889 results about "Triazole" patented technology

An aqueous ultraviolet-absorbing resin emulsion, and an aqueous resin emulsion composition containing the emulsion is provided, wherein the emulsion is excellent in compatibility with a synthetic resin and light resistance. Also, the emulsion improves stability in blending with an aqueous emulsion of the synthetic resin, and prevents bleed out of the ultraviolet-absorbing resin on the surface of a coating film. Further, the aqueous ultraviolet-absorbing resin emulsion imparts excellent alkali or solvent resistance to a synthetic resin poor in alkali or solvent resistance. More specifically, an aqueous resin emulsion composition comprising (I) an aqueous ultraviolet-absorbing resin emulsion and (II) an other aqueous resin emulsion is provided, wherein the emulsion (I) is obtained by urethanizing (A) a polyol component having an ultraviolet-absorbing group {e.g., 1,1-bis[3-(2H-benzotriazol-2-yl)-4-hydroxy-benzeneethanol]methane}, (B) a polyol if necessary, (C) an alkyl or aryl dialkanolamine compound, and (D) an organic polyisocyanate in (E) an organic solvent, diluting the reaction mixture with (F) an organic solvent having a boiling point lower than 100° C. to give a resin solution, neutralizing the resin solution with (G) a neutralizing agent, and dispersing the resultant in water.

Stable and bioavailable formulations and dosage forms comprising a dispersion (e.g., spray-dried dispersion) of solid amorphous 6-(cyclopropancamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide (Formula (I): BMS-986165) in a solid polymer matrix are provided for the treatment of auto-immune and auto-inflammatory diseases such as an inflammatory bowel disease (IBD) and psoriasis.

The invention relates to a hybridoma cell strain capable of secreting a mefos monoclonal antibody and application of the hybridoma cell strain, and belongs to the technical field of immunodetection. According to the invention, the hybridoma cell strain capable of secreting the fenofos monoclonal antibody is obtained through screening, the fenofos monoclonal antibody has high specificity and high sensitivity to the fenofos, IC50 to the fenofos is 0.231 ng / mL, and the fenofos monoclonal antibody has no cross reaction to structural analogues of the fenofos, such as triazophos, diazinon, phorate, acetyl phorate, methamidophos and the like; therefore, low-concentration isoprophos can be accurately detected.

The invention provides a cooling rate optimization control method and system for continuous cooling crystallization, and the method comprises the steps: collecting crystal slurry concentration data and temperature data of each stage of crystallization tank in real time; the crystal slurry concentration data, the temperature data and the feeding flow data are input into a deep learning model, and a prediction result is obtained; based on the prediction result and crystal mush concentration data, dynamically adjusting the cooling rate of each stage of crystallizing tank and the addition amount of a co-crystallizing solvent; and feeding back an outlet crystal mush concentration signal of the last-stage crystallizing tank to the solid-liquid separation unit, and adjusting the running rotating speed of the solid-liquid separation unit in a linkage manner. According to the cooling rate optimization control method and system for continuous cooling crystallization, prospective correction of the cooling rate is carried out by using the predicted supersaturation degree, and adjustment of the additive amount of the auxiliary crystallization solvent is carried out by using the predicted crystal particle size distribution; and finally, an outlet concentration signal of the last-stage crystallizing tank is fed back to the solid-liquid separation unit in real time to adjust the separation rotating speed in a linkage manner, so that the crystal particle size deviation is reduced, and the triazole crystallization recovery rate is improved.

The invention relates to the field of water treatment, and discloses a scale and corrosion inhibitor for seawater circulating cooling water, which is prepared from phosphonic acid grafted maleic anhydride-acrylic acid copolymer, hydroxyethylidene diphosphonic acid, amino trimethylene phosphonic acid, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N- The anti-corrosion coating is prepared from the following raw materials: N, N-diethylaminomethyl-benzotriazole, gamma-aminopropyltriethoxysilane, zinc salt and a polyoxyethylene-polyoxypropylene block copolymer. The core of the invention is that all the raw material components form the thermo-sensitive polyelectrolyte compound through a self-assembly process. The compound is stably dispersed at low temperature by utilizing the cloud point effect of the block copolymer, and is subjected to phase change and preferential deposition on a high-temperature heat exchange surface, so that targeted and efficient delivery of various active components is realized. According to the invention, the problems of incompatibility of components and poor stability of a traditional compound agent are solved, the product has excellent storage stability, and efficient and synergistic corrosion and scaling control can be realized under high-temperature and high-salinity working conditions.

The invention discloses a zinc transition metal complex and preparation and application thereof in fluorescence recognition of biomolecules, and relates to the technical field of metal organic framework materials, the chemical formula of the zinc transition metal complex is [Zn2 (L) 2 (bpe) (H2O) 2] n, and 3, 5-bis (3-carboxylic acid phenyl)-1, 2, 4-triazole, 1, 2, 4-triazole, 1, 3, 4-triazole, 1, 3, 4-triazole, 1, 3, 4-triazole, 1, 3, 4-triazole, 1, 3, 4-triazole, 1, 3, 4-triazole, 1, 3, 4-triazole, 1, 3, 4-triazole The complex material is prepared by co-dissolving 2, 2-bis (4-pyridyl) ethylene, Zn (NO3) 3.6 H2O and N, N-dimethylformamide in an aqueous solution, has excellent fluorescence performance, has the capability of specifically identifying ascorbic acid in various biomolecules, and also has relatively good anti-interference performance, excellent circularity and strong stability, and can be widely applied to the field of biochemistry, biochemistry, biochemistry, biochemistry, biochemistry, biochemistry, biochemistry, biochemistry, biochemistry, biochemistry, biochemistry, biochemistry, biochemistry, biochemistry, biochemistry and biochemistry. The method can be used for detecting ascorbic acid in water and beverages.

The invention discloses a phenolic resin material as well as a preparation method and application thereof in 3D printing, and relates to the technical field of high polymer materials. When the phenolic resin material is prepared, hydroxylated carbon nanotubes react with isocyanate propyl triethoxy silane to prepare pre-modified carbon nanotubes, and then the pre-modified carbon nanotubes react with 2-chloroethyl triethoxy silane to prepare modified carbon nanotubes; the preparation method comprises the following steps: reacting vanillin with 5-amino-1, 2-dihydro-2-methyl-3H-1, 2, 4-triazole-3-thioketone and 9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide in sequence, so as to obtain pre-modified vanillin; reacting the pre-modified vanillin with divinyl disulfide to obtain modified vanillin; the modified vanillin, phenol and formaldehyde react to prepare modified phenolic resin, and then the modified phenolic resin reacts with the modified carbon nanotubes to prepare the phenolic resin material. The phenolic resin material prepared by the invention has good flame retardance, heat resistance, aging resistance, self-repairing property and mechanical property.

To provide a method for producing a triazole skeleton-containing polymer having a desired substituent, and to provide the triazole skeleton-containing polymer.SOLUTION: The present invention provides a method for producing a triazole-skeleton-containing polymer, the method including a step of reacting an acetylene group contained in a starting material polymer with an azide group-containing compound to obtain the triazole-skeleton-containing polymer, the starting material polymer being a polymer containing a first monomer unit 1A derived from a monomer having the acetylene group and a second monomer unit derived from a second monomer, the triazole-skeleton-containing polymer having a triazole-skeleton-containing monomer unit and the second monomer unit.SELECTED DRAWING: None

A bimetal active site doped carbon-based catalyst, which is particularly a ZnMn-N-C catalyst. The ZnMn-N-C catalyst is prepared by using 1H-1,2,3-triazole, manganous nitrate and zinc chloride as reaction raw materials, subjecting same to a solvothermal reaction and then to drying to obtain a Mn-MET-ZnCl2 powder, and then sequentially subjecting the powder to primary pyrolysis, a sulfuric acid treatment and secondary pyrolysis. By respectively using 1H-1,2,3-triazole and zinc chloride as a mesopore forming agent and a micropore forming agent, and adjusting the pore-forming sequence and controlling the pore-forming process by means of pyrolysis, a large number of mesopores are preferentially formed, and then a large number of micropores are uniformly distributed in the mesopores, thereby forming a hierarchical pore channel structure and overcoming the problem of the collapse of the pore channel structure during the formation of the structure; and the obtained bimetal site doped carbon-based catalyst ZnMn-N-C has a high specific surface area of 1837.9 m2 / g and exhibits a good ORR activity (E1 / 2=0.867 V vs. RHE), and a primary zinc-air battery assembled by using the catalyst ZnMn-N-C as a positive oxygen reduction catalyst has a high energy density of 889 Wh / kg-1 Zn.

The invention discloses an activated carbon modification method which comprises the following steps: activating activated carbon through plasma, and then performing graft modification by using 3-amino-5-sulfydryl-1, 2, 4-triazole (AMT) to obtain the activated carbon. The method aims at solving the problems that in an existing modification process, the grafting rate is low, the adsorption performance is poor, and pores are prone to being damaged, and the method is suitable for continuous treatment of the m-phenylenediamine (MPD) oxidation color development aqueous solution. According to the process, the AMT grafting rate of the modified activated carbon is 1.0-1.2 mmol / g, the specific surface area is 950-1100 m < 2 > / g, the pore volume ratio of activated mesopores is increased to 43%, the decolorization rate is greatly increased, the saturated adsorption period of the activated carbon is prolonged, and the solution can be kept basically colorless within 120 hours by using 0.5 wt% of activated carbon under a static adsorption condition.

The invention relates to the field of cables, and discloses a flame-retardant extruded and insulated low-voltage power cable, which comprises a conductor core, an insulating layer, a filling layer, an inner sheath layer, an armor layer and an outer sheath layer, and is characterized in that the sheath layer is made of low-density polyethylene, ethylene propylene diene monomer, ethylene-tetrafluoroethylene copolymer, modified halloysite nanotubes, modified ammonium polyphosphate and auxiliaries; the modified halloysite nanotube is prepared by loading titanium dioxide on the surface of a halloysite nanotube by using a sol-gel method and then grafting octa-aminopropyl polyhedral oligomeric silsesquioxane; the modified ammonium polyphosphate is prepared by grafting a functional silane coupling agent prepared by reacting a cyclotriphosphazene derivative with 3-chloropropyltrimethoxysilane with polysiloxane-coated ammonium polyphosphate, and the cyclotriphosphazene derivative is prepared by reacting 3-amino-1, 2, 4-triazole with hexachlorocyclotriphosphazene and then coordinating with cobalt ions by adopting a hydrothermal method. Therefore, the material is endowed with good mechanical properties, ultraviolet resistance, heat and wear resistance, flame retardance and antibacterial activity.

The invention discloses yellowing-resistant light-cured organic silicon resin and a preparation method thereof, and belongs to the technical field of light-cured resin. The resin is prepared from the following raw materials in parts by weight: 80 to 100 parts of vinyl-terminated polysiloxane, 15 to 25 parts of trimethylolpropane tri (3-mercaptopropionate), 1 to 3 parts of yellowing-resistant aid, 2 to 4 parts of photoinitiator and 0.5 to 1 part of flatting agent. When the resin is prepared, the raw materials are uniformly mixed under a dark condition, and the resin is obtained after vacuum defoaming. Wherein the yellowing-resistant auxiliary agent is a benzotriazole ultraviolet light absorber and is synthesized through a multi-step reaction, the structure simultaneously contains a benzotriazole ring and anthryl, and the benzotriazole ring and the anthryl have a synergistic effect so that ultraviolet rays can be efficiently absorbed and yellowing can be inhibited. The obtained resin has excellent yellowing resistance and high curing speed, and is suitable for the fields of coatings, printing ink, adhesives, electronic packaging and the like.

The invention relates to the field of pipes, and discloses a high-flame-retardance MPP cable protection pipe and a preparation method thereof.The cable protection pipe comprises polypropylene resin, modified graphene oxide, modified maleic anhydride grafted polypropylene and auxiliaries; the modified graphene oxide is prepared by grafting a modified benzotriazole intermediate and a double-bond DOPO derivative substituted cyclotriphosphazene derivative into graphene oxide; the modified benzotriazole intermediate is prepared by grafting 2-(2, 4-dihydroxyphenyl)-2H-benzotriazole and ethyl bromoacetate, and then reacting with 2, 2, 6, 6-tetramethyl-4-piperidinol; the double-bond DOPO derivative is prepared through the reaction of DOPO-HQ and 4-vinyl benzyl chloride; the modified maleic anhydride grafted polypropylene is prepared by grafting octa-aminopropyl polyhedral oligomeric silsesquioxane prepared by a polycondensation reaction of 3-aminopropyltriethoxysilane and maleic anhydride grafted polypropylene. The pipe prepared by the invention has good mechanical properties, ultraviolet aging resistance, low-temperature toughness, heat resistance, flame retardance and wear resistance.

The invention relates to the field of pipes, and discloses a heat-resistant high-strength MPP cable protection pipe and a preparation method thereof.The cable protection pipe comprises polypropylene resin, composite filler, modified layered lanthanum phenylphosphonate and auxiliaries; the composite filler is prepared by carrying out amino functional covalent modification on halloysite nanotubes by using a modified silane coupling agent, then carrying out protonation treatment and carrying out cation exchange on nano montmorillonite grafted with the modified silane coupling agent, and the modified silane coupling agent is prepared by reacting gamma-methacryloxypropyltrimethoxysilane with polyether amine; the modified layered lanthanum phenylphosphonate is prepared by grafting and modifying the surface of the layered lanthanum phenylphosphonate by using a cyclotriphosphazene substitute, the cyclotriphosphazene substitute is prepared by reacting 4-amino-1, 2, 4-triazole with p-hydroxybenzaldehyde and then substituting with phosphonitrilic chloride trimer, and the prepared MPP cable protection tube has the advantages of good tensile property, high impact resistance, high heat resistance, good flame retardancy, good flame retardancy and good flame retardancy. Meanwhile, excellent flame retardance and antibacterial effect are achieved.

The invention discloses an anticorrosive coating composition based on a nano hybrid and a preparation method of the anticorrosive coating composition, and relates to the technical field of powder coatings. Comprising the following components in parts by weight: 60-70 parts of fluorosilicone modified epoxy resin, 8-10 parts of an aminoethylated acrylic polymer, 4-8 parts of a functionalized nano hybrid, 4-6 parts of a curing agent, 0.3-1.2 parts of an accelerant, 1-2 parts of benzoin, 2-4 parts of a functional aid, 10-15 parts of a micron-sized filler and 1-2 parts of a coupling agent. The curing agent is prepared by compounding dicyandiamide, bicyclo [2.2. 1] heptane dimethylamine and 3, 5-diamino-1, 2, 4-triazole according to a mass ratio of (3 to 5): 1: (0.8 to 1.2). The coating composition is high in adhesive force and excellent in impact resistance and corrosion resistance.

A MOF composition is formed from a reaction mixture comprising zinc ions, oxalate, and one or more substituted cycloazocarbyl compounds selected from either (a) at least two different cycloazocarbyl compounds, each of which is at least mono-substituted, or (b) at least one cycloazocarbyl compound that is di-substituted. The MOF composition can be used in a method of capturing carbon dioxide from a mixture of gases containing carbon dioxide. Also disclosed herein is a method of making the MOF composition.

1, 4-disubstituted-1, 2, 3 triazole compounds of formula (I): (I) capable of inhibiting heme oxygenase activity, their use as a medicament for the treatment and / or prophylaxis of pathological conditions associated with alteration of heme oxygenase activity and pharmaceutical compositions comprising the same.

The application discloses a triazolinone compound, and a preparation method thereof. The structural general formula (I) of the triazolinone compound is as follows: the preparation method is to perform esterification or amidation reaction on a compound containing a hydroxyl group or an amino group as raw material in a solvent and 2-chloro-3-(2-chloro-5-(4-difluoromethyl-3-methyl-5-oxo-1,2,4-triazol-1-yl)-4-fluorophenyl) propionyl chloride prepared through acyl chloride reaction, so as to obtain a triazolinone structure-containing herbicidal compound. The preparation method is simple, the reaction process is short, and the triazolinone structure-containing herbicidal compound has the advantages of novel structure, high herbicidal activity and the like.

The invention relates to a method for controlling wheat septospora which is resistant to a C14-demethylase inhibitor fungicide. The present invention relates to a method for controlling wheat septospora on a cereal plant, which wheat septospora comprises at least one mutation in the CYP51 gene and is resistant to a C14-demethylase (in sterol biosynthesis) inhibitor fungicide (DMI fungicide), the method comprises applying to these plants, seeds or soil of the plants a fungicidally effective amount of (I) methyl 2-[2-chloro-4-(4-chlorophenoxy) phenyl]-2-hydroxy-3-(1, 2, 4-triazol-1-yl) propionate or (II) 2-[2-chloro-4-(4-chlorophenoxy) phenyl]-2-hydroxy-3-(1, 2, 4-triazol-1-yl) propionic acid.

The application discloses a kind of temporary bonding glue and its application.Temporary bonding glue includes polyimide, the polyimide includes big conjugate unit, the conjugate atom number of big conjugate unit is greater than or equal to 40, and big conjugate unit includes at least one of diphenyl ether group, fluorenyl group or indane structural unit;The polyimide further includes at least one of benzotriazole group, nitro group.The application is improved on the structure of polyimide, and the temporary bonding glue is used in wafer processing, so that the absorbance of temporary bonding glue at target debonding wavelength 355nm is significantly increased, thereby significantly reducing threshold debonding energy, and it is expected to reduce the risk of wafer warping, cracking, or surface device failure, improve the life of laser and debonding efficiency.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of topiromilast. The preparation method comprises the following steps: taking a compound 1, namely 4-(1H-1, 2, 4-triazole-5-yl)-pyridine, and a compound 2, namely 2-cyanopyridine-4-formaldehyde as raw materials, and reacting under the action of a free radical initiator and a catalyst; and performing post-treatment to obtain the target compound topiromilast. According to the invention, the problems of low yield, use of a highly toxic cyaniding reagent and the like caused by construction of a triazole ring or introduction of a cyano group are avoided; the yield and the purity of the product are improved, the post-treatment operation is simple, and the method is suitable for industrial production.

A family of sulfonyl-azole compounds are described which include small molecule activators of phosphofructokinase-1, liver isoform (PFKL). The small molecule activators selectively form covalent adducts with PFKL, including particularly lysine 677 of the human PFKL. Also provided are methods for using the small molecule activators to activate PFKL, e.g., to provide increased glycolysis and / or T cell activation, to treat cancers and / or tumors, and / or to enhance fructose-1,6-bisphosphate (FBP) content in cells.

The present invention relates to a solid dispersion of a triazolopyrimidinone derivative having tankyrase inhibitory activity and a method for producing the same. The solid dispersion of the triazolopyrimidinone derivative represented by formula I according to the present invention has high solubility and excellent bioavailability, and can be usefully used as a pharmaceutical raw material.

The present disclosure relates to nanoemulsions of 5-amino-[4-(4-chlorobenzoyl)-3,5-dichlorobenzyl]-1,2,3-triazole-4-carboxamide (carboxy-amido-triazole or CAI), methods of preparing thereof, and their use in the treatment of inflammatory optic neuropathies.

The invention discloses a bactericide composition for preventing and treating earthen archaeological site mushroom diseases and application of the bactericide composition, triazole bactericides and methoxyl acrylate bactericides are used as active ingredients and compounded with a synergist, the mass ratio of triazole to azoxystrobin is 1: 1-1: 9, the content of the synergist is 0.01%-0.1% of the total mass, the content of the methoxyl acrylate bactericides is 0.01%-0.1% of the total mass, and the content of the methoxyl acrylate bactericides is 0.01%-0.1% of the total mass. The composition shows a remarkable synergistic effect, the FIC index is smaller than or equal to 0.5, and the composition has an efficient killing effect on spores, hyphae and sporocarps of common mushrooms in earthen ruins. The composition ensures safety to a ruins body material, shows a color difference value [delta] E < 3, a penetration depth greater than 5 cm, and maintains long-term stability in a humid environment for at least 12 months. The bactericide formula is systematically optimized for earthen ruins mushroom diseases for the first time, and various macro fungi including coprinus brachypoda, coprinus comatus, pleurotus ostreatus and pleurotus citrinopileatus are effectively prevented and treated. Through laboratory screening, synergistic effect testing, permeability and safety evaluation and field application verification, the composition has an excellent prevention and treatment effect.

The present invention relates to novel heteroaryl-triazole and heteroaryl-tetrazole compounds of the general formula (I), in which the structural elements R1, R2, R3, R4 and R5 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals.

This invention discloses a method for preparing a cyclic peptide compound containing a cisamide bioelectron isosteric cyclic peptide. The method involves introducing a thioamide unit at a specific position on the peptide backbone, making it a potential activatable reaction site. This site is selectively activated by a metal salt and undergoes an intramolecular condensation reaction with an acylhydrazine group located in the same peptide chain, generating a 1,2,4-triazole heterocyclic structure in situ. In a single reaction process, the cyclization of the peptide and the precise construction of the cisamide bioelectron isosteric group in the peptide backbone are achieved simultaneously.

This disclosure relates to N 2 -(3-(2-(2H-1,2,3-triazol-2-yl)propan-2-yl)-1-cyclopropyl-1H-pyrazol-5-yl)-N 4 The present invention relates to crystalline and amorphous forms of -ethyl-5-(trifluoromethyl)pyrimidine-2,4-diamine (compound of formula I), co-crystals, pharmaceutical compositions, and preparations thereof. TIFF2026504627000045.tif4857

To provide a type I receptor tyrosine kinase inhibitor.SOLUTION: Or a pharmaceutically acceptable salt thereof. Specific examples thereof include N - (4 - ([1,2,4] triazolo [1, 5-c] pyrimidin-7-yloxy) - 3-methylphenyl) - 5 - (3 - (dimethylamino) azetidin-1-yl) - 6-methoxyquinazolin-4-amine.SELECTED DRAWING: None