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Ocular in-situ gel preparatino with proper phase conversion temperature

A phase transition temperature, in-situ gel technology, which is used in medical preparations with non-active ingredients, sensory diseases, drug combinations, etc., to achieve the effects of improving local bioavailability, delaying drug elimination, and facilitating medication

Inactive Publication Date: 2002-11-06
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Based on all the retrieved literature, it has not been reported that different types of poloxamers are used in combination to prepare an ophthalmic in situ gel with a suitable phase transition temperature

Method used

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  • Ocular in-situ gel preparatino with proper phase conversion temperature
  • Ocular in-situ gel preparatino with proper phase conversion temperature
  • Ocular in-situ gel preparatino with proper phase conversion temperature

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Timolol maleate ophthalmic in situ gel; take timolol maleate 0.25%, brogeramine 0.02%, 21% poloxamer 407, 10% poloxamer 188, sterile isotonic Phosphate buffer solution (pH7.4) to full volume. The drug and benzalkonium chloride are dissolved in water, and the poloxamer is slowly added to the above solution under ice bath and stirring conditions, and stored under low temperature refrigeration until a clear solution is formed.

Embodiment 2

[0033]Ofloxacin ophthalmic in situ gel with hyaluronic acid; take ofloxacin 0.3%, sodium hyaluronate 0.2%, 21% poloxamer 407, 10% poloxamer 188, sterile Isotonic phosphate buffer solution (pH7.4) to full volume. Sodium hyaluronate was dissolved in the buffer solution, and then ofloxacin ophthalmic in situ gel was prepared according to the process of Example 1.

Embodiment 3

[0035] Acyclovir Ophthalmic In Situ Gel Containing Carbomer; Take Acyclovir 2%, Brogeramine 0.02%, Carbomer 934P 0.2%, Mannitol 5%, Poloxamer 407 22%, 10 % Poloxamer 188, sterile water to full volume. Disperse carbomer in water, adjust the pH to neutral with sodium hydroxide solution, add drugs, benzalkonium chloride and mannitol, slowly add poloxamer to the above solution under ice bath and stirring conditions, and store in low temperature refrigeration until a clear solution is formed.

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Abstract

The gel preparation has the merits of both solution and gel. By means of the combination of different type poloxamers, ocular in-situ gel preparation containing medicine and water soluble polymer supplementary material is prepared. The preparation contains poloxamer 407 and poloxament 188 as well as water soluble polymer supplementary material less than 3%. The preparation has proper phase conversion temperatur and may form gel on the surface of cornea of living body after being applied in liquid state at room temperature. The present invention can delay the disappearance of medicine and raise the biological utilization in some local area and is suitable for various ocular medicines.

Description

Technical field: [0001] The invention relates to a novel dosage form of ophthalmic medicine-an ophthalmic in-situ gel preparation with a suitable phase transition temperature. Specifically, it is a temperature-sensitive polymer aqueous solution, which is in a liquid state at room temperature, and quickly forms a gel on the corneal surface after administration in the form of eye drops, thereby delaying drug elimination and improving local bioavailability. Background technique: [0002] Many eye diseases, such as glaucoma, corneal infection and inflammation, etc., will eventually lead to serious consequences of blindness if they are not treated in time and effectively. The use of appropriate drugs can effectively control the disease, relieve or eradicate symptoms, and choosing a reasonable dosage form to ensure the safety and effectiveness of the drug and make the patient willing to accept it is an important issue in drug treatment. [0003] According to statistics, solution-...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/10A61K47/36A61P27/02
Inventor 魏刚郑俊民
Owner SHENYANG PHARMA UNIVERSITY
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