the dynamic reversible polysulfide bond contained in the epoxy polymer endows the material with excellent reworkability and reusability, so that the epoxy polymer has good recyclability and wide application prospect. The preparation method of the application does not need to use organic solvents, has mild conditions, and is simple to operate.

The present invention relates to cross-linkable elastomer compositions comprising modified cellulose, a process for the preparation of the corresponding elastomer compound, tyre components comprising said elastomer compound and tyres comprising said tyre components. In particular, the present invention relates to the use of cellulose functionalized by lipase catalysed esterification with 1,2-dithiolane derivative acids, in particular lipoic acid and derivatives thereof, as reinforcing filler in cross-linkable elastomer compositions, in particular for tyre applications.

The application discloses a silicon-based negative electrode binder and a preparation method thereof, a negative electrode slurry, a negative electrode sheet and a secondary battery, and belongs to the technical field of lithium ion batteries. The silicon-based negative electrode binder is 5-(1,2-dithiolane-3-yl) phenyl valerate, which is obtained by esterification reaction of thioctic acid and phenol in the presence of a catalyst. The silicon-based negative electrode binder provided by the application exists in the form of a small molecule in the slurry, is not prone to molecular chain rupture in the high-speed dispersion process, is beneficial to uniform dispersion of active materials and conductive agents, and can construct a dynamic cross-linking network in situ during electrode preparation and circulation, effectively buffers the volume expansion and shrinkage stress of silicon materials by using the self-healing characteristics, and significantly improves the structural stability and cycle life of the electrode.

The application relates to the technical field of organic chemistry, in particular to a novel high-sulfur-content photopolymerizable high-refraction monomer and a preparation method thereof. The high-refraction structure has not been reported in the prior art. Dithiolane is used as a connecting unit, combined with a series of structural units with high molar refraction and photocurable groups, so that the material refraction is improved, the monomer is in a liquid state, the monomer is easy to dissolve, the solid content is full, and pollution is avoided during the polymerization process; the structure contains a rigid large conjugated aromatic ring and dithiolane methyl mercaptan with high sulfur content, so that the material dispersion is reduced, and certain physical properties are endowed.

The invention relates to a modified carbon nanotube material and a preparation method and application thereof, and belongs to the technical field of conductive materials. The modified carbon nanotube material comprises a quaternary ammonium salt group and a dithiolane group, and the molar ratio of the dithiolane group to the quaternary ammonium salt group is 1: 1. The quaternary ammonium salt group in the modified carbon nanotube can conveniently inhibit the shuttle effect of polysulfide in the lithium-sulfur battery, and the dithiolane group can promote the rapid conversion between soluble polysulfide and insoluble lithium sulfide, so that the loss of an active material in the battery prepared by using the modified carbon nanotube disclosed by the invention is reduced, and the service life of the battery is prolonged. And the capacity and the cyclicity of the battery are improved.

The invention discloses a high-strength concrete material and a preparation method thereof, and relates to the technical field of concrete. The prepared high-strength concrete material is prepared from Portland cement, coarse aggregate, fine aggregate, pure water, a water reducing agent, modified polyacrylate emulsion and modified floating beads. The modified polyacrylate emulsion is obtained by carrying out a reaction on polyacrylate and 4-(dithiolane-3-yl) butyl-2-ketone, and the modified polyacrylate emulsion is obtained by carrying out a reaction on the polyacrylate and the 4-(dithiolane-3-yl) butyl-2-ketone; the modified floating beads are obtained by aminating caprylic acid-containing floating beads with a silane coupling agent and then reacting with a cage-shaped monomer; the preparation method comprises the following steps: reacting 2, 4, 6-tri (benzimidazole)-based trimethyl benzene with 2, 4, 6-tribromomethyl trimethyl benzene, and then carrying out bromination reaction to obtain the cage-shaped monomer. The prepared high-strength concrete material has high strength, anti-aging performance and antibacterial performance.