75 results about "Thiol group" patented technology

This invention discloses a G4-DNA tetrahedral probe electrode, its preparation method, applications, and application methods. This invention utilizes four DNA strands to self-assemble into a DNA tetrahedral structure based on Watson-Crick hybridization. The DNA tetrahedron and G4 strand can be connected to the electrode based on the interaction between thiol groups and the gold electrode, and complementary base pairing. The addition of the DNA tetrahedron, through the construction of a reasonable probe density, further improves the detection sensitivity. This invention utilizes square wave voltammetry for electrochemical detection of malachite green. The content of malachite green can be determined based on the strength of the current signal of its characteristic peak. Rapid detection of malachite green can be achieved in a short time, with a minimum detection concentration of 3.65 μg / kg, showing potential for on-site detection. Six repeated tests using this electrode yielded almost identical detection signals, indicating that the electrode has good reusability and stability.

The present invention relates to a composition for hard coating and a coating film thereof, the composition comprising: a first silsesquioxane oligomer including at least one first reactive functional group; and a second silsesquioxane oligomer including at least one second reactive functional group, wherein the first reactive functional group is a substituted or unsubstituted epoxy group, and the second reactive functional group is selected from a substituted or unsubstituted amine group, a substituted or unsubstituted thiol group, a substituted or unsubstituted epoxy group, a substituted or unsubstituted (meth)acrylate group, and a substituted or unsubstituted alkenyl group of 2 to 20 carbon atoms.

This invention relates to the field of adhesive technology, and discloses an environmentally friendly biomass-based underwater adhesive, its preparation method, and its applications. The adhesive is prepared by one-step melt copolymerization of three biomass raw materials: lipoic acid, caffeic acid, and cysteine. This system utilizes the ring-opening polymerization of lipoic acid to form a dynamic disulfide bond network providing cohesive force, the catechol groups of caffeic acid to provide various interfacial interactions with the substrate, and the thiol groups of cysteine ​​to simultaneously participate in network construction and inhibit catechol oxidation, thereby synergistically achieving high-strength and durable underwater adhesion. The adhesive achieves an underwater adhesion strength of up to 5.5 MPa on iron sheets, remains stable in various acid, alkali, and salt environments, and can be repeatedly recycled through hot melting. This invention uses entirely bio-based raw materials, employs a simple and non-toxic process, and is suitable for underwater remediation, marine engineering, and other fields.

The Invention relates to a method Method for making a ruthenium catalyst comprising the steps of - Providing an aromatic dithiol substituted on adjacent aromatic carbon atoms with thiol groups, wherein in a first step an aromatic compound substituted with two leaving groups on adjacent aromatic carbon atoms are reacted with alkali trithiocarbonate to obtain an aromatic benzodithiole-thione, which in a subsequent step is reacted / hydrolysed with a base; - providing a zinc dithiolate compound by reacting the aromatic dithiol with a zinc carboxylate in an organic solvent; Reacting the zinc dithiolate compound with a ruthenium compound wherein X1 and X2 are, independently of each other, are anionic ligands and are the same or different; L and L2 are, independently of each other, neutral electron donor ligands and are the same or different; Ar is an aromatic group which may be substituted and that can be bridged with L, if L is an alkoxy group; - Obtaining a ruthenium catalyst of formula 4 or 4a, wherein R1 to R4 are, independently of each other, are selected from hydrogen, halogen, alkyl, aryl, or R.1 with R3, R3 with R4 or R2 with R4 are forming together an aliphatic or aromatic ring.

This invention relates to a fractured solid-phase alkylation material, its preparation, and its application. Using epoxy-based microspheres as a carrier, polyethyleneimine, an acid-fractureable linker arm, and iodoacetic acid-N-succinamide ester are sequentially modified via covalent bonding to prepare the fractured solid-phase alkylation material. This material selectively reacts with thiol groups on proteins, enabling efficient enrichment and processing of proteins in complex biological samples such as cells, tissues, and body fluids. By cleaving the linker arm under acidic conditions, the protein and peptide fragments can be released without damage, potentially providing important technical support for deep proteomic coverage analysis and protein variant analysis.

This application belongs to the field of secondary battery technology, specifically relating to an adhesive, a secondary battery, and an electrical device. The adhesive provided in this application includes a polyacrylic acid backbone; it also includes grafted chains containing hydroxyl groups, grafted chains containing nitrogen atoms, grafted chains containing borate groups, grafted chains containing phosphate ester groups, and grafted chains containing thiol groups. By introducing multiple grafted chains onto the polyacrylic acid backbone, this application enables the adhesive to form a multidimensional synergistic reinforcement structure of "mechanics-electrochemistry," resulting in multidimensional adhesion between the adhesive and silicon-based materials, and improving the conductivity of the adhesive, thereby enhancing the cycle and rate performance of the battery.

A compound for bonding, potting, sealing and / or coating substrates, which is fixable by actinic radiation and heat-curable, comprises the following components: (A) an epoxy-containing compound; (B) a thiol hardener comprising a polythiol with at least three thiol groups directly or indirectly bonded to a cycloaliphatic ring comprising 7 to 15 carbon atoms, which is optionally substituted by one or more C1-C4 alkyl groups; (C) a nitrogen-containing compound as an accelerator; (D) a radical-curable component; (E) a radical photoinitiator; and (F) a stabilizer. Furthermore, a method for bonding, potting, sealing and / or coating substrates is specified, as well as a use of the curable mass for bonding, potting, sealing and / or coating substrates.

This invention relates to a method for preparing electronic-grade hydrofluoric acid. The invention utilizes a microchannel reactor for the fluorine oxidation reaction, significantly reducing fluorine consumption and safety hazards during production. Furthermore, the microchannel reactor enhances the gas-liquid two-phase mass transfer during the oxidation reaction, further improving impurity removal and product quality. The addition of multi-effect distillation to the distillation process not only enables secondary heat utilization but also saves on the use of high-temperature heating media at the bottom of the column, effectively reducing energy consumption. In the modified liquid, DMF serves as the solvent, cobalt nitrate provides cobalt ions, and vinylguanidine provides guanidine functional groups and amino groups. Ammonia and propanethiol are used as plasma gases to introduce amino and thiol groups onto the membrane surface. These groups help improve membrane selectivity, effectively separating metal and non-metal ions, as well as acidic impurities in the raw materials.

A method for producing and recycling a crosslinked photopolymer is disclosed. The method includes mixing reactive thiols, multifunctional alkenes, and a photoinitiator to create a homogeneous mixture that is crosslinked through exposure to light. The method also includes decrosslinking the crosslinked photopolymer through base-catalyzed thiol-disulfide exchange reactions by mixing the crosslinked photopolymer with a reactive thiol, a base catalyst, and a solvent to create a decrosslinked material including recycled thiol oligomers which are reactive. The method further includes removing the base catalyst and the solvent and recrosslinking the recycled thiol oligomers by mixing stoichiometric amounts of the recycled thiol oligomers and a reactive alkene such that a molar ratio between thiol end groups and ene end groups is maintained at 1:1. The method includes adding a photoinitiator and mixing to create a homogeneous mixture, and recrosslinking the homogeneous mixture through exposure to light. The recrosslinked photopolymer includes dynamic disulfide bonds.

Described herein are hyperbranched polythioethers comprising a plurality of terminal functional groups, wherein the terminal functional groups comprise terminal carbon-carbon double bonds or thiol groups, and wherein the hyperbranched polythioethers have a refractive index of at least 1.600 and a number average molecular weight of at least 1000 g / mol and at most 5000 g / mol. In some embodiments, the hyperbranched polythioethers are reacted with a multifunctional compound, wherein the multifunctional compound has complementary terminal functional groups that can react with the hyperbranched polythioethers in a thiol-ene reaction. These curable compositions have a high refractive index of at least 1.660 when cured (when measured at 450 nm) and can be used in optical devices.

The application discloses albumin site-directed modification lipid nanoparticles and preparation and application thereof, and relates to a kind of albumin site-directed modification lipid nanoparticles, which is prepared by synthesizing functionalized low molecular weight polyethylene glycol (PEG) lipid compound-maleimide derivative, together with the nucleic acid delivery lipid composition material usually used, to prepare nucleic acid-loaded lipid nanoparticles, then make the maleimide on its surface couple with the thiol group of albumin, to prepare the lipid nanoparticles with albumin site-directed modification on the surface.The application reduces the immunogenicity generated by the existing mRNA-loaded lipid nanoparticles outer layer covered PEG to the body, improves the related immune organ targeting of the nanoparticles, effectively delivers mRNA to lymph nodes to induce anti-tumor effect, and lays a foundation for further developing it as a new type of vaccine that can activate the immune system to produce anti-tumor effect.

The present invention relates to a composition comprising a solid carrier, an engineered phenylalanine ammonia lyase or fragment thereof immobilized on the surface of the solid carrier, a protective layer protecting the engineered phenylalanine ammonia lyase or fragment thereof by embedding it, and a functional component immobilized on the surface of the protective layer, wherein the functional component immobilized on the surface of the protective layer is a polymer comprising repeating units, each containing at least one amino group and / or thiol group. The present invention also relates to a method for producing the composition and its use.

The application discloses a preparation method of high-purity Fmoc-S-trityl-L-penicillamine and belongs to the field of synthetic chemistry. The method is characterized in that L-penicillamine is used as a starting material, dehydrated with methyl boronic acid to generate a cyclic protective structure, then a thiol group is selectively protected by trityl, and an acid is used to open a ring to obtain an S-trityl-L-penicillamine intermediate; then, in a sodium bicarbonate buffered water / dioxane weak alkaline system, Fmoc-OSu (9-fluorenylmethoxycarbonyl succinimidyl ester) is used to react with the S-trityl-L-penicillamine intermediate to protect an amino group, and racemization is effectively inhibited; finally, the product is refined by recrystallization in an ethyl acetate / n-heptane system to obtain a high-purity end product. The process route is simple and efficient, the conditions are mild, the purification method is unique and effective, the obtained product has high chemical purity and optical purity, good stability, is suitable for large-scale production, and can meet the needs of high-end polypeptide drug synthesis.

To provide a liquid crystal alignment agent that can produce a liquid crystal element exhibiting good liquid crystal alignment properties, low charge accumulation, and rapid residual charge relaxation, as well as a liquid crystal alignment film with high strength. [Solution] A polymer (A) containing structural units derived from a monomer having a substructure represented by formula (1), and a group F which is at least one selected from the group consisting of polymerizable carbon-carbon unsaturated bond-containing groups, isocyanate groups, protected isocyanate groups, cyclic carbonate groups, groups having a ketene structure, groups having a meldrum acid structure, cyclic ether groups, cyclic thioether groups, oxazoline groups, protected hydroxyalkylamide groups, protected thiol groups, and protected secondary amino groups. 1 A liquid crystal alignment agent containing a compound (B) having a total of two or more of in one molecule and lacking an aromatic ring. In formula (1), Ar 1 and Ar 2 This is a divalent aromatic ring group, etc. 1 X is a hydrogen atom, etc. 1 is -O- etc. TIFF2026087169000033.tif20169

This invention discloses a dendritic hybrid branched polymer copper bonding agent and its preparation method, belonging to the field of printed circuit board surface treatment technology. The active ingredient of this bonding agent is a three-dimensional dendritic polymer formed by grafting hybrid branches containing benzimidazole, triazole, and thiol groups onto a branched polyethyleneimine backbone through molecular design. Its aqueous solution contains 0.1%–5.0% of the polymer, 0.5%–10.0% of carboxylic acid, 0.01%–1.0% of surfactant, and the balance water. The preparation method includes polymer synthesis and the preparation of its aqueous solution. The synthesis process involves steps such as amine activation, functional group grafting, and thiol deprotection. This invention achieves ultra-high adhesion between the copper surface and dry film, wet film, or solder resist ink without completely corroding the copper surface, through the synergistic effect of multiple functional groups and the high-density bonding sites of the dendritic structure. Simultaneously, it perfectly maintains the smoothness of the copper surface, significantly reduces high-frequency signal transmission loss, and has the advantages of being environmentally friendly and having good process compatibility, making it particularly suitable for the manufacture of high-frequency, high-speed PCBs.

Disclosed herein are methods and formulations for curling hair, particularly methods, formulations, and kits for curling and / or preventing damage in hair curling. Hair can be curled by treating with a hydroxide-containing agent in combination with one or more active agents, without the need for a thiol group or peroxide-based agent. The active agents can be applied simultaneously with the hydroxide-containing agent to impart curl to the hair. They can be applied as a combined formulation or simultaneously as separate formulations. The active agents and the hydroxide-containing agent can be used together to control the level of curl imparted to the hair as compared to the amount of natural curl, if any, in untreated hair.

A method and compositions of matter for treating or preventing an auto-immune disorder or immune response in a patient, that includes providing a therapeutic dose to the patient of a substituted indole compound having at least one substitution, wherein the substituted indole compound has only one thiol group, and wherein the ring the thiol group is attached to only contains one N or O atom.

A method for producing or processing a protein medium of plant, dairy, animal, or microbial origin, characterized in that, during one or more phases of the production or processing method, the state of the sulfur-containing thiol groups in the medium is controlled or modified by injecting a chosen gas or gas mixture, the reducing or oxidizing nature of which produces a specific effect on said groups. Figure from the abstract: Fig. 1

This invention belongs to the field of electrocatalytic materials technology, specifically disclosing a nitrogen-sulfur co-doped porous carbon material with a vesicle morphology, its preparation method, and its applications. This invention uses cysteine ​​as a ligand and zinc acetate as a metal source, utilizing the amino and thiol groups of cysteine ​​with Zn... 2+ A twisted tetrahedral structure with N,S-bidate chelates was formed to construct a cysteine-zinc complex precursor. After high-temperature calcination in an inert atmosphere and acid leaching to remove the zinc template, a vesicle-shaped nitrogen-sulfur co-doped porous carbon material was obtained. This preparation process is simple, low-cost, and can be scald up, solving the technical pain points of traditional carbon material preparation processes such as severe agglomeration, insufficient exposure of active sites, and loss of heteroatoms. The resulting material is a CO2RR electrocatalyst with high activity, high selectivity, and high stability.

This invention discloses a nanoprobe for detecting thimerophos and an immunochromatographic method for detecting thimerophos. The nanoprobe for detecting thimerophos comprises a labeled antibody complex. This invention utilizes the reaction of dopamine with the thiol group of 4-MBA under alkaline conditions to polymerize a large amount of 4-MBA, providing a stronger SERS signal. Dopamine itself possesses a strong photothermal effect, enhancing the detection signal and thus increasing sensitivity. By adding a TEOS-coated silica shell, the coupling rate with the target antibody is increased, improving the inhibition rate of the immunochromatographic strip. The detection limit for thimerophos using micro Raman spectroscopy is 20.42 ng / mL, and the detection limit using an 808 near-infrared spectroscopy instrument is 23.53 ng / mL. The detection limit of the traditional colloidal gold immunochromatographic method is 82.49 ng / mL. Compared with the traditional colloidal gold immunochromatographic method, the multimodal high-sensitivity immunochromatographic technique using core-shell nanoprobes improves the sensitivity of thimerophos detection by approximately four times.

This invention relates to the field of epoxy resin floor coating technology, and discloses an antistatic epoxy resin floor coating and its preparation method. The invention involves mixing an active diluent, epoxy resin, filler, dispersant, defoamer, and leveling agent to obtain an epoxy emulsion component. A curing agent component containing a water-based epoxy curing agent and a thiol-terminated cationic rosin polymer is then added to obtain the antistatic epoxy resin floor coating. The thiol-terminated cationic rosin polymer contains thiol groups, which can react with the epoxy groups of the epoxy resin, improving the pencil hardness, abrasion resistance, corrosion resistance, and water resistance of the floor coating. The cationic rosin polymer contains quaternary ammonium salt antistatic groups, which, when introduced into the epoxy resin molecular chain, can form a conductive layer on the coating film surface, accelerating charge dissipation and reducing surface resistance, thus providing excellent antistatic properties.

The present invention relates to a coated cooking element (1) for a kitchen utensil or electrical cooking appliance, comprising a metal substrate (2) coated, on at least one face (2a), with at least the following layers in this order, starting from the metal substrate (2): (3a) a sol-gel base layer; (3c) a sol-gel layer obtained from a sol-gel mixture (SG) comprising a metal alkoxide precursor having an aliphatic chain that comprises at least one unsaturated compound and / or is substituted by a thiol group; and (3d) a finishing layer in contact with the layer (3c) and comprising an elastomer silicone obtained from at least one organopolysiloxane bearing reactive vinyl functional groups (-CH=CH2) and at least one other organopolysiloxane bearing reactive hydrosilane functional groups (-Si-H) or reactive thiol functional groups (-S-H).

The present invention relates to a coated cooking element (1) for a cooking article or electric cooking appliance, comprising a metallic substrate (2) coated on at least one face (2a) by a coating (3) consisting of the following layers and in this order from the metallic substrate (2): (3a) a sol-gel base layer obtained from at least one sol-gel mixture (SG) comprising a metal alkoxide precursor having an aliphatic chain comprising at least one unsaturation and / or substituted by a thiol group, (3b) optionally one or more discontinuous intermediate layer(s) which may be decorations,and (3c) a topcoat at least partially in contact with layer (3a) and comprising a silicone elastomer obtained from at least one organopolysiloxane bearing reactive vinyl (-CH=CH2) functions and at least one other organopolysiloxane bearing reactive silyl hydride (-Si-H) or reactive thiol (-SH) functions, wherein, when the silicone elastomer of layer (3c) is obtained from at least one organopolysiloxane bearing reactive thiol (-SH) functions, the metal alkoxide precursor of layer (3a) has an aliphatic chain comprising at least one unsaturation and which may further be substituted by a thiol (-SH) group. Figure for abbreviation: Figure 1,

The present invention relates to a coated cooking element (1) for a cooking article or electric cooking appliance, comprising a metallic substrate (2) coated on at least one face (2a) by at least the following layers and in this order from the metallic substrate (2): (3a) a sol-gel base layer; (3b) optionally one or more intermediate layer(s) which may be decorations;(3c) a sol-gel layer obtained from a sol-gel mixture (SG) comprising a metal alkoxide precursor having an aliphatic chain comprising at least one unsaturation and / or substituted with a thiol group, and (3d) a topcoat in contact with layer (3c) and comprising a silicone elastomer obtained from at least one organopolysiloxane bearing reactive vinyl functions (-CH=CH2) and at least one other organopolysiloxane bearing reactive silyl hydride functions (-Si-H) or reactive thiol functions (-SH), wherein, where the silicone elastomer of layer (3d) is obtained from at least one organopolysiloxane bearing reactive thiol functions (-SH), the metal alkoxide precursor of layer (3c) has an aliphatic chain comprising at least one unsaturation and which may further be substituted with a thiol group thiol (-SH). Figure for abbreviation: Figure 1;

This invention discloses a composite anticoagulant coating, its preparation method, and its applications, belonging to the field of biomedical technology. This invention provides a novel composite anticoagulant coating. Through the following innovative design: using multi-thiol proteins (bovine serum albumin, lysozyme, etc.) as coating substrates, in-situ bio-orthogonal multiple grafting is performed on their thiol groups and amino groups to achieve multifunctionality of anticoagulation, anti-inflammation, and antibacterial properties; through the amyloid aggregation of proteins, a strong target substrate is formed and anchored, resisting blood flow impact and improving coating stability. This invention, through bio-orthogonal design, modifies the thiol groups and amino groups of the coating proteins separately to achieve non-conflicting multifunctionality. Specifically, by modifying the disulfide bonds (-S-S-) and branched amino groups (-NH2) of the proteins, dual active sites of -SH and -GA are constructed for grafting modification, allowing the grafted substances to achieve their multifunctionality of anticoagulation, anti-inflammation, and antibacterial properties without interference.

Process for the preparation of a compound having at least one monothiocarbonic ester group, by reacting, in the presence of a catalyst, - a compound having at least one thiol group, and - a dialkyl carbonate, wherein the catalyst is a salt of a metal selected from group IIIb or IVb of the periodic table.

The present invention relates to a coated cooking element (1) for a kitchen utensil or electrical cooking appliance, comprising a metal substrate (2) coated, on at least one face (2a), with a coating (3) consisting of the following layers, in this order starting from the metal substrate (2): (3a) a sol-gel base layer obtained from at least one sol-gel mixture (SG) comprising a metal alkoxide precursor having an aliphatic chain comprising at least one unsaturation and / or substituted by a thiol group, and (3c) a finishing layer at least partially in contact with the layer (3a) and comprising a silicone elastomer obtained from at least one organopolysiloxane bearing vinyl reactive functions (-CH=CH2) and at least one other organopolysiloxane bearing silyl hydride reactive functions (-Si-H) or thiol reactive functions (-S-H).

Microfibers and nanofibers containing quaternary ammonium polymers and / or interpenetrating polymer networks are provided. For example, a microfiber or nanofiber including a blend, composite, or interpenetrating polymer network is provided. The blend, composite or interpenetrating polymer network can include (i) a polyethyleneimine intermediate, in which the polyethyleneimine intermediate includes a reaction product of reagents including a polyethyleneimine and one or more alkylating agents; at least one of the one or more alkylating agents introduces hydroxyl group functionality or thiol group functionality on the polyethyleneimine intermediate; and nitrogen atoms present in the polyethyleneimine intermediate that are partially or completely quaternized by the one or more alkylating agents; and (ii) a hydroxy-functionalized oligomer, polymer, or copolymer including pendant and / or terminal hydroxy group(s).

This invention relates to the field of silicone rubber technology and discloses a high-strength, low-pressure variable silicone rubber foam material and its preparation method. The invention involves mixing, thinning, sheeting, and foaming ethylene propylene diene monomer (EPDM) rubber, reinforcing agents, modified phenolic resin, methyl vinyl silicone rubber, and foaming agents to obtain a high-strength, low-pressure variable silicone rubber foam material. The modified phenolic resin exhibits a large number of thiol groups that undergo addition reactions with the alkenyl groups of EPDM and methyl vinyl silicone rubber, improving the interfacial properties and compatibility between the two. This results in higher tensile strength and lower compression set in the foam material, exhibiting excellent compression resistance. The modified phenolic resin has a high carbon content, strong ablation resistance, and contains a large number of phosphate ester flame-retardant groups. During combustion, it produces phosphoric acid, promoting the dehydration and charring of the phenolic resin and rubber groups, thus providing excellent cohesive flame retardancy and improving the limiting oxygen index and flame retardant properties of the foam material.