561 results about "Thiol group" patented technology

The invention provides a composite reagent system and a chalcopyrite and sphalerite collecting method, and belongs to the technical field of mineral processing. The composite reagent system comprises a histidine derived functional group collecting agent and a black agent, and the histidine derived functional group collecting agent (containing a total sulfur ester group, a sulfydryl functional group and a side chain imidazole ring) serves as a core and is compounded with the black agent according to a specific proportion to form a target combination-synergistic interaction flotation mechanism. The histidine derivative collecting agent derives high-activity functional groups under the alkaline condition, and after sulfydryl is dissociated, stable chemical bonds are formed by the dissociated sulfydryl and metal ions on the surfaces of the chalcopyrite and the zinc sulfide. The black powder serves as an auxiliary collecting agent, and the collecting capacity of fine-grain or low-activity sulfide minerals is enhanced through chemical adsorption of dithiophosphate radicals and metal ions on the surfaces of the chalcopyrite and the sphalerite. After the two components are compounded, the selective enrichment efficiency of copper-zinc minerals in the flotation process is remarkably improved.

The invention discloses a bionic lignin-based saline-alkali soil improvement material and a preparation method thereof, and belongs to the technical field of high polymer materials and soil improvement. According to the saline-alkali soil improving material, lignin or a derivative thereof serves as a framework, glutenin charge distribution and a dynamic disulfide bond sodium ion response function are simulated, and the sequence and the proportion of chain segments of sulfonic acid groups and quaternary ammonium salt groups are accurately regulated and controlled through step-by-step activation and alternate copolymerization in an aqueous solution polymerization reaction system; positive and negative charges form more uniform sequence distribution, so that the amphipathy of the lignin compound is realized; then, sulfydryl is introduced through click chemistry, linear regulation and control of material viscosity and water solubility are achieved through the chain transfer characteristic of multi-sulfydryl functional groups, and the requirements of different saline-alkali soil application scenes are met. The limitation that a traditional lignin product is single in function is broken through, efficient utilization of lignin is achieved, and the intelligent saline-alkali soil improvement material integrating high stability and pH and Na < + > multi-environment response is developed.

The invention relates to the technical field of immune carrier microspheres, in particular to an immune carrier microsphere constructed by individualized MHC-II combined polypeptide, a vaccine and application of the immune carrier microsphere and the vaccine. A core comprises microspheres constructed by a plurality of MHC-II binding polypeptides, sequences of the MHC-II binding polypeptides are obtained based on HLA gene typing results of an inoculator, and each HLA gene corresponds to at least one high-affinity MHC-II binding polypeptide; a shell is a glucan with sulfydryl or other polymer coating layer, and sulfydryl is used as a coupling group to be connected with an antigen to construct the vaccine. The method has the advantages that competition is avoided, inhibition is generated, a better immune effect is achieved, antibodies of high-titer carrier molecules are not generated, and cross reaction side effects are avoided. The carrier molecular diversity is reduced; side effects are avoided. And antibody immunity and cellular immunity functions are generated. The particle size of the microspheres is controllable, and the immunologic function can be achieved without adjuvants. The preparation process is simple to operate and good in repeatability.

A photocurable silicone composition is disclosed. A cured product of the composition is also disclosed. The photocurable silicone composition comprises: (A) an organopolysiloxane having at least one aryl group with 6 to 12 carbons and at least one alkenyl group with 2 to 12 carbons in a molecule; (B) an organic compound having at least two ether bonds and at least one aliphatic carbon-carbon double bond in a molecule; (C) a thiol group-containing organic compound comprising; (C1) an organic compound having two thiol groups in a molecule, and (C2) an organic compound having at least three thiol groups in a molecule; and (D) a photoradical initiator. The composition generally suppresses crack and delamination of a cured product laminated between two substrates after thermal aging.

The invention relates to a low-smoke halogen-free flame-retardant plastic and a preparation method thereof, and belongs to the technical field of flame-retardant high polymer materials. The flame-retardant plastic is prepared from the following components: 12 to 17 weight percent of magnesium hydroxide superfine powder, 4.5 to 6.2 weight percent of modified flame retardant, 5 to 7 weight percent of flexibilizer, 0.9 to 1.2 weight percent of lubricant, 0.3 to 0.4 weight percent of antioxidant and the balance of PBT (Polybutylene Terephthalate) resin, the modified flame retardant is prepared by the following steps: reacting pentaerythritol with phosphorus oxychloride to prepare hydroxyl-containing polyhedral oligomeric phosphate, esterifying acryloyl chloride and the hydroxyl of the polyhedral oligomeric phosphate to prepare a monoester intermediate, and finally performing click addition on sulfydryl of pentaerythritol tetramercaptoacetate and double bonds of the monoester intermediate. The modified flame retardant interacts with magnesium hydroxide, a stable hollow carbon net is formed in the flame retardant process, and the hollow carbon net has a multi-layer adsorption and filtration effect on smoke particles, so that the release of smoke is reduced, and the smoke density is greatly reduced.

The invention provides a low-cyanide gold leaching agent system and a dump leaching process thereof, and belongs to the technical field of hydrometallurgy. According to the method, a synergistic process of'interface activation, cyanide etching and iron precipitation inhibition 'is constructed by designing a low-cyanide gold leaching agent system. The amino acid auxiliary leaching agent adsorbs the gold surface to weaken lattice energy, so that the etching efficiency of trace cyanide ions is improved; mercapto-containing malic acid is used as a chelating agent, specific mercapto in molecules of the mercapto-containing malic acid and iron ions form an ultrahigh-stability water-soluble complex, generation of ferric hydroxide precipitates is thoroughly blocked, ferrous ions stabilized by the chelating agent are subjected to in-situ oxidation through dissolved oxygen and efficiently regenerated into potassium ferricyanide, and accumulation of free cyanogens in a solution system is eliminated; meanwhile, a chelating agent-iron complex forms a self-buffering pair, the pH of the dump leaching solution is accurately controlled, and secondary precipitation caused by local alkalization is prevented. According to the process, under the synergistic effect that the core chelating agent guarantees permeation stability and the leaching aid accelerates gold dissolution, the heap leaching period is compressed to 45 days.

The invention belongs to the technical field of biomedical materials and regenerative medicine, and relates to collagen-based injectable fiber hydrogel as well as a preparation method and application thereof. According to the injectable fiber hydrogel, methacrylated collagen and dithiothreitol are subjected to a thiol-ene click reaction rapidly under the action of a photoinitiator through illumination, a primary cross-linked network is formed, and the injection and in-situ gel forming requirements are met; then under the conditions that the pH is 6.5-8.0 and the temperature is 30-39 DEG C, collagen molecules are self-assembled into a nanofiber structure, and a bionic network similar to a natural extracellular matrix is obtained. The hydrogel disclosed by the invention has the advantages of rapid gelation, structural biomimetic property and biological activity; residual sulfydryl endows the hydrogel with active oxygen scavenging capacity, so that oxidative stress can be relieved, and immune response can be regulated; the fibrotic structure promotes cell adhesion, migration and tissue regeneration.

The present disclosure relates to the field of object surface finishing. More particularly, the disclosure relates to methods for surface finishing of objects and objects with surfaces finished with such methods. More in particular, the present disclosure relates to the use of organic compounds comprising hydrophilic groups for the surface finishing of objects, in particular using electrically conductive particles. Organic compounds comprising hydrophilic groups may be selected from organic compounds comprising carboxyl groups (e.g., fatty acids); hydroxyl groups (e.g., alcohols); sulfonic, sulfate, sulfone or thiol groups; nitro or nitrate groups; phosphate groups; and / or amine groups.

The invention discloses a preparation method of composite hydrogel for treating infectious wounds, which comprises the following steps: 1, dissolving double-bond modified recombinant collagen and a photoinitiator in deionized water containing vascular endothelial growth factor peptide under a dark condition to obtain a solution A; dissolving sulfhydrylated hyaluronic acid in deionized water containing the vascular endothelial growth factor peptide to obtain a solution B; and 2, mixing the solution A and the solution B, then adding an AgNO3 aqueous solution, carrying out vortex immediately, and then carrying out ultraviolet irradiation to obtain the composite hydrogel for treating infectious wounds. Thiolated hyaluronic acid and double-bond modified recombinant collagen are dissolved in an aqueous solution containing vascular endothelial growth factor peptide, an AgNO3 solution is added to enable Ag < + > and sulfydryl to be crosslinked, then photo-crosslinking is conducted to obtain the composite hydrogel, and the hydrogel has the advantages of being antibacterial, promoting cell proliferation and vascularization and the like and can be used for treating infectious wounds.

The invention relates to the technical field of biomedical material modification, in particular to a sulfhydrylation biocompatible polymer derivative, a preparation method thereof, extracellular matrix imitating injectable in-situ cross-linked hydrogel and application thereof. According to the invention, a pre-acylation strategy is firstly carried out on the biocompatible polymer containing both amino and carboxyl, so that a three-dimensional cross-linked byproduct formed by coupling of self amido bonds is avoided, meanwhile, the number of side chain carboxyl for sulfhydrylation modification is increased, and the accurate and adjustable pre-acylation rate can optimize the physical and chemical properties of the derivative; meanwhile, a disulfide bond is used as a protective precursor, active sulfydryl is introduced through amido bond coupling, self-oxidation of the active sulfydryl in the reaction process is avoided, sulfydryl activity is guaranteed, hydrazine-containing reagents are avoided, safety is further improved, virus residues and immunological rejection risks are avoided, universality is high, and the application prospect is wide; and in combination with a high-concentration preparation method, the method has the advantage of large-scale production, and further widens the industrial application potential.

The invention discloses sulfide solid electrolyte slurry, a high-density sulfide solid electrolyte film and a preparation method thereof, and belongs to the technical field of all-solid-state batteries. The preparation method of the sulfide solid electrolyte slurry comprises the following steps: mixing polythiol, a solvent, a binder and a sulfide solid electrolyte, and stirring to obtain the sulfide solid electrolyte slurry; wherein the polythiol refers to thiol containing more than two sulfydryl groups. The core innovation of the invention lies in that the polythiol is introduced into the sulfide solid electrolyte slurry, and the S-S interaction force between the sulfydryl of the polythiol and the sulfide solid electrolyte is utilized to effectively reduce the distance between the sulfide solid electrolyte and the sulfide solid electrolyte; and the gap between the sulfide solid electrolyte and the sulfide solid electrolyte is reduced, so that the sulfide solid electrolyte film with higher density is prepared.

A bio-electrode composition contains (A) an ionic polymer material, (B) an addition reaction-curable silicone having at least a hydrosilyl group, (C) a platinum-group catalyst, and a solvent. The bio-electrode composition has a water content of 0.2 mass % or less. The solvent includes one or more of an ether solvent, an ester solvent, and a ketone solvent each of which does not contain a hydroxy group, a carboxyl group, a nitrogen atom, or a thiol group. Thus, present invention provides: a bio-electrode composition capable of forming a living body contact layer for a bio-electrode which is excellent in electric conductivity and biocompatibility, light-weight, and manufacturable at low cost, and which does not leave residue on skin after attachment to and peeling from the skin; a bio-electrode including a living body contact layer formed of the bio-electrode composition; and a method for manufacturing the bio-electrode.

There is provided a method of producing a hydrogel. A first polymer functionalized with a homocysteine thiolactone of formula I is reacted to open the ring and obtain a pendant thiol group, wherein any three of the R2 are H, and the remaining R2 is selected from H, C1-C4 branched or linear alkyl, methoxy, ethoxy, and halogen;. (I) The pendant thiol group of the first polymer are then crosslinked with a pendant vinyl group on a second polymer in the presence of a gel former to obtain the hydrogel.

The present invention provides a high-adhesion low-solvent coating and a preparation method thereof, belonging to the field of coatings. The present invention synergistically improves the performance of waterborne coatings through a variety of modification strategies: the phosphate groups of the phosphorylated waterborne polyurethane dispersion form coordination bonds with the substrate to enhance adhesion; the thiol groups react with unsaturated groups to construct a stable crosslinked network. Oxidation and amination of graphene quantum dots improve dispersibility and form hydrogen bonds and crosslinking points to enhance mechanical properties; quaternized cellulose nanocrystals improve compatibility, and double bonds participate in the crosslinked network to enhance structural stability; mercapto- and borate-group modified polydopamine strengthens the network strength and flexibility and improves the interfacial binding force. These mechanisms provide a solid foundation for the development of high-adhesion, low-solvent high-performance coatings.

A polymer composition contains a polyether polymer having a thiol group, in which the polyether polymer having a thiol group has a polyether moiety represented by Formula (1) in a main chain and a structural unit represented by Formula (2) at a terminal, a thiol group content in the polyether polymer containing a thiol group is 8 wt / mass % or more, and the polymer composition further contains a cationic surfactantwhere R1 is a residue obtained by removing a hydrogen atom from a polyvalent amine or polyhydric alcohol having 10 or less carbon atoms, R2 is an alkylene group having 2 to 6 carbon atoms, n is 1 to 200, and m is 2 to 8.

The present invention relates to the technical field of tumor therapeutic drugs, and in particular to a composition of albumin and mercaptododecaborane and its application in the preparation of tumor therapeutic drugs. Its technical solution includes albumin, which is covalently coupled with mercaptododecaborane through the cysteine thiol group at position 34 to construct a nucleation site, and further point-loaded with mercaptododecaborane on the protein through the nucleation effect; the thiol group of the mercaptododecaborane is bound to the thiol group at position 34 of albumin cysteine through a disulfide bond. The present invention forms a nucleus by covalently coupling the free thiol group of albumin with mercaptododecaborane, and utilizes the nucleation effect to point-coat mercaptododecaborane, thereby avoiding the toxicity risks brought by organic solvents or chemical modifications in traditional solubilization methods, and effectively preventing oxidative degradation and free boron ion release, achieving pH-responsive targeted release, and significantly increasing the boron accumulation in tumor tissues, with both high stability, precise drug release, and low systemic toxicity.

A coating composition includes: (a) a polymeric resin including hydroxyl functional groups; (b) a polyisocyanate crosslinker; (c) a thiol including at least 2 active hydrogen groups, where the active hydrogen groups include a thiol group or a combination of a thiol and a hydroxyl group; and (d) a tin-based catalyst. The ratio of the number of moles of thiol to the number of moles of tin in the coating composition is less than or equal to 100:1 and the amount of (d) the tin-based catalyst is less than or equal to 0.25% by weight relative to the total resin solids, and / or the ratio of the number of moles of thiol to the number of moles of tin ranges from 3:1 to 50:1 and the amount of (d) the tin-based catalyst is less than or equal to 0.4% by weight relative to the total resin solids.

The invention belongs to the technical field of analytical chemistry, and particularly relates to application of a sulfydryl modified magnetic material in thallium enrichment and separation, namely a sample pretreatment method for detecting thallium in a water body. The sulfydryl modified magnetic material is prepared by grafting cystamine to the surface of a magnetic material through amidation reaction and then opening a disulfide bond by using a reducing agent to expose sulfydryl. It is found that the sulfydryl modified magnetic material can rapidly and efficiently conduct selective enrichment on trace thallium ions in a large-volume water sample, the sulfydryl modified magnetic material is used for pretreatment of thallium detection such as ICP-MS, AAS and ICP-OES and pretreatment matched with a portable on-site thallium detector, a more accurate thallium content detection result can be obtained, the detection sensitivity is greatly improved, and the method is suitable for large-scale popularization and application. Meanwhile, operation is easy, treatment time is short, waste liquid and waste gas are not generated, and cost is low.

The invention discloses twelve-hole polyester staple fiber and a preparation method thereof, and relates to the technical field of polyester. The preparation method comprises the following steps: reacting 3-thiophene isocyanate with phenol to prepare thienyl blocked isocyanate; carbon nanotubes are carboxylated by sulfuric acid and nitric acid and then react with 3-aminothiophene to prepare thienyl carbon nanotubes, and thiophene and thienyl blocked isocyanate are subjected to oxidative polymerization reaction on the surfaces of the thienyl carbon nanotubes to prepare polythiophene carbon nanotubes; the preparation method comprises the following steps: reacting N, N-dimethyl-n-octylamine with epoxy chloropropane to prepare functional diol; the preparation method comprises the following steps: carrying out polycondensation on ethylene glycol, terephthalic acid, 2-vinyl terephthalic acid and functionalized diol to prepare pre-modified polyester; carrying out a reaction on the pre-modified polyester and methoxyl polyethylene glycol sulfydryl to prepare modified polyester; and carrying out melt spinning on the modified polyester and the polythiophene carbon nanotubes to obtain the finished product fiber. The twelve-hole polyester staple fiber prepared by the method has the effects of resisting bacteria, absorbing moisture, resisting static electricity and being good in mechanical property.

This invention provides a method and kit for detecting arsenic content using a thiol-modified MIL(53)-Fe metal-organic framework. Utilizing the enzyme-mimicking properties of the iron-based metal-organic framework, combined with the strong coordination effect of As(III) with thiol groups and the binding interaction between As(V) and iron, quantitative analysis of different forms of arsenic in water is achieved by visible light spectrophotometry. The linear range for As(III) detection in water is 0.2–1.6 ppb, with a detection limit of 0.172 ppb; the linear range for As(V) detection is 0.1–1.0 ppb, with a detection limit of 0.095 ppb. Furthermore, common coexisting elements in water do not significantly interfere with the quantitative detection of arsenic. Compared to existing arsenic speciation detection technologies, this invention offers advantages such as ease of operation, high sensitivity, and low cost, fully meeting the needs of relevant departments for online water quality monitoring and control.

Provided are compounds for inhibiting prostaglandin E synthase 3 (PTGES3) along with methods of treating prostate cancer by administering such compounds to a subject. The PTGES3 inhibitors has a moiety that can form a covalent bond with a thiol group, for example, of a cysteine residue of PTGES3. By forming such a bond, the inhibitor can block a site on PTGES3 that is involved with the interaction between PTGES3 and androgen receptor (AR). Since the progression of prostate cancer can depend on AR activity, blocking the interaction of PTGES3 and AR can be used to treat prostate cancer.

The application provides a dithiol modified copolymer and a preparation method and application thereof, and particularly relates to the technical field of lithium batteries. In the dithiol modified copolymer, the copolymer is a branched diene-vinyl pyridine copolymer, which is mainly obtained by copolymerization of branched diene and vinyl pyridine. The dithiol modified copolymer provided by the application has a main chain composed of flexible branched diene units, which endows the copolymer with a good elastic skeleton structure; vinyl pyridine is introduced as a functional monomer, so that a pyridine group is formed on the side chain of the copolymer; a dithiol compound introduces a thiol group (-SH) to the copolymer, and finally, the dithiol modified copolymer has a flexible main chain structure, and the side chain simultaneously contains a pyridine group and a thiol group, and has good elasticity and functional characteristics.

This invention belongs to the field of environmental chemistry and relates to a method for quantitatively analyzing the concentrations of cystine and cysteine ​​in a mixed solution. Based on the theoretical characteristics of the reaction between the disulfide bond in cystine, a representative amino acid, and the thiol group in cysteine, and persulfate, this invention expands the detection capability of the traditional 5,5-dithio-bis-(2-nitrobenzoic acid) (DTNB), providing support for the quantitative analysis of cystine and cysteine ​​concentrations and the study of their transformation processes.

The invention relates to the technical field of polyurethane foam preparation, and discloses polyurethane foam for a heat insulation strip and a preparation method of the polyurethane foam. The polyurethane foam is prepared from the following raw materials in parts by weight: 40 to 60 parts of polytetrahydrofuran ether glycol, 10 to 15 parts of modified monomer, 1 to 5 parts of ethylenediamine, 1 to 5 parts of hydroxyethyl methylacrylate, 60 to 80 parts of diphenylmethane diisocyanate, 3 to 5 parts of modified filler, 0.3 to 0.5 part of benzophenone and 10 to 15 parts of n-pentane. Double bonds on hydroxyethyl methylacrylate can react with sulfydryl on the surface of the modified filler, then a cross-linked network is formed in the material, the foam structure is more uniform and stable by limiting molecular chain movement and reducing gas diffusion and heat conduction paths, and the closed-cell rate of the foam can be increased by matching with a multi-layer coated hollow structure of the modified filler, so that the thermal conductivity of the foam is improved. And gas diffusion is reduced, so that the long-term stable heat insulation effect is maintained.

One embodiment of the nonlinear light-absorbing material disclosed herein comprises a compound represented by the following formula (1) as its main component. In formula (1), R 1 ~R 10 Each group can be a hydrogen atom, halogen atom, saturated hydrocarbon group, haloalkyl group, unsaturated hydrocarbon group, hydroxyl group, carboxyl group, alkoxycarbonyl group, aldehyde group, acyl group, amide group, nitrile group, alkoxy group, acyloxy group, thiol group, alkylthio group, sulfonic acid group, acylthio group, alkylsulfonyl group, sulfonamide group, primary amino group, secondary amino group, tertiary amino group, or nitro group.

The invention provides responsive release polypeptide hydrogel. The hydrogel comprises a gel product of a raw material composition containing the following raw material components: (A) a biocompatible polymer containing at least two sulfydryl groups; (B) a matrix metalloproteinase substrate polypeptide; (C) a compound containing a phenolic hydroxyl group structure; (D) a cross-linking agent; and (E) water; the sequence of the matrix metalloproteinase substrate polypeptide is at least one of the following sequences (b1) to (b2): (b1) Cys-Pro-Leu-Gly-Val-Arg-Gly-Arg-Gly-Asp-Ser, (b2) Cys-Pro-Leu-Gly-Val-Arg-Gly-Asp-Ser, (b3) Cys-Pro-Leu-Gly-Val-Arg-Gly (b2), Dnp-Pro-Leu-Gly-Met-Trp-Ser-Arg-C-ys, and (b3), Dnp-Pro-Leu-Gly- The responsive release polypeptide hydrogel can release polypeptide in a cell microenvironment to promote tissue regeneration and repair, and can be used for preparing muscle-bone healing promoting materials and treating ligament injury diseases such as rotator cuff injury.

The purpose of this invention is to provide a polypeptide with anti-tuberculosis activity, its preparation method, and its application, belonging to the field of biotechnology. The preparation method of the polypeptide of this invention includes the following steps: (1) preparing a linear polypeptide, the sequence of which is shown in SEQ ID NO:1; (2) subjecting the thiol groups of two cysteine ​​residues in the linear polypeptide to a dehydration condensation reaction with 1,3-dihydroxymethylurea to obtain the polypeptide. The polypeptide of this invention has low cytotoxicity and good anti-tuberculosis effect.

The present invention discloses a high-oil-absorbing material, preparation method, and application of a styrene-butadiene-styrene block copolymer. Specifically, the crosslinked polymer is obtained by a light-promoted thiol-ene click reaction between the olefins of the photocrosslinked styrene-butadiene-styrene block copolymer and the thiol groups of a polythiol crosslinker. This method has the advantages of simple and convenient preparation, readily available raw materials, high oil absorption capacity and selectivity, floating on water before and after adsorption, good reusability, and low cost.

A composition is described comprising an epoxy resin that is a liquid at 25°C; an epoxy resin comprising constrained aromatic rings; an epoxy curative comprising at least two thiol groups; and a photobase. The composition is suitable for use as a coating, structural adhesive, or molded part. Also described are methods and articles.

This invention discloses a G4-DNA tetrahedral probe electrode, its preparation method, applications, and application methods. This invention utilizes four DNA strands to self-assemble into a DNA tetrahedral structure based on Watson-Crick hybridization. The DNA tetrahedron and G4 strand can be connected to the electrode based on the interaction between thiol groups and the gold electrode, and complementary base pairing. The addition of the DNA tetrahedron, through the construction of a reasonable probe density, further improves the detection sensitivity. This invention utilizes square wave voltammetry for electrochemical detection of malachite green. The content of malachite green can be determined based on the strength of the current signal of its characteristic peak. Rapid detection of malachite green can be achieved in a short time, with a minimum detection concentration of 3.65 μg / kg, showing potential for on-site detection. Six repeated tests using this electrode yielded almost identical detection signals, indicating that the electrode has good reusability and stability.