9results about How to "Increase fat solubility" patented technology

The invention relates to an N-terminal acetylation and C-terminal ethylamine dual-modified LMN-NKA polypeptide derivative or a pharmaceutically acceptable salt and a preparation method thereof. The chemical name of the LMN-NKA polypeptide derivative is N-acetyl-L-aspartic acid-L-lysine-L-phenylalanine-L-valine-glycine-N-methyl-L-leucine-L-n-leucine-ethylamine, and the structural general formula of the LMN-NKA polypeptide derivative is Ac-Asp-Lys-Phe-Val-Gly-NMe-Leu-Nle-NHCH2 CH3, and the structural general formula of the LMN-NKA polypeptide derivative is shown in the description. According to the dual-modification strategy, the binding activity of the NK2 receptor can be specifically reserved, the enzymolysis stability is high, the transmembrane efficiency is high, the lipid solubility is high, and the physicochemical property is stable. The LMN-NKA polypeptide derivative or the pharmaceutically acceptable salt thereof disclosed by the invention is particularly suitable for preparing a medicine for treating diseases related to an NK2 receptor.

The invention relates to the field of fluorescent dyes, in particular to a near-infrared fluorescent dye for brain imaging as well as a preparation method and application of the near-infrared fluorescent dye. The near-infrared fluorescent dye for brain imaging has the advantages of novel structure, good biocompatibility, large Stokes shift, high light stability, high fluorescence signal-to-noise ratio and the like; the near-infrared fluorescent dye prepared by the invention is simple in preparation process, mild in reaction condition, short in synthesis path and beneficial to industrial production, and has a wide application prospect.

This application relates to the field of polymer materials technology, specifically disclosing a high-efficiency, long-lasting antibacterial polyester composite material and its preparation method; the high-efficiency, long-lasting antibacterial polyester composite material comprises the following raw materials in parts by weight: 80-95 parts of polyester melt, 0.5-5 parts of composite antibacterial agent, 0.1-1 parts of dispersant, and 0.5-3 parts of interface compatibilizer; the composite antibacterial agent is a complex of nano-zinc dioxide and organic quaternary ammonium salt, wherein the organic quaternary ammonium salt is a double long-chain quaternary ammonium salt; the use of double long-chain quaternary ammonium salt in this application can compensate for the slow onset of action of nano-zinc dioxide, and nano-zinc dioxide can slowly release zinc ions to achieve a long-lasting protective effect. The combination of the two promotes the preparation of polyester material to achieve both good immediate contact sterilization and long-lasting protection.

This application relates to the field of biomedicine, specifically to the use of small molecule compounds in the preparation of drugs for the treatment and / or prevention of α-synuclein diseases, wherein the small molecule compounds are selected from at least one of AO-365 / 43264238 and AG-670 / 40728295. The small molecule compounds provided in this invention can precisely target and interfere with α-syn-VAPB interactions, improving neuronal damage caused by abnormal aggregation of α-synuclein, thereby safely and effectively treating and / or preventing α-synuclein diseases, particularly Parkinson's disease.

The present application relates to a kind of high-stable pyrylium alcohol derivatives with light protection, whitening activity and its preparation method and application.The present application is based on the molecular structure of pyrylium alcohol and is connected with different cinnamic acid side chain, obtains a series of cinnamic acid side chain modified pyrylium alcohol derivatives.The pyrylium alcohol derivatives of the present application can effectively improve the chemical stability of pyrylium alcohol, effectively solve the discoloration and inactivation problem of pyrylium alcohol in cosmetic formula.The pyrylium alcohol derivatives of the present application have excellent chemical stability, have the ability of rapid oxidation resistance, and can realize precise synergistic effect at cell level, the activity of inhibiting melanin, antioxidant and light protection in organism is significantly better than pyrylium alcohol.The pyrylium alcohol derivatives of the present application have higher fat solubility and lower effective concentration, can be used for preparing whitening, antioxidant, light protection and other cosmetics, and have important market value.

The application provides a viscosity-responsive luminescent probe, a preparation method and application. The luminescent probe has an ultra-sensitive viscosity response performance, and the viscosity response range thereof covers the viscosity change range of edible oil. After the luminescent probe is added into the edible oil, the fluorescence intensity has a high correlation with the content of the polar component in the edible oil. The change of the polar component of the edible oil is obtained by using the response of the luminescent probe to the viscosity change of the edible oil, so that the rapid and sensitive detection of the polarity of the frying oil is realized.

The application provides a fluorescence probe targeting endoplasmic reticulum and a preparation method and application thereof, and the fluorescence probe is an azido phosphorus corrole complex. F The complex has good solubility and fat solubility (LogP=1.08), a relatively high fluorescence quantum yield (Phi 2 Red light illumination for 1h, and basically no photobleaching phenomenon is observed), in addition, the complex can quickly penetrate the cell membrane and be taken up by cells (uptake time is within 30min), and is highly specific to the endoplasmic reticulum in cells (Pierce coefficient is as high as 0.92), and the labeling condition is simple and mild, and residues are easy to remove, and is a very potential endoplasmic reticulum fluorescence probe.

This invention provides a high-satiety chicken small molecule peptide and its application in chicken meal replacement powder. First, a gastric self-expanding microsphere is prepared, with yeast β-glucan and hydroxypropyl methylcellulose as the wall material and modified chicken small molecule peptide as the core material. The microsphere absorbs water and expands in the acidic environment of the stomach, generating a feeling of fullness. In the intestinal environment, it slowly releases the modified chicken small molecule peptide, promoting absorption and regulating intestinal health. Furthermore, solid-state fermentation of mixed grain powder using Aspergillus oryzae is used to prepare the chicken meal replacement powder. The addition of the gastric self-expanding microsphere and fermented mixed grain powder further enhances satiety, meeting the market demand for healthy meal replacement foods.

The application discloses a preparation method of a plant polyphenol chelate type decontamination agent, which comprises the following steps: adding tannin, anhydrous aluminum chloride and oleoyl chloride into a reactor, sufficiently stirring the mixture under a nitrogen atmosphere and at room temperature, grafting a hydrophobic carbon chain on the tannin through a Friedel-Crafts reaction, adding a NaOH solution into the reactor, sufficiently stirring and uniformly mixing, standing and separating, reserving the water solution part, and then freezing and drying the water solution to obtain the plant polyphenol chelate type decontamination agent. The hydrophobic carbon chain is grafted on the aromatic ring system in the tannin structure based on the Friedel-Crafts reaction, the plant polyphenol chelate type decontamination agent can be endowed with amphipathic properties in the case of maximizing the metal chelating capacity, the hydroxyl groups in the tannin molecules are protected, the liposolubility of the tannin is increased, and the biological activity is retained, and the obtained plant polyphenol chelate type decontamination agent has the characteristics of green environmental protection, high safety, easy biodegradation, environmental friendliness and the like.