185 results about "Cycloaddition" patented technology

The invention discloses a preparation method and application of a catalyst based on pyridine ionic liquid, and belongs to the technical field of catalyst preparation. According to the invention, a hydrolysis reaction of a silane coupling agent is utilized to prepare a silicon oxide nanotube containing a pyridine unit, and then a quaternization reaction is carried out to obtain the catalyst based on the pyridine ionic liquid. The catalyst has a high specific surface area and a rich pore channel structure, exposure of active sites and contact of the active sites and reactants are facilitated, and the catalytic rate is increased. Meanwhile, the silicon oxide nanotube contains hydroxyl, and can cooperate with a pyridine ionic liquid site to catalyze a carbon dioxide cycloaddition reaction. The obtained catalyst can catalyze the reaction of carbon dioxide and an epoxy compound to prepare cyclic carbonate under solvent-free and metal-free conditions, and the catalyst is easy to recover and simple in product purification, and has a good application prospect.

The invention relates to the technical field of organic synthesis, in particular to a method for synthesizing cyclopentane compounds through [3 + 2] cycloaddition reaction of aryl cyclopropane and olefin under the synergistic catalysis of bromide ions / visible light. The method comprises the following steps: in a nitrogen atmosphere, sequentially adding aryl cyclopropane, a benzyl malononitrile derivative, pyridine tribromide and a photocatalyst into a reaction solvent to obtain a mixture, stirring the mixture at the temperature of 40 DEG C under the irradiation of a 12W blue light LED lamp until the reaction is complete, and performing concentration and column chromatography purification to obtain the cyclopentane compound. The method has the advantages of mild reaction conditions, simple operation, simple and easily available raw materials and low cost.

The application relates to the technical field of catalysts, and discloses a limited type iodine-based homogeneous immobilized catalyst as well as a preparation method and application thereof. The catalyst comprises a carrier and iodine ions, magnesium ions and quaternary ammonium ions loaded on the carrier, wherein the molar ratio of the magnesium ions, the quaternary ammonium ions, the iodine ions and the carrier is 0.01-1:4-15:1-30:1. The limited type iodine-based homogeneous immobilized catalyst disclosed by the application enhances the electrostatic interaction between iodine ions and quaternary ammonium ions through the molecular sieve limiting effect to construct a limited type structure. The catalyst has significantly enhanced CO2 adsorption and activation capacity, can activate an epoxide compound, and accelerates the ring opening of the epoxide compound. In a cycloaddition reaction catalyzed by the catalyst under the conditions of no solvent and no auxiliary agent, the conversion rate of propylene oxide can reach more than 73%, and the propylene carbonate selectivity can reach more than 85%.

The invention belongs to the technical field of catalytic synthesis, particularly relates to a method for preparing a nitrogen-containing fused ring compound through quantum dot catalyzed [4 + 2] cycloaddition, and aims to solve the problems of limited product structure and complex reaction system in the existing synthesis method. The synthesis method disclosed by the invention comprises the following steps: in an inert atmosphere, adding 1-phenylpyrrole and fumarate as reaction raw materials, quantum dots as a photocatalyst and an organic solvent into a reaction container, carrying out [4 + 2] cycloaddition reaction under visible light irradiation, and then filtering, concentrating, separating and purifying to obtain the nitrogen-containing fused ring compound. The reaction condition is mild, and the method can be realized by irradiating the quantum dot catalyst with a visible light source at normal temperature and pressure; a reaction system is simple, strong oxidants and additives are not needed, operation steps are convenient, and atom economy is achieved.

The invention concerns homogenous antibody-conjugates with high payload loading (high DAR) obtained by site-specific conjugation to a single antibody N-glycan. The conjugates according to the invention are homogeneous, i.e. have a DAR at or close to the theoretical DAR with a narrow distribution, and do not require any genetic modification of the antibody. The invention further concerns a modular, non-genetic preparation method for such conjugates, involving three simple steps and starting from any antibody. These steps are (a) enzymatic remodeling of the glycan to give an antibody functionalized with two or four click probes per antibody, (b) strain-promoted cycloaddition with a multivalent, bifunctional reagent comprising one cyclic alkyne and at least two click probes that are not reactive towards the cyclic alkyne, and (c) inverse electron-demand Diels-Alder cycloaddition of the click probes with branched linker-drug constructs comprising one cyclic alkyne or strained alkene, connected to one or more payloads preferably connected through a cleavable linker. The resulting conjugates, with DAR6 or higher, are rapidly generated with high homogeneity and with surprising stability. In addition, HIC profiles of the resulting ADCs indicate small relative retention time and therefore show high potential in the targeting of tumour cells and / or the treatment of cancer.

The application discloses a low-viscosity nitrogen-modified flame-retardant and smoke-suppressing silicone oil and a preparation method thereof, relates to the technical field of modified silicone oil, and the flame-retardant and smoke-suppressing silicone oil is obtained by ring-opening addition reaction of double-end epoxy silicone oil and methyl urea. The nitrogen-containing group is introduced into the polysiloxane molecule in a reactive form by adopting the chemical modification of methyl urea on the end epoxy silicone oil, so that the flame-retardant and smoke-suppressing performance and the thermal stability of the silicone oil are improved without significantly sacrificing the material fluidity. The obtained low-viscosity nitrogen-modified flame-retardant and smoke-suppressing silicone oil still maintains a good flow state at normal temperature, and is convenient to use in the modification of high polymer materials, the blending of composite systems and subsequent processing applications.

The present invention relates to novel compounds of formula (I), optionally conjugated to peptide or protein molecules, and the synthesis thereof. The invention also relates to the use of the novel compounds for coupling reactions with linkers and other molecules. The invention also relates to the use of the novel compounds in bio-orthogonal strain promoted cycloaddition (copper-free), i.e. Click reaction. (I).

The invention discloses a chiral 1, 4-diazabicyclo [3.1. 1] heptane derivative as well as a synthesis method and application of the chiral 1, 4-diazabicyclo [3.1. 1] heptane derivative. According to the invention, a 1-azabicyclo [1.1. 0] butane derivative is taken as a raw material, under the catalytic action of a chiral iridium complex, the 1-azabicyclo [1.1. 1] butane derivative and an N-allyl carbonate derivative are subjected to [3 + 2] cycloaddition reaction, a series of chiral 1, 4-diazabicyclo [3.1. 1] heptane skeletons with diversified structures are constructed with high stereoselectivity, and the obtained product has the potential of further derivatization. The method has the advantages of easily available raw materials, mild reaction conditions, simplicity and convenience in operation, good functional group compatibility and the like.

The present invention provides an antibody-payload conjugate having a payload antibody ratio of 1. The antibody-payload conjugate has the structure (1): Formula (1) (wherein a, b, and c are each independently 0 or 1; L 1 , L 2 and L 3 is a linker; D is a payload; BM is a branching moiety; and Z is a connecting group obtainable by a cycloaddition reaction. The present invention further provides methods for preparing antibody-payload conjugates according to the invention, intermediate compounds in the preparation methods, and medical uses of antibody-payload conjugates according to the invention.

This invention relates to the field of organic synthetic chemistry, specifically to a polysubstituted furan compound and its synthetic method, wherein the method comprises... β Using ketone sulfones and olefins as starting materials, polysubstituted furans are synthesized via a [3+2] cycloaddition reaction in the presence of a copper catalyst and an oxidant. This invention employs cuprous bromide as the catalyst and di-tert-butyl peroxide (DTBP) as the oxidant, reacting in dimethyl sulfoxide solvent at 100°C–130°C for 6–24 h. This method offers advantages such as high atom and step economy, broad substrate applicability, good functional group tolerance, excellent position selectivity, and high yield, with a maximum yield reaching 84%. It is suitable for large-scale synthesis and provides a new strategy for the synthesis of furans in medicinal chemistry and materials science.

The application belongs to the technical field of photocatalytic CO2 cycloaddition reaction, and particularly relates to a preparation method of a vacancy defect layered bismuth semiconductor material and application of the vacancy defect layered bismuth semiconductor material in photocatalytic CO2 cycloaddition reaction. The material is based on a bismuth semiconductor material with a Sillen-Aurivillius structure, and a defect site is constructed by vacancy regulation of the material. Low-valence metal ions exposed by the vacancy defect can be used as Lewis acid sites to adsorb and activate epoxides, and the defect site can promote separation of photo-generated carriers, thereby enhancing surface reaction kinetics and effectively improving photocatalytic activity of the material, and finally promoting photocatalytic CO2 cycloaddition reaction performance.

The application provides a one-dimensional high-entropy alloy, a preparation method and application of the one-dimensional high-entropy alloy in CO2 ring addition reaction, and relates to the technical field of high-entropy alloys.The molar ratio of iron salt, cobalt salt, nickel salt, manganese salt, chromium salt and cerium salt in the one-dimensional high-entropy alloy is 1:1:1:1:1:1;the high-entropy alloy has a fiber structure, the fiber has a hierarchical pore structure which is interconnected, including macropores or mesopores formed by decomposition of the self-sacrificing template 1, and mesopores or micropores formed by decomposition of the self-sacrificing template 2.Through improvement of the process conditions, the one-dimensional high-entropy alloy material with a unique structure can be prepared under relatively mild conditions, so that the whole reaction process is safer and more economical, and meets the goal of green chemistry and sustainable development.Meanwhile, the one-dimensional high-entropy alloy material prepared provides a large specific surface area, fully exposes active sites, and can realize efficient and stable conversion of the carbon dioxide ring addition reaction.

This invention relates to the field of chemical synthesis technology, specifically disclosing a method for preparing vinyl ethylene carbonate. The method uses glycidyl as a starting material, first converting it to glycidaldehyde via a mild oxidation reaction with high selectivity. Then, using a cross-linked imidazole polymeric ionic liquid as a catalyst, glycidaldehyde undergoes an atom-economical cycloaddition reaction with carbon dioxide to construct a cyclic carbonate intermediate. Finally, under catalytic conditions, a condensation reaction introduces a vinyl functional group to obtain the vinyl ethylene carbonate product. This invention uses widely available, low-toxicity, and inexpensive glycidyl instead of highly toxic raw materials, and utilizes greenhouse gas carbon dioxide as a carbonyl source for resource utilization. The process route is highly atom-economical, the reaction conditions are mild, and the catalyst is easy to separate, recover, and recycle, effectively solving the prominent problems of high raw material toxicity, expensive catalysts, and difficult byproduct treatment in traditional preparation techniques.

This invention belongs to the field of organic synthesis technology and relates to a precursor of an obisec key intermediate and a method for preparing the key intermediate. The method involves a [4+2] cycloaddition reaction of 4-trifluoromethylaniline, propionaldehyde, and N-vinylformamide under the catalysis of chiral phosphoric acid, yielding the obisec key intermediate precursor with high enantioselectivity. N -((2) R 4 S )-2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinoline-4-yl)formamide; subsequently, the key intermediate of obisetri can be obtained through a deprotection reaction under acidic conditions. The method provided by this invention uses a small amount of chiral catalyst and commercially available reagents to efficiently obtain the key intermediate of obisetri in just two steps. R 4 S )-2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinoline-4-amine; under mild conditions without the need for chiral resolution, the utilization of starting materials is greatly improved, thereby significantly increasing the yield of the target product and the economic efficiency of the process.

The invention provides a preparation method and application of macrocyclic multi-amino porous organic aerogel, and belongs to the field of catalysts. The preparation method comprises the following steps: reacting tetraazacyclododecane with chloromethyl styrene to obtain an intermediate; and carrying out sol-gel polymerization on the intermediate, and drying to obtain the macrocyclic multi-amino porous organic aerogel. As a thermal insulation material and a heterogeneous catalyst, the macrocyclic multi-amino porous organic aerogel can be applied to thermal insulation and cycloaddition reaction of a halogenated epoxy substrate and carbon dioxide, and has the characteristics of high conversion rate and high selectivity.

The application discloses an ionic liquid polymer catalyst and a preparation method and application thereof, and relates to the field of ionic liquid polymer catalysts. The catalyst is obtained through polymerization reaction of a vinyl functionalized triphenylphosphine ligand, a vinyl functionalized triphenylphosphine ionic liquid and a metal source; wherein the vinyl functionalized triphenylphosphine ionic liquid is obtained from the vinyl functionalized triphenylphosphine ligand. The ionic liquid polymer catalyst has more excellent catalytic performance and better substrate universality, the preparation method is simple, flue gas can be directly used as a CO2 source, and the CO2 does not need to be purified, so that energy is effectively saved and the environment is protected; meanwhile, the cycloaddition reaction condition is mild, green and pollution-free; the yield of the product cyclic carbonate is as high as 99%, and the ionic liquid polymer catalyst shows good prospects for solving the problems of reactivity, good universality, difficulty in recycling of the catalyst, serious loss of active metals and ligands and other problems in a multiphase cycloaddition reaction.

The application discloses a preparation method of a catalyst based on a pyridine ionic liquid and application thereof, and belongs to the technical field of catalyst preparation. The catalyst based on the pyridine ionic liquid is prepared by utilizing the hydrolysis reaction of a silane coupling agent to obtain silica nanotubes containing a pyridine unit, and then through a quaternary ammonium reaction. The catalyst has a high specific surface area and a rich pore structure, is favorable for exposure of active sites and contact of the active sites with reactants, and improves a catalytic rate. Meanwhile, the silica nanotubes contain hydroxyl groups, can synergistically catalyze a carbon dioxide cycloaddition reaction with pyridine ionic liquid sites, and can catalyze a reaction of carbon dioxide and an epoxide compound to prepare a cyclic carbonate under a solvent-free and metal-free condition. The catalyst is easy to recycle, product purification is simple, and the catalyst has a good application prospect.

This invention provides a zinc-nickel single-atom alloy catalyst, its preparation method, and its applications. The invention relates to the field of catalyst synthesis technology. This zinc-nickel single-atom alloy catalyst has a carbon-coated structure with a porous surface. Zinc is dispersed in single-atom form on the surface of nickel particles, forming a single-atom alloy structure, and simultaneously possessing both Lewis acidic and Lewis basic sites. Through innovative material design and preparation methods, this invention successfully synthesizes a novel zinc-nickel single-atom alloy catalyst with superior performance. This catalyst cleverly combines efficient photothermal conversion, the electronic regulation characteristics of single-atom alloys, and the structural advantages of a porous carbon support. It achieves highly efficient and selective conversion of CO2 cycloaddition reactions under mild conditions, while exhibiting significant advantages in energy consumption, cost, and stability, showing promising prospects for industrial applications.

The invention relates to the technical field of information communication particularly suitable for specific application fields, and discloses a machine learning-based ionic liquid screening method for catalyzing CO2 cycloaddition reaction. The method comprises the following steps: constructing an ionic liquid three-dimensional structure database; calculating and generating a three-dimensional electrostatic potential and electron density data field through a density functional theory; voxelizing the data field into a standardized multi-channel three-dimensional tensor; utilizing a three-dimensional convolutional neural network regression model to automatically learn space electron characteristics and predict catalytic activity; and performing high-throughput virtual screening on the candidate library. Through end-to-end learning of the mapping relation between the three-dimensional electronic structure and the catalytic activity of the ionic liquid, the prediction accuracy and the screening efficiency are improved.

The application discloses a kind of high-efficiency heterogeneous catalyst for CO2 ring addition preparation cyclic carbonate and its preparation method and application, belong to catalyst technical field.The high-efficiency heterogeneous catalyst is transition metal doped polyoxometalate coordination polymer, chemical general formula is C 16 H 58 M2N2Na2O 48 V 10 Wherein, M is selected from Co 2+ , Ni 2+ , Cu 2+ Or Zn 2+ Its preparation method is: sodium vanadate, transition metal acetate and bis (2-hydroxyethyl) amino (trihydroxymethyl) methane ligand are dissolved in water with pH being 1~3, stirring reaction, after filtration, crystallization is stationary, and is obtained.In the ring addition reaction of CO2 and epoxide, the catalyst and cocatalyst tetrabutylammonium bromide synergistic effect, catalytic yield can be up to 98.2%, selectivity is more than 99%, and catalytic activity still remains at 88% after recycling five times.

The invention discloses a synthesis method of a polysubstituted cyclopropyl carbonyl derivative, and belongs to the technical field of organic synthesis and the technical field of medicine synthesis. The method comprises the following steps: (1) taking substituted olefin as a raw material, and obtaining alpha-chlorocyclobutanone through [2 + 2] cycloaddition and reduction reaction; and (2) carrying out rearrangement reaction on the alpha-chlorocyclobutanone and different types of Grignard reagents or organic lithium reagents to obtain the polysubstituted cyclopropyl carbonyl derivative. The synthesis method provided by the invention has the advantages of wide substrate range, good functional group compatibility, mild reaction conditions, no need of preparation of active intermediates or use of expensive transition metal catalysts, simple operation, capability of obtaining various types of cyclopropyl carbonyl compounds, and the like. The practicability of the method is further shown through later-stage functional group modification of complex bioactive molecules and abundant derivatization of polysubstituted cyclopropyl carbonyl products of the complex bioactive molecules.

The invention discloses a pyrazolo [5, 1-a] isoindole derivative as well as a synthesis method and application thereof, and belongs to the technical field of organic chemical synthesis. The invention solves the problems of harsh reaction conditions, limited substrate range and the like of continuous multi-step synthesis of a precursor in the existing pyrazolo [5, 1-a] isoindole compound synthesis process. According to the invention, a polarity reversal strategy is adopted, a cyano group is introduced into 1, 5-enyne to change the electronic characteristics of 1, 5-enyne, diazo, olefin and ethynyl benzene are reacted under mild conditions, two rings and three new chemical bonds are constructed through a series of intermolecular [3 + 2] cycloaddition, intramolecular cycloaddition and elimination reactions, and pyrazolo [5, 5-a]-1, 5-a-phenanthrene is efficiently synthesized. According to the present invention, the 1, 1-a] isoindole derivative has characteristics of good synthesis yield, simple operation of the synthesis method, easily available raw materials, good substrate universality and step economy, and provides the effective strategy for the drug design synthesis.

The invention discloses a phosphabicyclo [3, 2, 0] organic phosphorus compound as well as a preparation method and application thereof. Diallyl-containing tertiary phosphine oxide and phosphine sulfur compounds are used as raw materials, 10-phenyl phenothiazine is used as a photocatalyst, the photocatalyst is excited under a light source of 390 nm to activate double bonds, high-stereoselectivity [2 + 2] cycloaddition reaction is realized, the phosphorus heterocyclic bicyclo [3, 2, 0] organophosphorus compound containing two quaternary carbon centers is synthesized, diastereoisomers can be separated, and the yield is high. A single diastereoisomer product is as high as 97%, and excellent diastereoselectivity is achieved. The invention provides a green reaction mode for photocatalytic synthesis of the phosphabicyclo [3, 2, 0] organophosphorus compound, the conditions are mild, and the substrate universality is good. The obtained phosphabicyclo [3, 2, 0] organophosphorus compound is applied to a primary alcohol chlorination reaction as a catalyst, shows high reaction activity, and has more excellent catalytic activity compared with a reported catalytic system.

The invention provides a polymer compatilizer and application thereof, and relates to the technical field of organic materials. Specifically, a molecular chain of the polymer compatilizer comprises a polyolefin chain segment, a reversible covalent bond group and an active functional group which are connected in sequence; wherein the reversible covalent bond group comprises at least one of a cycloaddition reaction system, a disulfide bond system, a borate bond system, an acylhydrazone bond system, an oxime bond system, a trithiocarbonate bond system and a tetrazole-olefin light click chemical system. According to the compatilizer structure, a dynamic covalent cross-linked network can be constructed at the interface of the composite material, and the interface is endowed with an intelligent response characteristic through fracture and recombination of reversible covalent bonds, so that the interface bonding strength of the composite material is far higher than that of a traditional system; the technical problems that in the material service process in a traditional system, due to permanent covalent bonding, an interface is prone to being damaged and cannot be reversibly repaired are effectively solved.

The invention relates to a preparation method of a dimer-mediated organic polymer single crystal, and belongs to the technical field of organic polymer single crystals. The preparation method comprises the following steps: S1, carrying out coordination self-assembly on a metal salt, an alkenyl pyridine ligand and an auxiliary ligand in a solvent, and washing and drying to obtain a coordination polymer single crystal reaction template; s2, under irradiation of ultraviolet light or visible light, the coordination polymer single-crystal reaction template is subjected to a [2 + 2] light ring addition reaction, and a coordination polymer containing a cyclobutane dimer is obtained; s3, under the action of alkali liquor or acid liquor, dissociating the coordination polymer containing the cyclobutane dimer, extracting, concentrating and recrystallizing to obtain dimer single crystals; s4, under the irradiation of ultraviolet light or visible light, carrying out topological chemical polymerization reaction on the dimer single crystal to obtain an organic polymer single crystal; accurate and controllable preparation from the alkenyl pyridine ligand to the high-quality polymer single crystal with the self-supporting long-range ordered structure is successfully realized.

This invention provides an oligopeptide cyclic peptide and its applications. The cyclic peptide is obtained by truncating the linear Hst1 sequence to the shortest possible sequence that retains Hst1 activity. Then, a triazole ring-containing oligopeptide is prepared by a cycloaddition reaction under specific conditions targeting this shortest sequence. Its molecular weight is only 1 / 3 that of linear histamine, and its biological activity is 15 times that of linear histamine. To achieve the same activity, the cost of the oligopeptide cyclic peptide is only 1 / 100 that of linear histamine, and the yield is significantly higher than that of cyclic peptides directly cyclized with amide bonds. It also exhibits significantly improved stability and resistance to biodegradation. The entire cyclization process of this oligopeptide cyclic peptide is mild, simple, and efficient, and can produce high-purity oligopeptide cyclic peptides. It can be used to prepare anti-aging and repairing skincare products, health products, or pharmaceuticals, and has excellent prospects for large-scale industrialization.

The application provides a method and a kit for detecting Staphylococcus aureus. The method embeds multivalent binding probes on microspheres through strain-promoted azide-alkyne cycloaddition reaction, thereby forming microspheres loaded with multivalent binding probes. The microspheres loaded with multivalent binding probes are aggregated in a large size through multivalent binding between the probes and the genome of Staphylococcus aureus, so as to qualitatively and quantitatively identify Staphylococcus aureus through fluorescence. The method not only shortens the detection period and reduces the cost, but also has the advantages of high sensitivity and high specificity.

The invention belongs to the technical field of biological medicines, and particularly relates to a synthetic method and application of a cyclobutane and chroman skeleton molecular compound, which is a method for synthesizing a cyclobutane and chroman skeleton molecular compound through a triplet-triplet energy transfer mechanism by using a blue light excitation photocatalyst under a mild condition. The invention discloses a method for constructing a cyclobutane and chroman skeleton molecular compound by efficiently, highly regionally and stereoselectively catalyzing intramolecular [2 + 2] cycloaddition of a 2H-chromene compound, and further explores the application potential of the cyclobutane and chroman skeleton molecular compound in research and development of anti-glioma drugs. The obtained compound can specifically and effectively kill glioma stem cells, and a new lead compound and thought are provided for research and development of anti-glioma drugs.

The invention discloses a photocatalysis method for [2 + 2] cycloaddition reaction of indole and imine, and belongs to the field of organic synthesis. The problem that the reaction condition of the [2 + 2] cycloaddition reaction of the existing indole compounds is harsh is solved. The method comprises the following steps: carrying out photocatalytic reaction on 1-(3-oxocyclobutane-1-carbonyl)-1H-indole-3-carboxylic acid ethyl ester, ethyl (E)-2-((benzyloxy) amino) acetate, a catalyst, inorganic alkali and an organic solvent, carrying out reduced pressure distillation to remove the solvent after the reaction, and carrying out silica gel column chromatography separation and purification. The method is used for photocatalysis of [2 + 2] cycloaddition reaction of indole and imine.

The method includes providing a first substrate having a first surface comprising an alkyne moiety. The method includes providing a second substrate having a second surface comprising an azide moiety. The method further includes bonding the first substrate to the second substrate. Bonding the first substrate to the second substrate includes physical contact between the first surface and the second surface at an interface and chemically reacting the alkyne moiety with the azide moiety through a cycloaddition mechanism, thereby forming a triazole moiety-linked layer at the interface.