953 results about "Carbodiimide" patented technology

The present invention relates to a polyisocyanate composition comprising at least one bridging cistetrahydrofuran-2,5-diyl-dimethylene unit and at least one isocyanurate, iminooxadiazinedione, allophanate, urethane, urea, uretdione, oxadiazinetrione, carbodiimide, thiourethane, thioallophanate and / or biuret structure and / or comprising at least one bridging trans-tetrahydrofuran-2,5-diyl)-dimethylene unit and at least one isocyanurate, iminooxadiazinedione, allophanate, urethane, urea, uretdione, oxadiazinetrione, carbodiimide, thiourethane, thioallophanate and / or biuret structure.

The invention relates to the technical field of chemical synthesis, and particularly provides a preparation method of a semaglutide side chain, which comprises the following steps: step S1, carrying out reaction on octadecanedioic acid mono-tert-butyl ester and trifluoroacetic acid pentafluorophenyl ester to generate a first intermediate; s2, enabling the first intermediate to react with 1-tert-butyl L-glutamic acid to generate a second intermediate; s3, enabling the second intermediate to react with pentafluorophenyl trifluoroacetate to generate a third intermediate; and S4, carrying out an amidation reaction on the third intermediate and 17-amino-10-oxo-3, 6, 12, 15-tetraoxa-9-aza-heptadecanoic acid, so as to generate a semaglutide side chain, and carrying out an amidation reaction on the third intermediate and 17-amino-10-oxo-3, 6, 12, 15-tetraoxa-9-aza-heptadecanoic acid. According to the preparation method disclosed by the embodiment of the invention, the pentafluorophenyl trifluoroacetate is used as the condensation reagent for two times to activate the carboxylic acid, and the amidation reaction is carried out for two times to construct the amido bond after each activation, so that compared with the traditional carbodiimide and urea positive ion type condensation reagent, the chiral racemization in the condensation process can be effectively avoided, and the yield of the product is improved. The condensation chiral racemization impurity can be lower than 0.3%.

The invention belongs to the technical field of polyurethane pouring sealants, and particularly relates to a hydrolysis-resistant heat-conducting polyurethane pouring sealant and a preparation method thereof. The hydrolysis-resistant heat-conducting polyurethane pouring sealant is prepared from a component A and a component B according to the mass ratio of 100: (18.5-20.5), and the component A comprises the following raw materials: amine ether polyol, modified castor oil, a flame retardant, a heat-conducting filler, a silane coupling agent and a catalyst; the component B is prepared from the following raw materials: polymerized MDI (Diphenyl Diisocyanate), MDI-50 and carbodiimide modified MDI; the amine ether polyol is prepared by carrying out a reaction on 3, 3 '-dimethyl-4, 4'-diaminodiphenylmethane and epoxypropane. The hydrolysis-resistant heat-conducting polyurethane pouring sealant disclosed by the invention not only has good technological operation performance and heat-conducting performance, but also has excellent hydrolysis resistance, and still has good mechanical property and electrical insulation property after being aged; the invention also provides a scientific, reasonable, simple and feasible preparation method.

The invention discloses a preparation method of a cell inflammatory factor adsorbent, which comprises the following steps: mixing styrene, divinyl benzene and hydroxyethyl acrylate, and adding a pore-foaming agent and mesoporous SiO2 nano powder to prepare a porous microsphere carrier; the preparation method comprises the following steps: mixing chitosan and poly (N-isopropylacrylamide) in an acetic acid solution to obtain a temperature-sensitive chitosan hydrogel precursor solution; the preparation method comprises the following steps: activating the surface of a porous microsphere carrier by using 1-ethyl-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide, mixing the activated porous microsphere carrier and a temperature-sensitive chitosan hydrogel precursor solution to obtain a water phase, and assembling, washing and drying in an oil phase to obtain the cell inflammatory factor adsorbent. Through the design of the core-shell structure and the addition of the mesoporous SiO2 nano powder, the temperature response characteristic and the recyclable characteristic are given to the cell inflammatory factor adsorbent, the adsorption capacity of cell factors is also improved, and a new solution is provided for physical adsorption of the cell inflammatory factors.

The invention relates to the field of zipper processing, in particular to a processing method of a fluoride-free DWR waterproof zipper, which sequentially adopts four steps of pretreatment, padding treatment, drying treatment and heat treatment to carry out waterproof processing on the zipper, the fluorine-free DWR waterproof zipper prepared by matching paraffin, polyether modified silicone oil, carbodiimide, nano silicon dioxide dispersion liquid, fatty alcohol-polyoxyethylene ether and diethylene glycol monobutyl ether has the following advantages that 1, the fluorine-free DWR waterproof zipper meets the limitation requirements of Europe and America regulations and various standards on fluorine element, 2, the waterproof grade meets the grade 4.5 or above of standards such as AATCC / ISO / GB / T and the like, and the fluorine-free DWR waterproof zipper has a good waterproof effect. 3, the washing resistance can reach more than 20 times of washing and drying tests; 4, the phenomenon of white grasping in the market is avoided; and 5, the anti-siphon performance can reach 10H without climbing.

The invention belongs to the technical field of lithium ion batteries, and discloses a carbon compatible binder for a silicon-carbon negative electrode of a lithium ion battery and a preparation method and application of the carbon compatible binder for the silicon-carbon negative electrode of the lithium ion battery. Then N-hydroxysuccinimide and 1-ethyl-(3-dimethylaminopropyl) carbodiimide are added to activate carboxyl of sodium carboxymethyl cellulose, finally 1-pyrene methylamine hydrochloride is added, N2 is introduced at the room temperature, and a reaction is performed under stirring. According to the binding agent, sodium carboxymethyl cellulose is used as a main chain to be subjected to amidation reaction with 1-pyrene methylamine hydrochloride, pi-pi conjugation can be formed by introduced pyrene groups and graphite in a silicon-carbon material, the interface compatibility of the binding agent and the silicon-carbon material can be effectively improved, the dispersity and the binding property of the silicon-carbon material are enhanced, and the binding agent can be used for preparing the silicon-carbon material. And the electrochemical performance of the silicon-carbon negative electrode of the lithium ion battery is obviously improved.

The invention provides a preparation method of NMN nano microspheres with high stability, and belongs to the technical field of NMN. The preparation method comprises the steps of NMN pretreatment, primary microsphere preparation, functional microsphere preparation and mixing. The preparation method of the primary microspheres comprises the following steps: adding epsilon-polylysine and glutathione into an ethanol solution, uniformly stirring, adding 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide, and stirring for 28-32 minutes to obtain a mixed solution; adding the pretreated NMN solution into the chitosan solution, then adding the mixed solution, and carrying out heat preservation at 44-50 DEG C for 2.8-3.2 h to obtain primary microspheres; the NMN nano-microsphere prepared by the method disclosed by the invention is good in stability and good in slow release performance.

The invention discloses a multi-active targeting tumor nano-drug with a multimode imaging function and an immune activation effect and a preparation method thereof, and belongs to the technical field of nano-drugs. The preparation method comprises the following steps: coupling inorganic metal-based nano particles / nano drugs with a multimode imaging function or / and targeting active organic biomolecules with specific functions and specific therapeutic drugs through a silane cross-linking agent or a combination of the silane cross-linking agent and a carbodiimide condensing agent; the active targeting type organic-inorganic composite nano-drug aggregate with a multi-mode imaging function and an immune activation effect is prepared. Wherein the inorganic component is a metal-based heterostructure nanoparticle with a multimode imaging function, and the organic component is a bioactive molecule or / and a specific therapeutic drug. The obtained nano-drug aggregate is stable in system, uniform and controllable in size and good in biocompatibility, and has specific targeting, such as specific targeting liver cancer cells.

The invention relates to the technical field of polymethacrylimide foam, in particular to polymethacrylimide wave-absorbing foam and a preparation method thereof. The high-temperature-resistant acrylic resin is prepared from the following raw materials in parts by weight: 55 to 60 parts of methacrylic acid, 45 to 55 parts of methacrylonitrile, 5 to 8 parts of 1-amino octadecane, 0.3 to 0.6 part of N-acrylamide, 0.4 to 0.7 part of N-hydroxysuccinimide ester, 0.5 to 1.2 parts of carbodiimide, 4 to 7 parts of tridecyl methacrylate, 2 to 8 parts of functional filler, 0.35 to 0.40 part of initiator, 0.6 to 0.8 part of foaming agent, 12 to 15 parts of cross-linking agent and 8 to 12 parts of absorbent. 21-35 parts of modified cellulose, 12-25 parts of a biomass-based additive, and 5-18 parts of a dispersant. The prepared polymethacrylimide wave-absorbing foam is relatively good in mechanical property, and shows excellent chemical stability under the conditions of room temperature and extremely low temperature.

The invention provides a composition for forming a coating film which comprises (1) a polymer of a monomer mixture containing monomers represented by the following formulae (A) to (D):(wherein Ta, Tb, Tc, Td, Ua1, Ua2, Ub1, Ub2, Ub3, Qa, Qb, Qc, Ra, Rb, Rc, Rd, An−, m and n are as defined herein), where a ratio of a total of the anionic monomer represented by the above-mentioned formula (A) and the cationic monomer represented by the above-mentioned formula (B) based on total monomers contained in the monomer mixture is 40 mol % or more, and (2) a polycarbodiimide containing a structure represented by the following formula (E):—N═C═N—  (E)a coating film which is a cured product thereof and a process for producing the same, and a cured product and a process for producing the same.

The present invention relates to polyurethane elastomers, obtainable or obtained from the reaction of at least one NCO-terminated prepolymer (A), at least one polyol mixture (B), obtainable or obtained by mixing at least one polyester (B1) having a number average molecular weight (Mn) in the range of 900 g / mol to 3000 g / mol and a hydroxyl functionality of ≥1.7 and ≤4, wherein Mn has been determined by gel permeation chromatography and (B2) at least one carbodiimide (B2), at least one chain extender (C), wherein the polyol mixture (B) was stored for at least 4 weeks at 23° C. after mixing of (B1) and (B2), a process for the manufacturing of those polyurethane elastomers, a kit-of-parts and to the use of those polyurethane elastomers.

The present invention relates to the technical field of biodegradable sheets, and specifically discloses a bamboo crystal fiber filled biodegradable sheet, wherein the raw materials include by mass: 40-60 parts of polylactic acid, 10-20 parts of polybutylene adipate / terephthalate, 40-60 parts of bamboo, 1-5 parts of polyvinyl alcohol, 10-20 parts of glycerol, 1-5 parts of polyaspartic acid, 0.01-0.1 parts of 1-ethyl-(3-dimethylaminopropyl)carbodiimide, 0.01-0.02 parts of 1-hydroxybenzotriazole, 1-2 parts of chitosan, 1-3 parts of antioxidant, 1-3 parts of nucleating agent, 1-3 parts of coupling agent, 1-3 parts of dispersant, and 2-4 parts of talcum powder. The present invention also discloses a preparation method of the above-mentioned bamboo crystal fiber filled biodegradable sheet. The sheet obtained by the present invention has good mechanical properties, excellent aging resistance, and is easily degraded after being abandoned. After 72 days of degradation, its degradation rate can reach more than 60.5%.

The invention relates to the technical field of road crack repairing materials, in particular to a high-strength polyurethane-based road crack repairing material and a preparation method thereof. The composite material is prepared from the following components in parts by weight: 5 to 10 parts of 1, 4-butanediol, 3 to 8 parts of modified nano silicon dioxide, 10 to 20 parts of superfine calcium carbonate, 8 to 12 parts of chopped basalt fiber, 0.5 to 2 parts of 2-(2H-benzotriazole-2-yl)-4, 6-di-tert-pentylphenol, 0.3 to 1.5 parts of carbodiimide and 0.3 to 0.8 part of organic tin-amine composite catalyst. The mechanical strength and the temperature resistance of the material are remarkably improved through a rigid annular structure of dicyclohexylmethane diisocyanate, the material is endowed with elasticity and deformation resistance through a flexible chain segment of polyester polyol, and a repairing layer can bear load impact and can adapt to crack expansion deformation through the synergistic effect of dicyclohexylmethane diisocyanate and polyester polyol; the composite action of the fibers and the filler can disperse stress concentration, reduce the risk of secondary cracking caused by temperature shrinkage or load, and realize long-term stability of crack repair.

The invention provides an antistatic polypropylene material as well as a preparation method and application thereof, and belongs to the technical field of polypropylene materials. The preparation method comprises the following steps: modifying graphene, preparing a graphene / titanium dioxide compound, reacting, and performing extrusion molding. The method comprises the following reaction steps: putting a functionalized graphene / titanium dioxide compound into a reaction container, introducing N, N-dimethylformamide, uniformly stirring, adding modified graphene, dicyclohexylcarbodiimide and 4-dimethylaminopyridine, heating to 73-77 DEG C, carrying out ultrasonic treatment, and after ultrasonic treatment is finished, carrying out heat preservation stirring for 1.8-2.2 hours to obtain the graphene / titanium dioxide composite material. Then heating to 116-123 DEG C at the speed of 1.7-2.3 DEG C / min, stirring for 1.8-2.2 hours while keeping the temperature, after stirring is finished, filtering, washing, freeze-drying, and naturally recovering to room temperature, so as to obtain a graphene-graphene / titanium dioxide compound; the antistatic polypropylene material prepared by the invention is good in antistatic property, excellent in mechanical property and good in aging resistance.

The invention discloses a high-temperature-sintered graining ink as well as a preparation method and application of the high-temperature-sintered graining ink. The invention discloses high-temperature sintered pattern making ink. The ink comprises a component 1, a component 2 and a component 3, wherein the component 1 is prepared from the following raw materials in parts by mass: 30 to 50 parts of waterborne polyurethane resin, 1 to 5 parts of alcohol, 3 to 8 parts of nonionic polyurethane associated thickener, 1 to 5 parts of hand feeling agent, 0.5 to 1 part of wetting agent, 0.5 to 1 part of defoaming agent, 10 to 20 parts of waterborne nano color paste and the balance of deionized water; the component 2 is prepared from the following raw materials in parts by mass: 70 to 80 parts of hydrophilic isocyanate and 20 to 30 parts of propylene glycol methyl ether acetate; and the component 3 is polycarbodiimide. According to the water-based ink, carbodiimide and hydrophilic isocyanate are innovatively matched for use, use of a toxic curing agent aziridine is avoided, and the water-based ink does not contain toxic substances, is small in harm to human bodies and the environment, and meanwhile is high in adhesive force and better in stain resistance and wear resistance.

An adhesive composition (100) comprises: a polyester resin (A) that includes an ester bond which bonds repeating units together and one or more functional groups selected from the group consisting of carboxy groups and carboxylic acid anhydride structures; an epoxy compound (B) in the amount of 1-50 parts by mass with respect to 100 parts by mass of the polyester resin (A); and a cyclic carbodiimide (C) in the amount of 0.1-20 parts by mass with respect to 100 parts by mass of the polyester resin (A).

The invention provides a triazine covalent organic framework film as well as a preparation method and application thereof. A preparation method of a triazine covalent organic framework membrane comprises the following steps: (1) soaking and washing a polyacrylonitrile ultrafiltration membrane in a strong alkali solution to obtain a pretreated ultrafiltration membrane; (2) soaking the pretreated ultrafiltration membrane in a 2-morpholine ethanesulfonic acid buffer solution containing N-hydroxysuccinimide and 1-ethyl-(3-dimethylaminopropyl) carbodiimide, and washing with water to obtain an activated ultrafiltration membrane; (3) soaking the activated ultrafiltration membrane in a first organic phase solution of a polyamine monomer and 1, 4-dioxane, and washing with water; soaking in a second organic phase solution of a polyaldehyde monomer and 1, 4-dioxane to obtain a modified ultrafiltration membrane; and (4) immersing the modified ultrafiltration membrane into a mixed solution composed of a polyamine monomer, a polyaldehyde monomer, acetic acid and 1, 4-dioxane, and cleaning to obtain the triazine covalent organic framework membrane. The triazine covalent organic framework membrane provided by the invention has good separation performance and catalytic oxidation performance.

The invention discloses a high-temperature-resistant drilling fluid lubricant and a production process thereof, and relates to the field of lubricants, and the high-temperature-resistant drilling fluid lubricant comprises the following raw materials in parts by weight: 90-100 parts of biodiesel, 0.8-1.0 part of a surfactant, 0.8-1.0 part of an emulsifier, 12-16 parts of modified alkyl glycoside, 4-6 parts of modified microspheres, and 0.5-0.7 part of a dispersant. The synthesized modified alkyl glycoside comprises an imidazole quaternary ammonium cation, an ester group and a hindered phenol structure, and the oxidation resistance, the high temperature resistance and the corrosion resistance of the drilling fluid lubricant are improved. The synthesized modified microspheres comprise silicon dioxide microspheres and a polymerized carbodiimide structure, so that the hydrolysis resistance, high temperature resistance and wear resistance of the drilling fluid lubricant are improved.

The invention relates to a preparation method of a tumor microenvironment response type nano drug delivery system, which comprises the following steps: forming MnO2 nanoclusters through biomineralization induction under an alkaline condition, modifying HSA nanoparticles, then loading Ce6 through a carbodiimide method, and finally combining with a PD-L1 antibody by adopting a copper-free click chemistry method to obtain nanoparticles HMC and anti-PD-L1. The nanoparticle can be retained in a tumor tissue in a passive targeting manner through an EPR effect, and is decomposed into Mn < 2 + >, O2 and a small molecule drug through a high H2O2 and low pH microenvironment of the tumor tissue, so that the tumor permeability is greatly enhanced, the tumor immunogenicity is enhanced by combining sonodynamic therapy, the release of a tumor specific antigen and the aging of antigen presenting cells are promoted, and the tumor treatment effect is enhanced. The infiltration of tumor T cells is increased, and cold tumors are changed into hot tumors; the nanoparticles can generate O2 in situ at the same time, and the immunosuppressive ability and drug resistance caused by tumor hypoxia are overcome.

The invention discloses a synthesis method of oxyalkyl isourea and application of the oxyalkyl isourea as a free radical alkylation reagent. According to the synthesis method, cheap and rich alcohol compounds and carbodiimide are used as raw materials, oxygen alkyl isourea is synthesized in one step under the mild condition of metal catalysis, the synthesis process is simple and convenient, the yield is high, and hectogram-level large-scale preparation can be achieved. The synthesized oxyalkyl isourea can be used as a free radical alkylation reagent to be applied to a coupling reaction of metal catalysis, so that different alkylate products rich in saturated carbon sequence structures are prepared, and the method has a good application prospect.

The invention relates to the technical field of medical materials, in particular to a self-lubricating PEBAX / TPU material suitable for a medical catheter and a preparation process of the self-lubricating PEBAX / TPU material. 8-15 parts of a self-lubricating modified material; 1.5 to 3 parts of an antioxidant complexing agent; and 3-5 parts of a compatilizer. According to the self-lubricating PEBAX / TPU material, fluorocarbon chains are enriched on the surface to form a long-acting low-friction layer through fluorinated polyethylene and hydrophobic nano silicon dioxide, an external coating is not needed, an antioxidant Irganox 1010 and carbodiimide synergistically inhibit oxidation and hydrolysis, the chemical stability is remarkably improved, the compatibility of PEBAX / TPU is improved through maleic anhydride grafted POE, and the self-lubricating PEBAX / TPU material has the advantages that the self-lubricating performance is good; the rigid gradient of the conduit is optimized by combining a multi-layer co-extrusion process, the protein adsorption resistance of the surface is further enhanced through plasma treatment and perfluorosilane grafting, the integrity of the material is guaranteed through accurately controlled low-temperature extrusion and low-dose gamma sterilization, and the material is more stable and reliable while the biological safety is maintained. The synergistic improvement of the lubrication durability, the mechanical property and the aging resistance is realized.

The purpose of the present invention is to provide a coating composition which is capable of forming a coating film having excellent water tightness resistance, hardness, and weather resistance, and which has a low VOC content. The coating composition is characterized by containing (A) a compound containing an isocyanate reactive group, (B) a polyisocyanate compound, and (C) a carbodiimide group-containing compound, and the solid content concentration of the coating composition is 90 mass% or more. In the coating composition, the carbodiimide group-containing compound (C) has an isocyanate group. In the coating composition, the carbodiimide group-containing compound (C) has an aromatic ring structure.

The invention relates to an anti-blue light optical protective film and a preparation method thereof, belonging to the technical field of anti-blue light optical elements. The protective film comprises 0.2-1.4 parts of a blue light absorber, 9-27 parts of ultrapure water and 1-3 parts of polyvinyl alcohol, and the blue light absorber consists of 0.07-0.09 parts of graphene quantum dots, 110-130 parts of anhydrous ethanol, 0.05-0.07 parts of aminonitrobenzene compounds, 1-2 parts of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and 0.3-0.6 parts of N-hydroxysuccinimide. The preparation method comprises the following steps: mixing polyvinyl alcohol and ultrapure water, swelling and dissolving the mixture in sequence to obtain a polyvinyl alcohol solution; then mixing the polyvinyl alcohol solution and the blue light absorber to obtain a mixed material; and finally coating the mixed material on a glass substrate and then drying the mixture to obtain the anti-blue light optical protective film. The anti-blue light optical protective film prepared by using the blue light absorber will not change the high light transmittance of the optical film itself in the visible light region, and can also absorb harmful blue light.

The invention belongs to the technical field of high polymer materials, and discloses a two-component polyurethane pouring sealant and a preparation method thereof.The two-component polyurethane pouring sealant comprises a component A and a component B. The component A comprises, by weight, 40-60 parts of bio-based polyether polyol, 10-15 parts of boron nitride nanosheets, 5-10 parts of graphene modified epoxy resin, 1-3 parts of a silane coupling agent and 0.5-1.5 parts of a supercritical fluid foaming agent; the component B is prepared from 30 to 50 parts of carbodiimide modified MDI (methylene diphenyl diisocyanate), 10 to 20 parts of dendritic polyurethane cross-linking agent and 2 to 5 parts of nano aluminum hydroxide filler; the mixing ratio of the component A to the component B is (2-3): 1; the invention aims to provide the two-component polyurethane pouring sealant and the preparation method thereof, and through material innovation and process integration, the two-component polyurethane pouring sealant which is high in heat conductivity, environment-friendly, weather-resistant and low in internal stress is provided.

The invention belongs to the technical field of probiotic protection, and discloses a preparation method and application of probiotic-loaded sulfydryl hyaluronic acid-based hydrogel, sulfydryl hyaluronic acid is prepared by taking cysteamine hydrochloride as a substrate, and connection of L-glutamine is further catalyzed through a cross-linking agent, so that the sulfydryl hyaluronic acid-based hydrogel is obtained. The cross-linking agent is a mixture of N-hydroxysuccinimide and 1-ethyl-(3-dimethylaminopropyl) carbodiimide or a mixture of N-hydroxysuccinimide and 1-hydroxybenzotriazole (HOBT), and the cross-linking agent is a mixture of N-hydroxysuccinimide and 1-ethyl-(3-dimethylaminopropyl) carbodiimide and 1-hydroxybenzotriazole (HOBT). The hydrogel prepared by the preparation method disclosed by the invention is used as a probiotic carrier, so that the influence of complex gastrointestinal tracts is effectively resisted, the hydrogel accurately reaches an intestinal injury part and is split, and the targeted intestinal controllable release of probiotics is realized; meanwhile, the L-glutamine is introduced and has a synergistic effect with the probiotics to relieve specific intestinal diseases, so that the L-glutamine can be used as a probiotic supplement for the specific intestinal diseases.

The preparation method comprises the following steps: by taking natural chitosan, epsilon-polylysine and polyphenol as raw materials, firstly, respectively preparing polyphenol modified chitosan and carboxyphenylboronic acid modified polylysine through a carbodiimide coupling method, then, mixing single-component solutions of the polyphenol modified chitosan and the carboxyphenylboronic acid modified polylysine, and then, preparing the antibacterial and antioxidant glycopeptide hydrogel based on the polyphenol. And the antibacterial and antioxidant glycopeptide hydrogel is obtained by virtue of the synergistic effect of the phenolic hydroxyl group-boric acid group dynamic bond and the amino group-carboxyl group. The hydrogel disclosed by the invention has broad-spectrum antibacterial property and glucose response oxidation resistance, has self-healing capability and strong wound adhesion, is excellent in biocompatibility and can be naturally degraded; and the process is simple, convenient and controllable, large-scale production is easy to realize, the hydrogel can be used as a wound dressing for treating chronic difficult-to-heal wounds such as diabetes mellitus in a targeting manner, and integrated nursing of antibiosis, antioxidation, wound adhesion and self-repairing is realized.

The invention discloses a preparation method of a new energy battery pack cover plate flame-retardant PP material, and relates to the technical field of polymer flame-retardant materials. The preparation method comprises the following steps: sequentially adding phosphate esterified polypropylene, a maleic anhydride grafted polyolefin elastomer, polyether block amide, modified nano clay, a B-P-triazinyl charring agent, a carbodiimide type anti-hydrolysis agent, a hindered phenol antioxidant, short carbon fibers, polytetrafluoroethylene micro powder and modified hollow glass beads into a mixing mill; and adding the obtained premix into a twin-screw extruder, extruding, pelletizing, and carrying out injection molding to obtain the flame-retardant PP material for the cover plate of the new energy battery pack. The prepared new energy battery pack cover plate flame-retardant PP material has excellent mechanical performance, flame retardance, thermal stability, dimensional stability and antistatic performance, is light in weight, and has wide application prospects in the fields of new energy automobiles, energy storage systems, consumer electronics, aerospace and industrial equipment.

The invention discloses a functional hydrogel microsphere and a preparation method and application thereof, and relates to the technical field of medicines.The preparation method comprises the steps that a hyaluronic acid methacrylic acid precursor solution and an IL-1beta shRNA adenovirus stock solution are mixed to obtain an Ad-atHAMA precursor solution; preparing the Ad (at) HAMA precursor solution through an oil-in-water micro-fluidic technology to obtain an Ad (at) HAMA microsphere; and sequentially adding the Ad (at) HAMA microspheres, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide into a 2-morpholinoethanesulfonic acid buffer solution, carrying out activating treatment, adding E selectin, and incubating to obtain the functionalized hydrogel microspheres. The functionalized hydrogel microspheres can inhibit a related mechanism of acute spinal cord injury pathological progress and promote neural function repair by targeting adsorption of neutrophil to regulate Nets-triggered innate immune inflammation cascade.

The invention relates to the technical field of batteries, in particular to a low-hydrogen-evolution graphene material for a lead-acid battery and a preparation method thereof.The method comprises the steps that firstly, ethidene diamine is grafted to the surface of graphene oxide through a carbodiimide / active ester method, and aminated graphene is obtained; performing heat treatment in a nitrogen / ammonia gas atmosphere to realize nitrogen doping; compounding with titanium dioxide, and carrying out hydrothermal reaction to form a stable structure; then, sequentially grafting imidazolium silane and perfluorodecyl silane to carry out hydrophobic modification; and finally, stabilization and low-temperature re-nitridation curing are carried out through titanium tetrabutoxide. The graphene material prepared by the method endows the battery with excellent performance, and is low in direct-current internal resistance and high in capacity retention ratio.

The invention discloses an optimized 3-nitrophenylhydrazine derivatization method and an application of the optimized 3-nitrophenylhydrazine derivatization method. According to the optimized method disclosed by the invention, the alpha-keto acid metabolite is subjected to direct derivatization reaction by adopting 3-nitrophenylhydrazine; the method comprises the following steps: carrying out a 3-nitrophenylhydrazine / 1-ethyl-(3-dimethylaminopropyl) carbodiimide / pyridine derivatization reaction on a metabolite only containing carboxyl; a 3-nitrophenylhydrazine derivatization method or a 3-nitrophenylhydrazine / 1-ethyl-(3-dimethylaminopropyl) carbodiimide / pyridine derivatization method or a non-derivatization method is adopted for metabolites only containing carbonyl; a non-derivatization method is adopted for other metabolites. According to the method disclosed by the invention, a specific reaction with carbonyl and carboxyl can be carried out, so that non-targeted metabonomics analysis is enhanced, and metabolites in a biological sample can be more comprehensively analyzed.