4272 results about "Water soluble polymers" patented technology

The present invention relates to novel modified proteins having N-terminal free thiols that can be produced by recombinant methods and are ready for further chemical derivatization. In particular, the invention relates to erythropoietin conjugate compounds having altered biochemical, physiochemical and pharmacokinetic properties. More particularly, one embodiment of the invention relates to erythropoietin conjugate compounds of the formula:

(M)_n-X-A-cys-EPO   (I)

where EPO is an erythropoeitin moiety selected from erythropoietin or an erythropoietin variant having at least one amino acid different from the wild-type human EPO, or any pharmaceutical acceptable derivatives thereof having biological properties of causing bone marrow cells to increase production of red blood cells; cys represents the amino acid cysteine and occurs at position −1 relative to the amino acid sequence of the erythropoietin moiety; A indicates the structure of the residual moiety used to chemically attach X to the thiol group of −1Cys; X is a water soluble polymer such as a polyalkylene glycol or other polymer; M is an organic molecule (including peptides and proteins) that increases the circulating half-life of the construct; and N is an integer from 0 to 15.

Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates, and methods of administering compositions comprising the conjugates to a patient.

An encapsulation material, intended for use in encapsulated electrophoretic displays, comprises the coacervation product of a polyanionic polymer having a vinyl main chain and a plurality of anionic groups bonded to the main chain, with a cationic or zwitterionic water-soluble polymer capable of forming an immiscible second phase on contact with the polyanionic polymer.

There is provided the reagent layer composition that can substantially reduce the measurement bias arising from hematocrits. The addition of fatty acid (4-20 carbons) and quaternary ammonium salt to a commonly used reagent layer composition composed of an enzyme, an electron transfer mediator, and several water soluble polymers not only reduce the hematocrit level-dependent bias but also provide very stable performance for an extended period of time. Disclosed are also various types of sub microliter sample volume electrochemical biosensors that are suitable to use with the reagent layer composition of present invention.

Conjugates of an IL-2 moiety and one or more nonpeptidic, water-soluble polymers are provided. Typically, the nonpeptidic, water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, methods of administering compositions to an individual, nucleic acid sequences, expression systems, host cells, and methods for preparing IL-moieties.

A disintegrant assisted controlled release device is disclosed. The device is a combination of a swelling disintegrant or super-disintegrant and water insoluble polymer or water soluble polymer, or both, and one or more water soluble or water insoluble active pharmaceutical ingredient(s). The said device is stabilized by a humectant or trehalose.

A filtering apparatus for use in a hydrocarbon producing well for reducing water production therein includes a filtering medium treated with a relative permeability modifier such that the relative permeability modifier reduces the permeability of the filtering medium if the relative permeability modifier contacts water production. The relative permeability modifier may be used to treat a metal portion of the filtering medium in the case of a wire wrap screen or a wire mesh screen or may be use treat a metal portion or the prepacked component of a prepacked screen. The relative permeability modifier may be a polymer of at least one hydrophilic monomer and at least one hydrophobically modified hydrophilic monomer, a hydrophobically modified polymer, a hydrophobically modified water-soluble polymer, hydrophobically modified copolymers thereof or the like.

Articles such as medical devices are selectively coated with a lubricious coating. A temporary coating, formed from an aqueous solution of a water-soluble polymer of low to moderate molecular weight, is painted onto those portions of the article which are to remain free of any coating in the final product. Then, the entire article is coated with a material which forms a lubricious coating. The article is then soaked in water to loosen the coatings at the locations at which the temporary coating was applied. The coatings are cleanly removed from those locations, leaving an article with a lubricious coating in some portions, and which is uncoated in the remaining portions. The process can be used in coating portions of catheters, surgical gloves, contact lenses, and any other articles which require a lubricious coating only on a portion of the surface of the article.

The present invention relates to water-soluble films incorporating anti-tacking agents and methods of their preparation. Anti-tacking agents may improve the flow characteristics of the compositions and thereby reduce the problem of film adhering to a user's mouth or to other units of film. In particular, the present invention relates to edible water-soluble delivery systems in the form of a film composition including a water-soluble polymer, an active component selected from cosmetic agents, pharmaceutical agents, vitamins, bioactive agents and combinations thereof and at least one anti-tacking agent.

The present invention relates to a polymeric drug conjugate with one or more biologically active agents conjugated via an enzymatically cleavable linker to either a regular repeating linear unit comprising a water soluble polymer segment and a multifunctional chemical moiety, or a branched polymer comprising two or more water soluble polymer segments each bound to a common multifunctional chemical moiety, as well as to methods of making such conjugates. The present invention is also directed to pharmaceutical compositions comprising such conjugates and to the use of such conjugates to treat pathological conditions.

The present invention provides water-soluble, polymer derivatives having a thiol-selective terminus suitable for selective coupling to thiol groups, such as those contained in the cysteine residues of proteins.

The present invention relates to a dissolvable article in the form of a porous dissolvable solid structure, comprising from about 23% to about 75% surfactant; wherein the surfactant has an average ethoxylate/alkyl ratio of from about 0.001 to about 0.45; from about 10% to about 50% water soluble polymer; and from about 1% to about 15% plasticizer; and wherein the article has a density of from about 0.05 g/cm³ to about 0.25 g/cm³.

An oral care article in the form of a flexible porous dissolvable solid structure, comprising: from about 1% to about 70% surfactant; from about 10% to about 70% water soluble polymer, from about 0% to about 25% plasticizer; and wherein said article comprises an oral care component and has a density of from about 0.03 g/cm³ to about 0.5 g/cm³.

The present invention is directed to branched reactive water-soluble polymers comprising at least two polymer arms, such as poly(ethylene glycol), attached to a central aliphatic hydrocarbon core molecule through heteroatom linkages. The branched polymers bear at least one functional group for reacting with a biologically active agent to form a biologically active conjugate. The functional group of the branched polymer can be directly attached to the aliphatic hydrocarbon core or via an intervening linkage, such as a heteroatom, -alkylene-, —O-alkylene-O—, -alkylene-O-alkylene-, -aryl-O—, —O-aryl-, (—O-alkylene-)_m, or (-alkylene-O—)_m linkage, wherein m is 1–10.

Fabric conditioning compositions such as those that are typically provided to the consumer in liquid form are disclosed. The fabric care conditioning composition is in the form of a porous, dissolvable substrate. The substrate comprises diester quaternary ammonium compound, water soluble polymer and Remaining Water. The substrate may take any number of suitable shapes.

The gel preparation has the merits of both solution and gel. By means of the combination of different type poloxamers, ocular in-situ gel preparation containing medicine and water soluble polymer supplementary material is prepared. The preparation contains poloxamer 407 and poloxament 188 as well as water soluble polymer supplementary material less than 3%. The preparation has proper phase conversion temperatur and may form gel on the surface of cornea of living body after being applied in liquid state at room temperature. The present invention can delay the disappearance of medicine and raise the biological utilization in some local area and is suitable for various ocular medicines.

A hollow fiber microfiltration (MF) membrane is provided. The casting solution used to make this membrane includes a fiber-forming polymer having a degree of polymerization greater than about 1000, a water-soluble polymer, an anhydride with about 2 to 12 carbon atoms, and a solvent. The membrane is formed by mixing and heating these components to form a viscous dope and then extruding the dope through an annular orifice to form a hollow fiber MF membrane. The hollow fiber membrane is then fed through a coagulation bath and two leaching baths. The membrane is especially useful for filtering liquids, such as wine and juice, so as to remove bacteria, gel, and solid particles from the liquids.

A molded component or article for biomedical use is prepared from a crosslinkable non-water-soluble polymer which when crosslinked and saturated with water forms a hydrogel. The polymer is formulated as a composition containing a non-aqueous diluent in addition to the polymer, the diluent being present in a volumetric proportion that is substantially equal to the volumetric proportion of water in the hydrogel that would be formed when the polymer is crosslinked and saturated with water. The composition is cast in a mold where the composition is exposed to conditions that cause crosslinking to occur by a reaction to which the non-aqueous diluent is inert. The crosslinking reaction produces a molded non-aqueous gel which is then converted to a hydrogel by substituting an aqueous liquid such as water or physiological saline for the non-aqueous diluent. The use of a molding composition whose curing consists essentially entirely of crosslinking results in a molding process that entails little or no shrinkage, and dimensional integrity is maintained up through the formation of the hydrogel by using the non-aqueous diluent in essentially the same volumetric proportion as water in the hydrogel.