340 results about "Morpholine" patented technology

The invention discloses a cellulose coated diaphragm and a preparation method thereof in the field of lithium ion batteries, the diaphragm comprises alpha-cellulose pulp, a cellulose grafted phenylboronic acid-co-oligomeric ethylene oxide copolymer, a thermal response star zwitterionic polymer and nano aluminum oxide, and an N-methylmorpholine-N-oxide aqueous solution is adopted as a solvent system. The preparation method comprises the following steps: firstly synthesizing a cellulose grafted copolymer with dynamic borate bonds through atom transfer radical polymerization, then preparing a star polymer with thermal response arms and zwitter-ion terminals by taking cyclodextrin as a core, and finally mixing all the components to prepare coating slurry. And the composite diaphragm is prepared through the processes of coating, phase conversion, ultraviolet curing and drying. The diaphragm combines the thermal stability and lyophilic property of cellulose, forms a dynamic self-adaptive interface layer through the synergistic effect of two functional compounds, has the advantages of active safety protection, dendritic crystal inhibition, long cycle life and the like, and remarkably improves the comprehensive performance of the lithium ion battery.

The invention relates to a corrosion and scale inhibitor for TRT and a preparation method of the corrosion and scale inhibitor, and relates to the technical field of chemical reagents. The corrosion and scale inhibitor is prepared from the following components in percentage by mass: 15 to 20 percent of morpholine, 25 to 30 percent of aminoethyl ethanolamine, 15 to 20 percent of 1-hydroxyethyl-2-undecylimidazoline onium salt, 12 to 18 percent of sodium polyaspartate, 8 to 12 percent of itaconic acid-allylsulfonic acid copolymer, 1 to 3 percent of alkyl glycoside and the balance of a mixture of water and glycerol in a mass ratio of 1 to (1 to 3). The corrosion and scale inhibitor disclosed by the invention can synchronously inhibit corrosion of an acid medium and scale deposition of salts such as NH4Cl and the like, and the corrosion inhibition rate and the scale inhibition rate are effectively improved.

The invention provides dust-free antibacterial deodorant bentonite cat litter and a preparation method thereof, and belongs to the technical field of cat litter. Firstly, a certain amount of sodium bentonite, baking soda and calcium carbonate are used for preparing bentonite cat litter, then polyvinyl alcohol and sodium carboxymethyl cellulose which have the film forming property, polyhexamethylene guanidine hydrochloride which has the bactericidal property and soybean ethyl sulfate morpholine which has the deodorization function are used for preparing the bentonite cat litter; the components are compounded to obtain a functional dust suppressant with antibacterial, deodorant and film-forming effects, the functional dust suppressant is sprayed and coated on the surface layer of the bentonite cat litter, so that the prepared dust-free antibacterial and deodorant bentonite cat litter is remarkable in deodorant and antibacterial effects and good in wear resistance, and a layer of water-soluble film is formed on the surface of the dust suppressant after the functional dust suppressant is sprayed for dust suppression treatment, so that the dust suppression effect is good. The bentonite cat litter has the advantages that the structure and the film-forming property of the surface layer of the bentonite cat litter are improved, the hardness and the wear resistance of the surface are improved, the dust suppression effect of the cat litter is obviously improved, dust is extremely low under simulated falling and transportation conditions, and the cat litter has excellent water absorption and caking performance.

The invention discloses a preserving fluid for stably preserving sample DNA at normal temperature and a preparation method thereof, and belongs to the technical field of biological sample preservation. The preserving fluid comprises a lysis system, a nucleic acid protection system and a buffering and stabilizing system, the cracking system comprises a composite surfactant and an enzymolysis auxiliary agent; the composite surface active agent is prepared from polyether polyol fatty acid ester and cocamidopropyl hydroxy sulfobetaine; the enzymolysis auxiliary agent comprises lysozyme Lyso-V and protease K; the nucleic acid protection system comprises a nitrogen heterocyclic polyamine-carboxylic acid derivative and dextran sulfate; the nitrogen heterocyclic polyamine-carboxylic acid derivative comprises 1, 4, 7, 10-tetraazacyclododecane-N, N ', N' ', N ''tetraacetic acid, 1, 4, 7-triazacyclononane-N, N', N''-triacetic acid, disodium ethylene diamine tetraacetate-nitrogen heterocyclic derivative, and diethylenetriamine pentaacetic acid-piperazine derivative, and the nitrogen heterocyclic polyamine-carboxylic acid derivative comprises 1, 4, 7, 10-tetraazacyclododecane-N, N ', N '', N'' tetraacetic acid, 1, 4, 7-triazacyclononane-N, N', N ''-triacetic acid. The buffering and stabilizing system comprises an amphoteric buffering agent and a polymer stabilizer; the amphoteric buffering agent comprises 2-(N-morpholino) ethanesulfonic acid and N-tri (hydroxymethyl) methylglycine.

The invention provides synthesis of a T-2 toxin antigen and preparation and application of a monoclonal antibody. Relates to the technical field of biotoxin detection. The preparation method of the T-2 toxin antigen comprises the following steps: step 1, synthesizing an immunogen T-2-BSA by adopting a carbodiimide method, dissolving 2mg of T-2 adipic acid with 0.5 mL of dimethylformamide, and recording as a solution A; 5 mg of bovine serum albumin and 3 mg of EDC are dissolved with a 2-morpholine ethanesulfonic acid buffer solution with the pH being 5.5, and the solution is marked as a solution B; step 2, under the condition of stirring, dropwise adding the solution A into the solution B, stirring for 18 hours in a dark place at 4 DEG C, then dialyzing for 3 days by using a phosphate buffer solution, changing the solution once a day, centrifuging the dialysate for 10 minutes at 3,500 r / min, and discarding the precipitate; the adipic acid is coupled with the T-2 toxin through a chemical method, and the unique step enriches the structural characteristics of the hapten, so that the prepared T-2 toxin complete antigen is excellent in immune effect, can efficiently excite immune response of an organism, and shows high specificity and sensitivity.

The invention discloses a folic acid modified active oxygen response type sodium alginate nano-carrier and application thereof, and the preparation method comprises the following steps: firstly synthesizing-Se-Se-FA: stirring dicyclohexylcarbodiimide, 4-dimethylaminopyridine, dimethyl sulfoxide / pyridine, a double-selenium fragment and folic acid at room temperature for 18-22 hours in an argon environment; and carrying out acetone precipitation, centrifugation, washing, rotary evaporation concentration and freeze-drying. The preparation method comprises the following steps: preparing an ALG-Se-FA carrier, stirring sodium alginate, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and hydroxysuccinimide in a 2-morpholinoethanesulfonic acid buffer solution, adding DMSO, dissolving a double-selenium fragment and a-Se-Se-FA fragment in DMSO and deionized water, adding the dissolved double-selenium fragment and-Se-Se-FA fragment into a system, stirring, dialyzing, and freeze-drying to obtain the product. According to the carrier, a double-selenium bond ROS response unit and folic acid targeting molecules are introduced through covalent bonds, astaxanthin can be efficiently entrapped and protected, and after the carrier is stable in gastrointestinal environment and reaches a colitis disease part, high ROS level can be responded, and intelligent drug slow release is achieved through folic acid receptor targeting.

The application discloses an impact-resistant mine protective clothing and belongs to the technical field of mine protective clothing. The mine protective clothing is provided with an impact-resistant protective layer, and the impact-resistant protective layer comprises alternately stacked and connected first and second functional layers. The outermost layer of the impact-resistant protective layer towards the outside of a wearer of the protective clothing is the first functional layer, the first functional layer is a composite material layer composed of aramid woven fabric and a second resin, the second resin is filled in the fiber gap of the aramid woven fabric as a continuous matrix and covers the fiber surface, the weaving raw material of the aramid woven fabric is aramid monofilament subjected to first resin impregnation pretreatment, the first and second resins are both thermosetting resins, the first resin comprises a first compound, the first compound contains a morpholine ring and is bonded in a crosslinking network of the first resin, and the second functional layer is a dynamic crosslinking polymer layer. Compared with the prior art, the application can not only resist impact and be hard, but also absorb impact force and reduce the risk of blunt injury of personnel.

The application relates to a method for continuously preparing imidacloprid intermediate 3-methyl-2-(4-morpholinyl)cyclobutyl acid methyl ester, and the specific steps are as follows: raw material morpholinyl propylene and methyl acrylate are respectively introduced into a preheater, then the preheated raw materials are pumped into a micro-channel reactor for reaction, after the reaction is completed, the materials are discharged from the micro-channel reactor outlet into a reaction kettle, reaction is carried out, then the cyclization liquid obtained in the reaction kettle is subjected to light removal in a light removal tower, 3-methyl-2-(4-morpholinyl)cyclobutyl acid methyl ester after light removal is collected from the tower kettle of the light removal tower, the 3-methyl-2-(4-morpholinyl)cyclobutyl acid methyl ester is introduced into a pentyl ester synthesis process, and the recovered methyl acrylate collected from the top of the light removal tower is reused in the reaction kettle to participate in the ripening reaction. The application has the advantages of high product purity, low raw material unit consumption, good safety, low labor cost and the like.

The invention discloses a high-activity BODIPY type photosensitizer targeting double organelles as well as a preparation method and application of the high-activity BODIPY type photosensitizer, and relates to the technical field of medical photosensitizers. The high-activity BODIPY type photosensitizer is prepared by the following steps: reacting 2, 4-dimethyl pyrrole with 4-bromobutyryl chloride to obtain a compound Br-BY containing carboxyl, then reacting with morpholine to obtain a morpholine substituted compound Mor-BY, and finally reacting with N-iodosuccinimide (NIS) to obtain a single atom I substituted BODIPY compound Mor-IBY, namely the target photosensitizer. The photosensitizer prepared by the invention can target mitochondria and lysosome in cancer cells at the same time, and can be excited by visible light; the compound has good water solubility, can generate a large amount of reactive oxygen species (ROS) under irradiation of green light (520 nm), shows excellent photodynamic activity to tumor cells, and has low toxicity to normal cells.

The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, adducts, polymorphs, isomers and derivatives thereof useful as orexin antagonists, their preparation, their use in pharmaceutical compositions, and methods of using orexin antagonists to treat or prevent diseases or conditions mediated by orexin receptor activity.

The invention discloses a preparation method of a microbial preparation for preventing and treating powdery mildew of melons, which comprises the following steps: firstly preparing keratin microspheres, modifying the keratin microspheres with acryloylmorpholine, and compounding the modified keratin microspheres with mesoporous silica and an ethylene-vinyl alcohol copolymer to obtain a composite carrier; and finally, immersing the carrier into a mixed bacteria solution of ceriporia lacerata, bacillus velezensis and bacillus agave for adsorption and drying. Stable immobilization of strains is achieved through multiple interactions, a protective film can be formed on the surfaces of leaves through illumination after the preparation is sprayed, pathogenic bacteria are physically prevented from being attached and infected, and the fungicide can be intelligently released along with the change of environment humidity; the three strains have a synergistic effect to efficiently prevent and control powdery mildew pathogenic bacteria of melon crops by preempting sites, degrading pathogenic bacteria structures, secreting antibacterial substances and inducing plant immunity, meanwhile, the utilization efficiency and quality of crop nutrients are improved, and the application prospect is good.

The invention discloses a CO2 phase change absorbent based on N-formylmorpholine as well as a preparation method and application thereof, and belongs to the technical field of gas separation. The CO2 phase change absorbent based on N-formylmorpholine is prepared from the following components in percentage by mass: 30 to 40 percent of hydroxyethyl ethylenediamine, 30 to 40 percent of N-formylmorpholine and 27 to 37 percent of water, or 35% of compound amine composed of hydroxyethyl ethylenediamine and N-methylethylamine, 40% of N-formylmorpholine and 25% of water are contained. The preparation method of the CO2 phase change absorbent comprises the following steps: preparing the components in proportion, and uniformly mixing to obtain the CO2 phase change absorbent. The CO2 phase change absorbent is suitable for carbon capture of mixed gas with CO2 partial pressure of 10-20 kPa. The CO2 phase change absorbent can effectively reduce the volatility of the phase change absorbent and the CO2 enrichment phase viscosity, and has a good industrial application prospect.

The name of the invention is a method for preparing derivatives of substituted morpholines. Provided herein are methods of preparing derivatives and prodrugs of substituted morpholines, or pharmaceutically acceptable salts thereof. Methods of preparing substituted morpholine derivatives and prodrugs having the following chemical structure are also provided.

This invention relates to a method for preparing a broadband absorption hydrogel. The method comprises the following steps: S1, mixing solvent A (N,N-dimethylformamide or acetonitrile) with deionized water to obtain a mixed solvent; S2, adding polyethylene glycol methyl ether acrylate-480 and acryloylmorpholine to the solvent in S1 and dissolving them to obtain a mixed solution; S3, removing dissolved oxygen from the mixed solution in S2, sealing the container, and stirring under ice bath conditions; S4, adding potassium persulfate and N,N,N',N'-tetramethylethylenediamine to the mixed solution after stirring in S3, and sealing the container again; S5, completing the polymerization reaction in the container at 60 °C to obtain the hydrogel. Compared with the prior art, the hydrogel material provided by this invention has improved reflection loss intensity and effective absorption bandwidth performance, thus providing a new perspective for developing highly flexible and efficient electromagnetic wave absorbers.

The application discloses an anticoagulant biomaterial for blood purification and a preparation method and application thereof, and comprises the following steps: providing an amphiphilic copolymer P(AA-MMA); blending polyethersulfone, P(AA-MMA) and a solvent, stirring at a set temperature to obtain a casting solution, and preparing a blending membrane from the casting solution; soaking the blending membrane in a 2-morpholine-4-yl ethanesulfonic acid buffer solution containing argatroban, 1-ethyl-(3-dimethylaminopropyl) carbonyl diimide and hydroxy succinimide, and reacting at room temperature to obtain an argatroban grafted blending membrane, namely the anticoagulant biomaterial. The method improves the hydrophilicity of the membrane, reduces the albumin adsorption of the membrane, reduces the adhesion of platelets on the membrane, prolongs the coagulation time APTT, PT and TT of the membrane, and is better in biocompatibility and enhanced in anticoagulation performance.

The present application belongs to the technical field of pharmaceutical therapy, and particularly relates to an amide-substituted tryptophan ketone derivative, a preparation method and application thereof. The structural formula of the tryptophan ketone derivative is shown in formula (A) or formula (B). In the formula, n=1 or 2, and R is any one of dimethylamine group, diethylamine group, morpholine group, 1-methylpiperazine group, cyclopropylamine group and 4-hydroxypiperidyl group. The compound can selectively inhibit the activity of acetylcholinesterase, and has the potential to develop into a drug for treating Alzheimer's disease due to the abilities of self-aggregation and the like. 1‑42 ​

This invention discloses a chemical mechanical polishing (CMP) slurry. The raw materials of the CMP slurry include the following components: a water-soluble small molecule containing a morpholine ring, a water-soluble polymer with a main chain or side chain containing polyoxyethylene chains, an abrasive, an alkaline compound, and water. This technical solution can improve the edge collapse phenomenon of silicon wafers while achieving high flatness in the central region of the silicon wafer, thereby improving the overall surface flatness of the silicon wafer and meeting the needs of silicon wafer flatness in production.

This invention discloses a naphthimide-based fluorescent probe for detecting HClO and its preparation method. The fluorescent molecular probe uses naphthimide as the fluorophore and C=N as the specific reaction site for HClO. Due to the presence of the naphthimide fluorophore, the probe molecule exhibits two-photon properties, enabling deep tissue penetration, reducing background noise, and facilitating fluorescence imaging of biological systems. Furthermore, the introduced morpholine group allows for lysosomal targeting, enabling the monitoring of hypochlorous acid concentration levels in lysosomes, making it a valuable tool for early disease diagnosis. In addition, this type of probe molecule is simple to synthesize, operates under mild reaction conditions, exhibits stable optical properties, and has a high synthesis yield. It can detect a wide range of HClO, making it practically valuable in fields such as biochemistry and environmental science.

The application provides a gas-phase rust-proof oil and a preparation method and a rust-proof method thereof, and is characterized in that the gas-phase rust-proof oil comprises 60-80 parts by weight of base oil, 5-20 parts by weight of an oil-soluble sulfonate rust-proof agent and 3-15 parts by weight of a gas-phase corrosion inhibitor; wherein the gas-phase corrosion inhibitor comprises a first gas-phase corrosion inhibitor and a second gas-phase corrosion inhibitor; the weight ratio of the first gas-phase corrosion inhibitor and the second gas-phase corrosion inhibitor is 1-6:1; the first gas-phase corrosion inhibitor is selected from an amine with a morpholine structure; the second gas-phase corrosion inhibitor is different from the first gas-phase corrosion inhibitor and is selected from at least one of an amine with a benzene ring structure, an amine with a nitrous acid structure and an amine with a carboxylic acid structure; the gas-phase rust-proof oil of the application not only has excellent salt spray rust-proof performance and gas-phase rust-proof performance, but also does not separate for a long time, and the appearance is transparent and turbid; in the method for preparing the gas-phase rust-proof oil, the process temperature is lower than 50 DEG C, the energy consumption is low, the production process is simple, and the time consumption is less.

The application discloses a degradable gemini morpholine quaternary ammonium salt. The application further discloses a preparation method of the degradable gemini morpholine quaternary ammonium salt, comprising the following steps: S1, performing N-alkylation reaction on morpholine and halogenated alkane to obtain N-alkyl morpholine; S2, performing reaction on substance A and halogenated acetyl halide to obtain substance B; S3, continuously performing N-alkylation reaction on the N-alkyl morpholine and the substance B to obtain the degradable gemini morpholine quaternary ammonium salt. The application further discloses application of the degradable gemini morpholine quaternary ammonium salt in a bactericide and in preparation of a medicine for treating helicobacter pylori infection. The gemini morpholine quaternary ammonium salt has a good effect of killing helicobacter pylori; the gemini morpholine quaternary ammonium salt can be degraded in an alkaline environment, can avoid drug resistance of helicobacter pylori to the gemini morpholine quaternary ammonium salt, and can make the degradation product be rapidly discharged out of the body.

This application relates to the fields of chemistry and biomedicine, specifically to a tofenamic acid lipid composition, its preparation method, and its application. A tofenamic acid derivative is obtained by reacting a morpholine solution with tofenamic acid, ethyldimethylaminopropylcarbodiimide, and 4-dimethylaminopyridine, followed by purification. The morpholine in the morpholine solution is an N-alkylmorpholine compound. The tofenamic acid derivative is used to prepare tofenamic acid prodrug liposomes via ethanol injection, which are then used in combination with a STING agonist. The synergistic effect of the combined treatment stems from the dual regulation of the tumor immune microenvironment (TME), overcoming the immune escape induced by STING monotherapy. After STING agonist treatment, the intratumoral COX-2 / PGE2 axis is activated, leading to immunosuppression. The combination of tofenamic acid liposomes and a STING agonist inhibits COX-2, thus relieving this negative feedback loop.

This invention discloses a phosphorylated diamine morpholino oligonucleotide drug that regulates PAPOLA expression and its application, belonging to the field of biomedical technology. The nucleotide sequence of the drug is shown in SEQ ID NO:1, targeting the coding region of human PAPOLA mRNA. The formulation is a lyophilized powder for injection, with excipients including mannitol and phosphate buffer. This invention also discloses the application of this drug in the preparation of a treatment for gastric cancer, specifically advanced gastric cancer with high PAPOLA expression. The drug is administered intravenously at a dose of 8-12 mg / kg every 3 days. Its mechanism of action is to block PAPOLA protein translation, inhibit the G1 / S phase transition of gastric cancer cells, and induce apoptosis. In vitro and in vivo experiments have confirmed that this drug can specifically inhibit the proliferation and growth of gastric cancer cells, providing a new treatment option for advanced gastric cancer.

The present invention relates to compounds of formula (I) or formula (II) or pharmaceutically acceptable salt, solvate or hydrate thereof, wherein said compound of formula (I) and said compound of formula II each comprises at least one ONO2 or ONO moiety; R1 is C1-C3alkyl; R2 is H, C1-C6alkyl, C3-C6cycloalkyl, C1-C2alkoxy, C2-C4alkenyl; R3 is C1-C4alkyl optionally substituted with C1-C2alkoxy, C3-C4cycloalkyl, C2-C4alkenyl; R4 and R5 are each independently H or C1-C6alkyl optionally substituted with F, OH, ONO, ONO2, COOH, C1-C3alkoxy, C3-C6cycloalkyl; or together with the nitrogen atom to which they are attached form a heterocyclic ring, wherein preferably said heterocyclic ring is selected from aziridine, azetidine, pyrollidine, piperidine, morpholine, piperazine, homo-piperazine, 2,5-diazabicyclo[2,2,1]heptane and 3,7-diazabicyclo[3,3,0]octane, wherein said heterocyclic ring is optionally substituted with independently one or more R6; R6 is C1-C6alkyl optionally substituted with independently one or more halogen, OH, ONO, ONO2, C1-C3alkoxy, C1-C3haloalkoxy, COOR7, NR8R9, C═NR10; R7 is H, or C1-C4alkyl optionally substituted with F, OH, ONO, ONO2, NR8R9; R8 and R9 are independently H, or C1-C4alkyl optionally substituted with ONO, ONO2; R10 is C1-C4alkyl optionally substituted with F, ONO, ONO2; C3-C6cycloalkyl; pharmaceutical compositions thereof, and their use in methods of treating or preventing a disease alleviated by inhibition of PDE5 in a human or in a non-human mammal.

This composition comprises: at least one buffer selected from the group consisting of 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid and 2-morpholinoethanesulfonic acid; and a capping reagent containing a capping compound capable of bonding to a terminal of a transcription reaction product, wherein the buffer concentration is 5-35 mM, and the pH is 5.0-7.5.

The application provides an extraction method and application of artemisia fiber, and the artemisia fiber is efficiently prepared by the following steps: mild degradation of lignocellulose structure through microbial pretreatment, and dissolution and regeneration in combination with a green solvent system of N-methyl morpholine-N-oxide solution (hereinafter referred to as "NMMO solution"), so that high-value utilization of artemisia waste stems and stalks is realized. The obtained artemisia fiber can retain part of active ingredients from plants, has certain odor removal, antioxidant and anti-allergic potential in food-grade packaging materials and green wallpaper applications, and overcomes defects such as difficult degradation, easy damp and mildew, and single function of traditional packaging materials and wallpapers.

[Problem] To provide an active energy ray-curable ink composition for inkjet, which has excellent inkjet head discharge ability, forms a printed layer having excellent adhesion to various substrates, has excellent curability, does not tack on the surface after curing, has excellent flexibility when bent together with a substrate, has excellent image quality after curing, and can be used in the field of inkjet printing. The smell is very small after curing. [Solution] An active energy ray-curable inkjet ink composition satisfying the following conditions (A) to (D): (A) the content of an amine-modified oligomer accounting for 1.0% to 20.0% by mass of the total solid content, (B) the content of an alicyclic skeleton-containing monofunctional monomer forming a polymer having a Tg of 10 DEG C to 60 DEG C during polymerization accounting for 16.0% or more by mass of the total solid content, (C) 3-methyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3-trimethyl-1 the content of 1, 5-pentanediol diacrylate accounts for 8.0% to 25.0% by mass of the total solid content, and the content of acryloylmorpholine accounts for 3.0% to 15.0% by mass of the total solid content.

The synthesis method comprises the following steps: synthesizing an organic compound containing an alkenyl silicon skeleton by taking silaborane as a silicon free radical precursor, aryl bromide as a coupling component and morpholine as an accelerant and adopting a photooxidation reduction / nickel dual-catalysis system; according to the method, photo-oxidation reduction catalysis and nickel catalysis are combined, challenging alkenyl silicon bonds and carbon-carbon bonds are effectively constructed, conversion which is difficult to complete through a traditional method is achieved, the problems that a traditional transition metal catalytic catalyst is expensive and poor in selectivity are solved, and the method has the advantages of being mild, environmentally friendly, high in reaction efficiency and the like.

This application discloses a high-pressure brine-resistant filtration loss reducer and its preparation method, belonging to the field of oil and gas well drilling engineering. Based on the requirements for resistance to complex salts, especially calcium and magnesium, this application optimizes the molecular structure of the high-pressure brine-resistant filtration loss reducer and introduces an acryloylmorpholine monomer, significantly improving its temperature resistance, stability, and salt tolerance. Since the copolymerization reaction of the selected monomer is relatively simple, the polymerization reaction adopts free radical solution polymerization. The prepared filtration loss reducer has achieved good performance in both laboratory and field application evaluations.

This specification relates to crystalline forms of ((2R,6S)-2,6-dimethylmorpholino)(5-(2,4,5-trifluoro-3-hydroxyphenyl)-1,2,4-oxadiazol-3-yl)methanone, pharmaceutical compositions containing the crystalline forms, and uses of the crystalline forms in the treatment of diseases such as liver disease. Formula (I). (I)